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Tetrahydrocurcumin
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Additional Topics Details for this Page
Article Count
- 20
Cumulative Knowledge
- 35
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Related Topics
Tetrahydrocurcumin is a Sub of the following Topics
Turmeric
Curcuminoids
What is Cumulative Knowledge?
Cumulative Knowledge
is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.
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Quick Summary: Current access displays 2 out of 22 associated Diseases
Name
Cumulative Knowledge
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Focus Articles
Oxidative Stress
19
10
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Diabetes Mellitus: Type 2
12
6
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Quick Summary: Current access displays 2 out of 11 associated Pharmacological Actions
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Antioxidants
17
9
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Anticarcinogenic Agents
11
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View the Evidence: Substances
A combined dosage of tetrahydrocurcumin and chlorogenic acid protects against experimentally induced type 2 diabetes in rats.
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2010 Aug;341(1-2):109-17. Epub 2010 Mar 26. PMID:
20339905
Article Published Date
: Aug 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Chlorogenic Acid : CK(13) : AC(7)
,
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
Both curcumin and its metabolite tetrahydrocurcumin exert neuroprotection against chemically-induced neurotoxicity.
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2008 Apr;16(2):96-9. PMID:
18408903
Article Published Date
: Apr 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Flavonoids : CK(909) : AC(289)
,
Polyphenols : CK(427) : AC(174)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Neurodegenerative Diseases : CK(1743) : AC(420)
,
Parkinson Disease : CK(543) : AC(79)
Pharmacological Actions
:
Neuroprotective Agents : CK(962) : AC(480)
Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice.
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2001 Aug;131(8):2090-5. PMID:
11481399
Article Published Date
: Aug 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Kidney Damage : CK(120) : AC(42)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
,
Antioxidants : CK(3653) : AC(1318)
,
Renoprotective : CK(191) : AC(90)
Curcumin inhibit tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.
Click here to read the entire abstract
Pubmed Data
: Jpn J Cancer Res. 1998 Apr;89(4):361-70. PMID:
9617340
Article Published Date
: Apr 01, 1998
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Epstein-Barr Virus Infections : CK(100) : AC(43)
,
Leukemia : CK(670) : AC(258)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
Curcuminoids inhibit chemically-induced tumor promotion.
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 1995 Oct;16(10):2493-7. PMID:
7586157
Article Published Date
: Oct 01, 1995
Study Type
: Animal Study
Additional Links
Substances
:
Bisdemethoxycurcumin : CK(5) : AC(2)
,
Curcumin : CK(2910) : AC(1482)
,
Curcuminoids : CK(2701) : AC(1520)
,
Demethoxycurcumin : CK(9) : AC(7)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Tumors : CK(197) : AC(110)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
Fucoxanthin, lutein and tetrahydrocurcumin may have chemopreventive effects against colon carcinogenesis.
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 1998 Jan;19(1):81-5. PMID:
9472697
Article Published Date
: Jan 01, 1998
Study Type
: Animal Study
Additional Links
Substances
:
Carotenoids : CK(1055) : AC(213)
,
Curcumin : CK(2910) : AC(1482)
,
Fucoxanthin : CK(18) : AC(13)
,
Lutein : CK(124) : AC(22)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Colon Cancer : CK(895) : AC(233)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
,
Antiproliferative : CK(1052) : AC(775)
Nutritional antioxidants such as green tea polyphenols and tetrahydrocurcumin may beneficially modify the life span of animals.
Click here to read the entire abstract
Pubmed Data
: Biogerontology. 2007 Oct;8(5):567-73. Epub 2007 May 22. PMID:
17516143
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids : CK(909) : AC(289)
,
Green Tea : CK(930) : AC(294)
,
Polyphenols : CK(427) : AC(174)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Aging : CK(1351) : AC(369)
Additional Keywords
:
Plant Extracts : CK(3572) : AC(1216)
Tetrahydrocurcumin and rutin have cardioprotective properties in a rat model of myocardial infarction
Click here to read the entire abstract
Pubmed Data
: Pharmazie. 2009 Feb;64(2):132-6. PMID:
19320287
Article Published Date
: Feb 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Rutin : CK(93) : AC(30)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Myocardial Infarction : CK(2632) : AC(117)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Cardioprotective : CK(702) : AC(196)
Tetrahydrocurcumin displays antihyperlipidaemic effect in addition to its antidiabetic effect in type 2 diabetic rats.
Click here to read the entire abstract
Pubmed Data
: Basic Clin Pharmacol Toxicol. 2006 Aug;99(2):122-7. PMID:
16918712
Article Published Date
: Aug 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Hypolipidemic : CK(370) : AC(80)
Tetrahydrocurcumin has a protective effect on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats.
Click here to read the entire abstract
Pubmed Data
: Basic Clin Pharmacol Toxicol. 2007 Oct;101(4):241-5. PMID:
17845505
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Diabetes: Kidney Function : CK(75) : AC(22)
,
Diabetes: Liver Disease : CK(10) : AC(4)
,
Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Hepatoprotective : CK(557) : AC(272)
,
Renoprotective : CK(191) : AC(90)
Tetrahydrocurcumin has antioxidant and anti-diabetic activity in streptozotocin-nicotinamide induced diabetic rats.
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2006 Sep 27;79(18):1720-8. Epub 2006 Jun 9. PMID:
16806281
Article Published Date
: Sep 27, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
Tetrahydrocurcumin increases the number of total cellular insulin binding sites resulting in a significant increase in plasma insulin.
Click here to read the entire abstract
Pubmed Data
: J Biosci. 2008 Mar;33(1):63-72. PMID:
18376071
Article Published Date
: Mar 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
,
Insulin Resistance : CK(1034) : AC(221)
Tetrahydrocurcumin normalizes blood glucose and causes a marked improvement of altered carbohydrate metabolic enzymes in diabetic animals.
Click here to read the entire abstract
Pubmed Data
: J Basic Clin Physiol Pharmacol. 2005;16(4):257-74. PMID:
16438392
Article Published Date
: Jan 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Pharmacological Actions
:
Hypoglycemic Agents : CK(563) : AC(156)
Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats.
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2007 Jun;10(2):323-9. PMID:
17651069
Article Published Date
: Jun 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Diabetes: Cognitive Dysfunction : CK(35) : AC(12)
,
Lipid Peroxidation : CK(403) : AC(127)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Neuroprotective Agents : CK(962) : AC(480)
Tetrahydrocurcumin protects against oxidative stress in cholesterol-fed rabbits.
Click here to read the entire abstract
Pubmed Data
: J Atheroscler Thromb. 2002;9(5):243-50. PMID:
12409634
Article Published Date
: Jan 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
Tetrahydrocurcumin protectsagainst erythromycin estolate-induced lipid peroxidation in rats.
Click here to read the entire abstract
Pubmed Data
: J Basic Clin Physiol Pharmacol. 2005;16(1):1-15. PMID:
16187483
Article Published Date
: Jan 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Antibiotic Toxicity : CK(45) : AC(11)
,
Lipid Peroxidation : CK(403) : AC(127)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
,
Antioxidants : CK(3653) : AC(1318)
,
Hepatoprotective : CK(557) : AC(272)
Additional Keywords
:
Drug: Erythromycin : CK(2) : AC(1)
Tetrahydrocurcumin inhibits cell migration and invasion in fibrosarcoma cells.
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2008 Jul;29(7):853-60. PMID:
18565284
Article Published Date
: Jul 01, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Cancer Metastasis : CK(272) : AC(135)
,
Fibrosarcoma : CK(10) : AC(7)
Pharmacological Actions
:
Anti-metastatic : CK(192) : AC(115)
,
Anticarcinogenic Agents : CK(521) : AC(275)
Tetrahydrocurcumin may contribute to overcoming multi-drug resistance of human cancers.
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2007 Feb;296(1-2):85-95. Epub 2006 Sep 8. PMID:
16960658
Article Published Date
: Feb 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Cancers: Drug Resistant : CK(225) : AC(147)
,
Cancers: Multi-Drug Resistant : CK(92) : AC(73)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
Tetrahydrocurcumin protect against radiation-induced lipid peroxidation.
Click here to read the entire abstract
Pubmed Data
: Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID:
10803946
Article Published Date
: Dec 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Tetrahydrocurcumin : CK(37) : AC(20)
Diseases
:
Lipid Peroxidation : CK(403) : AC(127)
,
Oxidative Stress : CK(1945) : AC(710)
,
Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
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