Silibinin

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68 Diseases Researched for Silibinin
NameACCKFocus
Lung Cancer515Locked
Liver Cancer314Locked
Cancers: Drug Resistant513Locked
Colorectal Cancer312Locked
C-Reactive Protein110Locked
HIV Infections110Locked
Hepatitis C110Locked
Liver Damage: Drug-Induced110Locked
Rheumatoid Arthritis110Locked
Inflammation69Locked
Prostate Cancer79Locked
Breast Cancer77Locked
Carcinoma: Non-Small-Cell Lung37Locked
Brain Inflammation 36Locked
Neurodegenerative Diseases36Locked
Breast Cancer: estrogen receptor alpha-positive15Locked
Lipopolysaccharide-Induced Toxicity35Locked
Cancers: All23Locked
Oxidative Stress33Locked
Skin Cancer: Prevention23Locked
Ultraviolet Radiation Induced Damage23Locked
Aluminum Toxicity 12Locked
Alzheimer's Disease12Locked
Basal Cell Carcinoma12Locked
Bladder Cancer22Locked
Breast Cancer: Triple Negative 22Locked
Cachexia: Cancer12Locked
Candida Albicans22Locked
Chemically-Induced Liver Damage12Locked
Chronic Obstructive Pulmonary Disease12Locked
Colon Cancer22Locked
DNA damage12Locked
Depression12Locked
Drug Toxicity: Methotrexate12Locked
Head and Neck Cancer12Locked
Inflammation: Neutrophil-Mediated12Locked
Ischemia12Locked
Kidney Cancer12Locked
Lung Cancer: Prevention12Locked
Lung Injury: Smoke-Induced12Locked
Memory Disorders12Locked
Metabolic Syndrome X12Locked
Pancreatic Cancer12Locked
Parkinson's Disease12Locked
Radiation Induced Illness12Locked
Radiotherapy12Locked
Stress12Locked
Acute Myeloid Leukemia11Locked
Aging11Locked
Breast Cancer: Metastatic11Locked
Cancer Metastasis11Locked
Escherichia coli Infections11Locked
Glioblastoma11Locked
Glioma11Locked
Gout11Locked
Hepatic Steatosis11Locked
High Sugar Diet11Locked
Hyperuricemia11Locked
Leukemia: Acute myelogenous leukemia (AML) 11Locked
Lipid Peroxidation11Locked
Liver Fibrosis11Locked
Lymphoma11Locked
Multiple Myeloma11Locked
Ovarian Cancer11Locked
Promyelocytic leukemia 11Locked
Prostate Cancer: Prevention11Locked
Pseudomonas aeruginosa11Locked
Staphylococcus aureus infection11Locked
55 Pharmacological Actions Researched for Silibinin
NameACCKFocus
Apoptotic2543Locked
Anti-Inflammatory Agents1329Locked
Antiproliferative 2129Locked
Antioxidants1020Locked
Anticarcinogenic Agents517Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor516Locked
Cell cycle arrest514Locked
Hepatoprotective414Locked
Antineoplastic Agents413Locked
Chemosensitizer413Locked
Insulin-Like Growth Factor Inhibition/Downregulation212Locked
Interleukin-6 Downregulation212Locked
Anti-Retroviral Agents110Locked
Antiviral Agents110Locked
Interleukin-8 downregulation110Locked
Chemopreventive79Locked
Neuroprotective Agents48Locked
Autophagy Up-regulation26Locked
Chemotherapeutic56Locked
NF-kappaB Inhibitor46Locked
Radioprotective36Locked
Estrogen Receptor Modulators15Locked
Anti-metastatic44Locked
MicroRNA modulator34Locked
Angiogenesis Inhibitors33Locked
Photoprotective23Locked
Anti-Angiogenic12Locked
Antidepressive Agents12Locked
Bcl-2 protein down-regulation22Locked
Cyclooxygenase 2 Inhibitors12Locked
Cytoprotective12Locked
Enzyme Inhibitors22Locked
Genoprotective12Locked
Hypoglycemic Agents12Locked
Interleukin-4 downregulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor22Locked
Neurogenesis12Locked
Neuroplasticity enhancement12Locked
Radiosensitizer12Locked
Renoprotective12Locked
Superoxide Dismutase Up-regulation12Locked
Tumor Suppressor Protein p53 Upregulation12Locked
Vascular Endothelial Growth Factor A Inhibitor12Locked
Vascular Endothelial Growth Factor Inhibitors12Locked
Antimicrobial11Locked
Caspase-8 activation11Locked
DNA Repair Up-regulation11Locked
Epidermal growth factor receptor (EGFR) inhibitor11Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor11Locked
Immunomodulatory11Locked
Interleukin-1 beta downregulation11Locked
Malondialdehyde Down-regulation11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
STAT3 Inhibitor11Locked
Xanthine oxidase inhibitor11Locked

View the Evidence:
73 Abstracts with Silibinin Research

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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015;10(7):e0133028. Epub 2015 Jul 15. PMID: 26176696
Study Type : Human Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Anti-Retroviral Agents, Antiviral Agents
Additional Keywords : Significant Treatment Outcome
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Pubmed Data : Clin Cancer Res. 2006 May 1;12(9):2944-50. PMID: 16675592
Study Type : Human Study
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(3):4320-7. Epub 2015 Mar 15. PMID: 26064348
Study Type : Human Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Hepatoprotective
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238
Study Type : Human Study
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Pubmed Data : Fitoterapia. 2018 Jan ;124:42-48. Epub 2017 Oct 12. PMID: 29031537
Study Type : Human In Vitro
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Pubmed Data : J Pharmacol Sci. 2015 May 12. Epub 2015 May 12. PMID: 26117209
Study Type : Human In Vitro
[+]
Pubmed Data : J BUON. 2016 Jul-Aug;21(4):917-924. PMID: 27685914
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Liver Cancer
Pharmacological Actions : Chemosensitizer
[+]
Pubmed Data : Biol Trace Elem Res. 2015 May 28. Epub 2015 May 28. PMID: 26018497
Study Type : Animal Study
Additional Links
Substances : Hesperidin, Silibinin
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aluminum Chloride
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Pubmed Data : J Invest Surg. 2017 Apr 18:1-9. Epub 2017 Apr 18. PMID: 28418711
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Ischemia
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Carcinog. 2016 Jan ;55(1):3-14. Epub 2014 Dec 9. PMID: 25492239
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Silibinin
Additional Keywords : Dose Response
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Res. 2015 ;64 Suppl 4:S507-12. PMID: 26681080
Study Type : Animal Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Hypoglycemic Agents
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Pubmed Data : Chin J Nat Med. 2016 Jan ;14(1):40-7. PMID: 26850345
Study Type : Animal Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Hepatoprotective
Problem Substances : N-nitrosodimethylamine
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Pubmed Data : Neurochem Res. 2016 Mar 9. Epub 2016 Mar 9. PMID: 26961891
Study Type : Animal Study
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Open. 2015 Jul 3. Epub 2015 Jul 3. PMID: 26142316
Study Type : Animal Study, In Vitro Study
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Pubmed Data : Neurosci Lett. 2016 Jun 6 ;629:256-261. Epub 2016 Jun 6. PMID: 27276653
Study Type : Animal Study
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Pubmed Data : Phytother Res. 2016 Jul 29. Epub 2016 Jul 29. PMID: 27468706
Study Type : Animal Study
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Pubmed Data : Behav Brain Res. 2018 Apr 19. Epub 2018 Apr 19. PMID: 29680784
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Depression
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Pubmed Data : Mutat Res. 2010 Jan;695(1-2):55-60. Epub 2009 Nov 27. PMID: 19945544
Study Type : Animal Study
Additional Links
Substances : Milk Thistle, Silibinin
Pharmacological Actions : Antioxidants, Radioprotective
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Pubmed Data : Oncotarget. 2015 Jun 8. Epub 2015 Jun 8. PMID: 26090866
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Antiproliferative , MicroRNA modulator
Additional Keywords : Dose Response
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Pubmed Data : World J Gastroenterol. 2009 Apr 28 ;15(16):1943-50. PMID: 19399925
Study Type : Transgenic Animal Study
Additional Links
Substances : Milk Thistle, Silibinin
Diseases : Liver Cancer
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Natl Cancer Inst. 2006 Jun 21 ;98(12):846-55. PMID: 16788158
Study Type : Animal Study
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Pubmed Data : Neurobiol Aging. 2015 Feb 11. Epub 2015 Feb 11. PMID: 25771396
Study Type : Transgenic Animal Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Neurogenesis, Neuroprotective Agents
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Pubmed Data : Carcinogenesis. 2016 Oct 11. Epub 2016 Aug 11. PMID: 27729375
Study Type : Animal Study
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Pubmed Data : Brain Res. 2015 Nov 19 ;1627:233-42. Epub 2015 Oct 3. PMID: 26434409
Study Type : Animal Study
[+]
Pubmed Data : Oncol Rep. 2015 Aug 26. Epub 2015 Aug 26. PMID: 26323996
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Kidney Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]
Pubmed Data : Mol Cancer Ther. 2015 Dec ;14(12):2722-34. Epub 2015 Oct 29. PMID: 26516160
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Prostate Cancer
Pharmacological Actions : Radioprotective, Radiosensitizer
[+]
Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):933-9. PMID: 14504208
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pulm Med. 2015 ;15:68. Epub 2015 Jul 5. PMID: 26143275
Study Type : Animal Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Chemotherapeutic, Radioprotective
Additional Keywords : Significant Treatment Outcome
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 Aug ;10(2):503-507. Epub 2015 Jun 3. PMID: 26622344
Study Type : Animal Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Cytoprotective
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Dec 1 ;6(38):41146-61. PMID: 26510913
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Dose Response
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Pubmed Data : Carcinogenesis. 2015 Jun ;36(6):666-75. Epub 2015 Apr 20. PMID: 25896445
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 May ;23(3):245-50. Epub 2015 May 1. PMID: 25995823
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Depression, Stress
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Pubmed Data : J Biomed Res. 2016 Nov 20 ;30. Epub 2016 Nov 20. PMID: 27476880
Study Type : Review
Additional Links
Substances : Silibinin
Pharmacological Actions : Chemopreventive
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Pubmed Data : Biochem Biophys Res Commun. 2015 Dec 4 ;468(1-2):151-6. Epub 2015 Oct 30. PMID: 26522224
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic
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Pubmed Data : Cancer Lett. 2015 Jul 1 ;362(2):199-207. Epub 2015 Apr 3. PMID: 25846868
Study Type : In Vitro Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2015 Apr 14 ;21(14):4169-77. PMID: 25892866
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Apoptotic
Additional Keywords : Drug: Metformin
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Pubmed Data : Curr Pharmacol Rep. 2015 Jun 1 ;1(3):206-215. PMID: 26097804
Study Type : Review
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Res Ther. 2015 Apr-Jun;11(2):352-7. PMID: 26148599
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin, Silibinin
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
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Pubmed Data : Brain Res. 2015 Dec 10 ;1629:85-93. Epub 2015 Oct 22. PMID: 26471408
Study Type : In Vitro Study
Additional Links
Substances : Luteolin, Silibinin
Diseases : Glioblastoma
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic
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Pubmed Data : Planta Med. 2016 Aug 15. Epub 2016 Aug 15. PMID: 27525510
Study Type : In Vitro Study
Additional Links
Substances : Milk Thistle, Silibinin
Diseases : High Sugar Diet
Pharmacological Actions : Antioxidants
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Pubmed Data : Mol Cell Biochem. 2017 Sep 8. Epub 2017 Sep 8. PMID: 28887692
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Silibinin
Pharmacological Actions : Antioxidants
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Pubmed Data : J Nat Prod. 2009 Apr;72(4):725-31. PMID: 19388706
Study Type : In Vitro Study
Additional Links
Diseases : Gout, Hyperuricemia
Pharmacological Actions : Xanthine oxidase inhibitor
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2015 Mar ;35(3):1263-9. PMID: 25750273
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Antineoplastic Agents, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2015 Dec ;18(12):1209-14. PMID: 26877850
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, MicroRNA modulator
Additional Keywords : Dose Response
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Breast Cancer. 2016 Mar ;19(1):45-52. Epub 2016 Mar 25. PMID: 27066095
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, MicroRNA modulator
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Pubmed Data : Oncol Rep. 2015 Jun ;33(6):2711-8. Epub 2015 Apr 17. PMID: 25891311
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2016 ;16(1):452. Epub 2016 Jul 12. PMID: 27405931
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic
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Pubmed Data : Biochem Pharmacol. 2001 Jun 15;61(12):1487-95. PMID: 11377378
Study Type : In Vitro Study
Additional Links
Substances : Milk Thistle, Silibinin
Pharmacological Actions : Antioxidants, Enzyme Inhibitors
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Pubmed Data : Int J Biochem Cell Biol. 2016 Sep 14 ;80:1-9. Epub 2016 Aug 14. PMID: 27639679
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Candida Albicans
Pharmacological Actions : Apoptotic
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Pubmed Data : J Clin Exp Hepatol. 2016 Sep ;6(3):167-174. Epub 2016 Aug 13. PMID: 27746612
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Liver Fibrosis
Pharmacological Actions : Antiproliferative , Hepatoprotective
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Pubmed Data : Tumour Biol. 2015 Oct 19. Epub 2015 Oct 19. PMID: 26482609
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
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Pubmed Data : Food Chem Toxicol. 2018 Apr 14 ;116(Pt B):161-172. Epub 2018 Apr 14. PMID: 29660364
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Pharmacological Actions : STAT3 Inhibitor
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Pubmed Data : Leuk Lymphoma. 2015 Jul 1:1-27. Epub 2015 Jul 1. PMID: 26133723
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Lymphoma
Pharmacological Actions : Apoptotic, Chemosensitizer
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Pubmed Data : Cell Cycle. 2016 Oct 18:0. Epub 2016 Aug 18. PMID: 27753543
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
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Pubmed Data : Anticancer Res. 2011 Nov ;31(11):3767-73. PMID: 22110198
Study Type : In Vitro Study
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Pubmed Data : Hum Exp Toxicol. 2016 Jul 10. Epub 2016 Jul 10. PMID: 27402681
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Pharmacological Actions : Apoptotic
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Pubmed Data : Int J Oncol. 2017 Aug 2. Epub 2017 Aug 2. PMID: 28791405
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Bladder Cancer
Additional Keywords : Dose Response
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Nov 3 ;8(54):92032-92042. Epub 2017 Sep 8. PMID: 29190895
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative
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Pubmed Data : Tumour Biol. 2016 Mar 16. Epub 2016 Mar 16. PMID: 26984157
Study Type : In Vitro Study
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Pubmed Data : Oncogene. 2003 Nov 13;22(51):8271-82. PMID: 14614451
Study Type : In Vitro Study
Additional Links
Substances : Milk Thistle, Silibinin
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Enzyme Inhibitors
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Pubmed Data : Food Funct. 2015 Sep 8. Epub 2015 Sep 8. PMID: 26345246
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Dose Response
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Pubmed Data : Cancer Invest. 2011 Jan ;29(1):12-20. PMID: 21166494
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2017 May ;39(5):1111-1118. Epub 2017 Mar 27. PMID: 28350048
Study Type : In Vitro Study
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Pubmed Data : Mol Med Rep. 2016 Feb 10. Epub 2016 Feb 10. PMID: 26936429
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:292797. Epub 2015 Mar 11. PMID: 25866771
Study Type : In Vitro Study
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Pubmed Data : Nutr Cancer. 2010 Aug;62(6):811-24. PMID: 20661831
Study Type : In Vitro Study
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Pubmed Data : Mol Carcinog. 2016 Aug 17. Epub 2016 Aug 17. PMID: 27533043
Study Type : In Vitro Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2014 Oct 30 ;5(20):10017-33. PMID: 25294820
Study Type : In Vitro Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27867187
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
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Pubmed Data : Semin Cancer Biol. 2016 Jun 28. Epub 2016 Jun 28. PMID: 27370570
Study Type : Review
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Cancer. 2013 ;65 Suppl 1:3-11. PMID: 23682778
Study Type : Review
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Pubmed Data : Cancer Treat Rev. 2015 Jun ;41(6):540-6. Epub 2015 Apr 27. PMID: 25944486
Study Type : Review
Additional Links
Substances : Silibinin
Diseases : Cancers: All
Pharmacological Actions : STAT3 Inhibitor
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2016 Jul 14 ;22(26):6016-26. PMID: 27468193
Study Type : In Vitro Study

Silibinin Related Articles

For more than 2,000 years, a spiky purple plant known as the “liver herb,” has been used for healing conditions from mushroom poisoning to indigestion. Modern researchers have now added the prevention of photo-aging and skin cancer to the long list of milk thistle’s benefits.

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