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Article Count - 174
Cumulative Knowledge - 427

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View the Evidence: Substances

High polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio.

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Pubmed Data : Diabet Med. 2010 Nov;27(11):1318-21. PMID: 20968113

Article Published Date : Nov 01, 2010

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Cholesterol: LDL/HDL ratio : CK(432) : AC(58), Diabetes: Cardiovascular Illness : CK(666) : AC(104), HDL: Low : CK(255) : AC(45)

A Chinese green tea polyphenol extract has evident anti-plaque effect.

Click here to read the entire abstract

Pubmed Data : Zhonghua Kou Qiang Yi Xue Za Zhi. 2000 Sep;35(5):383-4. PMID: 11780252

Article Published Date : Sep 01, 2000

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174)

Diseases : Dental Caries : CK(275) : AC(32)

A polyphenol and antioxidant rich fruit and vegetable concentrate has therapeutic value in HIV patients due to enhanced proliferation, which could restore disturbances in T-cell homeostasis.

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Pubmed Data : Eur J Clin Nutr. 2004 Feb;58(2):317-25. PMID: 14749753

Article Published Date : Feb 01, 2004

Study Type : Human Study

Additional Links

Substances : Fruit: All : CK(1836) : AC(472), Polyphenols : CK(427) : AC(174), Vegetables: All : CK(551) : AC(69)

Diseases : AIDS : CK(636) : AC(9), HIV Infections : CK(577) : AC(184)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Immunomodulatory : CK(536) : AC(142)

A polyphenol-rich beverage reduces symptoms associated with the common cold.

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Pubmed Data : Br J Nutr. 2010 Oct;104(8):1156-64. Epub 2010 May 21. PMID: 20487584

Article Published Date : Oct 01, 2010

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Common Cold : CK(473) : AC(56)

Apple peel extract inhibits the growth of Helicobacter pylori, and attenuates damage to the gastric mucosa caused by neutrophils.

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Pubmed Data : J Agric Food Chem. 2009 Sep 9;57(17):7743-9. PMID: 19691323

Article Published Date : Sep 09, 2009

Study Type : Human Study

Additional Links

Substances : Apples : CK(179) : AC(57), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Helicobacter Pylori Infection : CK(305) : AC(61)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Proanthocyanidins : CK(159) : AC(46)

Bilberry has anti-inflammatory properties.

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Pubmed Data : Eur J Nutr. 2010 Sep;49(6):345-55. Epub 2010 Feb 2. PMID: 20119859

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : Bilberry : CK(39) : AC(11), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Inflammation : CK(1077) : AC(363), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)

Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.

Click here to read the entire abstract

Pubmed Data : J Nutr. 2008 Sep;138(9):1671-6. PMID: 18716168

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Hypertension : CK(2783) : AC(271), Insulin Resistance : CK(1034) : AC(221)

Cocoa inhibits LDL oxidation both in vitro and ex vivo.

Click here to read the entire abstract

Pubmed Data : Mutat Res. 1999 Apr 6;440(2):181-8. PMID: 11185658

Article Published Date : Apr 06, 1999

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Arteriosclerosis : CK(2154) : AC(123), Cholesterol: Oxidation : CK(457) : AC(98)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Coffee appears to have a beneficial effect on pulmonary function, among non-smokers.

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Pubmed Data : Int J Cancer. 2010 Oct 15;127(8):1758-68. PMID: 19372215

Article Published Date : Oct 15, 2010

Study Type : Human Study

Additional Links

Substances : Coffee : CK(412) : AC(58), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Pulmonary Diseases : CK(12) : AC(2), Smoking : CK(577) : AC(86)

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.

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Pubmed Data : Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9033-8. Epub 2009 May 18. PMID: 17344491

Article Published Date : Jun 02, 2009

Study Type : Human Study

Additional Links

Substances : Catechin : CK(403) : AC(130), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Cholesterol: Oxidation : CK(457) : AC(98), HDL: Low : CK(255) : AC(45)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans.

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol.2008 Dec;46(12):3586-92. Epub 2008 Sep 3 PMID: 15454274

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Chocolate : CK(243) : AC(32), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Cholesterol: LDL/HDL ratio : CK(432) : AC(58), Cholesterol: Oxidation : CK(457) : AC(98), HDL: Low : CK(255) : AC(45)

Green tea drinkers with susceptible IGF1 (CA)19/(CA)19 and (CA)19/X genotypes had a significant reduced risk of lung cancer.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2012 ;7(2):e30951. Epub 2012 Feb 7. PMID: 22347413

Article Published Date : Jan 01, 2012

Study Type : Human Study

Additional Links

Substances : Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174)

Diseases : Lung Cancer: Prevention : CK(20) : AC(1)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Chemopreventive : CK(1528) : AC(382)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Problem Substances : Tobacco: Smoking : CK(125) : AC(12)

Green tea drinking suppresses proliferation of HTLV-1-infected lymphocytes in vivo.

Click here to read the entire abstract

Pubmed Data : Cancer Sci. 2004 Jul;95(7):596-601. PMID: 15245597

Article Published Date : Jul 01, 2004

Study Type : Human Study

Additional Links

Substances : Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174)

Diseases : Adult T-cell leukemia/lymphoma (ATL) : CK(53) : AC(6), Human T-Cell Lymphotrophic Virus type 1 associated disease : CK(28) : AC(9)

Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)

Plasma antioxidant capacity can be increased by long-term ingestion of polyphenols from fruit juices or fruit-vegetable-concentrate in HIV-seropositive patients.

Click here to read the entire abstract

Pubmed Data : Toxicol In Vitro. 2000 Oct;14(5):405-8. PMID: 11528495

Article Published Date : Oct 01, 2000

Study Type : Human Study

Additional Links

Substances : Antioxidant formulas : CK(487) : AC(73), Fruit: All : CK(1836) : AC(472), Polyphenols : CK(427) : AC(174), Vegetables: All : CK(551) : AC(69)

Diseases : HIV Infections : CK(577) : AC(184)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Pomegranate juice consumption appears to slow the progression of the carotid intima-media thickness in subjects with increased oxidative stress and poor blood lipid profiles.

Click here to read the entire abstract

Pubmed Data : Am J Cardiol. 2009 Oct 1;104(7):936-42. PMID: 19766760

Article Published Date : Oct 01, 2009

Study Type : Human Study

Additional Links

Substances : Polyphenols : CK(427) : AC(174)

Diseases : Arterial Thickening : CK(1919) : AC(9), Carotid Artery Narrowing : CK(158) : AC(9), Intima Media Thickening : CK(1878) : AC(41)

Pharmacological Actions : Anti-atherogenic : CK(18) : AC(6), Antioxidants : CK(3653) : AC(1318)

Propolis has radioprotective properties.

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2009 Aug;23(8):1159-68. PMID: 19165751

Article Published Date : Aug 01, 2009

Study Type : Human Study

Additional Links

Substances : Bee Propolis : CK(220) : AC(83), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : DNA damage : CK(711) : AC(293), Radiation Induced Illness : CK(1018) : AC(249)

Pharmacological Actions : Radioprotective : CK(456) : AC(183)

Short-term cocoa consumption signficantly reduces blood cholesterol.

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2010 Jul;92(1):218-25. Epub 2010 May 26. PMID: 20504978

Article Published Date : Jul 01, 2010

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Cardiovascular Diseases : CK(5138) : AC(641), High Cholesterol : CK(1718) : AC(198)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Tea consumption reduces the risk of biliary tract and gallbladder diseases.

Click here to read the entire abstract

Pubmed Data : Zhonghua Zhong Liu Za Zhi. 2005 Nov;27(11):667-71. PMID: 16438888

Article Published Date : Nov 01, 2005

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174), Tea: Black : CK(167) : AC(40)

Diseases : Bile Duct Cancer : CK(23) : AC(11), Gallbladder Cancer : CK(56) : AC(10)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Tea polyphenols (primarily EGCG), significantly reduce PSA, Hepatocyte growth factor, VEG in men with prostate cancer.

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Jul;2(7):673-82. Epub 2009 Jun 19. PMID: 19542190

Article Published Date : Jul 01, 2009

Study Type : Human Study

Additional Links

Substances : EGCG (Epigallocatechin gallate) : CK(859) : AC(109), Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174)

Diseases : Prostate: PSA Doubling : CK(133) : AC(16), Prostate Cancer : CK(998) : AC(288)

Pharmacological Actions : Hepatocyte growth factor (HGF) inhibitor : CK(15) : AC(4), Vascular Endothelial Growth Factor Regulator : CK(28) : AC(12)

The Mediterranean diet, which includes a combination of antioxidant compounds and flavonoid-rich foods, appears effective to decrease LDL particle oxidizability, which reduces the risk for cardiovascular disease.

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2006 Oct;17(10):645-58. Epub 2006 Feb 3. PMID: 16517144

Article Published Date : Oct 01, 2006

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Arteriosclerosis : CK(2154) : AC(123), Cardiovascular Diseases : CK(5138) : AC(641), Cholesterol: Oxidation : CK(457) : AC(98)

Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(500) : AC(58)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Wine consumption reduces TNF-apha-induced adhesion of monocytes to endothelial cells.

Click here to read the entire abstract

Pubmed Data : Cell Physiol Biochem. 2010;26(3):471-82. Epub 2010 Aug 24. PMID: 15213052

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174), Wine : CK(132) : AC(35)

Diseases : Arteriosclerosis : CK(2154) : AC(123), Heart Disease: Ischemic : CK(201) : AC(16)

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

"Polyphenols decreased liver NADPH oxidase activity, increased muscle mitochondrial biogenesis and decreased gastrocnemius age-dependent autophagy in aged rats."

Click here to read the entire abstract

Pubmed Data : Free Radic Res. 2012 May 18. Epub 2012 May 18. PMID: 22607117

Article Published Date : May 18, 2012

Study Type : Animal Study

Additional Links

Substances : Grape : CK(998) : AC(274), Polyphenols : CK(427) : AC(174)

Additional Keywords : Mitochondrial Biogenesis : CK(17) : AC(10)

A cocoa diet enhances thymus antioxidant defenses and influences thymocyte differentiation.

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2007 Aug 8;55(16):6431-8. Epub 2007 Jul 14. PMID: 17630760

Article Published Date : Aug 08, 2007

Study Type : Animal Study

Additional Links

Substances : Catechin : CK(403) : AC(130), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Low Immune Function: Thymus Dysfunction : CK(19) : AC(6)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Immunomodulatory : CK(536) : AC(142)

A cocoa-enriched diet prevents gingival oxidative stress in experimental periodontitis.

Click here to read the entire abstract

Pubmed Data : J Periodontol. 2009 Nov;80(11):1799-808. PMID: 19905949

Article Published Date : Nov 01, 2009

Study Type : Animal Study

Additional Links

Substances : Cocoa : CK(243) : AC(32), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Periodontitis : CK(61) : AC(14)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

A polyphenol extract from red grapes redues fat content in an animal model of non-alcoholic liver disease.

Click here to read the entire abstract

Pubmed Data : Br J Nutr. 2010 Dec;104(12):1760-70. Epub 2010 Aug 2. PMID: 20673376

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289), Grape : CK(998) : AC(274), Polyphenols : CK(427) : AC(174), Resveratrol : CK(977) : AC(590)

Diseases : Fatty Liver : CK(493) : AC(122)

Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

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