Lion's Mane (Hericium Erinaceus)

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Quick Summary: Current access displays 2 out of 25 associated Diseases

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Quick Summary: Current access displays 2 out of 23 associated Pharmacological Actions

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View the Evidence: Substances

Hericium erinaceus intake results in a reduction of depression and anxiety in mice by 4 weeks.

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Pubmed Data : Biomed Res. 2010 Aug ;31(4):231-7. PMID: 20834180

Article Published Date : Aug 01, 2010

Study Type : Human Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Anxiety Disorders : CK(641) : AC(82), Depression: Unipolar : CK(631) : AC(79)

Pharmacological Actions : Anxiolytic : CK(268) : AC(41)

Lion's mane improves mild cognitive impairment in human subjects.

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Pubmed Data : Phytother Res. 2009 Mar ;23(3):367-72. PMID: 18844328

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87)

Lion's mane has antitumor effects in tumor-bearing mice.

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Pubmed Data : J Agric Food Chem. 2011 Sep 28 ;59(18):9861-9. Epub 2011 Aug 25. PMID: 21846141

Article Published Date : Sep 28, 2011

Study Type : Animal Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Colon Cancer : CK(819) : AC(233), Low Immune Function: Natural Killer Cells : CK(108) : AC(21), Tumors : CK(193) : AC(110)

Pharmacological Actions : 5-Lipoxygenase Inhibitor : CK(5) : AC(4), Anti-Angiogenic : CK(136) : AC(101), Antineoplastic Agents : CK(833) : AC(457), Cyclooxygenase 2 Inhibitors : CK(274) : AC(169), Vascular Endothelial Growth Factor Inhibitors : CK(13) : AC(8)

Lion's mane improves lipid metabolism in mice fed a high-fat diet.

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Pubmed Data : Biosci Biotechnol Biochem. 2010 ;74(7):1447-51. Epub 2010 Jul 7. PMID: 20622452

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Lipid Metabolism: Abnormalities : CK(2) : AC(1)

Lion's mane prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide.

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Article Publish Status : This is a free article. Click here to read the entire article.

Pubmed Data : Biomed Res. 2011 Feb ;32(1):67-72. PMID: 21383512

Article Published Date : Feb 01, 2011

Study Type : Animal Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Amyloid toxicity : CK(3) : AC(2), Amyloid β peptide toxicity : CK(2) : AC(1), Learning disorders : CK(154) : AC(36), Memory Disorders : CK(211) : AC(65), Neurodegenerative Diseases : CK(1701) : AC(420)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Lion's mane stimulates immune function.

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Pubmed Data : J Herb Pharmacother. 2005;5(1):17-26. PMID: 7950232

Article Published Date : Jan 01, 2005

Study Type : Animal Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Immune Disorders: Low Immune Function : CK(488) : AC(115)

Pharmacological Actions : Immunomodulatory : CK(536) : AC(142)

Wounds dressed with HEFB [lion's mane] significantly enhanced the acceleration of wound healing enclosure in rats.

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Pubmed Data : Int J Med Mushrooms. 2011 ;13(1):33-9. PMID: 22135902

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Wound Healing : CK(224) : AC(69)

"Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation."

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Pubmed Data : Phytomedicine. 2010 Dec 1 ;17(14):1082-5. Epub 2010 Jul 16. PMID: 20637576

Article Published Date : Dec 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Hericenone B : CK(1) : AC(1), Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Thrombosis : CK(731) : AC(74)

Pharmacological Actions : Platelet aggregation inhibitor: collagen-induced aggregation : CK(1) : AC(1), Platelet Aggregation Inhibitors : CK(161) : AC(36)

A polysaccharide from Lion's mane enhances nerve growth and reduces cell death in adrenal cells.

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Pubmed Data : Cytotechnology. 2002 Sep ;39(3):155-62. PMID: 19003308

Article Published Date : Sep 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Adrenal Gland: Enhanced Apoptosis : CK(1) : AC(1), Adrenal Gland Diseases : CK(3) : AC(2)

Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Neuritogenic : CK(94) : AC(43)

Lion's main enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells.

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Pubmed Data : Cancer Lett. 2010 Nov 28 ;297(2):144-54. PMID: 20554107

Article Published Date : Nov 28, 2010

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Liver Cancer : CK(1577) : AC(266)

Pharmacological Actions : Apoptotic : CK(1416) : AC(1089), Chemosensitizer : CK(188) : AC(156)

Additional Keywords : Drug: Doxorubicin : CK(140) : AC(54)

Lion's Mane (Hericium erinaceus) contains a compound, Erinacine Q, which stimulates nerve growth factor.

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Pubmed Data : Biosci Biotechnol Biochem. 2002 Mar;66(3):571-5. PMID: 12005051

Article Published Date : Mar 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Neurodegenerative Diseases : CK(1701) : AC(420), Parkinson Disease : CK(541) : AC(79)

Pharmacological Actions : Neuritogenic : CK(94) : AC(43)

Lion's Mane (Hericium Erinaceus), Reishi (Ganoderma) and Schizophyllum commune mushrooms have antioxidant properties.

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Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:464238. Epub 2011 Jun 18. PMID: 21716693

Article Published Date : Jan 01, 2012

Study Type : Plant Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18), Reishi Mushroom : CK(114) : AC(46), Schizophyllum commune : CK(1) : AC(1)

Diseases : Oxidative Stress : CK(1867) : AC(710)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Lion's mane contains active compounds that stimulate Neural Growth Factor synthesis.

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Pubmed Data : Colorectal Dis. 2007 Jul;9(6):549-52. PMID: 18758067

Article Published Date : Jul 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Neurologic Disorders : CK(63) : AC(21)

Pharmacological Actions : Neuritogenic : CK(94) : AC(43)

Lion's mane contains compounds with antimutagenicity.

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Pubmed Data : Kaohsiung J Med Sci. 2001 May;17(5):230-8. PMID: 11517861

Article Published Date : May 01, 2001

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Pharmacological Actions : Antimutagenic Agents : CK(75) : AC(44)

Lion's mane induces programmed cell death in monocytic leukemia cells.

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Pubmed Data : Food Funct. 2011 Jun ;2(6):348-56. Epub 2011 Jun 8. PMID: 21779573

Article Published Date : Jun 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Infant Acute Monocytic Leukemia : CK(2) : AC(2), Leukemia: Monocytic : CK(11) : AC(2)

Pharmacological Actions : Antiproliferative : CK(969) : AC(725), Apoptotic : CK(1416) : AC(1089), Caspase-3 Activation : CK(16) : AC(15), Caspase-9 Activation : CK(5) : AC(5)

Lion's mane stimulates nerve myelination.

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Pubmed Data : Fiziol Zh. 2003;49(1):38-45. PMID: 12675022

Article Published Date : Jan 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Demyelinating Diseases : CK(1396) : AC(250), Neurologic Disorders : CK(63) : AC(21)

Pharmacological Actions : Neuritogenic : CK(94) : AC(43)

Lion's mane suppresses LPS-induced pro-inflammation gene activation in macrophages.

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Pubmed Data : Immunopharmacol Immunotoxicol. 2011 Nov 29. Epub 2011 Nov 29. PMID: 22126451

Article Published Date : Nov 29, 2011

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(233) : AC(128)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1144) : AC(420), Nitric Oxide Enhancer : CK(137) : AC(35), Prostaglandin PGE2 downregulation : CK(30) : AC(14), Reactive Oxygen Species (ROS) attenuation : CK(1) : AC(1)

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