Lutein

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Quick Summary: Current access displays 2 out of 23 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Macular Degeneration	21	3	Log in \| Sign up
Vision Disorders	20	2	Log in \| Sign up

Quick Summary: Current access displays 2 out of 9 associated Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Antioxidants	35	6	Log in \| Sign up
Chemopreventive	20	2	Log in \| Sign up

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View the Evidence: Substances

Decreased intake of vegetables and fruits during pregnancy and the consequent decreased intake of nutrients such as folate and lutein/zeaxanthin, necessary for DNA methylation, synthesis, and retinal function, may increase risk for having a child with sp

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1433-40. PMID: 15941952

Article Published Date : Jun 01, 2005

Study Type : Human Study

Additional Links

Substances : Folate: Dietary : CK(62) : AC(7), Fruit: All : CK(1926) : AC(472), Lutein : CK(124) : AC(22), Vegetables: All : CK(590) : AC(69), Zeaxanthin : CK(67) : AC(9)

Diseases : Retinoblastoma : CK(25) : AC(7)

Additional Keywords : Risk Reduction : CK(1943) : AC(195)

High combined intakes of vitamins C and E, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food, or a diet high in their food sources, may protect against cumulative DNA damage in ionizing radiation persons.

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Pubmed Data : Am J Clin Nutr. 2009 Nov;90(5):1402-10. Epub 2009 Sep 30. PMID: 19793852

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Substances : beta-Carotene : CK(217) : AC(38), Carotenoids : CK(1055) : AC(213), Lutein : CK(124) : AC(22), Vitamin C : CK(1178) : AC(238), Vitamin E : CK(1290) : AC(218), Zeaxanthin : CK(67) : AC(9)

Diseases : DNA damage : CK(680) : AC(293), Radiation Induced Illness : CK(1024) : AC(249)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Intake of vegetables appears to decrease premenopausal breast cancer risk.

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Pubmed Data : J Natl Cancer Inst. 1996 Mar 20;88(6):340-8. PMID: 8609642

Article Published Date : Mar 20, 1996

Study Type : Human Study

Additional Links

Substances : Carotenoids : CK(1055) : AC(213), Lutein : CK(124) : AC(22), Vegetables: All : CK(590) : AC(69), Zeaxanthin : CK(67) : AC(9)

Diseases : Breast Cancer: Prevention : CK(513) : AC(73)

Pharmacological Actions : Chemopreventive : CK(1314) : AC(355)

Additional Keywords : Risk Reduction : CK(1943) : AC(195)

Lutein reduces oxidative stress in the term newborn.

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Pubmed Data : Neonatology. 2010;97(1):36-40. Epub 2009 Jul 7. PMID: 19590244

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : Lutein : CK(124) : AC(22)

Diseases : Infant Nutrition : CK(72) : AC(14), Oxidative Stress : CK(1867) : AC(710)

Lutein supplementation improves visual fatigue.

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Pubmed Data : Appl Ergon. 2009 Nov;40(6):1047-54. Epub 2009 Jun 21. PMID: 19541291

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Substances : Lutein : CK(124) : AC(22)

Diseases : Vision Disorders : CK(71) : AC(8), Visual Fatigue : CK(10) : AC(1)

Lutein supplementation improves visual function in patients with age-related cataracts.

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Pubmed Data : Nutrition. 2003 Jan;19(1):21-4. PMID: 12507634

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : Lutein : CK(124) : AC(22)

Diseases : Cataract : CK(175) : AC(55)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Lutein supplementation improves visual function in people exposed to long-term computer display light exposure.

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Pubmed Data : : Paediatr Perinat Epidemiol. 1998 Apr;12(2):176-81. PMID: 19586568

Article Published Date : Apr 01, 1998

Study Type : Human Study

Additional Links

Substances : Lutein : CK(124) : AC(22)

Diseases : Computer display light exposure : CK(28) : AC(6)

Lutein supplementation improves visual function in those with age-related macular degeneration.

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Pubmed Data : Optometry. 2004 Apr;75(4):216-30. PMID: 15117055

Article Published Date : Apr 01, 2004

Study Type : Human Study

Additional Links

Substances : Lutein : CK(124) : AC(22)

Diseases : Macular Degeneration : CK(162) : AC(23)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance.

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Pubmed Data : Ophthalmic Physiol Opt. 2006 Jul;26(4):362-71. PMID: 16792735

Article Published Date : Jul 01, 2006

Study Type : Human Study

Additional Links

Substances : Lutein : CK(124) : AC(22), Zeaxanthin : CK(67) : AC(9)

Diseases : Vision Disorders : CK(71) : AC(8), Vision Loss : CK(40) : AC(4), Visual Display Terminal Eye Fatigue : CK(28) : AC(6)

The carotenoids meso-zeaxanthin, lutein and zeaxanthin augment macular pigmentation.

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Pubmed Data : Curr Eye Res. 2010 Apr;35(4):335-51. PMID: 20373901

Article Published Date : Apr 01, 2010

Study Type : Human Study

Additional Links

Substances : Carotenoids : CK(1055) : AC(213), Lutein : CK(124) : AC(22), Zeaxanthin : CK(67) : AC(9)

Diseases : Macular Degeneration : CK(162) : AC(23)

Vegetables and fruits rich in lycopene and other carotenoids may be protective against prostate cancer.

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Pubmed Data : Int J Cancer. 2005 Mar 1;113(6):1010-4. PMID: 15514967

Article Published Date : Mar 01, 2005

Study Type : Human Study

Additional Links

Substances : beta-Carotene : CK(217) : AC(38), Carotenoids : CK(1055) : AC(213), Cryptoxanthin : CK(36) : AC(8), Lutein : CK(124) : AC(22), Lycopene : CK(194) : AC(38), Tomato : CK(271) : AC(47), Watermelon : CK(48) : AC(9), Zeaxanthin : CK(67) : AC(9)

Diseases : Prostate Cancer: Prevention : CK(145) : AC(16)

Pharmacological Actions : Chemopreventive : CK(1314) : AC(355)

Additional Keywords : Risk Reduction : CK(1943) : AC(195)

Fucoxanthin, lutein and tetrahydrocurcumin may have chemopreventive effects against colon carcinogenesis.

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Pubmed Data : Carcinogenesis. 1998 Jan;19(1):81-5. PMID: 9472697

Article Published Date : Jan 01, 1998

Study Type : Animal Study

Additional Links

Substances : Carotenoids : CK(1055) : AC(213), Curcumin : CK(2890) : AC(1511), Fucoxanthin : CK(18) : AC(13), Lutein : CK(124) : AC(22), Tetrahydrocurcumin : CK(37) : AC(20)

Diseases : Colon Cancer : CK(819) : AC(233)

Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265), Antiproliferative : CK(969) : AC(725)

Lutein prevents the effect of high glucose levels on immune system cells in vivo and in vitro.

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Pubmed Data : J Physiol Biochem. 2008 Jun;64(2):149-57. PMID: 19043985

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Substances : Lutein : CK(124) : AC(22)

Diseases : Diabetes: Low Immune Function : CK(22) : AC(3), Hyperglycemia : CK(2867) : AC(59), Immune Disorders: Low Immune Function : CK(488) : AC(115), Oxidative Stress : CK(1867) : AC(710)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), NF-kappaB Inhibitor : CK(599) : AC(397)

Oleic acid can be used as a suitable fat source to modulate the absorption of dietary lutein and zeaxanthin from green leafy vegetables to manage age-related macular degeneration.

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Pubmed Data : J Agric Food Chem. 2007 Jul 25;55(15):6395-400. Epub 2007 Jun 30. PMID: 17602649

Article Published Date : Jul 25, 2007

Study Type : Animal Study

Additional Links

Substances : Green Leafy Vegetables : CK(205) : AC(42), Lutein : CK(124) : AC(22), Oleic acid : CK(18) : AC(6), Zeaxanthin : CK(67) : AC(9)

Diseases : Maculopathy: Age-Related : CK(37) : AC(7)

Oleic acid significantly enhances the bioavailability of lutein.

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Pubmed Data : Lipids. 2009 Sep;44(9):799-806. Epub 2009 Aug 14. PMID: 19685091

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Substances : Lutein : CK(124) : AC(22), Oleic acid : CK(18) : AC(6)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Lutein and lycopene exhibit chemopreventive properties during hepatocarcinogenesis.

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Pubmed Data : Nutr Cancer. 2003 ;47(1):62-9. PMID: 14769539

Article Published Date : Jan 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : Lutein : CK(124) : AC(22), Lycopene : CK(194) : AC(38)

Diseases : Liver Cancer: Prevention : CK(109) : AC(21)

Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265)

Lutein and zeaxanthin are conditionally essential nutrients needed to protect the macula.

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Pubmed Data : Med Hypotheses. 2003 Oct;61(4):465-72. PMID: 13679014

Article Published Date : Oct 01, 2003

Study Type : Review

Additional Links

Substances : Lutein : CK(124) : AC(22), Zeaxanthin : CK(67) : AC(9)

Diseases : Macular Degeneration : CK(162) : AC(23)

Lutein may have a role in the prevention of dementia due to its anti-oxidant properties.

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Pubmed Data : Br J Nutr. 2009 Nov;102(9):1280-4. Epub 2009 Jul 22. PMID: 19622187

Article Published Date : Nov 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Lutein : CK(124) : AC(22)

Diseases : Dementia : CK(207) : AC(31), Oxidative Stress : CK(1867) : AC(710)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Lutein protects against Deoxynivalenol-induced toxicity.

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Pubmed Data : Nutr J. 2009 Feb 2;8:7. PMID: 20347963

Article Published Date : Feb 02, 2009

Study Type : In Vitro Study

Additional Links

Substances : Lutein : CK(124) : AC(22)

Diseases : Deoxynivalenol Induced Toxicity : CK(1) : AC(1), Oxidative Stress : CK(1867) : AC(710)

Pharmacological Actions : Apoptotic : CK(1416) : AC(1089), Cyclooxygenase 2 Inhibitors : CK(274) : AC(169), NF-kappaB Inhibitor : CK(599) : AC(397)

Various carotenoids and flavonoids from plants may contribute to the reversal of multidrug resistance.

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Pubmed Data : Curr Top Med Chem. 2010;10(17):1757-68. PMID: 20645919

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Antheraxanthin : CK(1) : AC(1), Capsaicin : CK(47) : AC(25), Capsorubin : CK(2) : AC(2), Carotenoids : CK(1055) : AC(213), Chrysin : CK(15) : AC(12), Flavonoids : CK(868) : AC(290), Lutein : CK(124) : AC(22), Lycopene : CK(194) : AC(38), Paprika : CK(8) : AC(6), Phloretin : CK(4) : AC(4), Sakuranetin : CK(1) : AC(1)

Diseases : Cancers: Multi-Drug Resistant : CK(88) : AC(73)

Pharmacological Actions : Chemosensitizer : CK(188) : AC(156), P-glycoprotein Inhibitors : CK(1) : AC(1)

Watermelon and guava contain significant amounts of the carotenoids lycopene, lutein and beta-carotene.

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Pubmed Data : Int J Food Sci Nutr. 2009 Nov;60(7):558-66. PMID: 19817635

Article Published Date : Nov 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Carotenoids : CK(1055) : AC(213), Guava : CK(18) : AC(9), Lutein : CK(124) : AC(22), Lycopene : CK(194) : AC(38), Watermelon : CK(48) : AC(9)

Lutein prevents cataract development and progression in diabetic rats.

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Pubmed Data : Graefes Arch Clin Exp Ophthalmol. 2008 Sep 3. PMID: 18766362

Article Published Date : Sep 03, 2008

Additional Links

Substances : Lutein : CK(124) : AC(22)

Diseases : Cataract : CK(175) : AC(55)

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