Milk Thistle

Milk Thistle

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View the Evidence: Substances

A triple antioxidant approach to the treatment of hepatitis C may be superior to traditional interferon and antiviral drug therapy.

Pubmed Data : Med Klin (Munich). 1999 Oct 15;94 Suppl 3:84-9. PMID: 10554539
Article Published Date : Oct 15, 1999
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid : CK(384) : AC(82), Milk Thistle : CK(226) : AC(55), Selenium : CK(574) : AC(94)
Diseases : Hepatitis C : CK(401) : AC(62)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

A combination of soy, isoflavones, lycopene, silymarin and antoxidants significantly increases PSA doubling time in men with prostate cancer.

Pubmed Data : Eur Urol. 2005 Dec;48(6):922-30; discussion 930-1. Epub 2005 Oct 17. PMID: 16263208
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Substances : Antioxidant formulas : CK(487) : AC(73), Isoflavones : CK(627) : AC(124), Lycopene : CK(194) : AC(38), Milk Thistle : CK(226) : AC(55), Soy : CK(1672) : AC(347)
Diseases : Prostate: PSA Doubling : CK(133) : AC(16), Prostate Cancer : CK(998) : AC(288)

A mixture of milk thislte and phosphatidylcholine (LiverPro) has therapeutic activity in patients with chronic viral hepatitis C.

Pubmed Data : Klin Med (Mosk). 2008;86(11):60-2. PMID: 19177797
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55), Phosphatidylcholine : CK(101) : AC(22)
Diseases : Hepatitis C : CK(401) : AC(62)

A multi antioxidative treatment in chronic hepatitis C virus patients is well tolerated and therapeutic.

Pubmed Data : J Clin Gastroenterol. 2005 Sep;39(8):737-42. PMID: 16082287
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid : CK(384) : AC(82), Antioxidant formulas : CK(487) : AC(73), Glutathione : CK(61) : AC(16), Licorice : CK(257) : AC(81), Milk Thistle : CK(226) : AC(55), Schisandra : CK(129) : AC(43), Vitamin C : CK(1274) : AC(238), Vitamin E : CK(1285) : AC(221)
Diseases : Hepatitis C : CK(401) : AC(62)

A multi-herbal product called Protandim has significant antioxidant properties in human subjects.

Pubmed Data : Arzneimittelforschung. 2006;56(6):387-93. PMID: 16413416
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Ashwagandha : CK(137) : AC(63), Bacopa : CK(47) : AC(18), Green Tea : CK(930) : AC(294), Milk Thistle : CK(226) : AC(55), Protandim : CK(20) : AC(7), Turmeric : CK(2995) : AC(1585)
Diseases : Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Catalase Up-Regulation : CK(22) : AC(8), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

Drug Interaction Study: Silymarin does not adversely interact with rosuvastatin (Crestor).

Pubmed Data : Pharm Res. 2008 Aug;25(8):1807-14. Epub 2008 Jan 31. PMID: 18236139
Article Published Date : Aug 01, 2008
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)
Additional Keywords : Drug: Rosuvastatin : CK(10) : AC(1), Drug Interaction Studies : CK(10) : AC(1)

Milk thistle (Silybum marianum) compares favorably with fluoxetine in the treatment of obsessive-compulsive disorder.

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):362-365. Epub 2009 Dec 24. PMID: 20035818
Article Published Date : Mar 17, 2010
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55)
Diseases : Obsessive-Compulsive Disorder : CK(823) : AC(22)
Additional Keywords : Drug: Fluoxetine : CK(12) : AC(2), Natural Substances Versus Drugs : CK(988) : AC(165)

MSM contributes to the improvement of the symptoms of rosacea.

Pubmed Data : J Cosmet Dermatol. 2008 Mar;7(1):8-14. PMID: 18254805
Article Published Date : Mar 01, 2008
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55), MSM (Methylsulfonylmethane) : CK(63) : AC(8)
Diseases : Rosacea : CK(175) : AC(21)

Oral silibinin, an IGF-1 binder, may result in lowered IGF-1 levels in liver and colorectal cancer patients as indicated by its accumulation in blood and tissue samples.

Pubmed Data : Clin Cancer Res. 2006 May 1;12(9):2944-50. PMID: 16675592
Article Published Date : May 01, 2006
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55), Silibinin : CK(58) : AC(10), Silymarin : CK(36) : AC(8)
Diseases : Colorectal Cancer : CK(877) : AC(321), Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Insulin-Like Growth Factor Inhibition/Downregulation : CK(66) : AC(16)

Silibinin, a compound found within milk thistle, is well tolerated and shows a substantial antiviral effects against hepatitis C.

Pubmed Data : Gastroenterology. 2008 Nov;135(5):1561-7. Epub 2008 Aug 3. PMID: 18771667
Article Published Date : Nov 01, 2008
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55)
Diseases : Hepatitis C : CK(401) : AC(62)

Silymarin (from milk thistle) is well-tolerated and improves the condition of patients with alcoholic liver cirrhosis.

Pubmed Data : Biol Pharm Bull. 2005 Dec;28(12):2211-5. PMID: 11841050
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55)
Diseases : Liver Cirrhosis: Alcoholic : CK(33) : AC(5)

Silymarin (milk thistle) may be safe and effective in improving symptoms of acute clinical hepatitis.

Pubmed Data : Phytomedicine. 2009 May;16(5):391-400. Epub 2009 Mar 19. PMID: 19303273
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55)
Diseases : Hepatitis: Acute : CK(13) : AC(2)

Silymarin has anti-inflammatory activity superior to the drugs piroxicam and meloxicam in the treatment of osteoarthritis of the knee.

Pubmed Data : J Proteomics. 2010 Mar 10;73(5):951-64. Epub 2010 Jan 4. PMID: 19139781
Article Published Date : Mar 10, 2010
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55)
Diseases : Osteoarthritis : CK(615) : AC(91), Osteoarthritis: Knee : CK(357) : AC(38)
Pharmacological Actions : Interleukin-1 alpha downregulation : CK(34) : AC(12), Interleukin-8 downregulation : CK(97) : AC(28)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Silymarin significantly imrpoves desferrioxamine treatment outcomes in patients with beta-thalassemia.

Pubmed Data : Fundam Clin Pharmacol. 2009 Jun;23(3):359-65. Epub 2009 May 7. PMID: 19453758
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55)
Diseases : Thalassemia : CK(118) : AC(13)

Spirulina has therapeutic value in hepatitis C patients.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Gastroenterol. 2012 ;12:32. Epub 2012 Apr 12. PMID: 22497849
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55), Spirulina : CK(75) : AC(21)
Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)

The compound found in milk thistle known as silybin and soy phosphatidylcholine reduces body iron stores in patients with chronic hepatitis C.

Pubmed Data : J Clin Gastroenterol. 2008 Sep;42(8):937-44. PMID: 18458640
Article Published Date : Sep 01, 2008
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55), Phosphatidylcholine : CK(101) : AC(22)
Diseases : Hepatitis C : CK(401) : AC(62)

Treatment with a milk thistle (silybin), vitamin E and phospholipid formula improves the condition of patients with hepatitis C infection.

Pubmed Data : J Med Virol. 2008 Nov;80(11):1900-6. PMID: 18814247
Article Published Date : Nov 01, 2008
Study Type : Human Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55), Phosphatidylcholine : CK(101) : AC(22), Vitamin E : CK(1285) : AC(221)
Diseases : Hepatitis C : CK(401) : AC(62)

A multi-herbal product called Protandim exhibits chemopreventive properties in a mouse model of skin cancer.

Pubmed Data : PLoS One. 2010;5(7):e11902. Epub 2010 Jul 30. PMID: 20689586
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Ashwagandha : CK(137) : AC(63), Bacopa : CK(47) : AC(18), Green Tea : CK(930) : AC(294), Milk Thistle : CK(226) : AC(55), Protandim : CK(20) : AC(7), Turmeric : CK(2995) : AC(1585)
Diseases : Skin Cancer : CK(417) : AC(171)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Chemopreventive : CK(1528) : AC(382), Superoxide Dismutase Up-regulation : CK(131) : AC(42), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

A multi-herbal product called Protandim has chemopreventive properties against skin cancer.

Pubmed Data : PLoS One. 2009;4(4):e5284. Epub 2009 Apr 22. PMID: 19384424
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Ashwagandha : CK(137) : AC(63), Bacopa : CK(47) : AC(18), Green Tea : CK(930) : AC(294), Milk Thistle : CK(226) : AC(55), Protandim : CK(20) : AC(7), Turmeric : CK(2995) : AC(1585)
Diseases : Oxidative Stress : CK(1945) : AC(710), Skin Cancer : CK(417) : AC(171)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), NF-kappa-B-inducing kinase (NIK) modulator : CK(3) : AC(2), Superoxide Dismutase Up-regulation : CK(131) : AC(42), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105), Vascular Cell Adhesion Molecule-1 Inhibitor : CK(94) : AC(24)

A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.

Pubmed Data : Circulation. 2009 Nov 17;120(20):1951-60. Epub 2009 Nov 2. PMID: 19884466
Article Published Date : Nov 17, 2009
Study Type : Animal Study
Additional Links
Substances : Ashwagandha : CK(137) : AC(63), Bacopa : CK(47) : AC(18), Green Tea : CK(930) : AC(294), Milk Thistle : CK(226) : AC(55), Protandim : CK(20) : AC(7), Turmeric : CK(2995) : AC(1585)
Diseases : Heart Failure : CK(711) : AC(97), Hypertension : CK(2783) : AC(271), Hypertension: Pulmonary : CK(1830) : AC(34)
Pharmacological Actions : Anti-Fibrotic : CK(30) : AC(19), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)

A poly-herbal formula named Protandim reduces oxidative stress in a mouse model of Duchenne muscular dystrophy.

Pubmed Data : J Diet Suppl. 2010 Jun 1;7(2):159-178. PMID: 20740052
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Ashwagandha : CK(137) : AC(63), Bacopa : CK(47) : AC(18), Green Tea : CK(930) : AC(294), Milk Thistle : CK(226) : AC(55), Protandim : CK(20) : AC(7), Turmeric : CK(2995) : AC(1585)
Diseases : Duchenne's Muscular Dystrophy : CK(12) : AC(6)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Both systemic and local administration of silymarin was effective against burn-induced oxidative damage and morphological alterations in rat skin.

Pubmed Data : Burns. 2007 Nov;33(7):908-16. Epub 2007 May 22. PMID: 17521818
Article Published Date : Nov 01, 2007
Study Type : Animal Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55)
Diseases : Burns : CK(84) : AC(22), Burns: Severe : CK(37) : AC(7)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Milk thistle sprouts have significant antioxidant value which increases with light exposure.

Pubmed Data : Br J Cancer. 2005 Sep 5;93(5):590-6. PMID: 17852500
Article Published Date : Sep 05, 2005
Study Type : Animal Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Milk Thistle : CK(226) : AC(55), Polyphenols : CK(427) : AC(174), Sprouts : CK(76) : AC(36)
Diseases : Oxidative Stress : CK(1945) : AC(710)
Therapeutic Actions : Light Therapy : CK(69) : AC(19)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Silibinin has radioprotective properties.

Pubmed Data : Mutat Res. 2010 Jan;695(1-2):55-60. Epub 2009 Nov 27. PMID: 19945544
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55), Silibinin : CK(58) : AC(10)
Diseases : DNA damage : CK(711) : AC(293), Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Radioprotective : CK(456) : AC(183)

Silibinin inhibits human hepatocellular carcinoma xenografts in nude mice.

Pubmed Data : World J Gastroenterol. 2009 Apr 28 ;15(16):1943-50. PMID: 19399925
Article Published Date : Apr 28, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Milk Thistle : CK(226) : AC(55), Silibinin : CK(58) : AC(10)
Diseases : Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Superoxide Dismutase Up-regulation : CK(131) : AC(42)

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