Pomegranate

Pomegranate

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View the Evidence: Substances

Antenatal intake of pomegranate may limit placental injury and thereby may confer protection to the exposed fetus.

Pubmed Data : Am J Physiol Endocrinol Metab. 2012 Feb 28. Epub 2012 Feb 28. PMID: 22374759
Article Published Date : Feb 28, 2012
Study Type : Human Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)

Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis.

Pubmed Data : Isr Med Assoc J. 2011 Aug ;13(8):474-9. PMID: 21910371
Article Published Date : Aug 01, 2011
Study Type : Human Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Lipid Peroxidation : CK(403) : AC(127), Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318)

Extracts of gotu kola and pomegranate improve clinical symptoms of chronic periodontitis.

Pubmed Data : J Int Acad Periodontol. 2005 Jul;7(3):70-9. PMID: 16022023
Article Published Date : Jul 01, 2005
Study Type : Human Study
Additional Links
Substances : Gotu Kola : CK(30) : AC(13), Pomegranate : CK(146) : AC(61)
Diseases : Periodontitis : CK(61) : AC(14)

Pomegranate juice has potent antiatherogenic effects in healthy humans and in atherosclerotic mice that may be attributable to its antioxidative properties.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Clin Nutr. 2000 May ;71(5):1062-76. PMID: 10799367
Article Published Date : May 01, 2000
Study Type : Animal Study, Human Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Arteriosclerosis : CK(2154) : AC(123), Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Cardiotonic Agents : CK(46) : AC(7)

Pomegranate juice prolongs PSA doubling time, inhibits cell proliferation and increases apoptosis in men with prostate cancer.

Pubmed Data : Forsch Komplementmed. 2007 Feb;14(1):39-44. Epub 2007 Mar 6. PMID: 16818701
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Prostate: PSA Doubling : CK(133) : AC(16), Prostate Cancer : CK(998) : AC(288)

Pomegranate reduces the intima media thickness size of the artery, while also reducing blood pressure and LDL oxidation.

Pubmed Data : Clin Nutr. 2004 Jun;23(3):423-33. PMID: 15158307
Article Published Date : Jun 01, 2004
Study Type : Human Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Carotid Stenosis : CK(209) : AC(14), Cholesterol: Oxidation : CK(457) : AC(98), Hypertension : CK(2783) : AC(271), Intima Media Thickening : CK(1878) : AC(41)

Safety: pomegranate juice does not adversely affect insulin sensitivity and contributes to reduction in weight gain.

Pubmed Data : Ann Nutr Metab. 2011 ;58(3):220-3. Epub 2011 Jul 28. PMID: 21811060
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Insulin Resistance : CK(1034) : AC(221), Overweight : CK(2176) : AC(342)

"Pomegranate (Punica granatum L.) flower improves learning and memory performances impaired by diabetes mellitus in rats."

Pubmed Data : Acta Physiol Hung. 2011 Dec ;98(4):409-20. PMID: 22173022
Article Published Date : Dec 01, 2011
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Diabetes: Cognitive Dysfunction : CK(35) : AC(12)

"Pomegranate Extract Attenuates Gentamicin-Induced Nephrotoxicity in Rats by Reducing Oxidative Stress."

Pubmed Data : Ren Fail. 2012 Nov 26. Epub 2012 Nov 26. PMID: 23176634
Article Published Date : Nov 25, 2012
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(22) : AC(10), Kidney Damage: Chemically-Induced : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)
Additional Keywords : Drug: Gentamicin : CK(2) : AC(1)
Problem Substances : Gentamicin : CK(2) : AC(1)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis.

Pubmed Data : Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26. Epub 2010 Oct 14. PMID: 20946358
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Lipid Peroxidation : CK(403) : AC(127), Skin Cancer: Prevention : CK(8) : AC(4)
Therapeutic Actions : Sunlight exposure : CK(432) : AC(39)
Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Chemopreventive : CK(1528) : AC(382), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Polyphenols potentiate dietary restriction-induced lifespan extension.

Pubmed Data : Biochim Biophys Acta. 2012 Jan 11 ;1822(4):522-526. Epub 2012 Jan 11. PMID: 22265987
Article Published Date : Jan 11, 2012
Study Type : Animal Study
Additional Links
Substances : Blueberry : CK(140) : AC(39), Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174), Pomegranate : CK(146) : AC(61)
Diseases : Aging : CK(1351) : AC(369)
Therapeutic Actions : Fasting/Caloric Restriction : CK(235) : AC(50)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

pomegranate extract and beta-sitosterol may be a useful uterine stimulant.

Pubmed Data : Reprod Sci. 2010 Mar;17(3):288-96. Epub 2009 Dec 4. PMID: 19966214
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Beta Sitosterol : CK(43) : AC(14), Pomegranate : CK(146) : AC(61)
Diseases : Uterus: Contraction/Expulsion Disorders : CK(24) : AC(10)
Pharmacological Actions : Uterotonic : CK(34) : AC(11)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Pomegranate extract protects against alcohol and aspirin-induced gastric mucosal injury.

Pubmed Data : J Ethnopharmacol. 2005 Jan 4;96(1-2):171-6. PMID: 15588667
Article Published Date : Jan 04, 2005
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91), NSAID-induced toxicity : CK(230) : AC(50), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Antioxidants : CK(3653) : AC(1318), Gastroprotective : CK(62) : AC(31)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Pomegranate extract reduced aortic sinus and coronary artery atherosclerosis in SR-BI/apoE dKO mice.

Pubmed Data : Atherosclerosis. 2013 May ;228(1):80-9. Epub 2013 Mar 7. PMID: 23528829
Article Published Date : Apr 30, 2013
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Atherosclerosis : CK(523) : AC(77), Clogged Arteries : CK(6460) : AC(285), Coronary Artery Disease : CK(1305) : AC(136)

Pomegranate fruit extract rich in punicalagin reverses the proatherogenic effects of perturbed shear stress on endothelial function in rats.

Pubmed Data : Cardiovasc Res. 2007 Jan 15;73(2):414-23. Epub 2006 Sep 1. PMID: 17014835
Article Published Date : Jan 15, 2007
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Arteriosclerosis : CK(2154) : AC(123), Endothelial Dysfunction : CK(897) : AC(173)

Pomegranate has blood sugar regulating properties.

Pubmed Data : Am J Chin Med. 2011 ;39(5):1015-27. PMID: 21905289
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Blood Sugar Problems : CK(4050) : AC(693), Hyperglycemia : CK(2892) : AC(59)
Pharmacological Actions : SGLT1 inducer : CK(4) : AC(2)

Pomegranate improves depressive symptoms and bone properties in a menopausal syndrome model due to its estrogen content (estradiol, estrone and estriol).

Pubmed Data : J Ethnopharmacol. 2004 May;92(1):93-101. PMID: 15099854
Article Published Date : May 01, 2004
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Estrogen Deficiency : CK(57) : AC(19), Menopausal Syndrome : CK(171) : AC(27), Osteoporosis : CK(1171) : AC(205)
Pharmacological Actions : Antidepressive Agents : CK(142) : AC(31)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Pomegranate juice has a chondroprotective effect in an animal mode of osteoarthritis of the knee joint.

Pubmed Data : Phytother Res. 2009 Jun 5. PMID: 19504467
Article Published Date : Jun 05, 2009
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Osteoarthritis : CK(615) : AC(91), Osteoarthritis: Knee : CK(357) : AC(38)

Pomegranate juice has a protective effect on kidney stone formation (nephrolithiasis) in rats.

Pubmed Data : Bone. 2010 Nov;47(5):926-37. Epub 2010 Aug 7. PMID: 19025399
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Kidney Stones : CK(157) : AC(28)

Pomegranate juice reduces blood pressure by inhibiting Angiotensin Converting Enzyme (ACE) activity in diabetic rats.

Pubmed Data : Phytother Res. 2009 Dec 17. PMID: 20020514
Article Published Date : Dec 17, 2009
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Diabetes: Cardiovascular Illness : CK(666) : AC(104), Hypertension : CK(2783) : AC(271)
Pharmacological Actions : Angiotensin-Converting Enzyme Inhibitors : CK(20) : AC(12)

Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats.

Pubmed Data : J Pharm Pharmacol. 2007 Sep;59(9):1287-95. PMID: 17939210
Article Published Date : Sep 01, 2007
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Biliary Obstruction : CK(140) : AC(5), Fibrosis: Liver : CK(24) : AC(9), Liver Fibrosis : CK(341) : AC(74)

Pomegranate peel extract protects against ionizing radiation-induced enteritis and leukocyte damage in rats.

Pubmed Data : J Radiat Res (Tokyo). 2009 Jul;50(4):345-53. Epub 2009 May 29. PMID: 19478462
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Radioprotective : CK(456) : AC(183)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Pomegranate seed extract attenuates chemotherapy-induced acute nephrotoxicity and hepatotoxicity.

Pubmed Data : J Med Food. 2011 May 6. Epub 2011 May 6. PMID: 21548807
Article Published Date : May 06, 2011
Study Type : Animal Study
Additional Links
Substances : Pomegranate Seed : CK(2) : AC(1)
Diseases : Chemotherapy-Induced Liver Toxicity : CK(14) : AC(8), Chemotherapy-Induced Toxicity : CK(704) : AC(184)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Glutathione S-transferase Inhibitor : CK(3) : AC(2), Hepatoprotective : CK(557) : AC(272), Renoprotective : CK(191) : AC(90)

Pomegranate seed oil fed to mice enhances B-cell function as measured by immunoglobulins G and M.

Pubmed Data : Nutrition. 2006 Jan;22(1):54-9. Epub 2005 Oct 12. PMID: 16226015
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61), Punicic acid : CK(7) : AC(5)
Diseases : Immune Disorders: Low Immune Function : CK(488) : AC(115)
Pharmacological Actions : Immunomodulatory : CK(536) : AC(142)

Pomegranate seed oil has a protective effect against pesticide-induced nephrotoxicity in rats.

Pubmed Data : Ren Fail. 2010 Jun;32(5):612-7. PMID: 20486845
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Kidney Damage : CK(120) : AC(42), Pesticide Toxicity : CK(147) : AC(45)
Pharmacological Actions : Renoprotective : CK(191) : AC(90)

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