Sulforaphane

Sulforaphane

Links of Interest

User Options

Purchase the Exhaustive Downloadable Document on this TopicMake a Request for GMI to add more Articles on this Topic Immediately (Purchase Required)Begin a Smart Search with this TopicA Membership is required. Please Login or Create an account to get startedView a Printer Friendly version of this pageE-mail this page to a friend
Hover over an icon for more information
- 167
Related Topics

Sulforaphane is a Sub of the following Topics

Quick Summary: Current access displays 2 out of 145 associated Diseases
NameCumulative KnowledgeArticle CountFocus Articles
Oxidative Stress2114Log in | Sign up
Prostate Cancer219Log in | Sign up
View the Evidence: Substances

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.

Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. PMID: 19349290
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(484) : AC(167)
Diseases : Gastritis : CK(48) : AC(8), Helicobacter Pylori Infection : CK(305) : AC(61)

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects.

Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Sulforaphane : CK(484) : AC(167)
Diseases : COPD : CK(138) : AC(17), Cystic Fibrosis : CK(703) : AC(77), Glutathione Deficiency : CK(63) : AC(14), Lung Diseases : CK(32) : AC(5), Pulmonary Fibrosis : CK(149) : AC(48), Respiratory Diseases : CK(174) : AC(29)
Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), Glutathione Upregulation : CK(154) : AC(48), Phase II Detoxification Enzyme Inducer : CK(64) : AC(31)
Additional Keywords : Isothiocyanates : CK(70) : AC(23)

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.

Pubmed Data : J Agric Food Chem. 2008 Nov 26;56(22):10505-9. PMID: 18950181
Article Published Date : Nov 26, 2008
Study Type : Human Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sulforaphane : CK(484) : AC(167)
Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265)
Additional Keywords : Raw versus Cooked : CK(68) : AC(12)

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.

Pubmed Data : Nutr Cancer. 2006;55(1):53-62. PMID: 16965241
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(484) : AC(167)
Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265)
Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3401) : AC(1158)

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). I

Pubmed Data : Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID: 17259330
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Substances : Sulforaphane : CK(484) : AC(167)
Diseases : Colon Cancer : CK(819) : AC(233), Prostate Cancer : CK(956) : AC(288), Prostate Cancer: Prevention : CK(145) : AC(16)
Pharmacological Actions : Chemopreventive : CK(1314) : AC(355), Enzyme Inhibitors : CK(386) : AC(208), Histone deacetylase inhibitor : CK(26) : AC(16)

Sulforaphane protects against chemically-induced damage in bladder cells and tissues.

Pubmed Data : Phytother Res. 2003 Jan;17(1):66-9. PMID: 20810543
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Sulforaphane : CK(484) : AC(167)
Diseases : Bladder Cancer : CK(179) : AC(60), Bladder Degeneration : CK(22) : AC(3), DNA damage : CK(680) : AC(293)
Pharmacological Actions : Chemopreventive : CK(1314) : AC(355), Genoprotective : CK(116) : AC(48)

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. PMID: 17416783
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sulforaphane : CK(484) : AC(167)
Diseases : Skin Diseases : CK(46) : AC(9)
Pharmacological Actions : Phase II Detoxification Enzyme Inducer : CK(64) : AC(31)
Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,

Pubmed Data : Nutr Cancer. 2000;38(2):168-78. PMID: 11525594
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sulforaphane : CK(484) : AC(167)
Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265)
Additional Keywords : Raw versus Cooked : CK(68) : AC(12)

The addition of broccoli and watercress in the diet may reduce risk of breast cancer

Pubmed Data : Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID: 15953625
Article Published Date : Dec 01, 2005
Study Type : Human In Vitro
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sulforaphane : CK(484) : AC(167), Watercress : CK(14) : AC(4)
Diseases : Breast Cancer : CK(2051) : AC(566)
Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(149) : AC(71)
Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3401) : AC(1158)

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.

Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831
Article Published Date : Sep 28, 2006
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate : CK(4) : AC(3), Sulforaphane : CK(484) : AC(167)
Diseases : Pancreatic Cancer : CK(513) : AC(162)
Pharmacological Actions : Chemopreventive : CK(1314) : AC(355), Cyclooxygenase 2 Inhibitors : CK(274) : AC(169)
Additional Keywords : Isothiocyanates : CK(70) : AC(23), Stilbenes : CK(414) : AC(242)

Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity.

Pubmed Data : Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 19144376
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane : CK(484) : AC(167)
Diseases : Oxidative Stress : CK(1867) : AC(710), Petroleum Exposure & Toxicity : CK(112) : AC(18), Polycyclic aromatic hydrocarbon (PAH) toxicity : CK(7) : AC(5)
Pharmacological Actions : Phase II Detoxification Enzyme Inducer : CK(64) : AC(31)

Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.

Pubmed Data : Pharm Res. 2009 Oct;26(10):2324-31. Epub 2009 Aug 8. PMID: 19669099
Article Published Date : Oct 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(484) : AC(167)
Diseases : Prostate Cancer : CK(956) : AC(288), Prostate Cancer: Prevention : CK(145) : AC(16)
Pharmacological Actions : Apoptotic : CK(1416) : AC(1089)
Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

Broccoli sprouts contain compounds which protect the skin against damage by UV radiation.

Pubmed Data : Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5. Epub 2007 Oct 23. PMID: 17956979
Article Published Date : Oct 30, 2007
Study Type : Animal Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(484) : AC(167)
Diseases : Aging Skin : CK(379) : AC(86)

Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue.

Pubmed Data : Carcinogenesis. 2007 Jul;28(7):1485-90. Epub 2007 Mar 7. PMID: 17347138
Article Published Date : Jul 01, 2007
Study Type : Animal Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sulforaphane : CK(484) : AC(167)
Diseases : Breast Cancer : CK(2051) : AC(566)
Pharmacological Actions : Chemopreventive : CK(1314) : AC(355)

Brussel sprouts induce detoxifying enzymes.

Pubmed Data : J Food Sci. 2010 Aug 1;75(6):H190-9. PMID: 20722931
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Brussel sprouts : CK(17) : AC(6), Sulforaphane : CK(484) : AC(167)
Diseases : Chemical Exposure : CK(49) : AC(15), Intoxication : CK(3) : AC(2)
Pharmacological Actions : Phase I Detoxification Enzyme Inducer : CK(4) : AC(2), Phase II Detoxification Enzyme Inducer : CK(64) : AC(31)
Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3401) : AC(1158)

Isothiocyanates exhibit anti-myeloma activity.

Pubmed Data : Haematologica. 2011 Aug ;96(8):1170-9. Epub 2011 Jun 28. PMID: 21712538
Article Published Date : Aug 01, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Isothiocyanate : CK(2) : AC(1), Sulforaphane : CK(484) : AC(167)
Diseases : Multiple Myeloma : CK(136) : AC(51)
Pharmacological Actions : Apoptotic : CK(1416) : AC(1089)

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

Pubmed Data : Cancer Res. 2005 Sep 15;65(18):8548-57. PMID: 16166336
Article Published Date : Sep 15, 2005
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine) : CK(258) : AC(62), Phenethyl isothiocyanate : CK(8) : AC(5), Sulforaphane : CK(484) : AC(167)
Diseases : Lung Cancer : CK(494) : AC(198), Nicotine/Tobacco Toxicity : CK(152) : AC(26), Smoking : CK(566) : AC(85)
Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265)
Additional Keywords : Isothiocyanates : CK(70) : AC(23)

Sufloraphane has a protective effect on preserved pancreas and may have a potential clinical implication to improve hemodynamically unstable pancreas donor condition.

Pubmed Data : Ann Transplant. 2004;9(3):68-71. PMID: 15759553
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Sulforaphane : CK(484) : AC(167)
Diseases : Organ Transplantation: Pancreatic Islet Cells : CK(8) : AC(5)
Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Suforaphane, a compound found within broccoli, inhibits lung metastasis induced by melanoma cells in tumor-bearing animals.

Pubmed Data : Breast Cancer Res Treat. 2006 Oct;99(3):333-40. Epub 2006 May 9. PMID: 16600309
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sulforaphane : CK(484) : AC(167)
Diseases : Lung Cancer : CK(494) : AC(198), Melanoma : CK(168) : AC(87), Melanoma: Metastatic : CK(21) : AC(13)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106)

Sulforaphane and dibenzoylmethane alone as well as their combination are potent natural dietary compounds for chemoprevention of gastrointestinal cancers.

Pubmed Data : Cancer Res. 2007 Oct 15;67(20):9937-44. PMID: 17942926
Article Published Date : Oct 15, 2007
Study Type : Animal Study
Additional Links
Substances : Dibenzoylmethane (DBM) : CK(2) : AC(1), Sulforaphane : CK(484) : AC(167)
Diseases : Adenomatous Polyposis Coli : CK(8) : AC(4), Gastrointestinal Cancer : CK(43) : AC(11)
Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265), Apoptotic : CK(1416) : AC(1089), Chemopreventive : CK(1314) : AC(355)

Sulforaphane and NAC (N-acetyl-L-cysteine) upregulate T(H)1 immunity in aging.

Pubmed Data : J Allergy Clin Immunol. 2008 May;121(5):1255-1261.e7. Epub 2008 Mar 5. PMID: 18325578
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine) : CK(258) : AC(62), Sulforaphane : CK(484) : AC(167)
Diseases : Aging : CK(1341) : AC(369), Immune Disorders: Low Immune Function : CK(488) : AC(115), Immune Dysregulation: TH1/TH2 imbalance : CK(146) : AC(36), Low Disorders: Low TH1 : CK(6) : AC(4)
Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), Immunomodulatory : CK(536) : AC(142)

Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.

Pubmed Data : J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID: 16211562
Article Published Date : Nov 15, 2005
Study Type : Animal Study
Additional Links
Substances : Sulforaphane : CK(484) : AC(167)
Diseases : Brain Edema : CK(14) : AC(3), Traumatic Brain Injury : CK(33) : AC(9)

Sulforaphane enhances the anticancer activity of a chemo-agent against pancreatic cancer.

Pubmed Data : Nutr Cancer. 2011 Aug 29. Epub 2011 Aug 29. PMID: 21875325
Article Published Date : Aug 29, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli : CK(426) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(484) : AC(167)
Diseases : Pancreatic Cancer : CK(513) : AC(162)
Pharmacological Actions : Chemosensitizer : CK(188) : AC(156)
Additional Keywords : Drug Synergy : CK(324) : AC(144)

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.

Pubmed Data : Clin Cancer Res. 2008 Nov 1;14(21):6855-66. PMID: 18980980
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane : CK(484) : AC(167)
Diseases : Prostate Cancer : CK(956) : AC(288)
Pharmacological Actions : Anti-metastatic : CK(169) : AC(106), Antiproliferative : CK(969) : AC(725), Apoptotic : CK(1416) : AC(1089)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Sulforaphane exhibits chemopreventive properties against intestinal polyps in mice.

Pubmed Data : Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 16952200
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane : CK(484) : AC(167)
Diseases : Adenomatous Polyposis Coli : CK(8) : AC(4), Intestinal Polyps : CK(18) : AC(9)
Pharmacological Actions : Anticarcinogenic Agents : CK(513) : AC(265), Cyclooxygenase 2 Inhibitors : CK(274) : AC(169)

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.