Sulforaphane

Name	AC	CK
Oxidative Stress	44	106
Inflammation	22	49
Prostate Cancer	27	42
Breast Cancer	28	36
Colon Cancer	17	35
Autism Spectrum Disorders	6	33
Breast Cancer: Triple Negative	8	29
Cancers: All	20	29
Pancreatic Cancer	17	28
Diabetes Mellitus: Type 2	10	27
DNA damage	7	26
Bladder Cancer	12	24
Insulin Resistance	6	23
Air Pollution Linked Toxicity	3	21
Liver Cancer	14	20
Lung Cancer	13	18
Helicobacter Pylori Infection	5	17
Melanoma	6	17
Lipopolysaccharide-Induced Toxicity	12	16
Prostate Cancer: Prevention	4	14
Alzheimer's Disease	6	13
Asthma	2	12
Autism	2	12
Chemotherapy-Induced Toxicity: Cisplatin	5	12
Colorectal Cancer	6	12
Diesel Exhaust Particle Toxicity	3	12
Fatty Liver	2	12
Glutathione Deficiency	3	12
Cancer Metastasis	9	11
Obesity	6	11
Ovarian Cancer	7	11
Schizophrenia	2	11
Skin Diseases	2	11
Anemia: Sickle Cell	1	10
Benzene Toxicity	1	10
Bladder Degeneration	1	10
COPD	1	10
Cancers: Drug Resistant	5	10
Cognitive Decline/Dysfunction	5	10
Cystic Fibrosis	1	10
Gastritis	1	10
Hyperinsulinism	1	10
Lung Diseases	1	10
Prostate: PSA Doubling	1	10
Psychiatric Disorders	1	10
Pulmonary Fibrosis	1	10
Radical Prostatectomy	1	10
Respiratory Diseases	1	10
Cadmium Poisoning	4	9
Gastric Cancer	4	9
Leukemia	5	9
Endothelial Dysfunction	3	8
Aging	2	7
Cancers	3	7
Cardiovascular Diseases	6	7
Cerebral Ischemia	4	7
Chemotherapy-Induced Toxicity: Doxorubicin	6	7
Hypoxia	5	7
Ischemia	4	7
Neurodegenerative Diseases	5	7
Adenomatous Polyposis Coli	3	6
Chemically-Induced Liver Damage	4	6
Skin Cancer: Prevention	3	6
Brain Damage	3	5
Breast Cancer: Estrogen	1	5
Cancer Stem Cells	5	5
Carcinoma: Non-Small-Cell Lung	4	5
Colorectal Cancer: Prevention	1	5
Endothelial Damage	1	5
Female	1	5
Fetal Alcoholism	1	5
Gastric Cancer: Prevention	1	5
Glioblastoma	4	5
Immune Disorders: Low Immune Function	3	5
Insulin Disorders	1	5
Lipid Peroxidation	1	5
Skin Cancer	4	5
Acetaminophen (Tylenol) Toxicity	2	4
Aflatoxicosis	3	4
Aspirin-Induced Toxicity	2	4
Brain Injury: Traumatic	2	4
Brain: Microglial Activation	2	4
Cardiomyopathy	2	4
Depression	2	4
Diabetes Mellitus: Type 1	2	4
Diabetic Complications	2	4
Head and Neck Cancer	4	4
Hydrogen Peroxide Induced Toxicity	4	4
Intestinal Polyps	2	4
Muscle Damage: Exercise-Induced	2	4
NSAID-induced toxicity	2	4
Nasopharyngeal Cancer	3	4
Nicotine/Tobacco Toxicity	2	4
Organ Transplantation: Pancreatic Islet Cells	2	4
Parkinson's Disease	4	4
Spinal Cord Injuries	2	4
Stroke	2	4
Traumatic Brain Injury	2	4
Advanced Glycation End products (AGE)	2	3
Aging Skin	2	3
Benzo[a]pyrene-induced Toxicity	2	3
Blood-Brain-Barrier Disorders	2	3
Brain Cancer	3	3
Brain Inflammation	2	3
Cervical Cancer	3	3
Chemotherapy-Induced Toxicity	2	3
Diabetes Mellitus: Type 1: Prevention	2	3
Diabetic Nephropathy	2	3
Drug-Induced Toxicity: Indomethacin	2	3
Gastric Ulcer	2	3
Intestinal Diseases	2	3
Liver Damage	2	3
Liver Damage: Aflatoxin-Induced	2	3
Low Disorders: Low TH1	2	3
Melanoma: Metastatic	2	3
Multiple Myeloma	2	3
Multiple Sclerosis	2	3
Myocardial Ischemia	2	3
Oral Cancer	2	3
Osteosarcoma	2	3
Petroleum Exposure And Toxicity	2	3
Polycyclic aromatic hydrocarbon (PAH) toxicity	2	3
Rheumatoid Arthritis	2	3
Skin Diseases: Photo-Aging	2	3
Aging: Heart	1	2
Alcohol Toxicity	1	2
Alcoholic Liver Disease	1	2
Amphetamine Addiction/Withdrawal	1	2
Anxiety Disorders	1	2
Atherosclerosis	1	2
Atopic Dermatitis	1	2
Autoimmune Diseases	1	2
Bacterial Infections and Mycoses	2	2
Bladder Dysfunction	1	2
Bladder Outlet Obstruction	1	2
Brain Edema	1	2
Brain Hypoxia	2	2
Breast Cancer: Metastatic	2	2
C-Reactive Protein	1	2
Cancers: Multi-Drug Resistant	1	2
Carbon Monoxide Poisoning	1	2
Chemical Exposure	1	2
Chemical Weapon Agent Injury	1	2
Chronic Pain	1	2
Coronavirus Infection	1	2
Depressive Disorder	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Memory Problems	1	2
Duchenne's Muscular Dystrophy	1	2
Dyslipidemias	1	2
Endometriosis	1	2
Epstein-Barr Virus Infections	1	2
Escherichia coli Infections	1	2
Gastrointestinal Cancer	1	2
Glioma	2	2
Gout	1	2
Heart Failure	1	2
Heavy Metal Toxicity	1	2
High Fat Diet	1	2
Hypertension	1	2
Hypoglycemia	2	2
Hypogonadism	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Infertility: Male	1	2
Intoxication	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Light Sensitivity	1	2
Liver Disease	1	2
Low Immune Function: Natural Killer Cells	1	2
Malathion Toxicity	1	2
Memory Disorders	1	2
Mercury Poisoning	1	2
Mitochondrial Dysfunction	1	2
Muscle Fatigue	1	2
Muscle Soreness	1	2
Musculoskeletal Diseases	1	2
Myocardial Infarction	1	2
Nephropathy	1	2
Neurologic Disorders	1	2
Neuropathic Pain	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Organ Transplantation	1	2
Promyelocytic leukemia	2	2
Pulmonary Hypertension	1	2
Respiratory Syncytial Virus Infections	1	2
Respiratory Tract Infections	1	2
Salivary Gland Adenoid Cystic Carcinoma.	2	2
Salivary Gland Diseases	2	2
Schwannoma: Vestibular	1	2
Seizures	1	2
Serotonin Disorders	1	2
Sickle Cell Anemia	1	2
Smoking	1	2
Stroke: Recovery	1	2
Testicular Injury: Cadmium-Induced	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Tumors	2	2
Ulcerative Colitis	1	2
Ultraviolet Radiation Induced Damage	2	2
Allergies	1	1
Androgen-Induced Diseases	1	1
Aortic Plaques	1	1
Arsenic Poisoning	1	1
Bone Destructive Diseases: Over-Active Osteoclasts	1	1
Brain Injury: Hippocampal Damage	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Breast Cancer: Prevention	1	1
Cardiac Hypertrophy	1	1
Cardiovascular Disease: Prevention	1	1
Cholesterol: LDL/HDL ratio	1	1
Chronic Kidney Disease (CKD)	1	1
Colon Cancer: Prevention	1	1
Colorectal Tumors	1	1
Dopamine Deficiency	1	1
Drug-Induced Toxicity	1	1
Dystrophic retinal detachment (DRD)	1	1
Encephalomyelitis	1	1
Excitotoxicity	1	1
Fibrosis	1	1
Fungal Infection	1	1
Gastrointestinal Diseases	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
HDL: Low	1	1
HIV Infections	1	1
Hepatitis C	1	1
Heterocyclic Aromatic Amine Induced Toxicity	1	1
Hyperglycemia	1	1
IgE-Mediated Hypersensitivity	1	1
Keloid	1	1
Kidney Damage	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Liver Cancer: Prevention	1	1
Liver Failure: Acute	1	1
Liver Fibrosis	1	1
Lung Cancer: Prevention	1	1
Lymphoma	1	1
Macular Degeneration	1	1
Malignant Melanoma	1	1
Medulloblastoma	1	1
Melanism	1	1
Microcystis aeruginosa	1	1
Mitochondrial Diseases	1	1
Muscle Atrophy	1	1
Neurological Conditions	1	1
Oral Cancer: Prevention	1	1
Osteoarthritis	1	1
Osteoporosis	1	1
Osteoporosis: Over-active Osteoclasts	1	1
Pancreatic Cancer Stem Cell	1	1
Pesticide Toxicity	1	1
Prediabetes	1	1
Restenosis	1	1
Retinal Diseases	1	1
Schizophrenic Disorders	1	1
Squamous cell carcinoma	1	1
Stomach Cancer	1	1
Striatonigral Degeneration: Autosomal Dominant	1	1
Sunburn	1	1

Name	AC	CK
Antioxidants	93	207
Apoptotic	95	157
Anticarcinogenic Agents	87	150
Anti-Inflammatory Agents	59	136
Nrf2 activation	69	132
Antiproliferative	68	126
Chemopreventive	61	110
Neuroprotective Agents	42	91
Phase II Detoxification Enzyme Inducer	17	44
Cell cycle arrest	31	39
Antioxidant Effects	14	38
NF-kappaB Inhibitor	25	34
Tumor Necrosis Factor (TNF) Alpha Inhibitor	20	32
Chemotherapeutic	23	31
Hepatoprotective	13	29
Anti-metastatic	18	25
Interleukin-1 beta downregulation	15	25
Interleukin-6 Downregulation	17	25
Histone deacetylase inhibitor	14	24
Cyclooxygenase 2 Inhibitors	15	23
Glutathione Upregulation	4	22
Cytoprotective	5	21
Antineoplastic Agents	12	20
Chemosensitizer	17	20
Enzyme Inhibitors	7	16
MicroRNA modulator	15	16
Cardioprotective	12	15
NF-E2-Related Factor-2 (Nrf2) Modulator	10	15
Anti-Apoptotic	6	14
Antioxidant	4	13
Anti-Angiogenic	6	12
Detoxifier	3	12
Genoprotective	2	11
Matrix metalloproteinase-2 (MMP-2) inhibitor	6	11
Anti-Allergic Agents	1	10
Heme oxygenase-1 up-regulation	8	10
Insulin Down-Regulation	1	10
Immunomodulatory	6	9
Insulin Sensitizers	3	9
Superoxide Dismutase Up-regulation	3	9
Tumor Suppressor Protein p53 Upregulation	5	9
Glucose Uptake Optimization	3	8
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	8
Anti-Tumor	2	7
Autophagy Up-regulation	3	7
Renoprotective	5	7
Anti Inflammatory	4	6
Anti-Proliferative	2	6
Chemoprotective Agents	5	6
Wnt/β-catenin pathway down-regulation	2	6
Anti-cancer	1	5
Gastrointestinal Agents	3	5
HER-2 oncoprotein down-regulation	1	5
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	4	5
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	5
Immune Enhancing Properties	1	5
NADPH Oxidase Inhibitors	1	5
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation	1	5
Regenerative	1	5
Antidepressive Agents	2	4
Antiviral Agents	3	4
Bcl-2 protein down-regulation	4	4
Immunomodulatory: Th17 downregulation	2	4
Malondialdehyde Down-regulation	2	4
Nitric Oxide Inhibitor	2	4
Vascular Endothelial Growth Factor Inhibitors	2	4
Anti-Bacterial Agents	3	3
Anti-Fibrotic	3	3
Anti-Ulcer Agents	2	3
Hypoglycemic Agents	2	3
Interferon Gamma Reducer	2	3
Interleukin-10 upregulation	2	3
Radioprotective	2	3
Telomerase Inhibitor	3	3
Wnt/β-catenin signaling pathway modulation	3	3
Angiogenesis Inhibitors	1	2
Anti-Anxiety Agents	1	2
Anticonvulsants	1	2
Antimicrobial	1	2
Antinoceceptive	1	2
Autophagy Inhibitors	1	2
Brain-derived neurotrophic factor modulator	1	2
Cytotoxic	2	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Male	1	2
Gastroprotective	1	2
Heat Shock Protein Inducer	1	2
Hypolipidemic	1	2
Hypotensive	1	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-2 upregulation	1	2
Interleukin-23 Downregulation	1	2
Leptin Down-Regulation	1	2
Lipolytic	1	2
Malonaldehyde (MDA) Down-Regulation	1	2
Metallothionein Up-regulation	1	2
Neurogenesis	1	2
PI3K-AKT inhibitor	1	2
Peroxisome Proliferators	1	2
Phase I Detoxification Enzyme Inducer	1	2
Platelet aggregation inhibitor: collagen-induced aggregation	1	2
Prostaglandin PGE2 downregulation	1	2
Proteasome Inhibitors	2	2
Serotonergic	1	2
Anti-Glycation Agents	1	1
Antifungal Agents	1	1
Antimitotic Agents	1	1
Beta-Defensin-2 Up-Regulation	1	1
Caspase-3 Activation	1	1
Cell Differentiation Inducer	1	1
Estrogen Receptor Modulators	1	1
Interleukin-4 upregulation	1	1
Interleukin-8 downregulation	1	1
Osteoprotective	1	1
P21 Activation	1	1
Postaglandin PGE2 downregulation	1	1
Quinone Reductase-Inducer	1	1
Radiopharmaceuticals	1	1
Radiosensitizer	1	1
Survivin Down-Regulation	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1

[+]

These results demonstrated that sulforaphane possesses effective anti-HCV activity.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(3):e0152236. Epub 2016 Mar 29. PMID: 27023634

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Hepatitis C

Pharmacological Actions : Antiviral Agents, Heme oxygenase-1 up-regulation, MicroRNA modulator

Additional Keywords : Dose Response

[+]

These results indicated a novel use for sulforaphane in attenuating hydrogen peroxide-induced oxidative stress in human trabecular meshwork cells.Jan 27, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Med Sci Monit. 2019 Jan 28 ;25:811-818. Epub 2019 Jan 28. PMID: 30689624

Article Published Date : Jan 27, 2019

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

These results suggest a potential therapeutic role for SFN in the treatment of psoriasis.Nov 24, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Death Dis. 2023 Nov 25 ;14(11):768. Epub 2023 Nov 25. PMID: 38007430

Article Published Date : Nov 24, 2023

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Inflammation, Psoriasis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

[+]

This article catalogues the rationale for a hypothesis that multifunctional sulforaphane can be utilised as the initial step in restoring the ecology of the gut ecosystem.Aug 29, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2023 Aug 30 ;24(17). Epub 2023 Aug 30. PMID: 37686253

Article Published Date : Aug 29, 2023

Study Type : Commentary

Additional Links

Substances : Sulforaphane

Diseases : Dysbiosis

Pharmacological Actions : Gastrointestinal Agents

[+]

This article focuses on the effects of sulforaphane on CSCs and self-renewal pathways.Jul 31, 2013

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Pubmed Data : Future Oncol. 2013 Aug ;9(8):1097-103. PMID: 23902242

Article Published Date : Jul 31, 2013

Study Type : Review

Additional Links

Substances : Broccoli, Broccoli Sprouts, Sulforaphane

Diseases : Cancers: All

Pharmacological Actions : Anticarcinogenic Agents, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Cancer Stem Cells, Isothiocyanates

[+]

This review describes the role of antioxidants like sulforaphane and curcumin in combatting chemoresistance and chemotherapy-induced oxidative stress through NF-kappaB and HIF-1a inhibition.Jun 29, 2019

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Pubmed Data : Eur J Pharmacol. 2019 Jun 29 ;859:172513. Epub 2019 Jun 29. PMID: 31260654

Article Published Date : Jun 29, 2019

Study Type : Review

Additional Links

Substances : Broccoli Sprouts, Curcumin, Sulforaphane, Turmeric

Pharmacological Actions : Anti Inflammatory, Antioxidant Effects, Chemosensitizer, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, NF-kappaB Inhibitor, Nrf2 activation

Additional Keywords : Anti-cancer, Chemoresistance, Chemosensitizer, Chemotherapy

Problem Substances : Chemotherapy

[+]

This review establishes sulforaphane as a safe and non-toxic chemopreventative agent and indicates the need for more research for its use in human cancers as a single agent or as part of combination therapy.Jan 01, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2018 ;12:2905-2913. Epub 2018 Sep 11. PMID: 30254420

Article Published Date : Jan 01, 2018

Study Type : Review

Additional Links

Substances : Sulforaphane

Diseases : Cancers

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Phase II Detoxification Enzyme Inducer

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

[+]

This review focuses on plant derived HDACi Sulforaphane as a promising molecule against pancreatic cancer therapy.Jun 05, 2016

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Pubmed Data : Anticancer Agents Med Chem. 2016 Jun 6. Epub 2016 Jun 6. PMID: 27281367

Article Published Date : Jun 05, 2016

Study Type : Review

Additional Links

Substances : Sulforaphane

Diseases : Pancreatic Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor

[+]

This review provides evidence that nutrition and natural compounds can help in prevention and treatment of this neuroinflammatory disease. Mar 31, 2015

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Pubmed Data : Pharmacol Ther. 2015 Apr ;148:85-113. Epub 2014 Nov 27. PMID: 25435020

Article Published Date : Mar 31, 2015

Study Type : Review

Additional Links

Substances : Broccoli, Curcumin, EGCG (Epigallocatechin gallate), Polyunsaturated Fatty Acids (PUFAs), Sulforaphane, Vitamin A, Vitamin D, Vitamin E

Diseases : Encephalomyelitis, Multiple Sclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Dietary Modification, Natural Substance Synergy, Significant Treatment Outcome

[+]

This review summarises the many health benefits of Sulforaphane as a antioxidant dietary supplement.May 04, 2015

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Pubmed Data : Recent Pat Endocr Metab Immune Drug Discov. 2015 May 5. Epub 2015 May 5. PMID: 25944116

Article Published Date : May 04, 2015

Study Type : Review

Additional Links

Substances : Sulforaphane

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Glutathione Upregulation , Nrf2 activation

Additional Keywords : Detoxification, Dose Response, Epigenetic Modification

[+]

This review summarizes evidence of the impact of SFN on epigenetic events related to the chemopreventive effects in preclinical and clinical studies of breast and prostate cancers.Mar 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Pharmacol Rep. 2015 Apr 1 ;1(2):102-111. PMID: 26042194

Article Published Date : Mar 31, 2015

Study Type : Review

Additional Links

Substances : Sulforaphane

Diseases : Breast Cancer, Prostate Cancer, Prostate Cancer: Prevention

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Epigenetic Modification In Cancer

[+]

This review summarizes the current status of pre-clinical chemoprevention studies with sulforaphane.Jan 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Semin Oncol. 2016 Feb ;43(1):146-53. Epub 2015 Sep 8. PMID: 26970133

Article Published Date : Jan 31, 2016

Study Type : Review

Additional Links

Substances : Sulforaphane

Diseases : Bladder Cancer, Breast Cancer, Colon Cancer, Lung Cancer, Prostate Cancer, Skin Cancer, Stomach Cancer

Pharmacological Actions : Chemopreventive, Nrf2 activation

[+]

This review summarizes the epigenetic events associated with breast cancer and the potential of dietary polyphenols to modulate these events.Jan 12, 2012

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Pubmed Data : Chem Res Toxicol. 2012 Jan 13 ;25(1):61-73. Epub 2011 Oct 28. PMID: 21992498

Article Published Date : Jan 12, 2012

Study Type : Review

Additional Links

Substances : Curcumin, EGCG (Epigallocatechin gallate), Genistein, Green Tea, Isothiocyanates, Resveratrol, Soy, Sulforaphane, Turmeric

Diseases : Breast Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Risk Reduction

[+]

This review summarizes the mechanisms, namely through targeting DNA methyltransferases, inhibiting histone deactylases, and activating Nrf2.Jan 01, 2018

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5438179. Epub 2018 Jun 6. PMID: 29977456

Article Published Date : Jan 01, 2018

Study Type : Review

Additional Links

Substances : Sulforaphane

Diseases : Oxidative Stress

Pharmacological Actions : Anticarcinogenic Agents, Antioxidant Effects, Histone deacetylase inhibitor, Nrf2 activation

Additional Keywords : DNA Methylation, DNA Methyltransferase, Epigenetic Modification, Isothiocyanates

[+]

This review summarizes the well established non epigenetic targets and highlights more recent evidence supporting these phytochemicals as epigenetic modulators for prostate cancer chemoprevention.Sep 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : AAPS J. 2013 Oct ;15(4):951-61. Epub 2013 Jun 26. PMID: 23800833

Article Published Date : Sep 30, 2013

Study Type : Review

Additional Links

Substances : Cruciferous Vegetables, Indole-3-Carbinol, Sulforaphane

Diseases : Prostate Cancer, Prostate Cancer: Prevention

Pharmacological Actions : Chemopreventive

Additional Keywords : Epigenetic Modification In Cancer

[+]

This review the evidence from clinical studies and animal experiments by which SFN modulates Nrf2 activation and protects against CVD.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2015 ;2015:407580. Epub 2015 Oct 25. PMID: 26583056

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Sulforaphane

Diseases : Cardiovascular Disease: Prevention

Pharmacological Actions : Antioxidants, Cardioprotective, NF-E2-Related Factor-2 (Nrf2) Modulator

[+]

This reviews the current literature on the role of natural products in ovarian cancer chemoprevention.Dec 27, 2017

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2017 Dec 28 ;411:191-200. Epub 2017 Oct 7. PMID: 29017913

Article Published Date : Dec 27, 2017

Study Type : Review

Additional Links

Substances : Curcumin, EGCG (Epigallocatechin gallate), Resveratrol, Sulforaphane

Diseases : Ovarian Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Autophagy Up-regulation, Chemopreventive

Additional Keywords : Cancer Stem Cells

[+]

This shows for the first time that Nrf2 action can potently block HIV infection.Mar 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS Pathog. 2016 Apr ;12(4):e1005581. Epub 2016 Apr 19. PMID: 27093399

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : HIV Infections

Pharmacological Actions : Antioxidants, Antiviral Agents, Nrf2 activation

Additional Keywords : Epigenetic Modification, Gene Expression

[+]

This study elucidates the mechanisms behind the neurovascular protective effects of sulforaphane.Aug 23, 2018

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Pubmed Data : Sci Rep. 2018 Aug 23 ;8(1):12708. Epub 2018 Aug 23. PMID: 30139948

Article Published Date : Aug 23, 2018

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Pharmacological Actions : Antioxidant Effects, Glucose Uptake Optimization, Phase II Detoxification Enzyme Inducer

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Drug Metabolism, Mitochondria, Mitochondrial Biogenesis

[+]

This study provides appealing evidence that the principal metabolites of sulforaphane retain the anticancer activity of the parent compound in HepG2 cells.May 08, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 May 9 ;10(5). Epub 2018 May 9. PMID: 29747418

Article Published Date : May 08, 2018

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Liver Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Metabolites

[+]

This study suggests that sulforaphane may be a novel keloid treatment.Jan 23, 2017

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Pubmed Data : Wound Repair Regen. 2017 Jan 24. Epub 2017 Jan 24. PMID: 28120534

Article Published Date : Jan 23, 2017

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Keloid

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antiproliferative , Cell cycle arrest, Interleukin-6 Downregulation

[+]

Treatment of human glioblastoma U251 cells with sulforaphane and a peptide nucleic acid has synergistic effects.Feb 14, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2022 Feb 15 ;27(4). Epub 2022 Feb 15. PMID: 35209084

Article Published Date : Feb 14, 2022

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Glioblastoma

Pharmacological Actions : Apoptotic, MicroRNA modulator

Additional Keywords : Natural Substance/Drug Synergy

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Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms.Apr 20, 2018

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Pubmed Data : Exp Cell Res. 2018 Apr 21. Epub 2018 Apr 21. PMID: 29689276

Article Published Date : Apr 20, 2018

Study Type : In Vitro Study

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Substances : Sulforaphane

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Cell cycle arrest

Additional Keywords : Epigenetic Modification In Cancer

[+]

Wulforaphane inhibits melanin synthesis and therefore might be an effective skin-whitening agent.Mar 23, 2010

Click here to read the entire abstract

Pubmed Data : Biosci Biotechnol Biochem. 2010 Mar 23;74(3):579-82. Epub 2010 Mar 7. PMID: 20208349

Article Published Date : Mar 23, 2010

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Melanism

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View the Evidence: 624 Abstracts with Sulforaphane Research

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These results demonstrated that sulforaphane possesses effective anti-HCV activity.Dec 31, 2015

These results indicated a novel use for sulforaphane in attenuating hydrogen peroxide-induced oxidative stress in human trabecular meshwork cells.Jan 27, 2019

These results suggest a potential therapeutic role for SFN in the treatment of psoriasis.Nov 24, 2023

This article catalogues the rationale for a hypothesis that multifunctional sulforaphane can be utilised as the initial step in restoring the ecology of the gut ecosystem.Aug 29, 2023

This article focuses on the effects of sulforaphane on CSCs and self-renewal pathways.Jul 31, 2013

This review describes the role of antioxidants like sulforaphane and curcumin in combatting chemoresistance and chemotherapy-induced oxidative stress through NF-kappaB and HIF-1a inhibition.Jun 29, 2019

This review establishes sulforaphane as a safe and non-toxic chemopreventative agent and indicates the need for more research for its use in human cancers as a single agent or as part of combination therapy.Jan 01, 2018

This review focuses on plant derived HDACi Sulforaphane as a promising molecule against pancreatic cancer therapy.Jun 05, 2016

This review provides evidence that nutrition and natural compounds can help in prevention and treatment of this neuroinflammatory disease. Mar 31, 2015

This review summarises the many health benefits of Sulforaphane as a antioxidant dietary supplement.May 04, 2015

This review summarizes evidence of the impact of SFN on epigenetic events related to the chemopreventive effects in preclinical and clinical studies of breast and prostate cancers.Mar 31, 2015

This review summarizes the current status of pre-clinical chemoprevention studies with sulforaphane.Jan 31, 2016

This review summarizes the epigenetic events associated with breast cancer and the potential of dietary polyphenols to modulate these events.Jan 12, 2012

This review summarizes the mechanisms, namely through targeting DNA methyltransferases, inhibiting histone deactylases, and activating Nrf2.Jan 01, 2018

This review summarizes the well established non epigenetic targets and highlights more recent evidence supporting these phytochemicals as epigenetic modulators for prostate cancer chemoprevention.Sep 30, 2013

This review the evidence from clinical studies and animal experiments by which SFN modulates Nrf2 activation and protects against CVD.Dec 31, 2014

This reviews the current literature on the role of natural products in ovarian cancer chemoprevention.Dec 27, 2017

This shows for the first time that Nrf2 action can potently block HIV infection.Mar 31, 2016

This study elucidates the mechanisms behind the neurovascular protective effects of sulforaphane.Aug 23, 2018

This study provides appealing evidence that the principal metabolites of sulforaphane retain the anticancer activity of the parent compound in HepG2 cells.May 08, 2018

This study suggests that sulforaphane may be a novel keloid treatment.Jan 23, 2017

Treatment of human glioblastoma U251 cells with sulforaphane and a peptide nucleic acid has synergistic effects.Feb 14, 2022

Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms.Apr 20, 2018

Wulforaphane inhibits melanin synthesis and therefore might be an effective skin-whitening agent.Mar 23, 2010

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Sulforaphane

View the Evidence:
624 Abstracts with Sulforaphane Research