Mangiferin

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View the Evidence: Substances

Mangifera indica and mangiferin has anti-parasitic and anti-allergic activities.

Pubmed Data : Phytother Res. 2003 Dec;17(10):1203-8. PMID: 14669257
Article Published Date : Dec 01, 2003
Study Type : Animal Study
Additional Links
Substances : Mangifera indica : CK(60) : AC(34), Mangiferin : CK(42) : AC(27)
Diseases : Allergies : CK(502) : AC(92), Parasitic Diseases : CK(57) : AC(20)
Pharmacological Actions : Anti-Allergic Agents : CK(89) : AC(38), Antiparasitic Agents : CK(26) : AC(15)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Xanthones : CK(50) : AC(28)

Mangifera indica exhibits ant-inflammatory properties.

Pubmed Data : Pharmacol Res. 2004 Aug;50(2):143-9. PMID: 15177302
Article Published Date : Aug 01, 2004
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Inflammation : CK(1077) : AC(363), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128), Pain : CK(616) : AC(91)
Pharmacological Actions : Analgesics : CK(372) : AC(78), Anti-Inflammatory Agents : CK(1230) : AC(433), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords : Drug: Indomethacin : CK(30) : AC(17), Plant Extracts : CK(3572) : AC(1216), Xanthones : CK(50) : AC(28)

Mangifera indica has immunomodulatory activity in mice.

Pubmed Data : J Ethnopharmacol. 2001 Dec;78(2-3):133-7. PMID: 11694357
Article Published Date : Dec 01, 2001
Study Type : Animal Study
Additional Links
Substances : Mangifera indica : CK(60) : AC(34), Mangiferin : CK(42) : AC(27)
Diseases : Hypersensitivity : CK(64) : AC(15)
Pharmacological Actions : Immunomodulatory : CK(536) : AC(142)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Xanthones : CK(50) : AC(28)

Mangiferin activates lymphocytes in normal and tumor bearing mice.

Pubmed Data : Cancer Lett. 1987 Nov;37(3):293-9. PMID: 3677060
Article Published Date : Nov 01, 1987
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Immune Disorders: Low Immune Function : CK(488) : AC(115), Tumors : CK(197) : AC(110)
Pharmacological Actions : Immunomodulatory : CK(536) : AC(142), Immunostimulatory : CK(143) : AC(33)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mangiferin exhibits anti-diabetic properties.

Pubmed Data : Phytomedicine. 2001 Mar;8(2):85-7. PMID: 11315760
Article Published Date : Mar 01, 2001
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hyperglycemia : CK(2892) : AC(59), Hyperinsulinism : CK(1182) : AC(41), Insulin Resistance : CK(1034) : AC(221)
Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Xanthones : CK(50) : AC(28)

Mangiferin inhibits bowel carcinogenesis in male rats.

Pubmed Data : Cancer Lett. 2001 Feb 26;163(2):163-70. PMID: 11165750
Article Published Date : Feb 26, 2001
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Colon Cancer : CK(895) : AC(233), Colon Polyps : CK(42) : AC(12)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Chemopreventive : CK(1528) : AC(382)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice.

Pubmed Data : Planta Med. 2009 Oct;75(13):1415-7. Epub 2009 Jun 16. PMID: 19533581
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Anemarrhena asphodeloides : CK(6) : AC(3), Mangiferin : CK(42) : AC(27)
Diseases : Allergies : CK(502) : AC(92), Anaphylaxis : CK(54) : AC(15), Pruritus : CK(12) : AC(2)
Pharmacological Actions : Anti-Allergic Agents : CK(89) : AC(38), NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Xanthones : CK(50) : AC(28)

Mangiferin may be of value in the prevention of benzo(a)pyrene-induced lung carcinogenesis.

Pubmed Data : Nutrition. 2003 Sep;19(9):794-9. PMID: 18816296
Article Published Date : Sep 01, 2003
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Mangiferin may reduce toxicity associated with hyperglycemia and atherogenicity in diabetic rats.

Pubmed Data : Med Hypotheses. 2001 May;56(5):610-3. PMID: 15740886
Article Published Date : May 01, 2001
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Arteriosclerosis : CK(2154) : AC(123), Diabetes: Cardiovascular Illness : CK(666) : AC(104)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Xanthones : CK(50) : AC(28)

Mangiferin prevents diabetic nephropathy progression in diabetic rats.

Pubmed Data : Gynecol Endocrinol. 2010 Jul 30. Epub 2010 Jul 30. PMID: 19960420
Article Published Date : Jul 30, 2010
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Diabetic Nephropathy : CK(43) : AC(17)

Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats.

Pubmed Data : Toxicology. 2002 Jul 15;176(3):165-73. PMID: 12093613
Article Published Date : Jul 15, 2002
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Diabetes Mellitus: Type 1: Prevention : CK(197) : AC(30), Kidney Damage : CK(120) : AC(42), Lipid Peroxidation : CK(403) : AC(127)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Cardioprotective : CK(702) : AC(196), Hypoglycemic Agents : CK(563) : AC(156), Renoprotective : CK(191) : AC(90)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mangiferin suppresses blood lipids in type 2 diabetes.

Pubmed Data : Scand J Immunol. 2000 Oct;52(4):348-55. PMID: 11558577
Article Published Date : Oct 01, 2000
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hyperlipidemia : CK(1211) : AC(109), Triglycerides: Elevated : CK(340) : AC(65)
Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mango leaves hae antioxidant and antiulcerogenic action.

Pubmed Data : Molecules. 2009;14(3):1098-110. Epub 2009 Mar 10. PMID: 19305363
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Mangiferin : CK(42) : AC(27), Mango : CK(60) : AC(34), Polyphenols : CK(427) : AC(174)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords : Xanthones : CK(50) : AC(28)

The Ayurvedic medicine Salacia oblonga (and the compound mangiferin) attenuates diabetic renal fibrosis in rats.

Pubmed Data : Evid Based Complement Alternat Med. 2009 Aug 25. Epub 2009 Aug 25. PMID: 19706694
Article Published Date : Aug 25, 2009
Study Type : Animal Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27), Salacia oblonga : CK(2) : AC(1)
Diseases : Diabetes: Kidney Function : CK(75) : AC(22), Renal Fibrosis : CK(4) : AC(2), Renal tubulointerstitial fibrosis : CK(15) : AC(7)
Therapeutic Actions : Ayurvedic Medicine : CK(63) : AC(4)
Pharmacological Actions : Angiotensin-Converting Enzyme Inhibitors : CK(20) : AC(12), Anti-Fibrotic : CK(30) : AC(19), Renoprotective : CK(191) : AC(90)

A Mangifera indica L. may have value for the treatment of neuropathic pain.

Pubmed Data : Molecules. 2010;15(12):9035-45. Epub 2010 Dec 9. PMID: 21150823
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Substances : Mangiferin : CK(42) : AC(27), Mango : CK(60) : AC(34)
Diseases : Neuropathic Pain : CK(157) : AC(24)

Gentiana lutea extract and mangiferin have radiprotective activities.

Pubmed Data : Phytother Res. 2010 Nov;24(11):1693-6. PMID: 21031630
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Gentian : CK(11) : AC(4), Mangiferin : CK(42) : AC(27)
Diseases : Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Radioprotective : CK(456) : AC(183)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Xanthones : CK(50) : AC(28)

Mangiferin and isomangiferin exhibit anti-herpse virus simplex acitivity.

Pubmed Data : Zhongguo Yao Li Xue Bao. 1989 Jan;10(1):85-90. PMID: 2554669
Article Published Date : Jan 01, 1989
Study Type : In Vitro Study
Additional Links
Substances : Isomangiferin : CK(2) : AC(2), Mangiferin : CK(42) : AC(27)
Diseases : HSV-1 : CK(53) : AC(48)
Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mangiferin and isomangiferin exhibit significant antiviral activity against herpes simplex virus.

Pubmed Data : Chin Med J (Engl). 1990 Feb;103(2):160-5. PMID: 2167819
Article Published Date : Feb 01, 1990
Study Type : In Vitro Study
Additional Links
Substances : Isomangiferin : CK(2) : AC(2), Mangiferin : CK(42) : AC(27)
Diseases : HSV-1 : CK(53) : AC(48)
Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)
Additional Keywords : Drug: Acyclovir : CK(1) : AC(1), Drug: Cyclocytidine : CK(1) : AC(1), Drug: Idoxuridine : CK(1) : AC(1), Superiority of Natural Substances versus Drugs : CK(826) : AC(164), Xanthones : CK(50) : AC(28)

Mangiferin attenuates mercury chloride induced cytotoxicity and genotoxicity in liver cells.

Pubmed Data : J Biochem Mol Toxicol. 2011 Feb 9. Epub 2011 Feb 9. PMID: 21308892
Article Published Date : Feb 09, 2011
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Mercury Poisoning : CK(162) : AC(44)
Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Mangiferin can inhibit the proliferation of HL-60 leukemia cells.

Pubmed Data : Zhong Yao Cai. 2010 Jan;33(1):81-5. PMID: 20518311
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Leukemia : CK(670) : AC(258), Promyelocytic leukemia : CK(136) : AC(74)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mangiferin exhibits 5-alpha reductase inhibitor activity indicating it may have value in the treatment of benign prostatic hyperplasia.

Pubmed Data : Yakugaku Zasshi. 2010 Sep;130(9):1207-14. PMID: 20823678
Article Published Date : Sep 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : 5alpha-dihydrotestosterone (DHT): Elevated Levels/Activity : CK(2) : AC(2), Prostatic Hyperplasia: Benign : CK(202) : AC(46)
Pharmacological Actions : 5-alpha reductase inhibitor : CK(42) : AC(13), Enzyme Inhibitors : CK(372) : AC(208)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mangiferin exhibits antiviral activity against herpes simplex virus type 2 in vitro.

Pubmed Data : Zhongguo Yao Li Xue Bao. 1993 Sep;14(5):452-4. PMID: 8010041
Article Published Date : Sep 01, 1993
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : HSV-2 : CK(53) : AC(29)
Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mangiferin has cytoprotective and antigenotoxic effects against cadmium chloride induced toxicity in liver cells.

Pubmed Data : Food Chem Toxicol. 2009 Mar;47(3):592-600. Epub 2008 Dec 25. PMID: 19138720
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Cadmium Poisoning : CK(64) : AC(30)
Pharmacological Actions : Antimutagenic Agents : CK(75) : AC(44), Apoptotic : CK(1489) : AC(1114), Cytoprotective : CK(10) : AC(8), Hepatoprotective : CK(557) : AC(272)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mangiferin has potent antitumor, immunomodulatory and anti-HIV activity.

Pubmed Data : J Obstet Gynaecol. 2009 Nov;29(8):681-5. PMID: 8957579
Article Published Date : Nov 01, 2009
Study Type : Review
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Fibrosarcoma : CK(10) : AC(7), HIV Infections : CK(577) : AC(184), Tumors : CK(197) : AC(110)
Pharmacological Actions : Anti-HIV Agents : CK(108) : AC(60), Antineoplastic Agents : CK(877) : AC(496)
Additional Keywords : Xanthones : CK(50) : AC(28)

Mangiferin protects against radiation-induced micronucleus formation in cultured human peripheral blood lymphocytes.

Pubmed Data : Environ Mol Mutagen. 2005 Jul;46(1):12-21. PMID: 15795888
Article Published Date : Jul 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(42) : AC(27)
Diseases : Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Antiproliferative : CK(1052) : AC(775), Genoprotective : CK(116) : AC(48), Radioprotective : CK(456) : AC(183)
Additional Keywords : Xanthones : CK(50) : AC(28)

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