Trigonelline

Trigonelline

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Article Count - 4
Cumulative Knowledge - 6

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Coffee

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Quick Summary: Current access displays 2 out of 8 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Auditory neuropathy	2	1	Log in \| Sign up
Diabetes Mellitus: Type 1	2	1	Log in \| Sign up

Quick Summary: Current access displays 2 out of 4 associated Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Hypoglycemic Agents	2	1	Log in \| Sign up
Insulin Sensitizers	2	1	Log in \| Sign up

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View the Evidence: Substances

Coffee consumption may have a protective/restorative function on diabetic auditory neuropathy.

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Pubmed Data : Neurosci Lett. 2008 Aug 29;441(3):302-6. Epub 2008 Jun 22. PMID: 18586072

Article Published Date : Aug 29, 2008

Study Type : Animal Study

Additional Links

Substances : Coffee : CK(412) : AC(58), Trigonelline : CK(6) : AC(4)

Diseases : Auditory neuropathy : CK(4) : AC(2), Diabetic Neuropathies : CK(203) : AC(32)

Trigonelline has beneficial effect for diabetes through decreasing blood glucose and lipid levels, increasing insulin sensitivity index and insulin content, up-regulating antioxidant enzyme activity and decreasing lipid peroxidation.

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Pubmed Data : Fundam Clin Pharmacol. 2011 Dec 16. Epub 2011 Dec 16. PMID: 22172053

Article Published Date : Dec 16, 2011

Study Type : Animal Study

Additional Links

Substances : Trigonelline : CK(6) : AC(4)

Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Hyperglycemia : CK(2892) : AC(59), Insulin: Low : CK(14) : AC(3), Insulin Resistance : CK(1034) : AC(221)

Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156), Insulin Sensitizers : CK(167) : AC(36)

Coffee contains a compound called trigonelline which promotes neurite outgrowth.

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Pubmed Data : Biol Pharm Bull. 1999 Jul;22(7):679-82. PMID: 10443461

Article Published Date : Jul 01, 1999

Study Type : In Vitro Study

Additional Links

Substances : Coffee : CK(412) : AC(58), Trigonelline : CK(6) : AC(4)

Diseases : Neurodegenerative Diseases : CK(1743) : AC(420)

Pharmacological Actions : Neuritogenic : CK(98) : AC(48)

Additional Keywords : Trigonelline : CK(1) : AC(1)

Coffee contains compounds which stimulate dopamine release.

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Pubmed Data : Food Chem Toxicol. 2011 Oct 13. Epub 2011 Oct 13. PMID: 22019894

Article Published Date : Oct 13, 2011

Study Type : In Vitro Study

Additional Links

Substances : 5-hydroxytryptamides : CK(1) : AC(1), Caffeine : CK(109) : AC(18), Catechols : CK(14) : AC(12), Chlorogenic Acid : CK(13) : AC(7), Coffee : CK(412) : AC(58), N-methylpyridinium : CK(1) : AC(1), Pyrogallol : CK(1) : AC(1), Trigonelline : CK(6) : AC(4)

Diseases : Dopamine Deficiency : CK(38) : AC(8)

Pharmacological Actions : Dopaminergic : CK(32) : AC(10)

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