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Hesperidin

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Article Count - 38
Cumulative Knowledge - 160

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Quick Summary: Current access displays 2 out of 41 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Hemorrhoids	61	7	Log in \| Sign up
Chronic Venous Insufficency	11	2	Log in \| Sign up

Quick Summary: Current access displays 2 out of 18 associated Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Anti-Inflammatory Agents	11	2	Log in \| Sign up
Analgesics	10	1	Log in \| Sign up

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View the Evidence: Substances

A combination of diosmin and hesperidin (Daflon) has been shown to be effective in alleviating (variable degree) haemorrhoidal symptoms and improving the proctoscopic appearance of haemorrhoids.

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Pubmed Data : Surgeon. 2004 Dec;2(6):335-8, 361. PMID: 15712573

Article Published Date : Dec 01, 2004

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Hemorrhoids : CK(122) : AC(13)

A combination of diosmin and hesperidin (Daflon) has been shown to be safe and effective in the treatment of all hemorrhoidal symptoms.

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Pubmed Data : Saudi Med J. 2002 Dec;23(12):1496-8. PMID: 12518200

Article Published Date : Dec 01, 2002

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Hemorrhoids : CK(122) : AC(13)

A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids.

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Pubmed Data : Clin Ther. 2005 Jun;27(6):746-54. PMID: 16117981

Article Published Date : Jun 01, 2005

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Flavonoids : CK(909) : AC(289), Hesperidin : CK(160) : AC(38)

Diseases : Hemorrhoids : CK(122) : AC(13)

A micronized purified flavonoid fraction (MPFF) consisting of diosmin and hesperidin significantly improves the symptoms of patients with acute hemorrhoids. - Article 1.

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Pubmed Data : Curr Med Res Opin. 2006 Jun;22(6):1141-7. PMID: 16846547

Article Published Date : Jun 01, 2006

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Hemorrhoids : CK(122) : AC(13)

A micronized purified flavonoid fraction (MPFF) consisting of diosmin and hesperidin significantly improves the symptoms of patients with acute hemorrhoids. - Article 2.

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Pubmed Data : Br J Surg. 2000 Jul;87(7):868-72. PMID: 10931020

Article Published Date : Jul 01, 2000

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Hemorrhoids : CK(122) : AC(13)

Daflon, a form of micronized diosmin and hesperidin, improves symptoms of chronic venous insufficiency.

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Pubmed Data : Vasc Surg. 2001 Nov-Dec;35(6):443-7. PMID: 16222383

Article Published Date : Nov 01, 2001

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Chronic Venous Insufficency : CK(73) : AC(12)

Daflon, a form of micronized diosmin and hesperidin, improves the healing of venous leg ulcers.

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Pubmed Data : Angiology. 2005 Sep-Oct;56 Suppl 1:S33-9. PMID: 16193225

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Leg Ulcer : CK(30) : AC(3), Venous Ulcer : CK(42) : AC(6)

Daflon, a form of micronized diosmin and hesperidin, restores pelvic circulation and relieves pelvic symptomatology in women with pelvic pain.

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Pubmed Data : Clin Exp Obstet Gynecol. 2007;34(2):96-8. PMID: 17629162

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Chronic Pelvic Pain Syndrome : CK(52) : AC(6), Pelvic Inflammatory Disease : CK(20) : AC(2)

Flavonoids (hesperidin) have therapeutic value in the treatment of bleeding bladder varices.

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Pubmed Data : Actas Urol Esp. 2003 Oct;27(9):732-4. PMID: 14626685

Article Published Date : Oct 01, 2003

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Hesperidin : CK(160) : AC(38)

Diseases : Bladder Degeneration : CK(22) : AC(3), Hematuria : CK(10) : AC(1), Vericose Veins: Bladder : CK(10) : AC(1)

Hesperidin has therapeutic value in the treatment of recurrent aphthous stomatitis.

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Pubmed Data : Georgian Med News. 2006 Apr(133):31-3. PMID: 16705221

Article Published Date : Apr 01, 2006

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Hesperidin : CK(160) : AC(38)

Diseases : Aphthous Ulcer : CK(131) : AC(14)

The flavonoids hesperidin and diosmin reduce bleeding and pain after stapled hemorrhoidopexy.

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Pubmed Data : Wien Klin Wochenschr. 2005 Aug;117(15-16):558-60. PMID: 16158207

Article Published Date : Aug 01, 2005

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Flavonoids : CK(909) : AC(289), Hesperidin : CK(160) : AC(38)

Diseases : Hemorrhoids : CK(122) : AC(13), Postoperative Recovery : CK(100) : AC(9)

Pharmacological Actions : Analgesics : CK(372) : AC(78), Anti-Inflammatory Agents : CK(1230) : AC(433)

The flavonoids hesperidin and diosmin strengthen capillaries in patients with epistaxis.

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Pubmed Data : Int Angiol. 1993 Mar;12(1):69-72. PMID: 8376915

Article Published Date : Mar 01, 1993

Study Type : Human Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Epistaxis : CK(10) : AC(1), Nose Bleed : CK(10) : AC(1)

A combination of diosmin and hesperidin (Daflon) improves lymphatic flow indicating its therapeutic role in conditions like perivascular edema.

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Pubmed Data : Int Angiol. 1995 Sep;14(3 Suppl 1):36-8. PMID: 8919263

Article Published Date : Sep 01, 1995

Study Type : Animal Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Lymphatic Diseases : CK(2) : AC(1), Lymphatic Stasis : CK(4) : AC(2), Lymphedema : CK(22) : AC(3)

Pharmacological Actions : Lymphagogue : CK(2) : AC(1)

A combination of diosmin and hesperidin (Detralex) attenuates adjuvant-induced arthritis in rats treated with methotrexate.

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Pubmed Data : Isr Med Assoc J. 2008 May;10(5):377-80. PMID: 18605365

Article Published Date : May 01, 2008

Study Type : Animal Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Vaccine-induced Toxicity : CK(1130) : AC(163)

Additional Keywords : Adjuvant Toxicity : CK(16) : AC(5), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

A combination of diosmin and hesperidin is effective in the prevention of intestinal reperfusion injury in an experimental model in rats.

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Pubmed Data : Acta Chir Belg. 2004 Nov-Dec;104(6):715-8. PMID: 15663281

Article Published Date : Nov 01, 2004

Study Type : Animal Study

Additional Links

Substances : Diosmin : CK(184) : AC(31), Hesperidin : CK(160) : AC(38)

Diseases : Gastrointestinal Surgical Procedures : CK(2) : AC(1)

Beta-Cryptoxanthin and Hesperidin are potential cancer chemopreventive agents against tongue, colon, and lung cancers.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biomed Biotechnol. 2012 ;2012:516981. Epub 2011 Nov 24. PMID: 22174562

Article Published Date : Jan 01, 2012

Study Type : Animal Study

Additional Links

Substances : Cryptoxanthin : CK(36) : AC(8), Hesperidin : CK(160) : AC(38), Orange: Mandarin : CK(6) : AC(2)

Diseases : Colon Cancer : CK(895) : AC(233), Inflammation : CK(1077) : AC(363), Lung Cancer : CK(496) : AC(198), Tongue Cancer : CK(14) : AC(10)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382)

Curcumin, beta-carontein and hesperidin prevent chemically-induced oral cancer.

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Pubmed Data : Cancer Res. 1994 Sep 1;54(17):4653-9. PMID: 8062259

Article Published Date : Sep 01, 1994

Study Type : Animal Study

Additional Links

Substances : beta-Carotene : CK(217) : AC(38), Carotenoids : CK(1055) : AC(213), Curcumin : CK(2910) : AC(1482), Hesperidin : CK(160) : AC(38)

Diseases : Oral Cancer : CK(66) : AC(43), Squamous cell carcinoma : CK(79) : AC(36), Tongue Cancer : CK(14) : AC(10)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Hesperidin a flavanoglycone protects against gamma-irradiation induced liver damage and oxidative stress in rats.

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Pubmed Data : Eur J Pharmacol. 2008 Jun 10;587(1-3):273-80. Epub 2008 Apr 4. PMID: 18485345

Article Published Date : Jun 10, 2008

Study Type : Animal Study

Additional Links

Substances : Hesperidin : CK(160) : AC(38)

Diseases : Radiation Induced Illness : CK(1018) : AC(249)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272), Radioprotective : CK(456) : AC(183)

Hesperidin a positive immunomodulatory effect in a clinically relevant model of Acute Respiratory Distress Syndrome.

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Pubmed Data : Life Sci. 2007 Apr 24;80(20):1821-31. Epub 2007 Feb 3. PMID: 17400256

Article Published Date : Apr 24, 2007

Study Type : Animal Study

Additional Links

Substances : Hesperidin : CK(160) : AC(38)

Diseases : Acute Respiratory Distress Syndrome : CK(15) : AC(3)

Pharmacological Actions : Interleukin-6 Downregulation : CK(470) : AC(135), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance.

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Pubmed Data : Toxicol Ind Health. 2009 Jul;25(6):417-27. PMID: 19671635

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Hesperidin : CK(160) : AC(38)

Diseases : Petroleum Exposure And Toxicity : CK(49) : AC(18)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Hesperidin has radioprotective properties in the liver of mice.

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Pubmed Data : Eur J Pharmacol. 2011 May 11;658(2-3):206-12. Epub 2011 Mar 1. PMID: 21371459

Article Published Date : May 11, 2011

Study Type : Animal Study

Additional Links

Substances : Hesperidin : CK(160) : AC(38)

Diseases : Radiation Induced Illness : CK(1018) : AC(249)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272), Radioprotective : CK(456) : AC(183)

Hesperidin has radioprotective properties.

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Pubmed Data : Mutat Res. 2009 May 31;676(1-2):54-61. Epub 2009 Mar 31. PMID: 19486865

Article Published Date : May 31, 2009

Study Type : Animal Study

Additional Links

Substances : Hesperidin : CK(160) : AC(38)

Diseases : DNA damage : CK(711) : AC(293), Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710), Radiation Induced Illness : CK(1018) : AC(249)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Radioprotective : CK(456) : AC(183)

Hesperidin has therapeutic effects in the formation and maintenance of bone mass and strength.

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Pubmed Data : J Appl Physiol. 2008 Mar;104(3):648-54. Epub 2008 Jan 3. PMID: 18174393

Article Published Date : Mar 01, 2008

Study Type : Animal Study

Additional Links

Substances : Hesperidin : CK(160) : AC(38)

Diseases : Osteoporosis : CK(1171) : AC(205)

Additional Keywords : Bone Quality : CK(8) : AC(4)

Hesperidin prevents endothelial dysfunction and oxidative stress in hypotensive rats.

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Pubmed Data : Nutrition. 2008 May;24(5):470-6. Epub 2008 Mar 10. PMID: 18329851

Article Published Date : May 01, 2008

Study Type : Animal Study

Additional Links

Substances : Hesperidin : CK(160) : AC(38)

Diseases : Hypertension : CK(2783) : AC(271)

Hesperidin, a flavonoid obtained from citrus fruits, has sedative properties.

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Pubmed Data : : Planta Med. 2009 Mar;75(4):295-301. Epub 2009 Feb 13. PMID: 19219759

Article Published Date : Mar 01, 2009

Study Type : Animal Study

Additional Links

Substances : Hesperidin : CK(160) : AC(38)

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