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Piperidines
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Additional Topics Details for this Page
Article Count
- 17
Cumulative Knowledge
- 47
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View the Evidence: Substances
Bioavailability Study: Piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.
Click here to read the entire abstract
Pubmed Data
: Planta Med. 1998 May;64(4):353-6. PMID:
9619120
Article Published Date
: May 01, 1998
Study Type
: Human Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Piperidines : CK(45) : AC(17)
Gingko biloba compares favorably to the drug Aricept (donepezil) for the treatment of Alzheimer's dementia.
Click here to read the entire abstract
Pubmed Data
: Eur J Neurol. 2006 Sep;13(9):981-5. PMID:
16930364
Article Published Date
: Sep 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Ginkgo biloba : CK(512) : AC(97)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
,
Dementia : CK(225) : AC(31)
Additional Keywords
:
Donepezil Alternatives : CK(20) : AC(2)
,
Natural Substances Versus Drugs : CK(988) : AC(165)
,
Plant Extracts : CK(3572) : AC(1216)
Curcumin and piperine prevents chemically-induced oral cancer.
Click here to read the entire abstract
Pubmed Data
: Singapore Med J. 2009 Feb;50(2):139-46. PMID:
19296028
Article Published Date
: Feb 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Oral Cancer : CK(66) : AC(43)
,
Oxidative Stress : CK(1945) : AC(710)
,
Squamous cell carcinoma : CK(79) : AC(36)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
,
Antioxidants : CK(3653) : AC(1318)
Curcumin protects against oxidative insult induced by pentylenetetrazol in epileptic rats.
Click here to read the entire abstract
Pubmed Data
: Methods Find Exp Clin Pharmacol. 2010 May;32(4):227-32. PMID:
20508869
Article Published Date
: May 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Drug-Induced Toxicity: Epilepsy Drugs : CK(2) : AC(1)
,
Epilepsy : CK(128) : AC(27)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords
:
Drug Synergy : CK(327) : AC(147)
Piperine exhibit chempreventive effects in chemically-induced lung cancer in mice.
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2005 Mar;271(1-2):101-6. PMID:
15881660
Article Published Date
: Mar 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Black Pepper : CK(88) : AC(35)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Lung Cancer : CK(496) : AC(198)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
,
Chemopreventive : CK(1528) : AC(382)
Piperine may extend its chemopreventive effect through modulating the protein bound carbohydrate levels, as they are one of the indicators of tumorigenesis.
Click here to read the entire abstract
Pubmed Data
: Pulm Pharmacol Ther. 2006;19(2):107-11. Epub 2005 Jun 21. PMID:
15975841
Article Published Date
: Jan 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Black Pepper : CK(88) : AC(35)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Benzo[a]pyrene-induced Toxicity : CK(62) : AC(33)
,
Lung Cancer : CK(496) : AC(198)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
,
Antioxidants : CK(3653) : AC(1318)
Piperine protects against cisplatin-induced toxicity in auditory cells.
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2007 Sep;18(9):615-22. Epub 2007 Apr 5. PMID:
17418561
Article Published Date
: Sep 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Piperidines : CK(45) : AC(17)
Diseases
:
Chemotherapy-Induced Toxicity : CK(704) : AC(184)
,
Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
,
Apoptotic : CK(1489) : AC(1114)
Piperine supplementation markedly protects erythrocytes from oxidative stress by improving the antioxidant status in high fat fed antithyroid drug treated rats.
Click here to read the entire abstract
Pubmed Data
: Cell Biochem Funct. 2006 Nov-Dec;24(6):491-8. PMID:
16927417
Article Published Date
: Nov 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Black Pepper : CK(88) : AC(35)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Hyperlipidemia : CK(1211) : AC(109)
,
Hyperthyroidism : CK(189) : AC(33)
,
Thyroid Diseases : CK(182) : AC(23)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
Additional Keywords
:
Antithyroid Drugs : CK(2) : AC(1)
Piperine, a major component of black pepper, inhibits cadmium-induced immunsuppression.
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2006 Aug 14;72(4):486-97. Epub 2006 Jun 14. PMID:
16780805
Article Published Date
: Aug 14, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Black Pepper : CK(88) : AC(35)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Cadmium Poisoning : CK(64) : AC(30)
,
Heavy Metal Toxicity : CK(607) : AC(177)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition.
Click here to read the entire abstract
Pubmed Data
: Bratisl Lek Listy. 2010;111(8):426-31. PMID:
21033621
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Piperidines : CK(45) : AC(17)
Diseases
:
Hypertension : CK(2783) : AC(271)
Pharmacological Actions
:
Hypotensive : CK(383) : AC(53)
Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats.
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2007 Sep;105(1):17-28. Epub 2006 Nov 17. PMID:
16910313
Article Published Date
: Sep 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Black Pepper : CK(88) : AC(35)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Hyperlipidemia : CK(1211) : AC(109)
The antidepressant-like effect of piperine is associated wtih its inhibitory effect on monoamine oxidase.
Click here to read the entire abstract
Pubmed Data
: Chem Pharm Bull (Tokyo). 2005 Jul;53(7):832-5. PMID:
15997146
Article Published Date
: Jul 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Piperidines : CK(45) : AC(17)
,
Piperine : CK(29) : AC(14)
Pharmacological Actions
:
Antidepressive Agents : CK(142) : AC(31)
,
Monoamine Oxidase Inhibitors : CK(2) : AC(1)
A variety of natural compounds may inhibit cancer stem cells.
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2011 Sep ;22(9):799-806. Epub 2011 Feb 4. PMID:
21295962
Article Published Date
: Sep 01, 2011
Study Type
: Review
Additional Links
Substances
:
Carotenoids : CK(1055) : AC(213)
,
Catechin : CK(403) : AC(130)
,
Curcumin : CK(2910) : AC(1482)
,
Isoflavones : CK(627) : AC(124)
,
Lycopene : CK(194) : AC(38)
,
Piperidines : CK(45) : AC(17)
,
Resveratrol : CK(977) : AC(590)
,
Stilbenes : CK(128) : AC(92)
,
Sulforaphane : CK(520) : AC(171)
Diseases
:
Cancer Stem Cells : CK(988) : AC(42)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
,
Antiproliferative : CK(1052) : AC(775)
Additional Keywords
:
Cancer Stem Cells : CK(30) : AC(24)
Black pepper and its pungent principle-piperine: a review of diverse physiological effects.
Click here to read the entire abstract
Pubmed Data
: Crit Rev Food Sci Nutr. 2007;47(8):735-48. PMID:
17987447
Article Published Date
: Jan 01, 2007
Study Type
: Review
Additional Links
Substances
:
Piperidines : CK(45) : AC(17)
Diseases
:
Tumors : CK(197) : AC(110)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
,
Antimutagenic Agents : CK(75) : AC(44)
,
Antioxidants : CK(3653) : AC(1318)
,
Enzyme Inhibitors : CK(372) : AC(208)
Black pepper contains pellitorine, a potential anti-cancer lead compound against tumor cell lines.
Click here to read the entire abstract
Pubmed Data
: Molecules. 2010;15(4):2398-404. Epub 2010 Apr 5. PMID:
20428051
Article Published Date
: Jan 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Black Pepper : CK(88) : AC(35)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Tumors : CK(197) : AC(110)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
If UVA radiation is used with piperine in the treatment of vitiligo, application of the compound and irradiation should be staggered to minimize photoisomerization.
Click here to read the entire abstract
Pubmed Data
: Photochem Photobiol. 2006 Nov-Dec;82(6):1541-8. PMID:
17387768
Article Published Date
: Nov 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Black Pepper : CK(88) : AC(35)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Vitiligo : CK(47) : AC(10)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
Piperine is a GABA modulator.
Click here to read the entire abstract
Pubmed Data
: J Nat Prod. 2010 Feb 26;73(2):185-91. PMID:
20085307
Article Published Date
: Feb 26, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Piperidines : CK(45) : AC(17)
Pharmacological Actions
:
GABA Modulators : CK(11) : AC(7)
Piperine, a major component of black pepper, has cyptoprotective and immunomodulating properties.
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2007 Dec 8;576(1-3):160-70. Epub 2007 Jul 25. PMID:
17706638
Article Published Date
: Dec 08, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Piperidines : CK(45) : AC(17)
Diseases
:
Immune Disorders: Low Immune Function : CK(488) : AC(115)
,
Low Immune Function: Splenic Dysfunction : CK(13) : AC(7)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Immunomodulatory : CK(536) : AC(142)
Preventive compounds curcumin and piperine are capable of targeting breast stem cells.
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res Treat. 2010 Aug ;122(3):777-85. Epub 2009 Nov 7. PMID:
19898931
Article Published Date
: Aug 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Piperidines : CK(45) : AC(17)
Diseases
:
Breast Cancer : CK(2354) : AC(621)
,
Cancer Stem Cells : CK(988) : AC(42)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
Additional Keywords
:
Cancer Stem Cells : CK(30) : AC(24)
,
Selective Cytotoxicity : CK(58) : AC(41)
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