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Flavonoids

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Article Count - 289
Cumulative Knowledge - 919

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View the Evidence: Substances

The intake of flavonoids, particularly from solid fruit, is associated with better pulmonary function in patients with COPD.

Click here to read the entire abstract

Pubmed Data : Am J Respir Crit Care Med. 2001 Jul 1;164(1):61-4. PMID: 11435239

Article Published Date : Jul 01, 2001

Study Type : Human Study

Additional Links

Substances : Catechin : CK(403) : AC(130), Flavonoids : CK(909) : AC(289), Fruit: All : CK(1836) : AC(472)

Diseases : Chronic Obstructive Pulmonary Disease : CK(269) : AC(42)

The Mediterranean diet, which includes a combination of antioxidant compounds and flavonoid-rich foods, appears effective to decrease LDL particle oxidizability, which reduces the risk for cardiovascular disease.

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2006 Oct;17(10):645-58. Epub 2006 Feb 3. PMID: 16517144

Article Published Date : Oct 01, 2006

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Arteriosclerosis : CK(2154) : AC(123), Cardiovascular Diseases : CK(5138) : AC(641), Cholesterol: Oxidation : CK(457) : AC(98)

Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(500) : AC(58)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

The regular consumption of cocoa products containing flavanols may reduce risk of cardiovascular disease.

Click here to read the entire abstract

Pubmed Data : Asia Pac J Clin Nutr. 2008;17 Suppl 1:284-7. PMID: 18296357

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Endothelial Dysfunction : CK(897) : AC(173), Hypertension : CK(2783) : AC(271)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Topical diosmin has therapeutic effects in the treatment of acute hemorrhoid pathology.

Click here to read the entire abstract

Pubmed Data : Minerva Med. 1988 May;79(5):387-90. PMID: 3287228

Article Published Date : May 01, 1988

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Flavonoids : CK(909) : AC(289)

Diseases : Hemorrhoids : CK(122) : AC(13)

Wine consumption reduces TNF-apha-induced adhesion of monocytes to endothelial cells.

Click here to read the entire abstract

Pubmed Data : Cell Physiol Biochem. 2010;26(3):471-82. Epub 2010 Aug 24. PMID: 15213052

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174), Wine : CK(132) : AC(35)

Diseases : Arteriosclerosis : CK(2154) : AC(123), Heart Disease: Ischemic : CK(201) : AC(16)

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2011 Feb 15 ;251(1):85-94. Epub 2010 Dec 15. PMID: 21167192

Article Published Date : Feb 15, 2011

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289)

Diseases : Liver Cancer: Prevention : CK(109) : AC(21)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

A cocoa diet enhances thymus antioxidant defenses and influences thymocyte differentiation.

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2007 Aug 8;55(16):6431-8. Epub 2007 Jul 14. PMID: 17630760

Article Published Date : Aug 08, 2007

Study Type : Animal Study

Additional Links

Substances : Catechin : CK(403) : AC(130), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Low Immune Function: Thymus Dysfunction : CK(19) : AC(6)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Immunomodulatory : CK(536) : AC(142)

A cocoa-enriched diet prevents gingival oxidative stress in experimental periodontitis.

Click here to read the entire abstract

Pubmed Data : J Periodontol. 2009 Nov;80(11):1799-808. PMID: 19905949

Article Published Date : Nov 01, 2009

Study Type : Animal Study

Additional Links

Substances : Cocoa : CK(243) : AC(32), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Periodontitis : CK(61) : AC(14)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. paradisiaca) protects the gastric mucosa from aspirin-induced erosions.

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 1999 Jun;65(3):283-8. PMID: 10404428

Article Published Date : Jun 01, 1999

Study Type : Animal Study

Additional Links

Substances : Banana : CK(123) : AC(36), Flavonoids : CK(909) : AC(289)

Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), NSAID-induced toxicity : CK(230) : AC(50)

Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)

A polyphenol extract from red grapes redues fat content in an animal model of non-alcoholic liver disease.

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2010 Dec;104(12):1760-70. Epub 2010 Aug 2. PMID: 20673376

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Grape : CK(998) : AC(274), Polyphenols : CK(427) : AC(174), Resveratrol : CK(977) : AC(590)

Diseases : Fatty Liver : CK(493) : AC(122)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Allomelanins suppress the tumor cell growth in vitro and in vivo.

Click here to read the entire abstract

Pubmed Data : Cancer Biother Radiopharm. 1997 Aug;12(4):273-6. PMID: 10851475

Article Published Date : Aug 01, 1997

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Lymphoma : CK(209) : AC(69)

Pharmacological Actions : Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Food Colors: Black : CK(3) : AC(2), Food Colors: Purple : CK(3) : AC(2)

An aqueous decoction of mango flowers has potential gastroprotective and ulcer-healing properties.

Click here to read the entire abstract

Pubmed Data : Planta Med. 2004 Aug;70(8):745-52. PMID: 16500058

Article Published Date : Aug 01, 2004

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Flowers : CK(27) : AC(14), Mango : CK(60) : AC(34), Polyphenols : CK(427) : AC(174)

Diseases : Gastric Ulcer : CK(246) : AC(91)

Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Cyclooxygenase Inhibitors : CK(64) : AC(32)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Apigenin has a protective role against lipid peroxidation and oxidative stress associated with the development of liver cancer in rats.

Click here to read the entire abstract

Pubmed Data : Atherosclerosis. 2009 Dec;207(2):420-7. Epub 2009 May 22. PMID: 15185843

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Flavonoids : CK(909) : AC(289)

Diseases : Liver Cancer : CK(1641) : AC(266)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Apigenin is a bioflavonoid that inhibits hypoxia-activated pathways linked to cancer progression in human prostate cancer

Click here to read the entire abstract

Pubmed Data : Mol Carcinog. 2008 Sep;47(9):686-700. PMID: 18240292

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(76) : AC(51), Flavonoids : CK(909) : AC(289)

Diseases : Hypoxia : CK(100) : AC(41), Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)

Apple fibers and polyphenols may play a role in preventing atherosclerosis by decreasing uric acid plasma level.

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2007 Apr;14(4):280-4. Epub 2007 Feb 12. PMID: 18558693

Article Published Date : Apr 01, 2007

Study Type : Animal Study

Additional Links

Substances : Apples : CK(179) : AC(57), Fiber : CK(484) : AC(70), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Atherosclerosis : CK(523) : AC(77), Hyperuricemia : CK(253) : AC(32)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Apples may exert their colon cancer protective effects through favorably altering gene patterns resulting in protection of cells against toxicological insults.

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2008 Jun 15;122(12):2647-55. PMID: 18351577

Article Published Date : Jun 15, 2008

Study Type : Animal Study

Additional Links

Substances : Apples : CK(179) : AC(57), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Colon Cancer : CK(895) : AC(233)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Additional Keywords : Epigenetic Modification : CK(71) : AC(32)

Apples rich polyphenols reduce colonic inflammation in rats.

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2009 Dec;102(11):1620-8. Epub 2009 Jul 22. PMID: 19622193

Article Published Date : Dec 01, 2009

Study Type : Transgenic Animal Study

Additional Links

Substances : Apples : CK(179) : AC(57), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Inflammatory Bowel Diseases : CK(1227) : AC(103), Irritable Bowel Syndrome : CK(829) : AC(66)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)

Baccharis dracunculifolia, the main botanical source of Brazilian green propolis, displays antiulcer activity.

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2007 Apr;59(4):603-8. PMID: 17430646

Article Published Date : Apr 01, 2007

Study Type : Animal Study

Additional Links

Substances : Baccharis dracunculifolia : CK(10) : AC(7), Bee Propolis : CK(220) : AC(83), Flavonoids : CK(909) : AC(289)

Diseases : Gastric Ulcer : CK(246) : AC(91)

Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)

Additional Keywords : Natural Substances Versus Drugs : CK(988) : AC(165), Plant Extracts : CK(3572) : AC(1216)

Banana prevents lipid oxidation in rats.

Click here to read the entire abstract

Pubmed Data : Indian J Med Res. 2005 Dec;122(6):540-6. PMID: 16518007

Article Published Date : Dec 01, 2005

Study Type : Animal Study

Additional Links

Substances : Banana : CK(123) : AC(36), Flavonoids : CK(909) : AC(289), Plantain : CK(39) : AC(12)

Diseases : Cholesterol: Oxidation : CK(457) : AC(98), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Blackberries improve motor and cognitive performance in aged rats.

Click here to read the entire abstract

Pubmed Data : Nutr Neurosci. 2009 Jun;12(3):135-40. PMID: 19356316

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Blackberry : CK(17) : AC(13), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Aging: Brain : CK(1747) : AC(68), Cognitive Decline/Dysfunction : CK(522) : AC(87)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Blue skullcap (S. lateriflora) has anticonvulsant activity.

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2009 May;16(5):485-93. Epub 2008 Sep 10. PMID: 18786819

Article Published Date : May 01, 2009

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Skullcap: Blue : CK(13) : AC(3)

Diseases : Convulsions : CK(10) : AC(5), Seizures : CK(122) : AC(28)

Pharmacological Actions : Anticonvulsants : CK(113) : AC(29)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Blueberry inhibits the growth and metastatic potential of triple negative breast cancer in vitro and in vivo.

Click here to read the entire abstract

Pubmed Data : Cancer Res. 2010 May 1;70(9):3594-605. Epub 2010 Apr 13. PMID: 20388778

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Substances : Blueberry : CK(140) : AC(39), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Metastatic : CK(82) : AC(33), Breast Cancer: Triple Negative : CK(61) : AC(13)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Both curcumin and its metabolite tetrahydrocurcumin exert neuroprotection against chemically-induced neurotoxicity.

Click here to read the entire abstract

Pubmed Data : Inflammopharmacology. 2008 Apr;16(2):96-9. PMID: 18408903

Article Published Date : Apr 01, 2008

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174), Tetrahydrocurcumin : CK(37) : AC(20)

Diseases : Neurodegenerative Diseases : CK(1743) : AC(420), Parkinson Disease : CK(543) : AC(79)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Buckwheat polyphenols protective effect against long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia.

Click here to read the entire abstract

Pubmed Data : J Pharmacol Sci. 2004 Apr;94(4):393-402. PMID: 15107579

Article Published Date : Apr 01, 2004

Study Type : Animal Study

Additional Links

Substances : Buckwheat : CK(48) : AC(16), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Brain Injury: Hippocampal Damage : CK(35) : AC(16), Cerebral Ischemia : CK(263) : AC(50), Memory Disorders : CK(221) : AC(67)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Buckwheat sprouts have an anti-inflammatory effect in lipopolysaccharide-activated human colon cancer cells and mice.

Click here to read the entire abstract

Pubmed Data : Biosci Biotechnol Biochem. 2008 Dec;72(12):3148-57. Epub 2008 Dec 7. PMID: 19060399

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : Buckwheat : CK(48) : AC(16), Flavonoids : CK(909) : AC(289), Sprouts : CK(76) : AC(36)

Diseases : Colon Cancer : CK(895) : AC(233), Inflammation : CK(1077) : AC(363), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

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