Pycnogenol (Pine Bark)

Pycnogenol (Pine Bark)

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View the Evidence: Substances

"Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition."

Pubmed Data : Panminerva Med. 2011 Sep ;53(3 Suppl 1):65-70. PMID: 22108479
Article Published Date : Sep 01, 2011
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Hot Flash : CK(203) : AC(19), Menopausal Syndrome : CK(171) : AC(27), Premenopausal Disorders : CK(30) : AC(3)

A combination of bilberry and pycnogenol reduces intraocular hypertension and may lower the risk of symptomatic glaucoma.

Pubmed Data : Mol Vis. 2008;14:1288-92. Epub 2008 Jul 10. PMID: 18618008
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Bilberry : CK(39) : AC(11), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Glaucoma : CK(111) : AC(19), Intraocular hypertension : CK(32) : AC(4)

A combination of pine bark extract and L-arginine is effective for long-term improvement of erectile function.

Pubmed Data : BJU Int. 2010 Feb 22. Epub 2010 Feb 22. PMID: 20184576
Article Published Date : Feb 22, 2010
Study Type : Human Study
Additional Links
Substances : Arginine : CK(970) : AC(169), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Erectile Dysfunction : CK(510) : AC(41)

A multi-nutrient mixture of marine proteins, alpha-lipoic acid, pine bark extract, vitamins and minerals is safe and efficacious in the treatment of aging symptoms of the skin in women.

Pubmed Data : J Int Med Res. 2005 May-Jun;33(3):267-72. PMID: 15938587
Article Published Date : May 01, 2005
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid : CK(384) : AC(82), Fish extract : CK(32) : AC(4), Multivitamin : CK(243) : AC(22), Pine Bark Extract : CK(395) : AC(62)
Diseases : Aging Skin : CK(360) : AC(86)

A multi-nutrient mixture of vitamin C, vitamin E, carotenoids, selenium, zinc, amino acids and glycosaminoglycans, blueberry extract and pycnogenol improves visible signs of ageing in women 45-73 years of age.

Pubmed Data : J Dermatolog Treat. 2004 Jul;15(4):222-6. PMID: 15764035
Article Published Date : Jul 01, 2004
Study Type : Human Study
Additional Links
Substances : Amino Acids : CK(100) : AC(16), Blueberry : CK(140) : AC(39), Glycosaminoglycans : CK(12) : AC(2), Pycnogenol (Pine Bark) : CK(385) : AC(61), Selenium : CK(574) : AC(94), Vitamin C : CK(1274) : AC(238), Vitamin E : CK(1285) : AC(221), Zinc : CK(870) : AC(127)
Diseases : Aging Skin : CK(360) : AC(86), Skin Diseases : CK(46) : AC(9)

Antioxidant therapy with pine bark, vitamin C and vitamin E may be beneficial in the treatment of drug-refractory migraine possibly reducing headache frequency and severity.

Pubmed Data : Headache. 2006 May;46(5):788-93. PMID: 16643582
Article Published Date : May 01, 2006
Study Type : Human Study
Additional Links
Substances : Pine Bark Extract : CK(395) : AC(62), Vitamin C : CK(1274) : AC(238), Vitamin E : CK(1285) : AC(221)
Diseases : Migraine Disorders : CK(486) : AC(58)

French maritime pine bark extract (Pycnogenol) displays anti-inflammatory effects in vivo.

Pubmed Data : J Inflamm (Lond). 2006;3:1. Epub 2006 Jan 27. PMID: 16441890
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Inflammation : CK(1077) : AC(363)
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30), NF-kappaB Inhibitor : CK(595) : AC(401)

Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Interv Aging. 2012 ;7:275-86. Epub 2012 Jul 27. PMID: 22956863
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Aging Skin : CK(360) : AC(86)
Additional Keywords : Phytotherapy : CK(177) : AC(27), Plant Extracts : CK(3616) : AC(1226), Proanthocyanidins : CK(159) : AC(46)

Pcynogenol has protective effects on kidney flow and function in hypertension and reduces C-reactive proein.

Pubmed Data : J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):41-6. Epub 2010 Jan 22. PMID: 20097689
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Elevated CRP : CK(72) : AC(8), Hypertension : CK(2783) : AC(271), Kidney Diseases : CK(424) : AC(71)

Pcynogenol significantly reduces severity of symptoms in patients with systemic lupus erythematosus.

Pubmed Data : Phytother Res. 2001 Dec;15(8):698-704. PMID: 11746863
Article Published Date : Dec 01, 2001
Study Type : Human Study
Additional Links
Substances : Pine Bark Extract : CK(395) : AC(62)
Diseases : Lupus Erythematosus: Systemic : CK(949) : AC(53)

Pine bark extract significantly lowers pain medication requirement in dysmenorrhea.

Pubmed Data : Prev Med. 2009 Aug-Sep;49(2-3):184-9. Epub 2009 Jun 23. PMID: 18567279
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Pine Bark Extract : CK(395) : AC(62)
Diseases : Dysmenorrhea : CK(409) : AC(26)
Pharmacological Actions : Analgesics : CK(372) : AC(78)
Additional Keywords : Drug Sparing : CK(451) : AC(49)

Pine bark extract significantly reduces oxidative stress in children with ADHD.

Pubmed Data : Redox Rep. 2006;11(4):163-72. PMID: 16984739
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Pine Bark Extract : CK(395) : AC(62)
Diseases : Attention Deficit Disorder with Hyperactivity : CK(240) : AC(30)

Pine bark extract significantly reduces pain in osteoarthritis.

Pubmed Data : Phytother Res. 2008 Aug;22(8):1087-92. PMID: 18570266
Article Published Date : Aug 01, 2008
Study Type : Human Study
Additional Links
Substances : Pine Bark Extract : CK(395) : AC(62), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Osteoarthritis : CK(615) : AC(91)
Additional Keywords : Drug Sparing : CK(451) : AC(49)

Pine bark inhibits Cox-1 and Cox-2 enzymes, reducing inflammation.

Pubmed Data : Biomed Pharmacother. 2006 Jan;60(1):5-9. Epub 2005 Oct 26. PMID: 16330178
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Pine Bark Extract : CK(395) : AC(62), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Inflammation : CK(1077) : AC(363)

Pinebark reduces urinary catecholamines (excitatory neurotransmitters) and reduces hyperactivity in children with ADHD.

Pubmed Data : Nutr Neurosci. 2007 Jun-Aug;10(3-4):151-7. PMID: 18019397
Article Published Date : Jun 01, 2007
Study Type : Human Study
Additional Links
Substances : Pine Bark Extract : CK(395) : AC(62)
Diseases : Attention Deficit Disorder with Hyperactivity : CK(240) : AC(30)

Pycnogenol has antidiabetic action in patients with type 2 diabetes.

Pubmed Data : Life Sci. 2004 Oct 8;75(21):2505-13. PMID: 15363656
Article Published Date : Oct 08, 2004
Study Type : Human Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Pycnogenol has therapeutic value in the prevention of jet lag in healthy and hypertensive patients.

Pubmed Data : Minerva Cardioangiol. 2008 Oct;56(5 Suppl):3-9. PMID: 19597404
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Brain Edema : CK(14) : AC(3), Hypertension : CK(2783) : AC(271), Jet Lag : CK(33) : AC(5)
Pharmacological Actions : Platelet Aggregation Inhibitors : CK(173) : AC(37)

Pycnogenol improves diabetes control, lowers cardiovascular disease risk factors, and reduces the need for hypertension medication in type diabetic patients.

Pubmed Data : Nutr Res. 2008 May;28(5):315-20. PMID: 19083426
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hypertension : CK(2783) : AC(271)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hypoglycemic Agents : CK(563) : AC(156)
Additional Keywords : Drug Sparing : CK(451) : AC(49), Plant Extracts : CK(3616) : AC(1226)

Pycnogenol improves endothelial function of hypertensive patients.

Pubmed Data : Life Sci. 2004 Jan 2;74(7):855-62. PMID: 14659974
Article Published Date : Jan 02, 2004
Study Type : Human Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Endothelial Dysfunction : CK(897) : AC(173), Hypertension : CK(2783) : AC(271)
Pharmacological Actions : Platelet Aggregation Inhibitors : CK(173) : AC(37)
Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Pycnogenol is efficacious as an adjunct in the management of mild-to-moderate childhood asthma.

Pubmed Data : West J Med. 1998 Dec;169(6):356-63. PMID: 15641632
Article Published Date : Dec 01, 1998
Study Type : Human Study
Additional Links
Substances : Pine Bark Extract : CK(395) : AC(62), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Asthma : CK(918) : AC(134), Asthma: Bronchial : CK(267) : AC(33)

Pycnogenol may alleviate adverse effects in oncologic treatment, e.g. deep vein thrombosis.

Pubmed Data : Mol Vis. 2008;14:1288-92. Epub 2008 Jul 10. PMID: 18927527
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Chemotherapy : CK(65) : AC(16), Deep Vein Thrombosis : CK(511) : AC(10), Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)
Additional Keywords : Drug Side Effect Attenuation : CK(252) : AC(49)

Pycnogenol may exert anti-inflammatory activity in osteoarthritic joints.

Pubmed Data : Redox Rep. 2008;13(6):271-6. PMID: 19017467
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : CRP : CK(30) : AC(3), Fibrinogen: Elevated : CK(114) : AC(13), Osteoarthritis : CK(615) : AC(91)

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