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Sulforaphane

Sulforaphane

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Article Count - 171
Cumulative Knowledge - 317

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View the Evidence: Substances

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. PMID: 19349290

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(520) : AC(171)

Diseases : Gastritis : CK(291) : AC(8), Helicobacter Pylori Infection : CK(305) : AC(61)

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects.

Click here to read the entire abstract

Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : COPD : CK(158) : AC(18), Cystic Fibrosis : CK(703) : AC(77), Glutathione Deficiency : CK(63) : AC(14), Lung Diseases : CK(32) : AC(5), Pulmonary Fibrosis : CK(135) : AC(46), Respiratory Diseases : CK(174) : AC(29)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Glutathione Upregulation : CK(144) : AC(48), Phase II Detoxification Enzyme Inducer : CK(64) : AC(32)

Additional Keywords : Isothiocyanates : CK(70) : AC(23)

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2008 Nov 26;56(22):10505-9. PMID: 18950181

Article Published Date : Nov 26, 2008

Study Type : Human Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sulforaphane : CK(520) : AC(171)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Raw versus Cooked : CK(69) : AC(13)

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.

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Pubmed Data : Nutr Cancer. 2006;55(1):53-62. PMID: 16965241

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(520) : AC(171)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3616) : AC(1226)

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). I

Click here to read the entire abstract

Pubmed Data : Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID: 17259330

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Colon Cancer : CK(895) : AC(233), Prostate Cancer : CK(998) : AC(288), Prostate Cancer: Prevention : CK(155) : AC(16)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Enzyme Inhibitors : CK(372) : AC(208), Histone deacetylase inhibitor : CK(26) : AC(16)

Sulforaphane protects against chemically-induced damage in bladder cells and tissues.

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2003 Jan;17(1):66-9. PMID: 20810543

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Bladder Cancer : CK(186) : AC(60), Bladder Degeneration : CK(22) : AC(3), DNA damage : CK(711) : AC(293)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Genoprotective : CK(118) : AC(48)

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.

Click here to read the entire abstract

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. PMID: 17416783

Article Published Date : Apr 01, 2007

Study Type : Human Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sulforaphane : CK(520) : AC(171)

Diseases : Skin Diseases : CK(46) : AC(9)

Pharmacological Actions : Phase II Detoxification Enzyme Inducer : CK(64) : AC(32)

Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2000;38(2):168-78. PMID: 11525594

Article Published Date : Jan 01, 2000

Study Type : Human Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sulforaphane : CK(520) : AC(171)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Raw versus Cooked : CK(69) : AC(13)

The addition of broccoli and watercress in the diet may reduce risk of breast cancer

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID: 15953625

Article Published Date : Dec 01, 2005

Study Type : Human In Vitro

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sulforaphane : CK(520) : AC(171), Watercress : CK(14) : AC(4)

Diseases : Breast Cancer : CK(2361) : AC(621)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3616) : AC(1226)

"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID: 23038615

Article Published Date : Oct 31, 2012

Study Type : Animal Study

Additional Links

Substances : Erucin : CK(2) : AC(1), Sulforaphane : CK(520) : AC(171)

Diseases : Bladder Cancer : CK(186) : AC(60)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

"Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane."

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Pubmed Data : Mol Carcinog. 2012 May 29. Epub 2012 May 29. PMID: 22641235

Article Published Date : May 28, 2012

Study Type : Insect Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Epstein-Barr Virus Infections : CK(100) : AC(43), Nasopharyngeal Cancer : CK(58) : AC(21)

"Neuroprotective effects of sulforaphane after contusive spinal cord injury."

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Pubmed Data : J Neurotrauma. 2012 Nov 1 ;29(16):2576-86. Epub 2012 Sep 20. PMID: 22853439

Article Published Date : Oct 31, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Spinal Cord Injuries : CK(98) : AC(28)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

"Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation."

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2012 ;2012:821936. Epub 2012 Sep 23. PMID: 23050040

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Diabetic Nephropathy : CK(43) : AC(17)

"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."

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Pubmed Data : Psychopharmacology (Berl). 2012 Jul ;222(1):37-45. Epub 2011 Dec 27. PMID: 22200890

Article Published Date : Jun 30, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Amphetamine Addiction/Withdrawal : CK(31) : AC(8), Brain: Microglial Activation : CK(67) : AC(38), Neurodegenerative Diseases : CK(1743) : AC(420)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2012 Nov 30. Epub 2012 Nov 30. PMID: 23201461

Article Published Date : Nov 29, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Chemical Weapon Agent Injury : CK(14) : AC(4), Skin Cancer: Prevention : CK(8) : AC(4)

Pharmacological Actions : Phase II Detoxification Enzyme Inducer : CK(64) : AC(32)

"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2011 Sep ;26(3):603-8. Epub 2011 May 20. PMID: 21617865

Article Published Date : Sep 01, 2011

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Breast Cancer : CK(2361) : AC(621)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1058) : AC(775), Apoptotic : CK(1535) : AC(1155)

"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."

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Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492

Article Published Date : Aug 22, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), NSAID-induced toxicity : CK(230) : AC(50)

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831

Article Published Date : Sep 28, 2006

Study Type : Animal Study

Additional Links

Substances : Benzyl isothiocyanate : CK(4) : AC(3), Sulforaphane : CK(520) : AC(171)

Diseases : Pancreatic Cancer : CK(530) : AC(168)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)

Additional Keywords : Isothiocyanates : CK(70) : AC(23), Stilbenes : CK(402) : AC(242)

Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity.

Click here to read the entire abstract

Pubmed Data : Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 19144376

Article Published Date : Mar 01, 2009

Study Type : Animal Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Oxidative Stress : CK(1945) : AC(710), Petroleum Exposure And Toxicity : CK(49) : AC(18), Polycyclic aromatic hydrocarbon (PAH) toxicity : CK(7) : AC(5)

Pharmacological Actions : Phase II Detoxification Enzyme Inducer : CK(64) : AC(32)

Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.

Click here to read the entire abstract

Pubmed Data : Pharm Res. 2009 Oct;26(10):2324-31. Epub 2009 Aug 8. PMID: 19669099

Article Published Date : Oct 01, 2009

Study Type : Transgenic Animal Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(520) : AC(171)

Diseases : Prostate Cancer : CK(998) : AC(288), Prostate Cancer: Prevention : CK(155) : AC(16)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155)

Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Broccoli sprouts contain compounds which protect the skin against damage by UV radiation.

Click here to read the entire abstract

Pubmed Data : Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5. Epub 2007 Oct 23. PMID: 17956979

Article Published Date : Oct 30, 2007

Study Type : Animal Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sprouts : CK(76) : AC(36), Sulforaphane : CK(520) : AC(171)

Diseases : Aging Skin : CK(360) : AC(86)

Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue.

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2007 Jul;28(7):1485-90. Epub 2007 Mar 7. PMID: 17347138

Article Published Date : Jul 01, 2007

Study Type : Animal Study

Additional Links

Substances : Broccoli : CK(449) : AC(185), Sulforaphane : CK(520) : AC(171)

Diseases : Breast Cancer : CK(2361) : AC(621)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Brussel sprouts induce detoxifying enzymes.

Click here to read the entire abstract

Pubmed Data : J Food Sci. 2010 Aug 1;75(6):H190-9. PMID: 20722931

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Substances : Brussel sprouts : CK(17) : AC(6), Sulforaphane : CK(520) : AC(171)

Diseases : Chemical Exposure : CK(49) : AC(15), Intoxication : CK(3) : AC(2)

Pharmacological Actions : Phase I Detoxification Enzyme Inducer : CK(4) : AC(2), Phase II Detoxification Enzyme Inducer : CK(64) : AC(32)

Additional Keywords : Isothiocyanates : CK(70) : AC(23), Plant Extracts : CK(3616) : AC(1226)

Isothiocyanates exhibit anti-myeloma activity.

Click here to read the entire abstract

Pubmed Data : Haematologica. 2011 Aug ;96(8):1170-9. Epub 2011 Jun 28. PMID: 21712538

Article Published Date : Aug 01, 2011

Study Type : Transgenic Animal Study

Additional Links

Substances : Isothiocyanate : CK(2) : AC(1), Sulforaphane : CK(520) : AC(171)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155)

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

Click here to read the entire abstract

Pubmed Data : Cancer Res. 2005 Sep 15;65(18):8548-57. PMID: 16166336

Article Published Date : Sep 15, 2005

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine) : CK(264) : AC(62), Phenethyl isothiocyanate : CK(8) : AC(5), Sulforaphane : CK(520) : AC(171)

Diseases : Lung Cancer : CK(496) : AC(198), Nicotine/Tobacco Toxicity : CK(152) : AC(26), Smoking : CK(577) : AC(86)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275)

Additional Keywords : Isothiocyanates : CK(70) : AC(23)

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