Valerian

Valerian

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Quick Summary: Current access displays 2 out of 20 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Insomnia	52	7	Log in \| Sign up
Dysmenorrhea	20	2	Log in \| Sign up

Quick Summary: Current access displays 2 out of 9 associated Pharmacological Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Antispasmodic	24	4	Log in \| Sign up
Anxiolytic	14	3	Log in \| Sign up

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View the Evidence: Substances

" Valerian seems to be an effective treatment for dysmenorrhea, probably because of its antispasmodic effects."

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Pubmed Data : Int J Gynaecol Obstet. 2011 Sep 27. Epub 2011 Sep 27. PMID: 21959068

Article Published Date : Sep 27, 2011

Study Type : Human Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Dysmenorrhea : CK(409) : AC(26), Menstrual Cramps : CK(30) : AC(3)

Pharmacological Actions : Antispasmodic : CK(110) : AC(29)

A combination of valerian and hops reduces sleep latency in patients suffering from non-organic insomnia.

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Pubmed Data : Phytother Res. 2007 Sep;21(9):847-51. PMID: 17486686

Article Published Date : Sep 01, 2007

Study Type : Human Study

Additional Links

Substances : Hops : CK(65) : AC(25), Valerian : CK(117) : AC(20)

Diseases : Insomnia : CK(471) : AC(56)

Kava and valerian root are effective in the treatment of stress-induced insomnia.

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Pubmed Data : Phytother Res. 2001 Sep;15(6):549-51. PMID: 11536390

Article Published Date : Sep 01, 2001

Study Type : Human Study

Additional Links

Substances : Kava Kava : CK(239) : AC(39), Valerian : CK(117) : AC(20)

Diseases : Insomnia : CK(471) : AC(56), Stress : CK(425) : AC(60)

Melissa officinalis and Valeriana officinalis have an anti-anxiety effect during laboratory-induced stress.

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Pubmed Data : Phytother Res. 2006 Feb;20(2):96-102. PMID: 16444660

Article Published Date : Feb 01, 2006

Study Type : Human Study

Additional Links

Substances : Melissa (Lemonbalm) : CK(78) : AC(14), Valerian : CK(117) : AC(20)

Diseases : Anxiety Disorders : CK(641) : AC(82), Stress : CK(425) : AC(60)

Pharmacological Actions : Anxiolytic : CK(268) : AC(41)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

Valerian attenuates the insomnia associated with benzodiazepine withdrawal.

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Pubmed Data : : Prog Neuropsychopharmacol Biol Psychiatry. 2002 Apr;26(3):539-45. PMID: 11999905

Article Published Date : Apr 01, 2002

Study Type : Human Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Benzodiazepine Dependence/Withdrawal : CK(10) : AC(1)

Valerian extract inhibits contractility of the human uterus justifying its traditional use in the treatment of uterine cramping associated with dysmenorrhoea.

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Pubmed Data : J Pharm Pharmacol. 2009 Feb;61(2):251-6. PMID: 19178774

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Dysmenorrhea : CK(409) : AC(26), Uterine Cramps : CK(24) : AC(4)

Pharmacological Actions : Antispasmodic : CK(110) : AC(29)

Valerian extract is comparable to the drug oxazepam in the treatment of non-organic insomnia.

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Pubmed Data : Eur J Med Res. 2002 Nov 25;7(11):480-6. PMID: 12568976

Article Published Date : Nov 25, 2002

Study Type : Human Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Insomnia : CK(471) : AC(56)

Additional Keywords : Natural Substances Versus Drugs : CK(1043) : AC(159)

Valerian improves sleep quality in postmenopausal women.

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Pubmed Data : Menopause. 2011 Jul 14. Epub 2011 Jul 14. PMID: 21775910

Article Published Date : Jul 14, 2011

Study Type : Human Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Insomnia : CK(471) : AC(56), Postmenopausal Disorders : CK(285) : AC(35)

Valerian improves symptoms of restless leg syndrome.

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Pubmed Data : Altern Ther Health Med. 2009 Mar-Apr;15(2):22-8. PMID: 19284179

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Restless Legs Syndrome : CK(91) : AC(8)

Valerian significantly improves sleep in a randomized human trial.

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Pubmed Data : Pharmacol Biochem Behav. 1989 Apr;32(4):1065-6. PMID: 2678162

Article Published Date : Apr 01, 1989

Study Type : Human Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Insomnia : CK(471) : AC(56)

Valerian contains compounds with antispasmodic effects on stimulated smooth muscle cells without activating the autonomic nervous system.

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Pubmed Data : Cancer Lett. 2008 Jun 18;264(2):218-28. Epub 2008 Mar 7. PMID: 7114974

Article Published Date : Jun 18, 2008

Study Type : Animal Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Muscle Spasm : CK(43) : AC(5), Muscle Spasticity : CK(34) : AC(5)

Pharmacological Actions : Antispasmodic : CK(110) : AC(29)

Valerian extract has anxiety-reducing and anti-depressant effects, but is not a sedative and does not interfere with muscle function.

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Pubmed Data : Phytomedicine. 2008 Jan;15(1-2):2-15. PMID: 18160026

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Anxiety Disorders : CK(641) : AC(82), Depression: Unipolar : CK(631) : AC(79)

Pharmacological Actions : Antidepressive Agents : CK(122) : AC(28)

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268), Plant Extracts : CK(3401) : AC(1158)

Valerian has anticonvulsive properties.

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Pubmed Data : J Ethnopharmacol. 2010 Feb 3;127(2):313-8. Epub 2009 Nov 10. PMID: 19900527

Article Published Date : Feb 03, 2010

Study Type : Animal Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Convulsions : CK(10) : AC(5), Convulsive Seizures : CK(12) : AC(2)

Pharmacological Actions : Anticonvulsants : CK(113) : AC(29)

Valerian root appears to reduce the symptoms of morphine withdrawal syndrome.

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Pubmed Data : Addict Biol. 2006 Jun;11(2):145-51. PMID: 16800827

Article Published Date : Jun 01, 2006

Study Type : Animal Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Morphine Tolerance/Dependence : CK(104) : AC(17)

Valerian root has antibronchospastic, antihypertensive and anticoronaryspastic properties.

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Pubmed Data : J Ethnopharmacol. 2007 Jun 13;112(2):361-7. Epub 2007 Mar 20. PMID: 17467210

Article Published Date : Jun 13, 2007

Study Type : Animal Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Bronchospasm: Acute : CK(21) : AC(7), Coronary Artery Spasm : CK(2) : AC(1)

Pharmacological Actions : Antispasmodic : CK(110) : AC(29), Bronchoconstrictor Agents : CK(2) : AC(1), Hypotensive : CK(372) : AC(49)

Additional Keywords : Drug: Nifedipine : CK(2) : AC(1), Natural Substances Versus Drugs : CK(1043) : AC(159)

Valerian's anti-anxiety action is due to its action on GABA receptors.

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Pubmed Data : Neuropharmacology. 2008 Jun 17. PMID: 18602406

Article Published Date : Jun 17, 2008

Study Type : Animal Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Anxiety: Generalized : CK(16) : AC(4), Anxiety Disorders : CK(641) : AC(82), Generalized Anxiety Disorder : CK(58) : AC(8)

Pharmacological Actions : Anxiolytic : CK(268) : AC(41), GABA Modulators : CK(11) : AC(7)

Valeriana officinalis root extracts have potent anxiolytic effects in rats.

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Pubmed Data : Phytomedicine. 2009 Dec 28. Epub 2009 Dec 28. PMID: 20042323

Article Published Date : Dec 28, 2009

Study Type : Animal Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Anxiety Disorders : CK(641) : AC(82)

Pharmacological Actions : Anxiolytic : CK(268) : AC(41)

A meta-analysis of 16 studies indicates that Valerian root might improve sleep quality without producing side effects.

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Pubmed Data : Am J Med. 2006 Dec;119(12):1005-12. PMID: 17145239

Article Published Date : Dec 01, 2006

Study Type : Review

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Insomnia : CK(471) : AC(56)

Valerian root contains the compound valtrate with has anti-HIV activity.

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Pubmed Data : Bioorg Med Chem Lett. 2002 Oct 21;12(20):2807-10. PMID: 12270151

Article Published Date : Oct 21, 2002

Study Type : In Vitro Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : HIV Infections : CK(564) : AC(184)

Pharmacological Actions : Reverse Transcriptase Inhibitors : CK(42) : AC(24)

Valerian root may be beneficial in reducing insomnia associated with oxidative stress.

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Pubmed Data : Neurochem Res. 2009 Aug;34(8):1372-9. Epub 2009 Feb 4. PMID: 19191025

Article Published Date : Aug 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Valerian : CK(117) : AC(20)

Diseases : Insomnia : CK(471) : AC(56)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

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