phytoestrogens

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View the Evidence: Substances

Exposure to isoflavone-containing soy products may improve endothelial function.

Pubmed Data : Nutr Metab Cardiovasc Dis. 2010 Aug 14. Epub 2010 Aug 14. PMID: 20709515
Article Published Date : Aug 14, 2010
Study Type : Meta Analysis
Additional Links
Substances : Isoflavones : CK(627) : AC(124), phytoestrogens : CK(699) : AC(210), Soy : CK(1688) : AC(350), Soy Protein : CK(2307) : AC(56)
Diseases : Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173)

Beer drinking contributes to higher bone density as a result of the phytoestrogen content (hops) of this alcoholic beverage.

Pubmed Data : Nutrition. 2009 Oct;25(10):1057-63. Epub 2009 Jun 13. PMID: 19527924
Article Published Date : Oct 01, 2009
Study Type : Human Study
Additional Links
Substances : Beer : CK(37) : AC(8), Hops : CK(51) : AC(20), phytoestrogens : CK(699) : AC(210)
Diseases : Osteoporosis : CK(1171) : AC(205)

Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users.

Pubmed Data : Breast Cancer Res Treat. 2009 Sep;117(1):111-9. Epub 2008 Oct 18. PMID: 18931907
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Substances : phytoestrogens : CK(699) : AC(210)
Diseases : Breast Cancer : CK(2361) : AC(621), Estrogen Dominance : CK(106) : AC(37)

Daidzein-rich isoflavone are effective in reducing hot flashes in menopausal women.

Pubmed Data : Life Sci. 2007 Apr 24;80(20):1821-31. Epub 2007 Feb 3. PMID: 18257146
Article Published Date : Apr 24, 2007
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Isoflavones : CK(627) : AC(124)
Diseases : Hot Flash : CK(203) : AC(19), Menopausal Syndrome : CK(171) : AC(27)

Dietary intake of isoflavone is inversely associated with the risk of lower urinary tract symptoms.

Pubmed Data : Br J Nutr. 2007 Dec;98(6):1237-42. Epub 2007 Jul 19. PMID: 17640419
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy : CK(1688) : AC(350)
Diseases : Lower Urinary Tract Symptoms : CK(12) : AC(2), Prostatic Hyperplasia: Benign : CK(202) : AC(46)

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer.

Pubmed Data : Gynecol Oncol. 2006 Jan;100(1):205-9. Epub 2005 Sep 19. PMID: 16171852
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124), Soy : CK(1688) : AC(350)
Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Ovarian Cancer : CK(154) : AC(58)
Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)

Genistein and daidzein consumption are associated with a lower risk of prostate cancer.

Pubmed Data : J Altern Complement Med. 2009 Aug;15(8):905-9. PMID: 19838933
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Genistein : CK(450) : AC(174), Isoflavones : CK(627) : AC(124)
Diseases : Prostate Cancer: Prevention : CK(155) : AC(16)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382)
Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Genistein appears to have a positive effect on hot flushes without a negative impact on endometrial thickness in early postmenopausal women.

Pubmed Data : Menopause. 2004 Jul-Aug;11(4):400-4. PMID: 15243277
Article Published Date : Jul 01, 2004
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Hot Flash : CK(203) : AC(19), Postmenopausal Disorders : CK(285) : AC(35)

Genistein compares favorably to HRT in supporting bone health in early postmenopausal women.

Pubmed Data : J Bone Miner Res. 2002 Oct;17(10):1904-12. PMID: 12369794
Article Published Date : Oct 01, 2002
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Osteopenia : CK(207) : AC(41), Osteoporosis : CK(1171) : AC(205), Postmenopausal Disorders : CK(285) : AC(35)
Additional Keywords : HRT Alternatives : CK(21) : AC(3), Natural Substances Versus Drugs : CK(988) : AC(165)

Genistein has a positive effect on bone metabolism in osteopenic postmenopausal women, without increasing endometrial thickness.

Pubmed Data : Ann Intern Med. 2007 Jun 19;146(12):839-47. PMID: 17577003
Article Published Date : Jun 19, 2007
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Osteoporosis : CK(1171) : AC(205)

Genistein has favorable effects on some predictors of cardiovascular risk in osteopenic, postmenopausal women.

Pubmed Data : Exp Gerontol. 2010 Jan 18. Epub 2010 Jan 18. PMID: 17682090
Article Published Date : Jan 18, 2010
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Osteopenia : CK(207) : AC(41), Postmenopausal Disorders : CK(285) : AC(35)
Pharmacological Actions : Vascular Cell Adhesion Molecule-1 Inhibitor : CK(94) : AC(24)

Genistein has therapeutic value in reducing PSA levels in men with prostate cancer.

Pubmed Data : Urology. 2004 Feb;63(2):259-63. PMID: 14972467
Article Published Date : Feb 01, 2004
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Prostate: PSA Doubling : CK(133) : AC(16), Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Genistein inhibits nonalcoholic fatty liver disease.

Pubmed Data : J Gastroenterol Hepatol. 2007 Nov;22(11):2009-14. PMID: 17914984
Article Published Date : Nov 01, 2007
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Fatty Liver : CK(493) : AC(122), Hepatic Steatosis : CK(102) : AC(21), Liver: Fatty : CK(490) : AC(118)
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Genistein is safe and effective in improving bone density without adverse responses in breast density or endometrium thickness in osteopenic, postmenopausal women.

Pubmed Data : J Clin Endocrinol Metab. 2008 Dec;93(12):4787-96. Epub 2008 Sep 16. PMID: 18796517
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Osteopenia : CK(207) : AC(41), Osteoporosis : CK(1171) : AC(205)

Genistein may block metastasis and mortality in prostate cancer through blocking the activation of MEK4 and MMP-2 expression.

Pubmed Data : J Natl Cancer Inst. 2009 Aug 19;101(16):1141-55. Epub 2009 Jul 28. PMID: 19638505
Article Published Date : Aug 19, 2009
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Prostate Cancer : CK(998) : AC(288)
Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), Mitogen-activated protein kinase kinase 4 (MEK4) : CK(11) : AC(2)

Genistein reduces vasomotor symptoms, e.g. hot flush, within postmenopausal women.

Pubmed Data : Menopause. 2007 Jul-Aug;14(4):648-55. PMID: 17251874
Article Published Date : Jul 01, 2007
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Hot Flash : CK(203) : AC(19), Postmenopausal Disorders : CK(285) : AC(35)

Genistein significantly decreases hot flash symptoms in healthy postmenopausal women.

Pubmed Data : Maturitas. 2011 Feb;68(2):189-96. Epub 2010 Dec 15. PMID: 21163595
Article Published Date : Feb 01, 2011
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Hot Flash : CK(203) : AC(19), Postmenopausal Disorders : CK(285) : AC(35)

High dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer.

Pubmed Data : J Natl Cancer Inst. 2007 Mar 21;99(6):475-86. PMID: 17374837
Article Published Date : Mar 21, 2007
Study Type : Human Study
Additional Links
Substances : Enterodiol : CK(34) : AC(12), Enterolactone : CK(301) : AC(10), Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31), phytoestrogens : CK(699) : AC(210)
Diseases : Breast Cancer : CK(2361) : AC(621), Breast Cancer: Prevention : CK(525) : AC(73)
Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Higher concentrations of circulating genistein may reduce the risk of prostate cancer.

Pubmed Data : Br J Cancer. 2009 Jun 2;100(11):1817-23. Epub 2009 May 12. PMID: 19436304
Article Published Date : Jun 02, 2009
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174), phytoestrogens : CK(699) : AC(210)
Diseases : Prostate Cancer: Prevention : CK(155) : AC(16)
Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Increased consumption of genistein is associated with better lung function in patients with asthma.

Pubmed Data : J Asthma. 2004;41(8):833-43. PMID: 15641633
Article Published Date : Jan 01, 2004
Study Type : Human Study
Additional Links
Substances : Genistein : CK(450) : AC(174)
Diseases : Asthma : CK(918) : AC(134)

Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.

Pubmed Data : Int J Gynaecol Obstet. 2008 Jul;102(1):44-9. Epub 2008 Apr 8. PMID: 18395723
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Substances : Daidzein : CK(965) : AC(28), Equol : CK(33) : AC(10), Isoflavones : CK(627) : AC(124)
Diseases : Menopausal Syndrome : CK(171) : AC(27)

Isolfavones have therapeutic value in the treatment of cyclical mastalgia.

Pubmed Data : Breast. 2002 Apr;11(2):170-4. PMID: 14965665
Article Published Date : Apr 01, 2002
Study Type : Human Study
Additional Links
Substances : Isoflavones : CK(627) : AC(124), phytoestrogens : CK(699) : AC(210)
Diseases : Mastalgia : CK(30) : AC(3)

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