Kaempferol

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41 Diseases Researched for Kaempferol
NameACCKFocus
Oxidative Stress37Locked
DNA damage15Locked
Asthma12Locked
Autoimmune Diseases12Locked
Bacterial Infections: Resistance/Biofilm Formation22Locked
Breast Cancer22Locked
Burns12Locked
Cancers: All22Locked
Carcinoma: Small Cell Lung12Locked
Cardiovascular Diseases12Locked
Diabetes12Locked
Esophageal Cancer22Locked
Excitotoxicity 12Locked
Immune Dysregulation: TH1/TH2 imbalance12Locked
Inflammation12Locked
MRSA22Locked
Neurodegenerative Diseases12Locked
Osteosarcoma12Locked
Pancreatic Cancer22Locked
Periodontitis12Locked
Advanced Glycation End products (AGE)11Locked
Brain Cancer11Locked
Cancer Metastasis11Locked
Cancers: Multi-Drug Resistant11Locked
Cholesterol: Oxidation11Locked
Cytomegalovirus Infections11Locked
Glioblastoma11Locked
H1N1 Infection11Locked
Human Influenza11Locked
Hyperinsulinism11Locked
Influenza11Locked
Influenza A11Locked
Intestinal Permeability 11Locked
Leukemia11Locked
Leukemia: Acute promyelocytic leukemia 11Locked
Lung Cancer11Locked
Non-Small-Cell Lung Carcinoma11Locked
Obesity11Locked
Pancreatic Cancer: Metastatic11Locked
Staphylococcus aureus infection11Locked
Weight Problems11Locked
30 Pharmacological Actions Researched for Kaempferol
NameACCKFocus
Apoptotic911Locked
Antioxidants59Locked
Anti-metastatic37Locked
Antiproliferative 67Locked
Chemopreventive26Locked
Antimutagenic Agents15Locked
Cell cycle arrest44Locked
Neuroprotective Agents24Locked
Anti-Bacterial Agents33Locked
Anti-Inflammatory Agents23Locked
NF-kappaB Inhibitor23Locked
Antiviral Agents22Locked
Enzyme Inhibitors12Locked
Excitatory Amino Acid Agonists12Locked
Matrix metalloproteinase-1 (MMP-1) inhibitor12Locked
Matrix metalloproteinase-8 (MMP-8) inhibitor12Locked
MicroRNA modulator12Locked
Radiosensitizer12Locked
Chemosensitizer11Locked
Cytotoxicity11Locked
Drug synergy11Locked
Epidermal growth factor receptor (EGFR) inhibitor11Locked
Estrogen Receptor Modulators11Locked
Hypoglycemic Agents11Locked
Interleukin-6 Downregulation11Locked
Neurominidase Inhibitor11Locked
Nrf2 activation11Locked
Phase II Detoxification Enzyme Inducer11Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor11Locked
Tumor Suppressor Protein p53 Upregulation11Locked

View the Evidence:
40 Abstracts with Kaempferol Research

[+]

An aqueous horseradish extract and its main flavonoids, kaempferol and quercetin has great potential to protect DNA from damage. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2014 ;19(3):3160-72. Epub 2014 Mar 14. PMID: 24637991
Article Published Date : Dec 31, 2013
Study Type : Human In Vitro
Additional Links
Substances : Horseradish, Kaempferol, Quercetin
Diseases : DNA damage, Oxidative Stress
Pharmacological Actions : Antimutagenic Agents, Antioxidants
Additional Keywords : Plant Extracts
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Kaempferol might act as a therapeutic potential candidate for cancer metastasis.Jan 31, 2015

Pubmed Data : Biochem Cell Biol. 2015 Feb ;93(1):16-27. Epub 2014 Sep 12. PMID: 25453494
Article Published Date : Jan 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Breast Cancer: Triple Negative , Melanoma
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Kaempferol and Catechin produced a concentration dependent anti-fibrillogenic effects.Jul 28, 2015

Pubmed Data : Int J Biol Macromol. 2015 Jul 29. Epub 2015 Jul 29. PMID: 26231329
Article Published Date : Jul 28, 2015
Study Type : Animal Study
Additional Links
Substances : Catechin , Kaempferol
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
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Kaempferol and chrysin have synergistic effects to improve septic mice survival.Jan 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Jan 6 ;22(1). Epub 2017 Jan 6. PMID: 28067837
Article Published Date : Jan 05, 2017
Study Type : Animal Study
Additional Links
Substances : Chrysin, Kaempferol
Diseases : Sepsis
Additional Keywords : Natural Substance Synergy
[+]

Kaempferol attenuated myocardial ischemia-reperfusion injury in diabetic ratsMay 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 May 15 ;18(5). Epub 2017 May 15. PMID: 28505121
Article Published Date : May 14, 2017
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Diabetic Complications, Ischemia: Myocardial
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Kaempferol downregulates TH2 cytokine production without inducing a TH1 pattern of inflammation in a manner that may have potential clinical use for the treatment of allergic asthma. Sep 12, 2009

Pubmed Data : Int Immunopharmacol. 2009 Sep 12. PMID: 19755174
Article Published Date : Sep 12, 2009
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Asthma, Immune Dysregulation: TH1/TH2 imbalance
[+]

Kaempferol has the potential to restore deranged activity of membrane-bound ATPases in STZ-induced diabetic rats.Apr 07, 2015

Pubmed Data : Pharm Biol. 2015 Apr 8:1-7. Epub 2015 Apr 8. PMID: 25853957
Article Published Date : Apr 07, 2015
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Diabetes
Pharmacological Actions : Enzyme Inhibitors
[+]

Kaempferol has therapeutic value in thermal burn-induced skin injuries.Jan 01, 2010

Pubmed Data : BMB Rep. 2010 Jan;43(1):46-51. PMID: 20132735
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Burns
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Kaempferol increased tumor cell killing by radiation in vitro and in vivo through inhibition of the AKT/PI3K and ERK pathways and activation of the mitochondria apoptosis pathwayAug 18, 2015

Pubmed Data : Oncol Rep. 2015 Aug 19. Epub 2015 Aug 19. PMID: 26323894
Article Published Date : Aug 18, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Carcinoma: Small Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic, Radiosensitizer
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Kaempferol induces programmed cell death in human osteosarcoma cells.Nov 01, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Nov;54(11):1585-95. PMID: 20564475
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic
[+]

Kaempferol may be useful in decreasing alveolar bone resorption, attachment loss and MMP-1 and -8 production in experimental periodontitis.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Periodontal Implant Sci. 2016 Apr ;46(2):84-95. Epub 2016 Apr 26. PMID: 27127689
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Periodontitis
Pharmacological Actions : Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-8 (MMP-8) inhibitor
[+]

Kaempferol may have a therapeutic role in preventing and/or treating autoimmune diseases. Sep 15, 2007

Pubmed Data : J Immunol. 2007 Sep 15;179(6):3881-7. PMID: 17785825
Article Published Date : Sep 15, 2007
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Autoimmune Diseases
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Oral administration of apigenin significantly reduced elevated levels of SASP and IκBζ mRNA in the kidneys of aged rats.Jun 16, 2015

Pubmed Data : Biochem Pharmacol. 2015 Jun 17. Epub 2015 Jun 17. PMID: 26093063
Article Published Date : Jun 16, 2015
Study Type : Animal Study
Additional Links
Substances : Apigenin, Flavonoids, Kaempferol
Diseases : Cardiovascular Diseases, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor
Additional Keywords : Senescence-associated Secretory Phenotype
[+]

Quercetin, kaempferol and biapigenin from St. John's wort are neuroprotective against excitotoxicity. May 01, 2008

Pubmed Data : Neurotox Res. 2008 May-Jun;13(3-4):265-79. PMID: 18522906
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Apigenin, Kaempferol, Quercetin, St. Johns Wort
Diseases : Excitotoxicity
Pharmacological Actions : Excitatory Amino Acid Agonists, Neuroprotective Agents
[+]

Berry constituents quercetin, kaempferol, and pterostilbene activated the Nrf2-ARE signaling pathway and exhibited synergistic antioxidative stress activity at appropriate concentrations.Sep 30, 2014

Pubmed Data : Food Chem Toxicol. 2014 Oct ;72:303-11. Epub 2014 Aug 8. PMID: 25111660
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Berries: All, Kaempferol, Pterostilbene, Quercetin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation, Phase II Detoxification Enzyme Inducer
Additional Keywords : Natural Substance Synergy
[+]

Compounds isolated from Bay leaf have anti-MRSA activity. Sep 01, 2008

Pubmed Data : Biol Pharm Bull. 2008 Sep;31(9):1794-7. PMID: 18758079
Article Published Date : Sep 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bay leaf, Kaempferol
Diseases : Bacterial Infections: Resistance/Biofilm Formation, MRSA
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

Flavanoid rich honey may act as chemosensitizers in multidrug resistant cancers.Jan 17, 2011

Pubmed Data : Med Hypotheses. 2011 Jan 17. Epub 2011 Jan 17. PMID: 21247706
Article Published Date : Jan 17, 2011
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Chrysin, Flavonoids, Genistein, Honey, Kaempferol, Naringenin , Quercetin
Diseases : Cancers: Multi-Drug Resistant
Pharmacological Actions : Chemosensitizer
[+]

Flavones and flavonols induces cell cycle arrest and programmed cell death in a human esophageal squamous cell carcinoma cell line. Aug 01, 2009

Pubmed Data : Toxicol In Vitro. 2009 Aug;23(5):797-807. Epub 2009 May 3. PMID: 19397994
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Chrysin, Kaempferol, Luteolin, Myricetin, Quercetin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Flavonoids are capable of inhibiting insulin-stimulated glucose uptake in fat cells. Jan 01, 2004

Pubmed Data : J Med Food. 2004;7(1):38-44. PMID: 18591783
Article Published Date : Jan 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Fisetin, Flavonoids, Kaempferol, Luteolin, Quercetin
Diseases : Hyperinsulinism, Obesity, Weight Problems
Pharmacological Actions : Hypoglycemic Agents
[+]

Flavonoids belonging to the kaempferol series exhibit antiviral activity against cytomegalovirus. May 01, 2000

Pubmed Data : Planta Med. 2000 May;66(4):377-9. PMID: 10865462
Article Published Date : May 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Kaempferol
Diseases : Cytomegalovirus Infections
Pharmacological Actions : Antiviral Agents
[+]

Flavonoids increase the resistance of LDL to oxidation and glycation. Jun 10, 2009

Pubmed Data : J Agric Food Chem. 2009 Jun 10;57(11):5058-64. PMID: 19489629
Article Published Date : Jun 10, 2009
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Kaempferol, Luteolin, Naringenin
Diseases : Advanced Glycation End products (AGE), Cholesterol: Oxidation
Pharmacological Actions : Antioxidants
[+]

Kaemferol induces programmed cell death in glioblastoma cells. Sep 01, 2007

Pubmed Data : Mol Cancer Ther. 2007 Sep;6(9):2544-53. PMID: 17876051
Article Published Date : Sep 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Brain Cancer, Glioblastoma
Pharmacological Actions : Apoptotic
[+]

Kaempferol activates G2-checkpoint of the cell cycle resulting in mitochondria-dependent apoptosis in human acute leukemia Jurkat T cells.Dec 22, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26699757
Article Published Date : Dec 22, 2015
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Kaempferol and myricetin can be potent inhibitors targeting PriA, an essential helicase for DNA replication restart, which is critical for bacterial survival.Apr 18, 2015

Pubmed Data : Protein J. 2015 Apr 19. Epub 2015 Apr 19. PMID: 25894858
Article Published Date : Apr 18, 2015
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol, Myricetin
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Kaempferol enhances intestinal barrier function.Jan 01, 2011

Pubmed Data : J Nutr. 2011 Jan;141(1):87-94. Epub 2010 Nov 10. PMID: 21068182
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Intestinal Permeability
[+]

Kaempferol glycosides purified from Bay leaf work synergistically with fluorioquinolones on MRSA. Mar 01, 2009

Pubmed Data : Biol Pharm Bull. 2009 Mar;32(3):489-92. PMID: 19252301
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bay leaf, Kaempferol
Diseases : Bacterial Infections: Resistance/Biofilm Formation, MRSA
Pharmacological Actions : Anti-Bacterial Agents, Drug synergy
Additional Keywords : Drug Synergy
[+]

kaempferol induced DNA damage and suppressed DNA repair and inhibited DNA repair associated protein expression in HL-60 cellsDec 31, 2014

Pubmed Data : Am J Chin Med. 2015 ;43(2):365-82. Epub 2015 Mar 17. PMID: 25779644
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Leukemia: Acute promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Cytotoxicity, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dose Response
[+]

Kaempferol induces apoptosis in human lung non-small carcinoma cellsOct 01, 2007

Pubmed Data : Food Chem Toxicol. 2007 Oct;45(10):2005-13. Epub 2007 May 18. PMID: 17583406
Article Published Date : Oct 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Lung Cancer, Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Apoptotic
[+]

Kaempferol may be a safe inhibitor against malignant pancreatic cancers.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(5):e0155264. Epub 2016 May 13. PMID: 27175782
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Pancreatic Cancer, Pancreatic Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Dose Response
[+]

Kaempferol may be suggested as a prominent agent to neutralize breast cancer risk caused by triclosan.Jan 31, 2016

Pubmed Data : J Nutr Biochem. 2016 Feb ;28:70-82. Epub 2015 Oct 23. PMID: 26878784
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive
Additional Keywords : Risk Reduction
Problem Substances : Triclosan
[+]

Kaempferol may modulate OPN-αvβ3 integrin pathway to inhibit NF-κB activation in human umbilical vein endothelial cells.Mar 20, 2016

Pubmed Data : J Physiol Biochem. 2016 Mar 21. Epub 2016 Mar 21. PMID: 27000882
Article Published Date : Mar 20, 2016
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Kaempferol may serve as a novel target for treatment of Intervertebral disc degeneration.Dec 29, 2016

Pubmed Data : Int Immunopharmacol. 2016 Dec 30 ;43:236-242. Epub 2016 Dec 30. PMID: 28043032
Article Published Date : Dec 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation
[+]

Kaempferol, a compound extracted from Ginkgo biloba, inhibits cell proliferation and induces programmed cell death in pancreatic cancer cells, in vitro. Jul 01, 2008

Pubmed Data : J Surg Res. 2008 Jul;148(1):17-23. Epub 2008 Mar 26. PMID: 18570926
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba, Kaempferol
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic
[+]

Lotus stamen has antioxidant properties.Apr 01, 2003

Pubmed Data : Arch Pharm Res. 2003 Apr;26(4):279-85. PMID: 12735685
Article Published Date : Apr 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Kaempferol, Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Phytoestrogens are potent compounds that abrogate the cell migration, invasion and metastasis of cancer.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2016 ;8(6). Epub 2016 May 24. PMID: 27231938
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Genistein, Kaempferol, Resveratrol
Diseases : Cancer Metastasis, Cancers: All
Pharmacological Actions : Anti-metastatic
[+]

Quercetin, Luteolin, Chrysin, Kaempferol, Apigenin, and Myricetin exhibit cytotoxic effeccts on a human esophageal cancer cell line. Jun 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Jun;46(6):2042-53. Epub 2008 Feb 7. PMID: 18331776
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Chrysin, Kaempferol, Luteolin, Myricetin, Quercetin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Resveratraol and kaempferol exhibit anti-breast cancer activity. Dec 28, 2010

Pubmed Data : Cancer Lett. 2010 Dec 28;299(2):119-29. Epub 2010 Sep 16. PMID: 20846786
Article Published Date : Dec 28, 2010
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol, Resveratrol
Diseases : Breast Cancer
Pharmacological Actions : Estrogen Receptor Modulators
Additional Keywords : Stilbenes
[+]

Rhodiola rosea has neuraminidase inhibitory activity against influenza viruses. Oct 01, 2009

Pubmed Data : Bioorg Med Chem. 2009 Oct 1;17(19):6816-23. Epub 2009 Aug 21. PMID: 19729316
Article Published Date : Oct 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol, Rhodiola (Tibetan Ginseng)
Diseases : H1N1 Infection, Human Influenza, Influenza, Influenza A
Pharmacological Actions : Antiviral Agents, Neurominidase Inhibitor
[+]

The dietary flavonoids ECGC, luteolin, quercetin, kaempferol, apigenin, and taxifolin inhibit cancer cell lipogenesis. Feb 18, 2005

Pubmed Data : J Biol Chem. 2005 Feb 18;280(7):5636-45. Epub 2004 Nov 8. PMID: 15533929
Article Published Date : Feb 18, 2005
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Flavonoids, Kaempferol, Luteolin, Polyphenols, Quercetin, Taxifolin
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

We believe that studies described in this paper will be helpful in elucidating molecular mechanisms of action of genistein as modulator of cell cycle and inhibitor of DNA replication in humans.May 23, 2015

Pubmed Data : Mol Cell Biochem. 2015 May 24. Epub 2015 May 24. PMID: 26003441
Article Published Date : May 23, 2015
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Flavonoids, Genistein, Kaempferol
Pharmacological Actions : Cell cycle arrest
Additional Keywords : Dose Response, Gene Expression Regulation, Natural Substance Synergy

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