Genistein

Genistein

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View the Evidence: Substances

Dietary intake of isoflavone is inversely associated with the risk of lower urinary tract symptoms.

Pubmed Data : Br J Nutr. 2007 Dec;98(6):1237-42. Epub 2007 Jul 19. PMID: 17640419
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187), Isoflavones : CK(630) : AC(128), Soy : CK(1692) : AC(353)
Diseases : Lower Urinary Tract Symptoms : CK(12) : AC(2), Prostatic Hyperplasia: Benign : CK(202) : AC(46)

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer.

Pubmed Data : Gynecol Oncol. 2006 Jan;100(1):205-9. Epub 2005 Sep 19. PMID: 16171852
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(109) : AC(30), Genistein : CK(480) : AC(187), Isoflavones : CK(630) : AC(128), Soy : CK(1692) : AC(353)
Diseases : Cancers: Drug Resistant : CK(278) : AC(159), Ovarian Cancer : CK(197) : AC(65)
Additional Keywords : Drug: Doxorubicin : CK(144) : AC(58)

Genistein and daidzein consumption are associated with a lower risk of prostate cancer.

Pubmed Data : J Altern Complement Med. 2009 Aug;15(8):905-9. PMID: 19838933
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(109) : AC(30), Genistein : CK(480) : AC(187), Isoflavones : CK(630) : AC(128)
Diseases : Prostate Cancer: Prevention : CK(193) : AC(17)
Pharmacological Actions : Anticarcinogenic Agents : CK(756) : AC(282), Chemopreventive : CK(2078) : AC(530)
Additional Keywords : Risk Reduction : CK(3534) : AC(380)

Genistein appears to have a positive effect on hot flushes without a negative impact on endometrial thickness in early postmenopausal women.

Pubmed Data : Menopause. 2004 Jul-Aug;11(4):400-4. PMID: 15243277
Article Published Date : Jul 01, 2004
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Hot Flash : CK(233) : AC(23), Postmenopausal Disorders : CK(295) : AC(37)

Genistein compares favorably to HRT in supporting bone health in early postmenopausal women.

Pubmed Data : J Bone Miner Res. 2002 Oct;17(10):1904-12. PMID: 12369794
Article Published Date : Oct 01, 2002
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Osteopenia : CK(209) : AC(39), Osteoporosis : CK(1198) : AC(221), Postmenopausal Disorders : CK(295) : AC(37)
Additional Keywords : HRT Alternatives : CK(21) : AC(3), Natural Substances Versus Drugs : CK(1533) : AC(250)

Genistein has a positive effect on bone metabolism in osteopenic postmenopausal women, without increasing endometrial thickness.

Pubmed Data : Ann Intern Med. 2007 Jun 19;146(12):839-47. PMID: 17577003
Article Published Date : Jun 19, 2007
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Osteoporosis : CK(1198) : AC(221)

Genistein has favorable effects on some predictors of cardiovascular risk in osteopenic, postmenopausal women.

Pubmed Data : Exp Gerontol. 2010 Jan 18. Epub 2010 Jan 18. PMID: 17682090
Article Published Date : Jan 18, 2010
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Cardiovascular Diseases : CK(5898) : AC(665), Osteopenia : CK(209) : AC(39), Postmenopausal Disorders : CK(295) : AC(37)
Pharmacological Actions : Vascular Cell Adhesion Molecule-1 Inhibitor : CK(94) : AC(24)

Genistein has therapeutic value in reducing PSA levels in men with prostate cancer.

Pubmed Data : Urology. 2004 Feb;63(2):259-63. PMID: 14972467
Article Published Date : Feb 01, 2004
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Prostate: PSA Doubling : CK(143) : AC(17), Prostate Cancer : CK(1342) : AC(311)
Pharmacological Actions : Enzyme Inhibitors : CK(417) : AC(225)
Additional Keywords : Plant Extracts : CK(5359) : AC(1705)

Genistein inhibits nonalcoholic fatty liver disease.

Pubmed Data : J Gastroenterol Hepatol. 2007 Nov;22(11):2009-14. PMID: 17914984
Article Published Date : Nov 01, 2007
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Fatty Liver : CK(540) : AC(127), Hepatic Steatosis : CK(104) : AC(21), Liver: Fatty : CK(535) : AC(127)
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1224) : AC(444)

Genistein is safe and effective in improving bone density without adverse responses in breast density or endometrium thickness in osteopenic, postmenopausal women.

Pubmed Data : J Clin Endocrinol Metab. 2008 Dec;93(12):4787-96. Epub 2008 Sep 16. PMID: 18796517
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Osteopenia : CK(209) : AC(39), Osteoporosis : CK(1198) : AC(221)

Genistein may block metastasis and mortality in prostate cancer through blocking the activation of MEK4 and MMP-2 expression.

Pubmed Data : J Natl Cancer Inst. 2009 Aug 19;101(16):1141-55. Epub 2009 Jul 28. PMID: 19638505
Article Published Date : Aug 19, 2009
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Prostate Cancer : CK(1342) : AC(311)
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(205) : AC(88), Mitogen-activated protein kinase kinase 4 (MEK4) : CK(11) : AC(2)

Genistein reduces vasomotor symptoms, e.g. hot flush, within postmenopausal women.

Pubmed Data : Menopause. 2007 Jul-Aug;14(4):648-55. PMID: 17251874
Article Published Date : Jul 01, 2007
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Hot Flash : CK(233) : AC(23), Postmenopausal Disorders : CK(295) : AC(37)

Genistein significantly decreases hot flash symptoms in healthy postmenopausal women.

Pubmed Data : Maturitas. 2011 Feb;68(2):189-96. Epub 2010 Dec 15. PMID: 21163595
Article Published Date : Feb 01, 2011
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Hot Flash : CK(233) : AC(23), Postmenopausal Disorders : CK(295) : AC(37)

Higher concentrations of circulating genistein may reduce the risk of prostate cancer.

Pubmed Data : Br J Cancer. 2009 Jun 2;100(11):1817-23. Epub 2009 May 12. PMID: 19436304
Article Published Date : Jun 02, 2009
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187), phytoestrogens : CK(714) : AC(221)
Diseases : Prostate Cancer: Prevention : CK(193) : AC(17)
Pharmacological Actions : Chemopreventive : CK(2078) : AC(530)

Increased consumption of genistein is associated with better lung function in patients with asthma.

Pubmed Data : J Asthma. 2004;41(8):833-43. PMID: 15641633
Article Published Date : Jan 01, 2004
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Asthma : CK(991) : AC(140)

Lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer.

Pubmed Data : J Pharm Pharmacol. 2009 Jul;61(7):961-7. PMID: 17927495
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Substances : Carotenoids : CK(1125) : AC(226), Genistein : CK(480) : AC(187), Isoflavones : CK(630) : AC(128), Lycopene : CK(195) : AC(40)
Diseases : Prostate Cancer : CK(1342) : AC(311)
Pharmacological Actions : Antineoplastic Agents : CK(1055) : AC(505)

Soy extract appears to rejuvenate the structure of mature skin.

Pubmed Data : J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):487-92. PMID: 15623355
Article Published Date : Nov 01, 2004
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187), Soy : CK(1692) : AC(353)
Diseases : Aging Skin : CK(387) : AC(93)
Additional Keywords : Plant Extracts : CK(5359) : AC(1705)

Soy isoflavone consumption reduce symptoms of premenstrual syndrome.

Pubmed Data : Br J Nutr. 2005 May;93(5):731-9. PMID: 15975174
Article Published Date : May 01, 2005
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187), Isoflavones : CK(630) : AC(128)
Diseases : Premenstrual syndrome : CK(180) : AC(18)

Soy isoflavones ameliorate the adverse effects of chemotherapy in children.

Pubmed Data : J Infect Dis. 1996 Oct;174(4):747-51. PMID: 20924976
Article Published Date : Oct 01, 1996
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187), Isoflavones : CK(630) : AC(128)
Diseases : Chemotherapy Induced Myelotoxicity : CK(48) : AC(13)

Soy isoflavones may benefit some patients with prostate cancer.

Pubmed Data : Nutr Cancer. 2003;47(2):111-7. PMID: 15087261
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(109) : AC(30), Genistein : CK(480) : AC(187), Isoflavones : CK(630) : AC(128), Soy : CK(1692) : AC(353)
Diseases : Prostate Cancer : CK(1342) : AC(311)
Pharmacological Actions : Antineoplastic Agents : CK(1055) : AC(505), Apoptotic : CK(2058) : AC(1476)

Soy protein reduces cholesterol oxidation in patients on hemodialysis.

Pubmed Data : J Med Food. 2006;9(3):368-72. PMID: 17004900
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(109) : AC(30), Genistein : CK(480) : AC(187), Isoflavones : CK(630) : AC(128), Soy Protein : CK(331) : AC(56)
Diseases : Cholesterol: Oxidation : CK(504) : AC(105), Hemodialysis : CK(363) : AC(39)
Pharmacological Actions : Antioxidants : CK(5301) : AC(1618)

The soy isoflavone genistein does not adversely effect thyroid function in osteopenic, postmenopausal women.

Pubmed Data : J Clin Endocrinol Metab. 2010 Mar 31. Epub 2010 Mar 31. PMID: 20357174
Article Published Date : Mar 31, 2010
Study Type : Human Study
Additional Links
Substances : Genistein : CK(480) : AC(187), Soy : CK(1692) : AC(353)
Diseases : Hypothyroidism : CK(570) : AC(86)

There is a modest inverse association between lignan excretion and uterine fibroid risk.

Pubmed Data : Cytotechnology. 2005 Jan;47(1-3):97-105. PMID: 16960173
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(109) : AC(30), Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Equol : CK(33) : AC(10), Genistein : CK(480) : AC(187), Isoflavones : CK(630) : AC(128), Lignans : CK(122) : AC(36)
Diseases : Fibroids: Uterine : CK(46) : AC(16)

"Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats."

Pubmed Data : Nutr Res. 2012 Nov ;32(11):844-55. Epub 2012 Nov 8. PMID: 23176795
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Insulin Resistance : CK(1237) : AC(235), Ovariectomy Associated Adverse Changes : CK(18) : AC(7)
Pharmacological Actions : Insulin Sensitizers : CK(239) : AC(42)

"Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome."

Pubmed Data : Environ Health Perspect. 2006 Apr ;114(4):567-72. PMID: 16581547
Article Published Date : Mar 31, 2006
Study Type : Animal Study
Additional Links
Substances : Genistein : CK(480) : AC(187)
Diseases : Prenatal Nutrition : CK(180) : AC(25)
Additional Keywords : Nutrigenomics : CK(2) : AC(2), soy-gene connection, Transgenerational Epigenetic Modification : CK(6) : AC(3)

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