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Additional Topics Details for this Page
Article Count
- 12
Cumulative Knowledge
- 34
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Quick Summary: Current access displays 2 out of 11 associated Diseases
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View the Evidence: Substances
High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer.
Click here to read the entire abstract
Pubmed Data
: J Natl Cancer Inst. 2007 Mar 21;99(6):475-86. PMID:
17374837
Article Published Date
: Mar 21, 2007
Study Type
: Human Study
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Flaxseed : CK(275) : AC(57)
,
Lignans : CK(110) : AC(31)
,
phytoestrogens : CK(699) : AC(210)
Diseases
:
Breast Cancer : CK(2361) : AC(621)
,
Breast Cancer: Prevention : CK(525) : AC(73)
Additional Keywords
:
Risk Reduction : CK(1909) : AC(196)
There is a modest inverse association between lignan excretion and uterine fibroid risk.
Click here to read the entire abstract
Pubmed Data
: Cytotechnology. 2005 Jan;47(1-3):97-105. PMID:
16960173
Article Published Date
: Jan 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Daidzein : CK(965) : AC(28)
,
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Equol : CK(33) : AC(10)
,
Genistein : CK(450) : AC(174)
,
Isoflavones : CK(627) : AC(124)
,
Lignans : CK(110) : AC(31)
Diseases
:
Fibroids: Uterine : CK(46) : AC(16)
Enterolactone and enterodiol have been shown to negate the tumor-stimulating effect of genistein in a mouse model of breast cancer.
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2007 Jul;51(7):845-56. PMID:
17579892
Article Published Date
: Jul 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Flaxseed : CK(275) : AC(57)
,
Genistein : CK(450) : AC(174)
,
Isoflavones : CK(627) : AC(124)
,
Lignans : CK(110) : AC(31)
,
phytoestrogens : CK(699) : AC(210)
,
Soy Protein : CK(2307) : AC(56)
Diseases
:
Breast Cancer : CK(2361) : AC(621)
,
Breast Cancer: Prevention : CK(525) : AC(73)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
,
Antiproliferative : CK(1058) : AC(775)
Flaxseed and its lignans have potent antiestrogenic effects on estrogen receptor-positive breast cancer and may prove to be beneficial in breast cancer prevention strategies in the future.
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2007 Feb 1;13(3):1061-7. PMID:
17289903
Article Published Date
: Feb 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Flaxseed : CK(275) : AC(57)
,
Lignans : CK(110) : AC(31)
Diseases
:
Breast Cancer : CK(2361) : AC(621)
,
Breast Cancer: Prevention : CK(525) : AC(73)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
,
Antiproliferative : CK(1058) : AC(775)
,
Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)
Flaxseed lignan attenuates high-fat diet-induced visceral and liver fat accumulation and induces adiponectin expression in mice.
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2008 Sep;100(3):669-76. Epub 2008 Feb 6. PMID:
18252024
Article Published Date
: Sep 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Flaxseed : CK(275) : AC(57)
,
Lignans : CK(110) : AC(31)
,
Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)
Diseases
:
Abdominal Obesity (Midsection Fat) : CK(348) : AC(53)
,
Adiponectin: Low Levels : CK(88) : AC(25)
,
Fatty Liver : CK(493) : AC(122)
Pharmacological Actions
:
Anti-Adipogenic : CK(91) : AC(44)
The lignan precursor from flaxseed known as secoisolariresinol diglucoside (SDG) may inhibit the progression of lupus nephritis.
Click here to read the entire abstract
Pubmed Data
: Lupus. 2000;9(6):429-36. PMID:
10981647
Article Published Date
: Jan 01, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Flaxseed : CK(275) : AC(57)
,
Lignans : CK(110) : AC(31)
,
Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)
Diseases
:
Lupus Nephritis : CK(64) : AC(12)
Dietary lignans reduce breask cancer risk.
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2007 Jul;51(7):857-66. PMID:
17576639
Article Published Date
: Jul 01, 2007
Study Type
: Review
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Lignans : CK(110) : AC(31)
Diseases
:
Breast Cancer: Prevention : CK(525) : AC(73)
Pharmacological Actions
:
Chemopreventive : CK(1528) : AC(382)
Lignans and flavonoids act as aromatase inhibitors in human preadipocytes.
Click here to read the entire abstract
Pubmed Data
: J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):205-12. PMID:
8049151
Article Published Date
: Aug 01, 1994
Study Type
: In Vitro Study
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Flavonoids : CK(909) : AC(289)
,
Lignans : CK(110) : AC(31)
Diseases
:
Breast Cancer : CK(2361) : AC(621)
,
Estrogen Dominance : CK(106) : AC(37)
Pharmacological Actions
:
Aromatase Inhibitors : CK(33) : AC(23)
Mammalian lignans and the soy isoflavone genistein inhibit breast cancer via down-regulation of estrogen production.
Click here to read the entire abstract
Pubmed Data
: J Steroid Biochem Mol Biol. 2005 Apr;94(5):461-7. Epub 2005 Mar 16. PMID:
15876411
Article Published Date
: Apr 01, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Genistein : CK(450) : AC(174)
,
Lignans : CK(110) : AC(31)
Diseases
:
Breast Cancer : CK(2361) : AC(621)
,
Estrogen Dominance : CK(106) : AC(37)
Pharmacological Actions
:
Aromatase Inhibitors : CK(33) : AC(23)
Mammalian lignans formed as a byproduct of flaxseed consumption inhibit prostate cancer cell growth.
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2001 Nov-Dec;21(6A):3995-9. PMID:
11911282
Article Published Date
: Nov 01, 2001
Study Type
: In Vitro Study
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Flaxseed : CK(275) : AC(57)
,
Lignans : CK(110) : AC(31)
Diseases
:
Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
Mammalian lignans inhibit the growth of estrogen-independent human colon tumor cells.
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 1998 May-Jun;18(3A):1405-8. PMID:
9673348
Article Published Date
: May 01, 1998
Study Type
: In Vitro Study
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Flaxseed : CK(275) : AC(57)
,
Lignans : CK(110) : AC(31)
Diseases
:
Colon Cancer : CK(895) : AC(233)
Pharmacological Actions
:
Antiproliferative : CK(1058) : AC(775)
The mammalian phytoestrogens enterodiol and enterolactone may protect against breast and prostate cancer through hormone modulating activities.
Click here to read the entire abstract
Pubmed Data
: J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):289-309. PMID:
12270221
Article Published Date
: Sep 25, 2002
Study Type
: Review
Additional Links
Substances
:
Enterodiol : CK(34) : AC(12)
,
Enterolactone : CK(301) : AC(10)
,
Flaxseed : CK(275) : AC(57)
,
Lignans : CK(110) : AC(31)
,
phytoestrogens : CK(699) : AC(210)
,
Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)
Diseases
:
Breast Cancer : CK(2361) : AC(621)
,
Cancers: All : CK(9062) : AC(2869)
,
Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions
:
Aromatase Inhibitors : CK(33) : AC(23)
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