Orange

Orange

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View the Evidence: Substances

Ambient odor of orange in a dental office reduces anxiety and improves mood in female patients.

Pubmed Data : Physiol Behav. 2000 Oct 1-15;71(1-2):83-6. PMID: 11134689
Study Type : Human Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Anxiety Disorders : CK(659) : AC(82), Mood Disorders : CK(123) : AC(13)
Therapeutic Actions : Aromatherapy : CK(371) : AC(37)

Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office.

Pubmed Data : Physiol Behav. 2005 Sep 15;86(1-2):92-5. PMID: 16095639
Article Published Date : Sep 15, 2005
Study Type : Human Study
Additional Links
Substances : Lavender : CK(318) : AC(33), Orange : CK(127) : AC(28)
Diseases : Anxiety Disorders : CK(659) : AC(82), Mood Disorders : CK(123) : AC(13)
Therapeutic Actions : Aromatherapy : CK(371) : AC(37)

Aroma-massage therapy with ginger and orange oil have potential as an alternative method for short-term knee pain relief.

Pubmed Data : Microbes Infect. 2006 May;8(6):1450-4. Epub 2006 Mar 29. PMID: 18534325
Article Published Date : May 01, 2006
Study Type : Human Study
Additional Links
Substances : Ginger : CK(310) : AC(89), Orange : CK(127) : AC(28)
Diseases : Osteoarthritis: Knee : CK(357) : AC(38)
Therapeutic Actions : Aromatherapy : CK(371) : AC(37), Massage/Therapeutic Touch : CK(710) : AC(72)

Common fruit provide a dietary source of melatonin.

Pubmed Data : J Agric Food Chem. 2013 Jan 17. Epub 2013 Jan 17. PMID: 23252791
Article Published Date : Jan 16, 2013
Study Type : Human Study
Additional Links
Substances : Banana : CK(123) : AC(36), Orange : CK(127) : AC(28), Pineapple : CK(141) : AC(39)
Diseases : Hormone Imbalances: Low Melatonin : CK(64) : AC(7)

Dietary consumption of fruits high in antioxidant nutrients reduce the risk of incident cervical intraepithelial neoplasia.

Pubmed Data : Gynecol Oncol. 2010 Sep;118(3):289-94. Epub 2010 Jun 18. PMID: 20691333
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Substances : Alpha-Carotene : CK(30) : AC(3), Cryptoxanthin : CK(36) : AC(8), Fruit: All : CK(1836) : AC(472), Orange : CK(127) : AC(28), Papaya : CK(96) : AC(39)
Diseases : Cervical Dysplasia : CK(128) : AC(15)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer.

Pubmed Data : Arch Intern Med. 2000 Apr 10;160(7):1009-13. PMID: 17192901
Article Published Date : Apr 10, 2000
Study Type : Human Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Fruit: All : CK(1836) : AC(472), Grapefruit : CK(109) : AC(30), Lemon Juice : CK(46) : AC(7), Orange : CK(127) : AC(28), Vitamin C : CK(1274) : AC(238)
Diseases : Esophageal Cancer : CK(328) : AC(55)
Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Orange juice may have a therapeutic effect in reducing stone-forming risk.

Pubmed Data : Clin J Am Soc Nephrol. 2006 Nov;1(6):1269-74. Epub 2006 Aug 30. PMID: 17699358
Article Published Date : Nov 01, 2006
Study Type : Human Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Kidney Stones : CK(157) : AC(28)

Orange juice raises HDL cholesterol in subjects with high cholesterol.

Pubmed Data : Am J Clin Nutr. 2000 Nov;72(5):1095-100. PMID: 11063434
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : HDL: Low : CK(255) : AC(45)

Supplementation with orange and blackcurrant juice improves inflammatory markers in patients with peripheral arterial disease.

Pubmed Data : Br J Nutr. 2009 Jan;101(2):263-9. Epub 2008 May 28. PMID: 18507878
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Black Currant : CK(58) : AC(10), Orange : CK(127) : AC(28), Sweet Orange : CK(12) : AC(2)
Diseases : Elevated CRP : CK(72) : AC(8), Fibrinogen: Elevated : CK(114) : AC(13), Inflammation : CK(1077) : AC(363), Peripheral Arterial Disease : CK(260) : AC(26)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords : Oranges are Anti-inflammatory : CK(10) : AC(1)

Tropical fruit consumption increases the serum melatonin concentrations and also raises the antioxidant capacity in the serum of healthy volunteers in proportion to serum melatonin levels.

Pubmed Data : J Pineal Res. 2012 Oct 5. Epub 2012 Oct 5. PMID: 23137025
Article Published Date : Oct 04, 2012
Study Type : Human Study
Additional Links
Substances : Banana : CK(123) : AC(36), Orange : CK(127) : AC(28), Pineapple : CK(141) : AC(39)
Diseases : Hormone Imbalances: Low Melatonin : CK(64) : AC(7)

Citrus juice positively affects serum antioxidant status and bone strength.

Pubmed Data : Nutrition. 2006 May;22(5):559-63. Epub 2006 Feb 10. PMID: 16472977
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Osteoporosis : CK(1171) : AC(205)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Orange juice and hesperetin supplementation have significant therapeutic activity in hyperuricemic rats.

Pubmed Data : J Clin Biochem Nutr. 2009 Nov;45(3):285-91. Epub 2009 Oct 28. PMID: 19902018
Article Published Date : Nov 01, 2009
Study Type : Animal Study
Additional Links
Substances : Hesperidin : CK(160) : AC(38), Orange : CK(127) : AC(28)
Diseases : Hyperuricemia : CK(253) : AC(32)

Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin induced toxicity.

Pubmed Data : Am J Clin Nutr. 2010 Apr;91(4):940-9. Epub 2010 Mar 3. PMID: 20200256
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Endotoxemia : CK(187) : AC(40), Inflammation : CK(1077) : AC(363)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Orange peel extract has chemopreventive properties against lesions in the mouse mammary gland.

Pubmed Data : J Med Food. 2007 Mar;10(1):18-24. PMID: 17472462
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Breast Cancer : CK(2361) : AC(621)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Apoptotic : CK(1535) : AC(1155), Chemopreventive : CK(1528) : AC(382)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Orange peel extract inhibited tumorigenesis in this preclinical mouse model of adenomatous polyposis and increases programmed cell death.

Pubmed Data : J Med Food. 2007 Mar;10(1):11-7. PMID: 17472461
Article Published Date : Mar 01, 2007
Study Type : Animal Study
Additional Links
Substances : Citrus Peel : CK(65) : AC(8), Orange : CK(127) : AC(28)
Diseases : Adenomatous Polyposis Coli : CK(8) : AC(4), Intestinal Cancer : CK(37) : AC(9), Intestinal Polyps : CK(18) : AC(9)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Apoptotic : CK(1535) : AC(1155)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Orange peel flavonoids inhibit experimental adjuvant-induced rat arthritis.

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2010 May;35(10):1298-301. PMID: 20707201
Article Published Date : May 01, 2010
Study Type : Animal Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Orange : CK(127) : AC(28)
Diseases : Arthritis : CK(1430) : AC(218), Inflammation : CK(1077) : AC(363), Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords : Adjuvant-Induced Injury : CK(11) : AC(6), Plant Extracts : CK(3616) : AC(1226)

Orange pulp improved bone quality in a rat model of male osteoporosis.

Pubmed Data : J Med Food. 2009 Apr;12(2):298-303. PMID: 19459729
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Osteoporosis: Male : CK(15) : AC(8)

Sweet Orange peel has antithyroidal activity which may be therapeutic in hyperthyroidism.

Pubmed Data : J Med Food. 2008 Jun;11(2):376-81. PMID: 18598183
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Orange : CK(127) : AC(28), Sweet Orange : CK(12) : AC(2)
Diseases : Hyperthyroidism : CK(189) : AC(33)

Carotenoids extracted from red paprika, Valencia orange and Golden delicious apple exhibit anti-H. pylori and anti-multidrug resistance activity.

Pubmed Data : Phytother Res. 2005 Aug;19(8):700-7. PMID: 16177974
Article Published Date : Aug 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Apple: Golden Delicious : CK(2) : AC(2), Carotenoids : CK(1055) : AC(213), Orange : CK(127) : AC(28), Paprika : CK(8) : AC(6)
Diseases : Cancers: All : CK(9062) : AC(2869), Cancers: Multi-Drug Resistant : CK(92) : AC(73), Helicobacter Pylori Infection : CK(305) : AC(61)
Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316), Antioxidants : CK(3653) : AC(1318), Chemosensitizer : CK(197) : AC(159)

Citrus fruit extracts represent an important source of antioxidants and reduces advanced glycation end products (AGEs).

Pubmed Data : J Agric Food Chem. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20882960
Article Published Date : Sep 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Diabetes: Oxidative Stress : CK(65) : AC(18), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Compounds from orange peel have anti-cancer activity against breast cancer cells.

Pubmed Data : Mol Nutr Food Res. 2007 Dec;51(12):1478-84. PMID: 17979096
Article Published Date : Dec 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Breast Cancer : CK(2361) : AC(621)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155)

Compounds from orange peel inhibit the proliferation of promyelocytic leukemia (HL-60) cells.

Pubmed Data : Bioorg Med Chem. 2007 May 15;15(10):3381-9. Epub 2007 Mar 13. PMID: 17391969
Article Published Date : May 15, 2007
Study Type : In Vitro Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Promyelocytic leukemia : CK(136) : AC(74)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Compounds from sweet orange peel inhibit the growth of human lung cancer cells.

Pubmed Data : Mol Nutr Food Res. 2009 Mar;53(3):398-406. PMID: 19065586
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Orange : CK(127) : AC(28)
Diseases : Lung Cancer : CK(496) : AC(198)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antioxidants : CK(3653) : AC(1318), Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155)

Limonene and essential oil from orange has gastroprotective actions.

Pubmed Data : Chem Biol Interact. 2009 Aug 14;180(3):499-505. Epub 2009 May 3. PMID: 19410566
Article Published Date : Aug 14, 2009
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene : CK(20) : AC(8), Orange : CK(127) : AC(28)
Diseases : Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)

Orange juice inhibits prostate cell proliferation.

Pubmed Data : Fitoterapia. 2006 Apr;77(3):151-5. Epub 2006 Feb 23. PMID: 16530345
Article Published Date : Apr 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Orange : CK(127) : AC(28)
Diseases : Prostatic Hyperplasia: Benign : CK(202) : AC(46)
Pharmacological Actions : Antiproliferative : CK(1058) : AC(775)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

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Researchers from China's State Agriculture Ministry and Zhejiang University have determined that two ingredients commonly found in many citrus fruits, naringin and neohesperidin, will effectively reduce blood sugar.

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