Shiitake Mushroom

Shiitake Mushroom

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Quick Summary: Current access displays 2 out of 18 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Cancers: All	3	2	Log in \| Sign up
HIV Infections	3	3	Log in \| Sign up

Quick Summary: Current access displays 2 out of 14 associated Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Antifungal Agents	3	3	Log in \| Sign up
Apoptotic	3	2	Log in \| Sign up

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View the Evidence: Substances

An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice.

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Pubmed Data : Cancer Lett. 2005 Mar 18;220(1):21-8. PMID: 15737684

Article Published Date : Mar 18, 2005

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Skin Cancer : CK(438) : AC(171)

Pharmacological Actions : Apoptotic : CK(1416) : AC(1089), Cell cycle arrest : CK(371) : AC(309)

Additional Keywords : Antiproliferative : CK(5) : AC(3), Selective Cytotoxicity : CK(42) : AC(37)

Lentinan from shiitake mushrooms (Lentinus edodes) inhibits of human colon cancer cells.

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Pubmed Data : J Altern Complement Med. 2002 Oct;8(5):581-9. PMID: 12470439

Article Published Date : Oct 01, 2002

Study Type : Animal Study

Additional Links

Substances : Beta-glucan : CK(225) : AC(40), Lentinan : CK(55) : AC(8), Shiitake Mushroom : CK(24) : AC(17)

Diseases : Colon Cancer : CK(819) : AC(233)

Additional Keywords : Antineoplastic Agents : CK(69) : AC(28)

Shiitake contains compounds with hypoglycemic activity in a rat model of type 1 diabetes.

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Pubmed Data : Biosci Biotechnol Biochem. 2002 May;66(5):937-42. PMID: 12092843

Article Published Date : May 01, 2002

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Diabetes Mellitus: Type 1 : CK(1041) : AC(221), Triglycerides: Elevated : CK(366) : AC(65)

Pharmacological Actions : Hypoglycemic Agents : CK(554) : AC(154)

Shiitake extract inhibits cancer cell proliferation possibly through a reduction in Natural Killer cell cytotoxicity.

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Pubmed Data : Actas Urol Esp. 2003 Oct;27(9):732-4. PMID: 19059811

Article Published Date : Oct 01, 2003

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Cancers: All : CK(8467) : AC(2708)

Additional Keywords : Antineoplastic Agents : CK(69) : AC(28)

Shiitake extract significantly inhibits atherosclerosis development in a rabbit model.

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Pubmed Data : J Atheroscler Thromb. 2002;9(3):149-56. PMID: 12226557

Article Published Date : Jan 01, 2002

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Arteriosclerosis : CK(2128) : AC(123)

Pharmacological Actions : Anti-atherogenic : CK(18) : AC(6)

Shiitake has antioxidant and liver-protective effects against paracetamol-induced liver damage.

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Pubmed Data : Molecules. 2010 Jun;15(6):4478-89. Epub 2010 Jun 23. PMID: 20657455

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(96) : AC(26), Chemically-Induced Liver Damage : CK(453) : AC(175)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), Hepatoprotective : CK(534) : AC(261)

White button and shiitake mushrooms reduce the incidence and severity of collagen-induced arthritis mice.

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Pubmed Data : J Nutr. 2011 Jan;141(1):131-6. Epub 2010 Nov 24. PMID: 21106932

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17), White Button Mushroom : CK(16) : AC(11)

Diseases : Arthritis : CK(1430) : AC(218)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1144) : AC(420)

A proprietary shitake/rice bran extract, encourages human leukemic cells to programmed cell death.

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Pubmed Data : Cancer Lett. 2003 Nov 10;201(1):41-9. PMID: 14580685

Article Published Date : Nov 10, 2003

Study Type : In Vitro Study

Additional Links

Substances : Modified Arabinoxylan Rice Bran (MGN-3) : CK(2) : AC(2), Shiitake Mushroom : CK(24) : AC(17)

Diseases : Leukemia : CK(670) : AC(258)

A shiitake/rice bran combination known as MGN-3 has potent anti-HIV activity.

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Pubmed Data : Biochem Biophys Res Commun. 1998 Feb 4;243(1):25-9. PMID: 9473473

Article Published Date : Feb 04, 1998

Study Type : In Vitro Study

Additional Links

Substances : Modified Arabinoxylan Rice Bran (MGN-3) : CK(2) : AC(2), Rice Bran : CK(29) : AC(14), Shiitake Mushroom : CK(24) : AC(17)

Diseases : HIV Infections : CK(564) : AC(184)

Pharmacological Actions : Anti-HIV Agents : CK(106) : AC(57)

Lentin, a beta-glucan rich protein from shitake mushroom, demonstrates inhibitory effects on activity of HIV-1 reverse transcriptase and proliferation of leukemia cells.

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Pubmed Data : J Med Chem. 2009 Dec 10;52(23):7887-91. PMID: 19526990

Article Published Date : Dec 10, 2009

Study Type : In Vitro Study

Additional Links

Substances : Beta-glucan : CK(225) : AC(40), Shiitake Mushroom : CK(24) : AC(17)

Diseases : HIV Infections : CK(564) : AC(184), Leukemia : CK(670) : AC(258)

Pharmacological Actions : Anti-HIV Agents : CK(106) : AC(57), Antifungal Agents : CK(172) : AC(109)

Lentin, a novel and potent antifungal protein from shitake mushroom exhibits inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells.

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Pubmed Data : Life Sci. 2003 Nov 14;73(26):3363-74. PMID: 14572878

Article Published Date : Nov 14, 2003

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Fungal Infection : CK(241) : AC(119), HIV Infections : CK(564) : AC(184), Leukemia : CK(670) : AC(258)

Pharmacological Actions : Antifungal Agents : CK(172) : AC(109)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

Shiitake aqueous extracts have demonstrated direct inhibition of the proliferation of human breast cancer cells in vitro and immunostimulatory properties.

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Pubmed Data : Phytomedicine. 2008 Jun;15(6-7):512-9. Epub 2008 Feb 1. PMID: 18242970

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Breast Cancer : CK(2051) : AC(566)

Pharmacological Actions : Antiproliferative : CK(969) : AC(725), Immunomodulatory : CK(536) : AC(142)

Shiitake exhibits anti-platelet activity.

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Pubmed Data : Biofactors. 2004;22(1-4):177-9. PMID: 15630278

Article Published Date : Jan 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Clotting : CK(177) : AC(36)

Pharmacological Actions : Platelet Aggregation Inhibitors : CK(161) : AC(36)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

Shiitake inhibits the growth of breast and myeloma tumor cells.

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Pubmed Data : J Altern Complement Med. 2006 Mar;12(2):125-32. PMID: 16566671

Article Published Date : Mar 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Breast Cancer : CK(2051) : AC(566), Cancers: All : CK(8467) : AC(2708), Multiple Myeloma : CK(136) : AC(51)

Pharmacological Actions : Apoptotic : CK(1416) : AC(1089), Cell cycle arrest : CK(371) : AC(309)

Additional Keywords : Selective Cytotoxicity : CK(42) : AC(37)

Shiitake potentiates intestinal immunity.

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Pubmed Data : Biomed Res. 2007 Apr;28(2):71-7. PMID: 17510491

Article Published Date : Apr 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Immune Disorders: Low Immune Function : CK(488) : AC(115)

Pharmacological Actions : Immunomodulatory : CK(536) : AC(142)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

Shitake has significant antibacterial and antifungal activity.

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Pubmed Data : Complement Ther Clin Pract. 2009 Feb;15(1):5-7. Epub 2008 Dec 2. PMID: 19161947

Article Published Date : Feb 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Bacterial Infections and Mycoses : CK(126) : AC(51)

Pharmacological Actions : Anti-Bacterial Agents : CK(895) : AC(291), Antifungal Agents : CK(172) : AC(109)

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