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Shiitake Mushroom

Shiitake Mushroom

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Article Count - 17
Cumulative Knowledge - 23

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Quick Summary: Current access displays 2 out of 18 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Cancers: All	3	2	Log in \| Sign up
HIV Infections	3	3	Log in \| Sign up

Quick Summary: Current access displays 2 out of 14 associated Pharmacological Actions

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Antifungal Agents	3	3	Log in \| Sign up
Apoptotic	3	2	Log in \| Sign up

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View the Evidence: Substances

An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice.

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Pubmed Data : Cancer Lett. 2005 Mar 18;220(1):21-8. PMID: 15737684

Article Published Date : Mar 18, 2005

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Skin Cancer : CK(417) : AC(171)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Antiproliferative : CK(5) : AC(3), Selective Cytotoxicity : CK(58) : AC(41)

Lentinan from shiitake mushrooms (Lentinus edodes) inhibits of human colon cancer cells.

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Pubmed Data : J Altern Complement Med. 2002 Oct;8(5):581-9. PMID: 12470439

Article Published Date : Oct 01, 2002

Study Type : Animal Study

Additional Links

Substances : Beta-glucan : CK(225) : AC(40), Lentinan : CK(55) : AC(8), Shiitake Mushroom : CK(24) : AC(17)

Diseases : Colon Cancer : CK(895) : AC(233)

Additional Keywords : Antineoplastic Agents : CK(69) : AC(28)

Shiitake contains compounds with hypoglycemic activity in a rat model of type 1 diabetes.

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Pubmed Data : Biosci Biotechnol Biochem. 2002 May;66(5):937-42. PMID: 12092843

Article Published Date : May 01, 2002

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Triglycerides: Elevated : CK(340) : AC(65)

Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)

Shiitake extract inhibits cancer cell proliferation possibly through a reduction in Natural Killer cell cytotoxicity.

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Pubmed Data : Actas Urol Esp. 2003 Oct;27(9):732-4. PMID: 19059811

Article Published Date : Oct 01, 2003

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Cancers: All : CK(9062) : AC(2869)

Additional Keywords : Antineoplastic Agents : CK(69) : AC(28)

Shiitake extract significantly inhibits atherosclerosis development in a rabbit model.

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Pubmed Data : J Atheroscler Thromb. 2002;9(3):149-56. PMID: 12226557

Article Published Date : Jan 01, 2002

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Arteriosclerosis : CK(2154) : AC(123)

Pharmacological Actions : Anti-atherogenic : CK(18) : AC(6)

Shiitake has antioxidant and liver-protective effects against paracetamol-induced liver damage.

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Pubmed Data : Molecules. 2010 Jun;15(6):4478-89. Epub 2010 Jun 23. PMID: 20657455

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Chemically-Induced Liver Damage : CK(475) : AC(175)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

White button and shiitake mushrooms reduce the incidence and severity of collagen-induced arthritis mice.

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Pubmed Data : J Nutr. 2011 Jan;141(1):131-6. Epub 2010 Nov 24. PMID: 21106932

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17), White Button Mushroom : CK(16) : AC(11)

Diseases : Arthritis : CK(1430) : AC(218)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

A proprietary shitake/rice bran extract, encourages human leukemic cells to programmed cell death.

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Pubmed Data : Cancer Lett. 2003 Nov 10;201(1):41-9. PMID: 14580685

Article Published Date : Nov 10, 2003

Study Type : In Vitro Study

Additional Links

Substances : Modified Arabinoxylan Rice Bran (MGN-3) : CK(2) : AC(2), Shiitake Mushroom : CK(24) : AC(17)

Diseases : Leukemia : CK(670) : AC(258)

A shiitake/rice bran combination known as MGN-3 has potent anti-HIV activity.

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Pubmed Data : Biochem Biophys Res Commun. 1998 Feb 4;243(1):25-9. PMID: 9473473

Article Published Date : Feb 04, 1998

Study Type : In Vitro Study

Additional Links

Substances : Modified Arabinoxylan Rice Bran (MGN-3) : CK(2) : AC(2), Rice Bran : CK(29) : AC(14), Shiitake Mushroom : CK(24) : AC(17)

Diseases : HIV Infections : CK(577) : AC(184)

Pharmacological Actions : Anti-HIV Agents : CK(108) : AC(60)

Lentin, a beta-glucan rich protein from shitake mushroom, demonstrates inhibitory effects on activity of HIV-1 reverse transcriptase and proliferation of leukemia cells.

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Pubmed Data : J Med Chem. 2009 Dec 10;52(23):7887-91. PMID: 19526990

Article Published Date : Dec 10, 2009

Study Type : In Vitro Study

Additional Links

Substances : Beta-glucan : CK(225) : AC(40), Shiitake Mushroom : CK(24) : AC(17)

Diseases : HIV Infections : CK(577) : AC(184), Leukemia : CK(670) : AC(258)

Pharmacological Actions : Anti-HIV Agents : CK(108) : AC(60), Antifungal Agents : CK(178) : AC(111)

Lentin, a novel and potent antifungal protein from shitake mushroom exhibits inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells.

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Pubmed Data : Life Sci. 2003 Nov 14;73(26):3363-74. PMID: 14572878

Article Published Date : Nov 14, 2003

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Fungal Infection : CK(243) : AC(119), HIV Infections : CK(577) : AC(184), Leukemia : CK(670) : AC(258)

Pharmacological Actions : Antifungal Agents : CK(178) : AC(111)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Shiitake aqueous extracts have demonstrated direct inhibition of the proliferation of human breast cancer cells in vitro and immunostimulatory properties.

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Pubmed Data : Phytomedicine. 2008 Jun;15(6-7):512-9. Epub 2008 Feb 1. PMID: 18242970

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Breast Cancer : CK(2354) : AC(621)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Immunomodulatory : CK(536) : AC(142)

Shiitake exhibits anti-platelet activity.

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Pubmed Data : Biofactors. 2004;22(1-4):177-9. PMID: 15630278

Article Published Date : Jan 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Clotting : CK(177) : AC(36)

Pharmacological Actions : Platelet Aggregation Inhibitors : CK(173) : AC(37)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Shiitake inhibits the growth of breast and myeloma tumor cells.

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Pubmed Data : J Altern Complement Med. 2006 Mar;12(2):125-32. PMID: 16566671

Article Published Date : Mar 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Breast Cancer : CK(2354) : AC(621), Cancers: All : CK(9062) : AC(2869), Multiple Myeloma : CK(156) : AC(53)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Shiitake potentiates intestinal immunity.

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Pubmed Data : Biomed Res. 2007 Apr;28(2):71-7. PMID: 17510491

Article Published Date : Apr 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Immune Disorders: Low Immune Function : CK(488) : AC(115)

Pharmacological Actions : Immunomodulatory : CK(536) : AC(142)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Shitake has significant antibacterial and antifungal activity.

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Pubmed Data : Complement Ther Clin Pract. 2009 Feb;15(1):5-7. Epub 2008 Dec 2. PMID: 19161947

Article Published Date : Feb 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Shiitake Mushroom : CK(24) : AC(17)

Diseases : Bacterial Infections and Mycoses : CK(127) : AC(51)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316), Antifungal Agents : CK(178) : AC(111)

Related Blogs

Beginner's Guide to Edible Mushrooms as Medicine

Written by Margie King, Health Coach

Although mushrooms get good press as a low-calorie, high fiber, low-cholesterol, low-sodium decoration for your pizza, there is much more to the mushroom story than that. Mushrooms have been valued for their culinary and medicinal properties for thousands of years and ancient cultures associated them with immortality for good reason.

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