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Article Count - 31
Cumulative Knowledge - 112

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View the Evidence: Substances

A flaxseed-derived lignan supplement has therapeutic value in type 2 diabetics.

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Pubmed Data : PLoS One. 2007 Nov 7;2(11):e1148. PMID: 17987126

Article Published Date : Nov 07, 2007

Study Type : Human Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31)

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

A lignan rich diet reduces body mass index, abdominal fat and insulin resistance in post-menopausal women.

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Pubmed Data : Mutat Res. 2001 Sep 1;480-481:201-7. PMID: 19586570

Article Published Date : Sep 01, 2001

Study Type : Human Study

Additional Links

Substances : Lignans : CK(110) : AC(31)

Diseases : Abdominal Obesity (Midsection Fat) : CK(348) : AC(53), Insulin Resistance : CK(1034) : AC(221)

Flaxseed may reduce circulating total and LDL-cholesterol levels.

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Pubmed Data : Am J Clin Nutr. 2009 Aug;90(2):288-97. Epub 2009 Jun 10. PMID: 19515737

Article Published Date : Aug 01, 2009

Study Type : Human Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31)

Diseases : Cholesterol: LDL/HDL ratio : CK(432) : AC(58), High Cholesterol : CK(1718) : AC(198)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Flaxseed meal and flaxseed extract is effective in reducing menopausal symptoms without increasing blood levels of follicle stimulating hormone and estradiol, as well as in the endometrial thickness, and vaginal epithelial maturation value.

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Pubmed Data : J Med Food. 2012 Sep ;15(9):840-5. PMID: 22925074

Article Published Date : Aug 31, 2012

Study Type : Human Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57), Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)

Diseases : Hot Flash : CK(203) : AC(19), Menopausal Syndrome : CK(171) : AC(27)

High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer.

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Pubmed Data : J Natl Cancer Inst. 2007 Mar 21;99(6):475-86. PMID: 17374837

Article Published Date : Mar 21, 2007

Study Type : Human Study

Additional Links

Substances : Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31), phytoestrogens : CK(699) : AC(210)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Prevention : CK(525) : AC(73)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

There is a modest inverse association between lignan excretion and uterine fibroid risk.

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Pubmed Data : Cytotechnology. 2005 Jan;47(1-3):97-105. PMID: 16960173

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Daidzein : CK(965) : AC(28), Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Equol : CK(33) : AC(10), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Lignans : CK(110) : AC(31)

Diseases : Fibroids: Uterine : CK(46) : AC(16)

Dietary flaxseed may be chemopreventive for intestinal and colon tumor development in mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels.

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Pubmed Data : Nutr Cancer. 2009;61(2):276-83. PMID: 19235044

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31), Omega-3 Fatty Acids : CK(3333) : AC(319)

Diseases : Colon Cancer : CK(895) : AC(233), Intestinal Cancer : CK(37) : AC(9)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Cyclooxygenase 1 Inhibitor : CK(22) : AC(18), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Cyclooxygenase Inhibitors : CK(64) : AC(32)

Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels.

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2006;54(2):216-22. PMID: 16898866

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31), Omega-3 Fatty Acids : CK(3333) : AC(319)

Diseases : Colon Cancer : CK(895) : AC(233)

Pharmacological Actions : Cyclooxygenase 1 Inhibitor : CK(22) : AC(18), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)

Enterolactone and enterodiol have been shown to negate the tumor-stimulating effect of genistein in a mouse model of breast cancer.

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Pubmed Data : Mol Nutr Food Res. 2007 Jul;51(7):845-56. PMID: 17579892

Article Published Date : Jul 01, 2007

Study Type : Animal Study

Additional Links

Substances : Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Flaxseed : CK(275) : AC(57), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Lignans : CK(110) : AC(31), phytoestrogens : CK(699) : AC(210), Soy Protein : CK(2307) : AC(56)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Prevention : CK(525) : AC(73)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775)

Flaxseed and its lignans have potent antiestrogenic effects on estrogen receptor-positive breast cancer and may prove to be beneficial in breast cancer prevention strategies in the future.

Click here to read the entire abstract

Pubmed Data : Clin Cancer Res. 2007 Feb 1;13(3):1061-7. PMID: 17289903

Article Published Date : Feb 01, 2007

Study Type : Animal Study

Additional Links

Substances : Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31)

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Prevention : CK(525) : AC(73)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)

Flaxseed has radioprotective properties against lung injury.

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Pubmed Data : Radiat Res. 2012 Oct 29. Epub 2012 Oct 29. PMID: 23106213

Article Published Date : Oct 28, 2012

Study Type : Animal Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57), Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)

Diseases : Radiation-induced illness: Lung : CK(2) : AC(1)

Pharmacological Actions : Radioprotective : CK(456) : AC(183)

Flaxseed lignan attenuates high-fat diet-induced visceral and liver fat accumulation and induces adiponectin expression in mice.

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2008 Sep;100(3):669-76. Epub 2008 Feb 6. PMID: 18252024

Article Published Date : Sep 01, 2008

Study Type : Animal Study

Additional Links

Substances : Enterodiol : CK(34) : AC(12), Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31), Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)

Diseases : Abdominal Obesity (Midsection Fat) : CK(348) : AC(53), Adiponectin: Low Levels : CK(88) : AC(25), Fatty Liver : CK(493) : AC(122)

Pharmacological Actions : Anti-Adipogenic : CK(87) : AC(44)

Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.

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Pubmed Data : J Pharmacol Sci. 2006 Oct;102(2):196-204. Epub 2006 Oct 7. PMID: 17031070

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Bamboo : CK(45) : AC(22), Lignans : CK(110) : AC(31)

Diseases : Brain Damage : CK(89) : AC(41), Neurodegenerative Diseases : CK(1743) : AC(420)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Neuroprotective Agents : CK(962) : AC(480), Proteasome Inhibitors : CK(41) : AC(27)

Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer.

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):203-8. Epub 2011 Nov 10. PMID: 22080573

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Lignan-converting bacteria : CK(2) : AC(1), Lignans : CK(110) : AC(31), Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Additional Keywords : bacterial biotransformation

Rye lignan reduces estradiol-induced uterine growth.

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2009 Aug;53(8):996-1006. PMID: 19603405

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Isoflavones : CK(627) : AC(124), Lignans : CK(110) : AC(31), Rye : CK(40) : AC(8)

Diseases : Estrogen Dominance : CK(106) : AC(37), Uterine Cancer : CK(24) : AC(10)

Secoisolariciresinol diglucoside is effective in slowing the progression of atherosclerosis and partially effective in regression of hypercholesterolemic atherosclerosis.

Click here to read the entire abstract

Pubmed Data : Curr Pharm Biotechnol. 2010 Dec;11(8):794-800. PMID: 20874684

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57), Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)

Diseases : Atherosclerosis : CK(523) : AC(77)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Additional Keywords : Disease Regression : CK(138) : AC(20)

Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats.

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2010 Jan 5;183(1):255-63. PMID: 19835851

Article Published Date : Jan 05, 2010

Study Type : Animal Study

Additional Links

Substances : Lignans : CK(110) : AC(31)

Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Sesamin lignan reduced the growth of human breast tumors at high levels of circulating estrogen in athymic mice.

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2012 ;64(1):65-71. Epub 2011 Dec 2. PMID: 22136581

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Lignans : CK(110) : AC(31), Sesamin : CK(4) : AC(2)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

Sesamin may prevent the development of atherosclerosis and inflammatory responses

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2010 Sep ;54(9):1340-50. PMID: 20306475

Article Published Date : Sep 01, 2010

Study Type : Animal Study

Additional Links

Substances : Lignans : CK(110) : AC(31), Sesamol : CK(79) : AC(30)

Diseases : Atherosclerosis : CK(523) : AC(77), Endothelial Dysfunction : CK(897) : AC(173)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Soy and rye diets have an inhibitory effect on the development of prostate cancer in rats.

Click here to read the entire abstract

Pubmed Data : Med Princ Pract. 2008;17(2):131-5. Epub 2008 Feb 19. PMID: 9687986

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Lignans : CK(110) : AC(31), phytoestrogens : CK(699) : AC(210), Rye : CK(40) : AC(8), Soy Protein : CK(2307) : AC(56)

Diseases : Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

The lignan precursor from flaxseed known as secoisolariresinol diglucoside (SDG) may inhibit the progression of lupus nephritis.

Click here to read the entire abstract

Pubmed Data : Lupus. 2000;9(6):429-36. PMID: 10981647

Article Published Date : Jan 01, 2000

Study Type : Animal Study

Additional Links

Substances : Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31), Secoisolariciresinol diglucoside (SDG) : CK(387) : AC(5)

Diseases : Lupus Nephritis : CK(64) : AC(12)

Turmeric and curcumin reverse aflatoxin-induced liver damage.

Click here to read the entire abstract

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 1992 Aug;38(4):353-63. PMID: 1291640

Article Published Date : Aug 01, 1992

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482), Lignans : CK(110) : AC(31)

Diseases : Aflatoxicosis : CK(214) : AC(37), Liver Damage: Aflatoxin-Induced : CK(26) : AC(10)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Related Blogs

Protect Yourself from Radiation with Flaxseeds

Written by Margie King, Health Coach

We are bombarded every day by harmful radiation from medical tests like X-rays and CT scans, radon gas and radiation from space. And there is always worry about fallout from disasters like the meltdown at the Fukushima nuclear power plant in Japan. How do you protect yourself from radiation?

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