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SAMe (S-adenosylmethionine)
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Additional Topics Details for this Page
Article Count
- 17
Cumulative Knowledge
- 91
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Quick Summary: Current access displays 2 out of 13 associated Diseases
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View the Evidence: Substances
A multi-vitamin/nutrient formula has therapeutic value in early-stage Alzheimer's diease.
Click here to read the entire abstract
Pubmed Data
: Am J Alzheimers Dis Other Demen. 2008 Dec-2009 Jan;23(6):571-85. Epub 2008 Dec 1. PMID:
19047474
Article Published Date
: Dec 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Carnitine, Acetyl-L- : CK(40) : AC(4)
,
Folic Acid : CK(542) : AC(77)
,
NAC (N-acetyl-L-cysteine) : CK(264) : AC(62)
,
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
,
Vitamin B-6 : CK(412) : AC(48)
,
Vitamin E : CK(1285) : AC(221)
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
A multi-vitamin/nutrient formula has therapeutic value in moderate-stage to later-stage Alzheimer's diease.
Click here to read the entire abstract
Pubmed Data
: Am J Alzheimers Dis Other Demen. 2009 Feb-Mar;24(1):27-33. Epub 2008 Dec 3. PMID:
19056706
Article Published Date
: Feb 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Carnitine, Acetyl-L- : CK(40) : AC(4)
,
Folic Acid : CK(542) : AC(77)
,
NAC (N-acetyl-L-cysteine) : CK(264) : AC(62)
,
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
,
Vitamin B-12 : CK(752) : AC(94)
,
Vitamin E : CK(1285) : AC(221)
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
Sam-e appears to be well tolerated and effect in the treatment of depression in Parkinson's disease.
Click here to read the entire abstract
Pubmed Data
: Mov Disord. 2000 Nov;15(6):1225-9. PMID:
11104210
Article Published Date
: Nov 01, 2000
Study Type
: Human Study
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Parkinson Disease : CK(543) : AC(79)
Sam-e improves symptoms in primary fibromyalgia.
Click here to read the entire abstract
Pubmed Data
: Scand J Rheumatol. 1991;20(4):294-302. PMID:
1925418
Article Published Date
: Jan 01, 1991
Study Type
: Human Study
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Fibromyalgia : CK(537) : AC(57)
Sam-e significantly improves osteoarthritis symptoms and depression.
Click here to read the entire abstract
Pubmed Data
: Am J Med. 1987 Nov 20;83(5A):89-94. PMID:
3318447
Article Published Date
: Nov 20, 1987
Study Type
: Human Study
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Depression : CK(674) : AC(88)
,
Osteoarthritis : CK(615) : AC(91)
Sam-e supplementation reduces aggressive behavior and improves quality of life in patients with schizophrenia.
Click here to read the entire abstract
Pubmed Data
: Eur Neuropsychopharmacol. 2009 Jan;19(1):14-22. Epub 2008 Sep 27. PMID:
18824331
Article Published Date
: Jan 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Schizophrenia : CK(247) : AC(29)
Sam-e works as good as Piroxicam, but sustained clinical improvement longer.
Click here to read the entire abstract
Pubmed Data
: Am J Med. 1987 Nov 20;83(5A):72-7. PMID:
3318443
Article Published Date
: Nov 20, 1987
Study Type
: Human Study
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Osteoarthritis : CK(615) : AC(91)
Additional Keywords
:
Natural Substances Versus Drugs : CK(988) : AC(165)
,
Superiority of Natural Substances versus Drugs : CK(826) : AC(164)
Sam-e works like NSAIDs against inflammation in osteoarthritis, but is more tolerable.
Click here to read the entire abstract
Pubmed Data
: Am J Med. 1987 Nov 20;83(5A):60-5. PMID:
3318441
Article Published Date
: Nov 20, 1987
Study Type
: Human Study
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Osteoarthritis : CK(615) : AC(91)
Additional Keywords
:
Superiority of Natural Substances versus Drugs : CK(826) : AC(164)
S-adenosylmethionine attenuates hepatic lipid synthesis in pigs fed alchohol with a folate deficient diet.
Click here to read the entire abstract
Pubmed Data
: Alcohol Clin Exp Res. 2007 Jul;31(7):1231-9. PMID:
17577393
Article Published Date
: Jul 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Alcohol Toxicity : CK(212) : AC(85)
,
Fatty Liver : CK(493) : AC(122)
Pharmacological Actions
:
Hepatoprotective : CK(557) : AC(272)
S-adenosylmethionine may have a therapeutic role in the treatment of hemochromatosis.
Click here to read the entire abstract
Pubmed Data
: Comp Med. 2004 Feb;54(1):100-3. PMID:
15027625
Article Published Date
: Feb 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Hemochromatosis : CK(32) : AC(4)
S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice.
Click here to read the entire abstract
Pubmed Data
: Neurobiol Aging. 2012 Jul ;33(7):1482.e1-16. Epub 2012 Jan 4. PMID:
22221883
Article Published Date
: Jun 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Alzheimer's Disease: Homocysteine Associated : CK(2) : AC(1)
,
Vitamin B Deficiency : CK(1) : AC(1)
A number of complementary/alternative therapies may have therapeutic potential in treating postpartum depression.
Click here to read the entire abstract
Pubmed Data
: J Affect Disord. 2009 Jan;112(1-3):1-10. Epub 2008 Aug 8. PMID:
18692251
Article Published Date
: Jan 01, 2009
Study Type
: Commentary
Additional Links
Substances
:
Folic Acid : CK(542) : AC(77)
,
Omega-3 Fatty Acids : CK(3333) : AC(319)
,
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Postpartum Depression : CK(211) : AC(24)
Therapeutic Actions
:
Exercise : CK(482) : AC(69)
,
Light Therapy : CK(69) : AC(19)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Arginine and S-adenosylmethionine may contribute to nerve regeneration.
Click here to read the entire abstract
Pubmed Data
: J Appl Physiol. 2008 Jun;104(6):1727-35. Epub 2008 Mar 6. PMID:
7941963
Article Published Date
: Jun 01, 2008
Study Type
: Review
Additional Links
Substances
:
Arginine : CK(970) : AC(169)
,
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Demyelinating Diseases : CK(1278) : AC(250)
Additional Keywords
:
Myelination : CK(2) : AC(2)
,
Remyelination : CK(15) : AC(10)
Deficiency of dietary sources of methyl groups (e.g. methionine, choline, b12, folate, sam-e) reduce DNA methylation in the liver which leads to liver cancer.
Click here to read the entire abstract
Pubmed Data
: Clin Chem Lab Med. 2003 Aug;41(8):1012-9. PMID:
12964806
Article Published Date
: Aug 01, 2003
Study Type
: In Vitro Study
Additional Links
Substances
:
Choline : CK(14) : AC(5)
,
Folic Acid : CK(542) : AC(77)
,
Methionine : CK(52) : AC(12)
,
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
,
Vitamin B-12 : CK(752) : AC(94)
Diseases
:
Liver Cancer : CK(1641) : AC(266)
S-Adenosylmethionine is an attractive agent for both chemoprevention and treatment of liver cancer.
Click here to read the entire abstract
Pubmed Data
: J Gastroenterol Hepatol. 2008 Mar;23 Suppl 1:S73-7. PMID:
18336669
Article Published Date
: Mar 01, 2008
Study Type
: Commentary
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Liver Cancer : CK(1641) : AC(266)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Chemopreventive : CK(1528) : AC(382)
Sam-e's potential to encourage remyelination may be of value in Multiple Sclerosis.
Click here to read the entire abstract
Pubmed Data
: Drugs. 1994 Aug;48(2):137-52.PMID:
7527320
Article Published Date
: Aug 01, 1994
Study Type
: Commentary
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Diseases
:
Multiple Sclerosis : CK(716) : AC(133)
Sam-e protects against azoxymethane-induced colonic abberations and suppresseshuman colon cancer cells.
Click here to read the entire abstract
Pubmed Data
: Int J Cancer. 2008 Jan 1;122(1):25-30. PMID:
17724725
Article Published Date
: Jan 01, 2008
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
Sam-e treats depression in postmeopausal women.
Click here to read the entire abstract
Pubmed Data
: Psychother Psychosom. 1993;59(1):34-40. PMID:
8441793
Article Published Date
: Jan 01, 1993
Additional Links
Substances
:
SAMe (S-adenosylmethionine) : CK(89) : AC(17)
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