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Vitamin C
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401 Diseases Researched for Vitamin C
Name
AC
CK
Focus
Oxidative Stress
68
281
Endothelial Dysfunction
13
107
Inflammation
18
100
Vitamin C Deficiency
21
94
Diabetes Mellitus: Type 2
7
70
Cardiovascular Diseases
9
65
Lung Cancer
12
61
Hypertension
6
53
Pancreatic Cancer
5
53
C-Reactive Protein
5
50
DNA damage
18
50
Sickle Cell Anemia
5
41
Atrial Fibrillation
2
40
Cortisol: High
4
40
Smoking
4
40
Breast Cancer
19
36
Tuberculosis
5
36
Osteoporosis
6
34
Obesity
5
33
Prostate Cancer
5
33
Asthma
4
32
Aging Skin
4
31
Cancers: All
18
31
Coronary Artery Disease
4
31
Endometriosis
4
31
Macular Degeneration
4
31
Autism
3
30
Cardiac Surgery
2
30
Diabetes Mellitus: Type 2: Prevention
3
30
Hemodialysis
3
30
Hepatitis A
3
30
Hepatitis C
3
30
Insulin Resistance
3
30
Peripheral Vascular Diseases
3
30
Pre-Eclampsia
3
30
Upper Respiratory Infections
3
30
Aging
7
28
Lead Poisoning
14
28
Gastric Cancer
6
25
Cataract
5
24
Alcohol Toxicity
8
23
Atherosclerosis
4
22
Helicobacter Pylori Infection
3
22
Common Cold
3
21
Cystic Fibrosis
3
21
Endometrial Cancer
2
21
Anxiety Disorders
2
20
Aortic Aneurysm
2
20
Cervical Neoplasia
1
20
Chronic Obstructive Pulmonary Disease
2
20
Ehlers-Danlos Syndrome
2
20
Esophageal Cancer
2
20
Lipid Peroxidation
8
20
Peripheral Arterial Disease
2
20
Prostate Cancer: Prevention
1
20
Urinary Tract Infections
2
20
Sepsis
7
19
Bone Fractures
6
18
Radiation Induced Illness
5
18
Cervical Cancer
6
17
Air Pollution Linked Toxicity
3
16
Colorectal Cancer
5
16
Pneumonia
5
16
Prenatal Chemical Exposures
4
16
Cholesterol: Oxidation
5
15
Hyperlipidemia
4
15
Liver Cancer
9
15
Alzheimer's Disease
8
14
Diabetic Complications
3
14
Hyperthyroidism
3
14
Stress
3
14
Arteriosclerosis
3
13
Neuralgia: Post Herpetic
2
13
Triglycerides: Elevated
3
13
Acute Myeloid Leukemia
3
12
Anemia
2
12
Cancer Metastasis
2
12
Chemotherapy and Radiation Toxicity
2
12
Colon Cancer
9
12
Gastric Ulcer
2
12
Histamine: Elevated
2
12
Infertility: Female
2
12
Infertility: Male
2
12
Ischemia
2
12
Lipopolysaccharide-Induced Toxicity
2
12
Melanoma
8
12
Nephropathy
2
12
Septic Shock
3
12
Thyroid Cancer
3
12
Autism Spectrum Disorders
2
11
Barrett Esophagus
3
11
Hyperuricemia
3
11
Migraine Disorders
2
11
Non-Hodgkin Lymphoma
2
11
Periodontitis
2
11
Surgery: All
2
11
Ultraviolet Radiation Induced Damage
2
11
A1C
1
10
Adiponectin: Low Levels
1
10
Advanced Glycation End products (AGE)
1
10
Anemia: Hemolytic
1
10
Anemia: Iron Deficiency
1
10
Aortic Stenosis
1
10
Aspirin-Induced Toxicity
1
10
Asthma: Bronchial
1
10
Athletic Performance
1
10
Athletic Performance: Recovery
1
10
Attention Deficit Disorder with Hyperactivity
1
10
Back Pain
1
10
Breast Cancer: Prevention
1
10
COPD
1
10
Catecholamines: Elevated
1
10
Childhood Cognitive Disorders
1
10
Childhood Deficiencies
1
10
Childhood Infections
1
10
Chronic Kidney Disease (CKD)
1
10
Chronic Obstructive Lung Disease
1
10
Cold: Common
1
10
Connective Tissue Diseases
1
10
Coronary Bypass Surgery
1
10
Diabetes: Glycation/A1C
1
10
Diabetic Neuropathies
1
10
Diesel Exhaust Particle Toxicity
1
10
Duodenal Ulcer
1
10
Epidermolysis Bullosa
1
10
Exercise-Induced Tissue Damage
1
10
Fibromyalgia
1
10
Gastrointestinal Infections
1
10
Genital Warts
1
10
Gestational Diabetes
1
10
Graves Disease
1
10
Head and Neck Cancer
1
10
Headache: Migraine
1
10
Heart Failure
1
10
Herpes Simplex Virus Type 1
1
10
High Cortisol
1
10
High Homocysteine
1
10
Hip Fracture
1
10
Hypertension: Sickle Cell Anemia
1
10
Immunotherapy: Adoptive
1
10
Influenza A
7
10
Ischemic Heart Disease
1
10
Kidney Cancer
1
10
Kidney Stones
1
10
Knee Replacement Surgery: Adverse Effects
1
10
Larsen Syndrome
1
10
Leukoplakia
1
10
Lichen Planus
1
10
Lymphoma: Mantle Cell
1
10
Marfan Syndrome
1
10
Metabolic Syndrome X
1
10
Mortality: All-Cause
1
10
Muscle Damage: Exercise-Induced
1
10
Myelodysplastic Syndrome
1
10
NSAID-induced toxicity
1
10
Neck Pain
1
10
Neutrophils: Elevated
1
10
Nonalcoholic fatty liver disease (NAFLD)
1
10
Oral Lichen Planus
1
10
Perfluorinated Compound Toxicity
1
10
Periodontal Wound Healing
1
10
Peripheral Neuropathies
1
10
Postmenopausal Disorders
1
10
Postpartum Depression
1
10
Precancerous Conditions
1
10
Pregnancy: Prevention of Problems
1
10
Pregnancy: Urinary Tract Infections
1
10
Purpura: Thrombocytopenic
1
10
Quality of Life: Poor
1
10
Raynaud Disease
1
10
Reflex Sympathetic Dystrophy
1
10
Respiratory Infections
1
10
Restless Leg Syndrome: Hemodialysis Patients
1
10
Rheumatoid Arthritis
1
10
Rhinosinusitis
1
10
Sclerosis: Systemic
1
10
Sitting Sickness
1
10
Skin Diseases
1
10
Sleep Apnea: Central
1
10
Stroke: Prevention
1
10
Thalassemia
1
10
Trauma Patients
1
10
Varicocele
1
10
Vision Loss
1
10
Xerostomia
1
10
Promyelocytic leukemia
5
9
Pyrethroid Insecticide Induced Toxicity
4
8
Cadmium Poisoning
4
7
Metabolic Diseases
3
7
Nicotine/Tobacco Toxicity
4
7
Celiac Disease
2
6
Cognitive Decline/Dysfunction
3
6
Fluoride Toxicity
3
6
Hypothyroidism
3
6
Nickel Poisoning
3
6
Ovarian Cancer
3
6
Pesticide Toxicity
3
6
Tumors
4
6
Werner Syndrome
3
6
Advanced Glycation Endproduct (AGE) Formation
1
5
Aflatoxicosis
3
5
Breast Cancer: Triple Negative
4
5
Cancers: Drug Resistant
4
5
Chemotherapy-Induced Toxicity: Doxorubicin
3
5
Fructose-Induced Toxicity
1
5
Hearing Loss
2
5
Leukemia
4
5
Leukemia: Acute promyelocytic leukemia
1
5
Lymphoma
4
5
Melanoma: Metastasis
3
5
Melanoma: Metastatic
4
5
Myocardial Infarction
3
5
Neurodegenerative Diseases
4
5
Neutrophils: Damaged
1
5
Scurvy
3
5
Wound Healing
3
5
Acetaminophen (Tylenol) Toxicity
2
4
Aluminum Toxicity
2
4
Brain Inflammation
2
4
Charcot-Marie-Tooth Disease
2
4
Diabetes Mellitus: Type 1
2
4
Drug-Induced Toxicity: Methotrexate
2
4
Dyslipidemias
2
4
Gastrointestinal Inflammation
2
4
Learning disorders
2
4
Memory Disorders
2
4
Mycobacterium tuberculosis
3
4
Periodontal Diseases
2
4
Pesticide-Induced Toxicity: Organochlorines
2
4
Sperm Quality: Low
2
4
Dementia
2
3
Endothelial Damage
2
3
Fatigue: Cancer-Associated
1
3
Gallstones
2
3
Gingivitis
1
3
Glioblastoma
2
3
High Cholesterol
2
3
Insomnia
1
3
Kidney Damage
2
3
Movement Disorders
1
3
Parkinson's Disease
3
3
Parkinsonism
1
3
Parvovirus
1
3
Skin Cancer
2
3
Staphylococcus aureus infection
2
3
Allergic Airway Diseases
1
2
Allodynia
1
2
Alloxan toxicity
1
2
Amebiasis
1
2
Anxiety
1
2
Arsenic Poisoning
1
2
Ascites
1
2
Azo compound toxicity
1
2
Barium Toxicity
1
2
Benzene Toxicity
2
2
Bisphenol Toxicity
1
2
Blood-Brain-Barrier Disorders
1
2
Brain: Oxidative Stress
1
2
Breast Cancer: Estrogen
1
2
Breast Cancer: Metastatic
1
2
Breast Cancer: estrogen receptor alpha-positive
1
2
Breastfeeding Concerns: Chemical Exposure
1
2
Cancers: Multi-Drug Resistant
2
2
Candida Albicans
1
2
Candidiasis
1
2
Chemical Exposure: Nitrobenzene
1
2
Chemically-Induced Liver Damage
1
2
Chemotherapy-Induced Toxicity: Cyclophosphamide
1
2
Chemotherapy-Induced Toxicity: 5-fluorouracil
1
2
Chemotherapy-Induced Toxicity: Cisplatin
1
2
Chemotherapy-Induced Toxicity: Gentamicin
1
2
Cholestasis
1
2
Cytomegalovirus Infections
1
2
Degenerative Disk Disease
2
2
Dental Plaque
1
2
Depression
1
2
Diabetes: Oxidative Stress
1
2
Diabetic Neuropathy
1
2
Emphysema: Pulmonary
1
2
Encephalitis
1
2
Eosinophilia
1
2
Eye Damage
1
2
Fetal Origin of Adult Disease
1
2
Gingival melanin pigmentation
1
2
Glioma
1
2
H1N1 Infection
1
2
H3N2 Infection
1
2
Hearing Loss: Noise-Induced
1
2
Hepatitis
1
2
Hepatoma
1
2
Human Influenza
2
2
Hydrogen Peroxide Induced Toxicity
2
2
Hypercholesterolemia
1
2
Hyperglycemia
1
2
Hypertension: Pulmonary
1
2
Kidney Damage: Drug-Induced
1
2
Kidney Failure
1
2
Liver Damage
1
2
Liver Damage: Drug-Induced
1
2
Liver Fibrosis
1
2
Low Immune Function: Natural Killer Cells
1
2
Lung Cancer: Metastatic
1
2
Lung Damage
1
2
Lung Diseases
1
2
Malignant Melanoma
1
2
Memory Disorders: Drug-Induced
1
2
Memory Loss
1
2
Multiple Myeloma
1
2
Neuropathic Pain
1
2
Osteoarthritis
2
2
Parainfluenza Virus Infections
1
2
Paramyxoviridae Infections
1
2
Pesticide-Induced Toxicity: Organophosphates
1
2
Polychlorinated biphenyl toxicity
1
2
Prophyrias
1
2
Prostatic Hyperplasia: Benign
1
2
Radiation Induced Illness: Bone Marrow
1
2
Radiation-Induced Illness: Americium
1
2
Radiation-Induced Illness: Plutonium
1
2
Radiation-Induced Illness: Radioiodine (Iodine-131)
1
2
Radiotherapy
1
2
Seizures
1
2
Smoking: Pulmonary
1
2
Smoldering multiple myeloma (SMM)
1
2
Spinal Cord Injuries
1
2
Statin-Induced Pathologies
1
2
Stroke: Attenuation/Recovery
1
2
Surgery: Anesthesiology
1
2
Tendon Injury
1
2
Testicular Diseases
1
2
Tin Poisoning
1
2
Traumatic Brain Injury
1
2
Ulcerative Colitis
1
2
Acinetobacter baumannii infection
1
1
Acute T cell Leukemias
1
1
Aging: Brain
1
1
Anemia: Sickle Cell
1
1
Arterial Plaque
1
1
Benzo[a]pyrene-induced Toxicity
1
1
Bladder Cancer
1
1
Blood Storage Problems
1
1
Bone Diseases
1
1
Breast Cancer Stem Cells
1
1
Bronchial Asthma
1
1
Burkitt Lymphoma
1
1
Burns
1
1
Candida Infection
1
1
Cartilage Diseases
1
1
Chagas Disease
1
1
Chronic Pain
1
1
Colorectal Cancer: Prevention
1
1
Complex Regional Pain Syndrome: Type I
1
1
Congestive Heart Failure
1
1
Corneal Neovascularization
1
1
Corticosteroid-Induced Toxicity
1
1
Encephalitis: Herpes Simplex
1
1
Eye Diseases: Vitreous Disorders
1
1
Gastrointestinal Diseases
1
1
Glaucoma
1
1
Gout
2
1
HSV-1
1
1
Heat Stroke
1
1
Herpes Simplex Virus Type 2
1
1
Hormone Imbalances
1
1
Human Papillomavirus (HPV)
1
1
Human T-Cell Lymphotrophic Virus type 1 associated disease
1
1
Human T-cell leukemia virus type I (HTLV-I)
1
1
Infection: Antibiotic Resistant
1
1
Iron Overload
1
1
Iron Poisoning
1
1
Kidney Diseases
1
1
Laryngeal Cancer
1
1
Liver Diseases
1
1
Lyme Borreliosis
1
1
Lyme Disease
1
1
Lymphoma: T-cell
1
1
Menstrual Migraine
1
1
Mesothelioma
1
1
Migraine: Menstrual Cycle Induced
1
1
Mineral Imbalances
1
1
Mitochondrial Diseases
1
1
Neuralgia
1
1
Neuroblastoma
1
1
Nutritional Deficiencies
1
1
Organ Transplantation: Cornea
1
1
Para-phenylenediamine Induced Toxicity
1
1
Petroleum Exposure And Toxicity
1
1
Polio
1
1
Polycyclic aromatic hydrocarbon (PAH) toxicity
1
1
Pseudomonas Infections
1
1
Pseudomonas aeruginosa
1
1
Psychiatric Disorders
1
1
Rosacea
1
1
Skin Diseases: Photo-Aging
1
1
Squamous cell carcinoma
1
1
Staphylococcus aureus: Methicillin-resistant (MRSA)
1
1
Stem Cell Transplant
1
1
Sunburn
1
1
Tetanus
1
1
Vitamin D Deficiency
1
1
Wound Healing: Delayed
1
1
99 Pharmacological Actions Researched for Vitamin C
Name
AC
CK
Focus
Antioxidants
192
860
Chemopreventive
16
87
Anti-Inflammatory Agents
22
83
Interleukin-6 Downregulation
9
75
Cardioprotective
12
63
Antiproliferative
37
54
Apoptotic
33
48
Chemotherapeutic
18
46
Tumor Necrosis Factor (TNF) Alpha Inhibitor
10
45
Malondialdehyde Down-regulation
9
44
Neuroprotective Agents
23
40
Radioprotective
12
35
Prophylactic Agents
4
33
Renoprotective
14
33
Immunomodulatory
6
30
Analgesics
5
25
Antiviral Agents
9
24
Hepatoprotective
11
22
NF-kappaB Inhibitor
11
21
Telomere Protective
2
20
Hypolipidemic
5
17
Anti-metastatic
10
16
Chemosensitizer
13
16
Anticarcinogenic Agents
4
15
Hypoxia-inducible factor-1 (HIF-1) inhibitor
4
15
Anti-Bacterial Agents
4
14
Antimicrobial
4
14
Cyclooxygenase 2 Inhibitors
3
14
Cytoprotective
6
14
Hypoglycemic Agents
3
14
Anti-Anxiety Agents
2
12
Anti-Glycation Agents
2
12
Immunostimulatory
2
12
Telomerase Upregulation
2
12
Anti-atherogenic
2
11
Antihypertensive Agents
2
11
Cell cycle arrest
10
11
Chemoprotective Agents
6
11
Gastrointestinal Agents
2
11
Heat Shock Protein Inducer
2
11
MicroRNA modulator
2
11
Photoprotective
2
11
Anti-Apoptotic
5
10
Anti-Infective Agents
1
10
Anti-Ulcer Agents
1
10
Anticholesteremic Agents
1
10
Enzyme Inhibitors
1
10
Immune Enhancing Properties
1
10
Insulin Sensitizers
1
10
Monocyte chemotattractant protein-1 (MCP-1) Inhibitor
1
10
Nitric Oxide Enhancer
1
10
Prostaglandin PGE2 downregulation
1
10
Uricosuric Agents
1
10
Vasodilator Agents
1
10
Cytotoxic
6
9
Interleukin-1 beta downregulation
3
9
Antineoplastic Agents
6
8
Genoprotective
5
8
Autophagy Up-regulation
2
7
Tumor Suppressor Protein p53 Upregulation
6
7
Matrix metalloproteinase-9 (MMP-9) inhibitor
3
6
Chondroprotective
1
5
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
4
5
Vascular Endothelial Growth Factor A Inhibitor
3
5
Acetylcholinesterase Inhibitor
2
4
Superoxide Dismutase Up-regulation
2
4
Antimutagenic Agents
3
3
Cytotoxicity
2
3
Osteoprotective
2
3
Radiosensitizer
2
3
Regenerative
2
3
Vascular Endothelial Growth Factor Inhibitors
2
3
Anti Inflammatory
1
2
Anti-Tumor
1
2
Antidepressive Agents
1
2
Antinoceceptive
1
2
Antioxidant
1
2
Autophagy Inhibitors
1
2
Bcl-2 protein down-regulation
2
2
Cholinesterase Inhibitors
1
2
Gastroprotective
1
2
Heme oxygenase-1 up-regulation
1
2
Histamine down-regulation
1
2
Interferon Gamma Reducer
1
2
Matrix metalloproteinase-2 (MMP-2) inhibitor
1
2
Neurominidase Inhibitor
2
2
Nrf2 activation
1
2
Antifungal Agents
1
1
Antiprotozoal Agents
1
1
Caspase-3 Inhibition
1
1
Cell Differentiation Inducer
1
1
Gene Protective
1
1
Glucose transporter-1 (GLUT1) expression down-regulation
1
1
Histone deacetylase inhibitor
1
1
Matrix Metalloproteinases Inhibitors
1
1
Matrix metalloproteinase-3 (MMP-3) inhibitor
1
1
Nitric Oxide Inhibitor
1
1
P21 Activation
1
1
Spermatogenic
1
1
Research Articles
569
Cumulative Knowledge Score
920
Overall Research Rating
EXCELLENT
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View the Evidence:
593 Abstracts with Vitamin C Research
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[+]
Supplementation with a nutrient mixture in female mice demonstrated a potent inhibition of tumor growth and enhancement of extracellular matrix proteins.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2015 Sep ;10(3):901-906. Epub 2015 Jun 23. PMID:
26622412
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Green Tea
,
Lysine
,
Proline
,
Vitamin C
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
Additional Keywords
:
Micronutrients
[+]
Supplementation with Vitamin C and E improve lung repair aftery emphysema induced by long-term cigarette smoke exposure in mice.
Sep 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2008 Sep;19(9):604-11. Epub 2007 Dec 21. PMID:
18155509
Article Published Date
: Sep 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Antioxidant formulas
,
Vitamin C
,
Vitamin E
Diseases
:
Emphysema: Pulmonary
,
Nicotine/Tobacco Toxicity
,
Smoking: Pulmonary
Additional Keywords
:
Smoking
[+]
The co-administration of vitamin E during chelation treatment with DMSA or MiADMSA could be recommended for achieving optimum effects of chelation therapy.
Jun 14, 2003
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2003 Jun 15 ;145(3):267-80. PMID:
12732454
Article Published Date
: Jun 14, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
,
Vitamin E: alpha tocopherol
Diseases
:
Lead Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Chelation
[+]
The combination of α-tocopherol acetate and ascorbic acid produced radioprotective effects and enhanced apoptosis in irradiated cells.
Jul 06, 2016
Click here to read the entire abstract
Pubmed Data
: Bull Exp Biol Med. 2016 Jul 7. Epub 2016 Jul 7. PMID:
27383172
Article Published Date
: Jul 06, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E: alpha tocopherol
Diseases
:
Cancers: All
Pharmacological Actions
:
Apoptotic
,
Radioprotective
[+]
The combined treatments with vitamins has a protective effect on forced swimming-induced oxidative stress.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Afr J Tradit Complement Altern Med. 2016 ;13(4):29-33. Epub 2016 Jul 3. PMID:
28852717
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E: alpha tocopherol
Diseases
:
Oxidative Stress
Therapeutic Actions
:
Exercise: Endurance
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Natural Substance Synergy
[+]
The present results imply that ascorbic acid treatment during pregnancy may protect against lead mediated developmental impairments in the cerebellum.
Feb 16, 2018
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2018 Feb 17. Epub 2018 Feb 17. PMID:
29462607
Article Published Date
: Feb 16, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Lead Poisoning
,
Prenatal Chemical Exposures
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Problem Substances
:
Lead
[+]
The present study indicates that vitamin C may be a novel therapeutic method for patients with advanced tumors.
Oct 31, 2016
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Article Publish Status
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Pubmed Data
: Exp Ther Med. 2016 Nov ;12(5):3058-3062. Epub 2016 Sep 16. PMID:
27882116
Article Published Date
: Oct 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Breast Cancer
,
Cancers: All
,
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
The protective effects of vitamin C on influenza virus-caused pneumonia might be related to its inhibition of CORT synthesis.
Dec 31, 2014
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Article Publish Status
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Pubmed Data
: Biomed Res Int. 2015 ;2015:675149. Epub 2015 Feb 1. PMID:
25710018
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Pneumonia
Pharmacological Actions
:
Anti Inflammatory
,
Antioxidant
Additional Keywords
:
Enzyme Modulating Properties
[+]
The results indicate the potential anxiolytic effect of ascorbic acid.
Feb 12, 2018
Click here to read the entire abstract
Pubmed Data
: J Psychiatr Res. 2018 Feb 13 ;100:16-23. Epub 2018 Feb 13. PMID:
29475017
Article Published Date
: Feb 12, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
[+]
The results obtained in vivo after treatment with AA showed a large reduction in the rate of tumor growth.
Dec 31, 2011
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2012 ;64(7):1049-57. Epub 2012 Sep 13. PMID:
22974001
Article Published Date
: Dec 31, 2011
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
,
Cytotoxic
[+]
The significant radioprotective effect of vitamin C at doses used in this study opens new horizons in developing non-toxic, cost effective, easily available radioprotectors.
May 31, 2015
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Article Publish Status
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Pubmed Data
: J Biomed Phys Eng. 2015 Jun ;5(2):59-66. Epub 2015 Jun 1. PMID:
26157731
Article Published Date
: May 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin A
,
Vitamin C
,
Vitamin E
Diseases
:
Radiotherapy
Pharmacological Actions
:
Radioprotective
Additional Keywords
:
Supplementation
[+]
These findings indicate a synergistic protective effect of ferulic acid and ascorbic acid on lipid peroxidation and antioxidant defense system during ISO-induced myocardial infarction.
Jan 31, 2006
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2006 Feb ;283(1-2):139-46. PMID:
16444596
Article Published Date
: Jan 31, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Ferulic acid
,
Vitamin C
Diseases
:
Lipid Peroxidation
,
Myocardial Infarction
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
Additional Keywords
:
Drug: Isoproterenol
,
Natural Substance Synergy
[+]
These results offer support for vitamin C and its potential use as protective treatment in cases of chronic paracetamol overdose.
Aug 02, 2017
Click here to read the entire abstract
Pubmed Data
: J Basic Clin Physiol Pharmacol. 2017 Aug 3. Epub 2017 Aug 3. PMID:
28771433
Article Published Date
: Aug 02, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Acetaminophen (Tylenol) Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Malondialdehyde Down-regulation
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
These results suggest that a long-term high-dose intake of VC is effective in the maintenance of immune cells.
Feb 27, 2015
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2015 Feb 28 ;113(4):603-9. Epub 2015 Jan 22. PMID:
25608928
Article Published Date
: Feb 27, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Aging
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
[+]
These results support the suppression of the hypoxic response by ascorbate as a plausible mechanism of action of its anti-tumour activity.
Aug 23, 2016
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2016 Aug 24 ;99:451-462. Epub 2016 Aug 24. PMID:
27567539
Article Published Date
: Aug 23, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Cancers: All
,
Lung Cancer
Pharmacological Actions
:
Hypoxia-inducible factor-1 (HIF-1) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
This animal study found that vitamin C depletion increased the growth and metastasis of melanoma cells.
Nov 30, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Exp Oncol. 2011 Dec ;33(4):226-30. PMID:
22217712
Article Published Date
: Nov 30, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Melanoma: Metastasis
,
Skin Cancer
,
Vitamin C Deficiency
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Antiproliferative
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
Additional Keywords
:
Risk Factors
[+]
This in vivo study provides novel data that vitamin C improves cardiac structure and function in doxorubicin-induced cardiomyopathy
Sep 30, 2017
Click here to read the entire abstract
Pubmed Data
: Am J Physiol Heart Circ Physiol. 2017 Oct 1 ;313(4):H795-H809. Epub 2017 Jul 14. PMID:
28710069
Article Published Date
: Sep 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
[+]
This study demonstrated the results of interactions between ascorbic acid and tramadol or morphine.
Jul 31, 2014
Click here to read the entire abstract
Article Publish Status
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Pubmed Data
: Anesth Pain Med. 2014 Aug ;4(3):e19529. Epub 2014 Jun 22. PMID:
25289375
Article Published Date
: Jul 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Pharmacological Actions
:
Analgesics
,
Antinoceceptive
Additional Keywords
:
Dose Response
,
Natural Substance/Drug Synergy
[+]
This study demonstrates the impact of suboptimal levels of ascorbate on longevity and the metabolic profile of a mouse model.
Feb 19, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Aging (Albany NY). 2016 Feb 20. Epub 2016 Feb 20. PMID:
26922388
Article Published Date
: Feb 19, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Inflammation
,
Metabolic Diseases
,
Vitamin C Deficiency
Additional Keywords
:
Risk Factors
[+]
This study showed that vitamin C improved the effect of ASC transplantation on tendonitis by inducing a better stem cell niche.
Apr 30, 2017
Click here to read the entire abstract
Pubmed Data
: In Vivo. 2017 May-Jun;31(3):343-348. PMID:
28438861
Article Published Date
: Apr 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Tendon Injury
Additional Keywords
:
Adult Stem Cells
[+]
This study shows direct therapeutic benefits of ascorbic acid on corneal epithelial wound healing.
Mar 08, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Stem Cells Transl Med. 2017 Mar 9. Epub 2017 Mar 9. PMID:
28276172
Article Published Date
: Mar 08, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Eye Damage
,
Wound Healing
[+]
Treatment with ascorbic acid and α-tocopherol modulates oxidative-stress markers in the spinal cord of rats with neuropathic pain.
Feb 28, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Braz J Med Biol Res. 2018 Mar 1 ;51(4):e7097. Epub 2018 Mar 1. PMID:
29513797
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E: alpha tocopherol
Diseases
:
Neuropathic Pain
Pharmacological Actions
:
Antioxidants
[+]
Treatment with berberine prevents the changes in oxidative stress and ChE activity, and consequently memory impairment in ethanol treated rats.
Jul 05, 2015
Click here to read the entire abstract
Pubmed Data
: Pharmacol Biochem Behav. 2015 Jul 6 ;136:13-20. Epub 2015 Jul 6. PMID:
26159088
Article Published Date
: Jul 05, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Vitamin C
Diseases
:
Alcohol Toxicity
,
Cognitive Decline/Dysfunction
,
Memory Disorders: Drug-Induced
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cholinesterase Inhibitors
,
Neuroprotective Agents
[+]
Vitamin A, C and E reduce azo-dye binding protein in liver of rats.
Apr 01, 2010
Click here to read the entire abstract
Pubmed Data
: Indian J Exp Biol. 2010 Apr;48(4):373-7. PMID:
20726335
Article Published Date
: Apr 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin A
,
Vitamin C
,
Vitamin E
Diseases
:
Azo compound toxicity
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Vitamin C administration has a possibility to prevent hippocampal neuronal damage caused by neonatal and juvenile hypothyroidism in rats.
Nov 23, 2017
Click here to read the entire abstract
Pubmed Data
: J Chem Neuroanat. 2017 Nov 24. Epub 2017 Nov 24. PMID:
29179976
Article Published Date
: Nov 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Hypothyroidism
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Vitamin C ameliorates aflatoxin-induced adverse effects in rabbits.
Mar 01, 2003
Click here to read the entire abstract
Pubmed Data
: J Environ Sci Health B. 2003 Mar;38(2):193-209. PMID:
12617557
Article Published Date
: Mar 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Aflatoxicosis
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C ameliorates alterations in thyroid hormones concentrations induced by subchronic coadministration of chlorpyrifos and lead in wistar rats.
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: J Thyroid Res. 2011;2011:214924. Epub 2011 May 23. PMID:
21687644
Article Published Date
: Jan 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Hypothyroidism
,
Lead Poisoning
,
Pesticide-Induced Toxicity: Organophosphates
Problem Substances
:
Chlorpyrifos
,
Lead
,
Organophosphates
,
Pesticides
[+]
Vitamin C ameliorates aluminium-induced deterioration in reproductive performance and seminal plasma biochemistry of male rabbits.
Nov 05, 2005
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2005 Nov 5;215(1-2):97-107. Epub 2005 Aug 10. PMID:
16098653
Article Published Date
: Nov 05, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Aluminum Toxicity
,
Sperm Quality: Low
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C ameliorates fluoride-induced embryotoxicity in pregnant rats.
Dec 01, 2001
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2001 Dec;20(12):619-23. PMID:
11936575
Article Published Date
: Dec 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Fluoride Toxicity
[+]
Vitamin C and alpha-naphthoflavone prevent estrogen-induced mammary tumors and decrease oxidative stress in female rats.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2009 Jul ;30(7):1202-8. Epub 2009 Apr 30. PMID:
19406931
Article Published Date
: Jul 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-naphthoflavone
,
Vitamin C
Diseases
:
Breast Cancer: Estrogen
,
Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions
:
Antioxidants
,
Chemopreventive
[+]
Vitamin C and Baicalin inhibits tumor growth by enhancing the antioxidant capacity in vivo.
Aug 31, 2015
Click here to read the entire abstract
Pubmed Data
: J BUON. 2015 Sep-Oct;20(5):1368-72. PMID:
26537087
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Chinese Skullcap
,
Vitamin C
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
,
Malondialdehyde Down-regulation
Additional Keywords
:
Natural Substance Synergy
[+]
Vitamin C and E protects against against lead-induced genotoxicity and sperm abnormalities in mice.
Jan 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Trace Elem Med Biol. 2004;18(2):173-8. PMID:
15646264
Article Published Date
: Jan 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
DNA damage
,
Lead Poisoning
[+]
Vitamin C and E reduce the endocrine disruptive effects of polychlorinated biphenyl on testicular function.
Apr 11, 2007
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2007 Apr 11;232(3):170-82. Epub 2007 Jan 16. PMID:
17280759
Article Published Date
: Apr 11, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Polychlorinated biphenyl toxicity
Additional Keywords
:
Endocrine Disruptors
[+]
Vitamin C and Nigella sativa oil proved to have synergistic nephro-protective effect.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2012 Oct ;25(4):727-30. PMID:
23009987
Article Published Date
: Sep 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
,
Vitamin C
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
Additional Keywords
:
Natural Substance Synergy
,
Plant Oils
[+]
Vitamin C and rosemary leaf extract showed ameliorative potential to reduce tissue accumulation of cadmium and associated oxidative stress.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Environ Biol. 2015 Nov ;36(6):1401-8. PMID:
26688980
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Rosemary
,
Vitamin C
Diseases
:
Cadmium Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Plant Extracts
[+]
Vitamin C and silymarin supplements ameliorate lead toxicity on rat liver.
Apr 01, 2009
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2009 Apr;16(4):369-76. Epub 2009 Feb 6. PMID:
15590105
Article Published Date
: Apr 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Milk Thistle
,
Vitamin C
Diseases
:
Lead Poisoning
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Hepatoprotective
[+]
Vitamin C and vitamin E exert significant protective effects from 50 Hz ELF-EMF radiation.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Public Health. 2017 Jan ;46(1):23-34. PMID:
28451526
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Pharmacological Actions
:
Anti-Apoptotic
,
Radioprotective
Anti Therapeutic Actions
:
Electromagnetic Fields
[+]
Vitamin C and vitamin E might play an important role in reducing oxidative stress and kidney damage induced by diclofenac sodium.
Sep 21, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Sep 22 ;84:314-322. Epub 2016 Sep 22. PMID:
27665477
Article Published Date
: Sep 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Kidney Damage: Drug-Induced
Pharmacological Actions
:
Antioxidants
,
Renoprotective
Problem Substances
:
Diclofenac
[+]
Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species.
Feb 29, 2004
Click here to read the entire abstract
Pubmed Data
: Mol Cells. 2004 Feb 29;17(1):132-9. PMID:
15055539
Article Published Date
: Feb 29, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Cadmium Poisoning
[+]
Vitamin C and vitamin E supplementation alleviates oxidative stress induced by dexamethasone and improves fertility of breeder roosters.
Jul 31, 2016
Click here to read the entire abstract
Pubmed Data
: Anim Reprod Sci. 2016 Aug ;171:1-6. Epub 2016 Apr 4. PMID:
27297178
Article Published Date
: Jul 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Problem Substances
:
Dexamethasone
[+]
Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations.
Mar 29, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2017 Mar 30. Epub 2017 Mar 30. PMID:
28370562
Article Published Date
: Mar 29, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Malignant Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Vitamin C at lower doses showed anti-oxidant effect and at higher dose resulted in pro-oxidant effects in colchicine induced Alzheimer's disease.
Sep 23, 2016
Click here to read the entire abstract
Pubmed Data
: J Mol Neurosci. 2016 Sep 24. Epub 2016 Sep 24. PMID:
27665568
Article Published Date
: Sep 23, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Alzheimer's Disease
,
Brain Inflammation
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C attenuates the mutagenicity of the antiamebic drug diiodohydroxyquinoline.
Mar 01, 1989
Click here to read the entire abstract
Pubmed Data
: Mutat Res. 1989 Mar;222(3):219-22. PMID:
2493578
Article Published Date
: Mar 01, 1989
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Amebiasis
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Vitamin C can ameliorate the toxic effect of methotrexate in liver and kidney tissues of rat.
Jun 28, 2017
Click here to read the entire abstract
Pubmed Data
: Physiol Int. 2017 Jun 29:1-11. Epub 2017 Jun 29. PMID:
28658959
Article Published Date
: Jun 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Renoprotective
[+]
Vitamin C can be effective on some of the sperm parameters and can reduce cyclophosphamide-induced complications in animal model.
Mar 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Adv Pharm Technol Res. 2017 Apr-Jun;8(2):73-79. PMID:
28516060
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions
:
Cytoprotective
Problem Substances
:
Cyclophosphamide
[+]
Vitamin C can reduce oxidative stress, increase antioxidants, and recover the threshold for mechanical allodynia.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Med Sci. 2017 ;14(1):97-101. Epub 2017 Jan 15. PMID:
28138314
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Allodynia
,
Ischemia
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C contributes to accelerated healing of experimental fractures.
Jul 01, 2001
Click here to read the entire abstract
Pubmed Data
: Arch Orthop Trauma Surg. 2001 Jul;121(7):426-8. PMID:
11510911
Article Published Date
: Jul 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Bone Fractures
[+]
Vitamin C contributes to healing bone fractures.
Mar 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Bone Joint Surg Br. 2007 Mar;89(3):402-7. PMID:
17356161
Article Published Date
: Mar 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Bone Fractures
[+]
Vitamin c could be beneficial in Werner syndrome.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: Exp Gerontol. 2015 Dec ;72:192-203. Epub 2015 Oct 29. PMID:
26521679
Article Published Date
: Nov 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Oxidative Stress
,
Werner Syndrome
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Gene Expression Regulation
[+]
Vitamin C could prevent the adverse effects of bisphenol A on rat ovary.
May 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Reprod Biomed (Yazd). 2016 Jun ;14(6):403-10. PMID:
27525324
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Bisphenol Toxicity
Pharmacological Actions
:
Antioxidants
Problem Substances
:
Bisphenol A
[+]
Vitamin C could remit isoflurane-induced apoptosis and relieve the decline in learning and memory ability of rats.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: J Biol Regul Homeost Agents. 2016 Oct-Dec;30(4):961-969. PMID:
28078842
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Cognitive Decline/Dysfunction
,
Surgery: Anesthesiology
Pharmacological Actions
:
Anti-Apoptotic
Additional Keywords
:
Anti-Apoptotic
,
Cognitive Decline/Dysfunction
,
Risk Reduction
,
Surgery: Anesthesiology
,
Vitamin C
[+]
Vitamin C enhances semen quality in rabbits treated with sublethal doses of aflatoxin.
May 21, 2001
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2001 May 21;162(3):209-18. PMID:
11369116
Article Published Date
: May 21, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Aflatoxicosis
,
Sperm Quality: Low
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C enhances the analgesic effect of gabapentin on rats with neuropathic pain.
Jul 14, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Jul 15 ;157:25-31. Epub 2016 May 28. PMID:
27245275
Article Published Date
: Jul 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Neuropathic Pain
,
Oxidative Stress
Pharmacological Actions
:
Analgesics
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Vitamin C favorably impacts the spatiotemporal expression of transcripts associated with early resolution of inflammation and tissue remodelling.
Aug 19, 2015
Click here to read the entire abstract
Pubmed Data
: Int Wound J. 2015 Aug 20. Epub 2015 Aug 20. PMID:
26290474
Article Published Date
: Aug 19, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Wound Healing
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Vitamin C had a significant role in ameliorating the damage of testes induced by doxorubicin.
Mar 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pak Med Assoc. 2017 Apr ;67(4):586-589. PMID:
28420921
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Chemoprotective Agents
,
Chemotherapeutic
[+]
Vitamin C had hepatoprotective effect against cholestatic liver injury in animals.
Jun 05, 2015
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2015 Jun 6. Epub 2015 Jun 6. PMID:
26057690
Article Published Date
: Jun 05, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Liver Fibrosis
Pharmacological Actions
:
Anti-Apoptotic
,
Hepatoprotective
[+]
Vitamin C has a protective effect against the toxicity of stannous chloride (tin).
Jun 25, 2007
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2007 Jun 25;235(3):194-202. Epub 2007 Mar 18. PMID:
17433520
Article Published Date
: Jun 25, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Tin Poisoning
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C has a protective effect against alloxan-induced testicular damage in diabetic rats.
Nov 01, 1999
Click here to read the entire abstract
Pubmed Data
: Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Nov;124(3):233-7. PMID:
10661714
Article Published Date
: Nov 01, 1999
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Alloxan toxicity
,
Diabetes Mellitus: Type 1
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C has a protective effect against the toxicity of aluminium.
Sep 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Dent Res. 2007 Sep;86(9):848-51. PMID:
15125998
Article Published Date
: Sep 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Aluminum Toxicity
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C has protective effects against spinal cord injury-induced kidney damage.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Neurol Sci. 2015 Apr ;36(4):521-6. Epub 2014 Nov 18. PMID:
25403314
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Vitamin C holds the potential of being applied as a novel type of treatment of Werner syndrome.
Jun 05, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Protein Cell. 2016 Jun 6. Epub 2016 Jun 6. PMID:
27271327
Article Published Date
: Jun 05, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Werner Syndrome
Additional Keywords
:
Gene Expression Regulation
,
Mesenchymal Stem Cells
[+]
Vitamin C in combination with vitamin K3 inhibits primary tumor growth and exhibits antimetastastic potential in vivo through attenuated tumor invasion and proliferation.
Dec 31, 2010
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2011 ;63(7):1036-43. Epub 2011 Sep 2. PMID:
21888506
Article Published Date
: Dec 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin K
Diseases
:
Lung Cancer
,
Lung Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Disease Regression
,
Dose Response
[+]
Vitamin C inhibits the growth of human mammary tumor xenografts.
Dec 01, 1991
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 1991 Dec;54(6 Suppl):1274S-1280S. PMID:
1962582
Article Published Date
: Dec 01, 1991
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
[+]
Vitamin C inhibits the inflammation associated ROS that promotes gastric tumorigenesis.
Mar 25, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Prev Res (Phila). 2015 Mar 26. Epub 2015 Mar 26. PMID:
25813526
Article Published Date
: Mar 25, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Gastric Cancer
,
Gastrointestinal Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Tumor
,
Anticarcinogenic Agents
,
Antioxidants
,
Chemopreventive
Additional Keywords
:
Risk Reduction
Problem Substances
:
Tamoxifen
[+]
Vitamin C is a nutritional stimulator of autophagy.
Aug 09, 2017
Click here to read the entire abstract
Pubmed Data
: Biochimie. 2017 Aug 10. Epub 2017 Aug 10. PMID:
28804003
Article Published Date
: Aug 09, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Autophagy Up-regulation
[+]
Vitamin C is an important nutrient for adequate immune function and the limitation of pathogenesis following influenza virus infection.
Sep 30, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutr. 2006 Oct ;136(10):2611-6. PMID:
16988135
Article Published Date
: Sep 30, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Influenza A
,
Vitamin C Deficiency
Pharmacological Actions
:
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Risk Factors
[+]
Vitamin C is essential for inducing of radioprotective effect and maintaining optimum people health.
Aug 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biomed Phys Eng. 2016 Sep ;6(3):157-164. Epub 2016 Sep 1. PMID:
27853723
Article Published Date
: Aug 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Hepatoprotective
,
Radioprotective
Anti Therapeutic Actions
:
Wi-Fi Radiation
[+]
Vitamin C is essential for natuarl killer cell cytotoxicity against cancer cells.
Jan 02, 2012
Click here to read the entire abstract
Pubmed Data
: Immunobiology. 2012 Jan 2. Epub 2012 Jan 2. PMID:
22306178
Article Published Date
: Jan 02, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Low Immune Function: Natural Killer Cells
,
Ovarian Cancer
[+]
Vitamin C is essential for the renal function maintenance in diabetes.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta. 2017 09 ;1861(9):2186-2195. Epub 2017 Jun 23. PMID:
28652077
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Vitamin C Deficiency
Pharmacological Actions
:
Renoprotective
[+]
Vitamin C is selectively toxic to colorectal cancers cells with mutant KRAS or BRAF.
Nov 04, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Science. 2015 Nov 5. Epub 2015 Nov 5. PMID:
26541605
Article Published Date
: Nov 04, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Cytotoxic
Additional Keywords
:
Selective Cytotoxicity
[+]
Vitamin C lowered the serum glucose and hesperidin reduced the DNA damage in a sucrose overload model.
Apr 15, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: An Acad Bras Cienc. 2018 Apr 16:0. Epub 2018 Apr 16. PMID:
29668805
Article Published Date
: Apr 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Hesperidin
,
Vitamin C
Diseases
:
DNA damage
,
Sugar (Sucrose) Toxicity
Pharmacological Actions
:
Genoprotective
,
Hypoglycemic Agents
Problem Substances
:
Sucrose
[+]
Vitamin C may have a positive effect on fracture healing.
Sep 01, 2007
Click here to read the entire abstract
Pubmed Data
: Arch Orthop Trauma Surg. 2007 Sep;127(7):493-501. Epub 2007 Jul 17. PMID:
17639432
Article Published Date
: Sep 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Bone Fractures
[+]
Vitamin C may have a therapeutic role in ameliorating pulmonary hypertension.
Dec 01, 2002
Click here to read the entire abstract
Pubmed Data
: Br Poult Sci. 2002 Dec;43(5 Suppl):705-12. PMID:
12555895
Article Published Date
: Dec 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Hypertension: Pulmonary
[+]
Vitamin C may have a therapeutic role in the treatment of Charcot-Marie Tooth disease - Article 2.
Apr 01, 2004
Click here to read the entire abstract
Pubmed Data
: Nat Med. 2004 Apr;10(4):396-401. Epub 2004 Mar 21. PMID:
15034573
Article Published Date
: Apr 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Charcot-Marie-Tooth Disease
[+]
Vitamin C may have a therapeutic role in the treatment of Charcot-Marie Tooth disease.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2009;4(2):e4409. Epub 2009 Feb 6. PMID:
19197388
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Charcot-Marie-Tooth Disease
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Vitamin C mitigated 5-fluorouracil-induced liver damage in rats.
Feb 24, 2016
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2016 Feb 25. Epub 2016 Feb 25. PMID:
26921358
Article Published Date
: Feb 24, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Chemotherapy-Induced Toxicity: 5-fluorouracil
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
,
NF-kappaB Inhibitor
[+]
Vitamin C mitigated ethanol-induced oxidative stress, neuroinflammation and apoptotic neuronal loss.
Nov 09, 2015
Click here to read the entire abstract
Pubmed Data
: CNS Neurol Disord Drug Targets. 2015 Nov 10. Epub 2015 Nov 10. PMID:
26831257
Article Published Date
: Nov 09, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Alcohol Toxicity
,
Brain Inflammation
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Vitamin C mitigates the genotoxic properties of nicotine in mice.
Feb 06, 2012
Click here to read the entire abstract
Pubmed Data
: Mutat Res. 2012 Feb 6. Epub 2012 Feb 6. PMID:
22331007
Article Published Date
: Feb 06, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Nicotine/Tobacco Toxicity
Pharmacological Actions
:
Genoprotective
Problem Substances
:
Nicotine
Adverse Pharmacological Actions
:
Genotoxic
[+]
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty.
Sep 05, 2017
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2017 Sep 6 ;109(Pt 1):272-283. Epub 2017 Sep 6. PMID:
28887090
Article Published Date
: Sep 05, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Statin-Induced Pathologies
Pharmacological Actions
:
Cytoprotective
Problem Substances
:
Rosuvastatin
[+]
Vitamin C plays a critical role in vivo anti-viral immune responses against influenza virus.
Mar 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Immune Netw. 2013 Apr ;13(2):70-4. Epub 2013 Apr 30. PMID:
23700397
Article Published Date
: Mar 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
H3N2 Infection
,
Influenza A
Pharmacological Actions
:
Antiviral Agents
,
Immunomodulatory
[+]
Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin.
Jan 02, 2018
Click here to read the entire abstract
Pubmed Data
: Antimicrob Agents Chemother. 2018 Jan 3. Epub 2018 Jan 3. PMID:
29298757
Article Published Date
: Jan 02, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Mycobacterium tuberculosis
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Vitamin C pre-treatment effectively improved renal function and tissue damage caused by nickel.
Aug 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Arh Hig Rada Toksikol. 2016 Sep 1 ;67(3):210-215. PMID:
27749260
Article Published Date
: Aug 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Nickel Poisoning
Pharmacological Actions
:
Renoprotective
[+]
Vitamin C pretreatment ameliorated the chronic chlorpyrifos induced hemotoxicity in wistar rats.
Dec 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Vet Med Int. 2011 ;2011:945439. Epub 2011 Apr 27. PMID:
21647348
Article Published Date
: Dec 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Problem Substances
:
Chlorpyrifos
[+]
Vitamin C prevents stress-induced damage on the heart .
Nov 30, 2013
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2013 Dec ;65:573-83. Epub 2013 Jul 23. PMID:
23886864
Article Published Date
: Nov 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Cardiovascular Diseases
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Vitamin C prevents the endothelial dysfunction induced by acute ethanol intake.
Sep 15, 2015
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2015 Sep 16. Epub 2015 Sep 16. PMID:
26386369
Article Published Date
: Sep 15, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Alcohol Toxicity
,
Endothelial Damage
,
Endothelial Dysfunction
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C protects against internal radioiodine-131 associated toxicity.
Mar 01, 1994
Click here to read the entire abstract
Pubmed Data
: Radiat Res. 1994 Mar;137(3):394-9. PMID:
8146284
Article Published Date
: Mar 01, 1994
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Radiation-Induced Illness: Radioiodine (Iodine-131)
Pharmacological Actions
:
Radioprotective
[+]
Vitamin C protects against ischemia-reperfusion-induced acute kidney injury.
Jul 31, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2015 Aug ;406(1-2):1-7. Epub 2015 Jul 5. PMID:
26142728
Article Published Date
: Jul 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Kidney Damage
Pharmacological Actions
:
Renoprotective
[+]
Vitamin C protects against nickel sulfate induced lung damage in rats.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Basic Clin Physiol Pharmacol. 2006;17(2):87-100. PMID:
16910314
Article Published Date
: Jan 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Nickel Poisoning
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C protects against nickel sulfate induced testicular damage in rats.
Jan 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Basic Clin Physiol Pharmacol. 2007;18(4):255-66. PMID:
18380167
Article Published Date
: Jan 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Nickel Poisoning
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C provides cardioprotection from Doxorubicin induced toxicity.
Jan 17, 2017
Click here to read the entire abstract
Pubmed Data
: Am J Physiol Cell Physiol. 2017 Jan 18:ajpcell.00356.2016. Epub 2017 Jan 18. PMID:
28100487
Article Published Date
: Jan 17, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
[+]
Vitamin C reduces the incidence of ascites caused by sodium chloride in broiler chicks.
Jan 01, 1990
Click here to read the entire abstract
Pubmed Data
: Int J Vitam Nutr Res. 1990;60(4):366-71. PMID:
2101829
Article Published Date
: Jan 01, 1990
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Ascites
[+]
Vitamin C restores healthy aging in a mouse model for Werner syndrome.
Dec 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: FASEB J. 2010 Jan ;24(1):158-72. Epub 2009 Sep 9. PMID:
19741171
Article Published Date
: Dec 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Aging
,
Oxidative Stress
,
Werner Syndrome
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C supplementation can prevent or attenuate the development of ventilator-associated pneumonia in patients receiving oxygen support.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Respir Cell Mol Biol. 2016 Oct ;55(4):511-520. PMID:
27120084
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Pneumonia
Additional Keywords
:
Dose Response
,
Risk Reduction
[+]
Vitamin C supplementation may alleviate acute inflammation in recovery phase and ameliorated subchronic inflammation in early colon cancer.
Mar 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Res Pract. 2018 Apr ;12(2):101-109. Epub 2018 Mar 22. PMID:
29629026
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Colitis
,
Colon Cancer: Prevention
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemopreventive
[+]
Vitamin C supplementation prevents testosterone-induced hyperplasia of the rat prostate.
Aug 26, 2009
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2009 Aug 26. PMID:
19716283
Article Published Date
: Aug 26, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Prostatic Hyperplasia: Benign
[+]
Vitamin C supplementation protects against lead-induced histopathological alterations in male rats.
Apr 27, 2009
Click here to read the entire abstract
Pubmed Data
: Arch Intern Med. 2009 Apr 27;169(8):788-96. PMID:
20056397
Article Published Date
: Apr 27, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Lead Poisoning
[+]
Vitamin C supplementation reduces deltamethrin induced stress in freshwater catfish.
Dec 01, 2003
Click here to read the entire abstract
Pubmed Data
: Chemosphere. 2003 Dec;53(8):883-8. PMID:
14505710
Article Published Date
: Dec 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Pyrethroid Insecticide Induced Toxicity
[+]
Vitamin c treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity.
Aug 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Physiol. 2012 Sep ;227(9):3216-24. PMID:
22105792
Article Published Date
: Aug 31, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Vitamin C
Pharmacological Actions
:
Regenerative
,
Telomerase Upregulation
[+]
Vitamin C, D, and E have an ameliorative effect on sodium-fluoride-induced hypoproteinemia and hypoglycemia in rats.
Dec 01, 2002
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2002 Dec;40(12):1781-8. PMID:
12419692
Article Published Date
: Dec 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin D
,
Vitamin E
Diseases
:
Fluoride Toxicity
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C, E and melatonin ameliorate insecticide-induced nephrotoxicity in rats.
Apr 01, 2002
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2002 Apr;21(4):223-30. PMID:
12099624
Article Published Date
: Apr 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Vitamin C
,
Vitamin E
Diseases
:
Oxidative Stress
,
Pesticide Toxicity
Pharmacological Actions
:
Antioxidants
,
Renoprotective
[+]
Vitamin C, E and melatonin may protect against insecticide-induced oxidative stress.
Apr 01, 2001
Click here to read the entire abstract
Pubmed Data
: Arch Toxicol. 2001 Apr;75(2):88-96. PMID:
11354911
Article Published Date
: Apr 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
,
Vitamin C
,
Vitamin D
Diseases
:
Oxidative Stress
,
Pesticide Toxicity
Pharmacological Actions
:
Antioxidants
[+]
Vitamin E and C exhibit radioprotective properties.
Nov 15, 1998
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 1998 Nov 15;56(10):1295-304. PMID:
9825728
Article Published Date
: Nov 15, 1998
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Radiation Induced Illness
Pharmacological Actions
:
Radioprotective
[+]
Vitamin E and C protects against lymphocyte DNA damage in rats.
Apr 01, 2004
Click here to read the entire abstract
Pubmed Data
: Taehan Kanho Hakhoe Chi. 2004 Apr;34(2):324-32. PMID:
15363578
Article Published Date
: Apr 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
DNA damage
,
Pyrethroid Insecticide Induced Toxicity
Pharmacological Actions
:
Antioxidants
[+]
Vitamin E and vitamin C supplementation improves antioxidant status and immune function in oxidative-stressed breeder roosters.
Mar 31, 2018
Click here to read the entire abstract
Pubmed Data
: Poult Sci. 2018 Apr 1 ;97(4):1238-1244. PMID:
29452404
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Immunomodulatory
[+]
Vitamin E and vitamin C supplementation protect against lipid peroxidation and oxidation of lipoproteins in experimental hyperthyroidism.
Feb 01, 1999
Click here to read the entire abstract
Pubmed Data
: J Med Invest. 1999 Feb;46(1-2):29-33. PMID:
10408154
Article Published Date
: Feb 01, 1999
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Hyperthyroidism
[+]
Vitamin E, vitamin C, resveratrol, and alpha-lipoic acid have a protective effect against insecticide-induced toxicity in mice.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Crit Care. 2008;12(6):R136. Epub 2008 Nov 6. PMID:
20663516
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
,
Resveratrol
,
Vitamin C
,
Vitamin E
Diseases
:
Pesticide-Induced Toxicity: Organochlorines
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Chemical: Lindane
,
Stilbenes
[+]
Vitamins C and E provide synergistic neuroprotection in the jejunum in experimental diabetes.
Sep 27, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pathophysiology. 2015 Sep 28. Epub 2015 Sep 28. PMID:
26433445
Article Published Date
: Sep 27, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E: alpha tocopherol
Diseases
:
Diabetes: Oxidative Stress
,
Diabetic Complications
,
Diabetic Neuropathy
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
When used before therapy vitamin C was able to decrease methotrexate induced testicular histological injuries.
Nov 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Turk J Urol. 2016 Dec ;42(4):235-239. PMID:
27909615
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Chemoprotective Agents
[+]
The use of dietary supplements in children with autism seems to be a safe practice with encouraging data about their clinical efficacy.
Apr 20, 2017
Click here to read the entire abstract
Pubmed Data
: Brain Dev. 2017 Apr 21. Epub 2017 Apr 21. PMID:
28438367
Article Published Date
: Apr 20, 2017
Study Type
: Review
Additional Links
Substances
:
Amino Acids
,
Essential Fatty Acids
,
Magnesium
,
Vitamin B-12
,
Vitamin C
Diseases
:
Autism Spectrum Disorders
[+]
"Sickle cell anemia: a potential nutritional approach for a molecular disease."
May 01, 2000
Click here to read the entire abstract
Pubmed Data
: Nutrition. 2000 May ;16(5):330-8. PMID:
10793299
Article Published Date
: May 01, 2000
Study Type
: Review
Additional Links
Substances
:
Alpha-Lipoic Acid
,
beta-Carotene
,
Black Tea
,
Green Tea
,
Pycnogenol (Pine Bark)
,
Vitamin C
,
Vitamin E
Diseases
:
Sickle Cell Anemia
Pharmacological Actions
:
Antioxidants
[+]
"The genetics of vitamin C loss in vertebrates."
Aug 01, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Curr Genomics. 2011 Aug ;12(5):371-8. PMID:
22294879
Article Published Date
: Aug 01, 2011
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Scurvy
,
Vitamin C Deficiency
[+]
A combination of lysine, proline, arginine, ascorbic acid and green tea extract inhibits a pancreatic cancer cell line.
Jan 01, 2005
Click here to read the entire abstract
Pubmed Data
: Int J Gastrointest Cancer. 2005;35(2):97-102. PMID:
15879623
Article Published Date
: Jan 01, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Arginine
,
Green Tea
,
Lysine
,
Proline
,
Vitamin C
Diseases
:
Pancreatic Cancer
[+]
A combination of Lysine, Proline, Vitamin C, Arginine, Polyphenols, NAC (N-acetyl-L-cysteine), Selenium, Copper, Manganese induces apoptosis in HTLV-1 positive and negative malignant T-cells.
Jul 01, 2006
Click here to read the entire abstract
Pubmed Data
: Leuk Res. 2006 Jul;30(7):869-81. Epub 2006 Jan 19. PMID:
16427125
Article Published Date
: Jul 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Arginine
,
Copper
,
Lysine
,
Manganese
,
NAC (N-acetyl-L-cysteine)
,
Polyphenols
,
Proline
,
Selenium
,
Vitamin C
Diseases
:
Human T-Cell Lymphotrophic Virus type 1 associated disease
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
Antineoplastic Agents
[+]
A combination of pomegranate rind extract, copper and vitamin C have antimicrobial activity against multidrug resistant Pseudomonas aeruginosa.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Br J Biomed Sci. 2009;66(3):129-32. PMID:
19839222
Article Published Date
: Jan 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Copper
,
Pomegranate
,
Vitamin C
Diseases
:
Infection: Antibiotic Resistant
,
Pseudomonas aeruginosa
,
Pseudomonas Infections
Pharmacological Actions
:
Anti-Bacterial Agents
Additional Keywords
:
Multi-Drug Resistant Pathogens
[+]
A combination of vitamin C and selenium may have anticancer activity against human gastric cancer via enhancing antioxidant enzymes and inducing the formation of H202.
Sep 01, 2002
Click here to read the entire abstract
Pubmed Data
: Biomed Environ Sci. 2002 Sep;15(3):223-32. PMID:
12500663
Article Published Date
: Sep 01, 2002
Study Type
: In Vitro Study
Additional Links
Substances
:
Hydrogen Peroxide
,
Selenium
,
Vitamin C
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antioxidants
[+]
A decrease in external symptoms of burn injury was noted in the damaged epidermis incubated in l-ascorbic acid.
May 29, 2017
Click here to read the entire abstract
Pubmed Data
: Spectrochim Acta A Mol Biomol Spectrosc. 2017 May 30 ;185:279-285. Epub 2017 May 30. PMID:
28591686
Article Published Date
: May 29, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Burns
[+]
A nutrient mixture containing lysine, proline, ascorbic acid, and green tea extract inhibits corneal neovascularization.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: Arch Med Res. 2007 Oct;38(7):789-91. Epub 2007 Jun 21. PMID:
17845900
Article Published Date
: Oct 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Green Tea
,
Lysine
,
Proline
,
Vitamin C
Diseases
:
Corneal Neovascularization
Pharmacological Actions
:
Matrix Metalloproteinases Inhibitors
,
Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords
:
Plant Extracts
[+]
A nutrient mixture inhibits a human liver cancer cell line.
Jul 01, 2010
Click here to read the entire abstract
Pubmed Data
: Exp Oncol. 2010 Jul ;32(2):84-91. PMID:
20693968
Article Published Date
: Jul 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Lysine
,
Proline
,
Tea
,
Vitamin C
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Plant Extracts
[+]
A nutrient mixture, containing ascorbic acid, lysine, proline, green tea extract exhibit significant antiproliferative effects against aggressive non-Hodgkin's lymphoma cell lines.
Sep 01, 2009
Click here to read the entire abstract
Pubmed Data
: Exp Oncol. 2009 Sep;31(3):149-55. PMID:
19783966
Article Published Date
: Sep 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Green Tea
,
Lysine
,
Proline
,
Proprietary Nutrient Formulas
,
Vitamin C
Diseases
:
Burkitt Lymphoma
,
Lymphoma
,
Lymphoma: T-cell
,
Non-Hodgkin Lymphoma
Pharmacological Actions
:
Antiproliferative
[+]
A nutrient mixure containing green tea, vitamin c, lysine and other factors exerts an antiviral effect against influenza A.
Jan 01, 2007
Click here to read the entire abstract
Pubmed Data
: Biofactors. 2007;31(1):1-15. PMID:
18806304
Article Published Date
: Jan 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Green Tea
,
Lysine
,
Vitamin C
Diseases
:
Human Influenza
,
Influenza A
Pharmacological Actions
:
Antiviral Agents
,
Neurominidase Inhibitor
[+]
A remarkable preventive role of many vitamins like B6, B9, B12 and D on the risk of developing CRC was suggested by a large number of observational studies.
May 06, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2015 May 7 ;21(17):5191-5209. PMID:
25954093
Article Published Date
: May 06, 2015
Study Type
: Review
Additional Links
Substances
:
Folate
,
Vitamin B-12
,
Vitamin B-6
,
Vitamin C
,
Vitamin D
,
Vitamin E
Diseases
:
Celiac Disease
,
Colorectal Cancer
,
Colorectal Cancer: Prevention
,
Gastrointestinal Diseases
Pharmacological Actions
:
Gastrointestinal Agents
[+]
A review of the anti-atherosclerotic effects of vitamins D and E in suppression of atherogenesis.
Dec 13, 2016
Click here to read the entire abstract
Pubmed Data
: J Cell Physiol. 2016 Dec 14. Epub 2016 Dec 14. PMID:
27966778
Article Published Date
: Dec 13, 2016
Study Type
: Review
Additional Links
Substances
:
Vitamin C
,
Vitamin D
,
Vitamin E
,
Vitamin E: Gamma-Tocopherol
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-atherogenic
Additional Keywords
:
Risk Reduction
[+]
A review of the epigenetic role of vitamin C in health and disease.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Cell Mol Life Sci. 2016 Apr ;73(8):1645-58. Epub 2016 Aug 4. PMID:
26846695
Article Published Date
: Mar 31, 2016
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Aging
,
Cancers: All
,
Neurodegenerative Diseases
Additional Keywords
:
Epigenetic Modification
,
Epigenetic Modification In Cancer
[+]
A review of the molecular mechanisms of pharmacological doses of ascorbate on cancer cells.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Wien Med Wochenschr. 2015 Jun ;165(11-12):251-7. Epub 2015 Jun 12. PMID:
26065536
Article Published Date
: May 31, 2015
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Cancers: All
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
Additional Keywords
:
Epigenetic Modification
[+]
A review of the preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases.
Oct 03, 2017
Click here to read the entire abstract
Pubmed Data
: CNS Neurosci Ther. 2017 Oct 4. Epub 2017 Oct 4. PMID:
28980404
Article Published Date
: Oct 03, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
A review of the role vitamin C plays on inflammation.
Feb 05, 2017
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2017 Feb 6. Epub 2017 Feb 6. PMID:
28168552
Article Published Date
: Feb 05, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Cardiovascular Diseases
,
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Aged garlic extract and other antioxidant nutritional supplements exhibit potentially therpeutic properties in sickle erythrocytes.
Mar 01, 2001
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutr. 2001 Mar ;131(3s):1085S-92S. PMID:
11238822
Article Published Date
: Mar 01, 2001
Study Type
: In Vitro Study
Additional Links
Substances
:
Antioxidant formulas
,
Garlic
,
Vitamin C
,
Vitamin E
Diseases
:
Anemia: Sickle Cell
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Alpha lipoic acid and vitamin C prevent LDL oxidation and oxidant stress in endothelial cells.
Feb 01, 2008
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2008 Feb;309(1-2):125-32. Epub 2007 Nov 16. PMID:
18026819
Article Published Date
: Feb 01, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Alpha-Lipoic Acid
,
Vitamin C
Diseases
:
Cholesterol: Oxidation
,
Endothelial Damage
[+]
Antioxidant regeneration is significantly enhanced in these complexes.
Apr 20, 2015
Click here to read the entire abstract
Pubmed Data
: Chem Commun (Camb). 2015 Apr 21 ;51(36):7713-6. PMID:
25851839
Article Published Date
: Apr 20, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Quercetin
,
Vitamin C
,
Vitamin E
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Antioxidant Systems
,
Natural Substance Synergy
[+]
Antioxidant vitamins C, E, β-carotene and B vitamins and related compounds possess the capability to emit solvated electrons.
Mar 31, 2013
Click here to read the entire abstract
Pubmed Data
: Nutrition. 2013 Apr ;29(4):597-604. Epub 2013 Jan 8. PMID:
23306138
Article Published Date
: Mar 31, 2013
Study Type
: Review
Additional Links
Substances
:
B-Carotene
,
Vitamin C
,
Vitamin E
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
B Vitamins
,
Free Radicals
[+]
Antioxidants, like vitamin C, may reduce genotoxicity to oesophageal cells in Barrett's oesophagus. - Article 1
Jan 01, 2007
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2007 Jan;28(1):136-42. Epub 2006 Aug 11. PMID:
16905748
Article Published Date
: Jan 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Barrett Esophagus
[+]
Arginine may play a role in ameliorating scurvy.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Ethnobiol Ethnomed. 2009;5:5. Epub 2009 Feb 2. PMID:
19187550
Article Published Date
: Jan 01, 2009
Study Type
: Review
Additional Links
Substances
:
Arginine
,
Vitamin C
Diseases
:
Scurvy
Pharmacological Actions
:
Nitric Oxide Inhibitor
[+]
Ascorbate could act as an adjuvant therapy for severe sepsis and septic shock.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Crit Care. 2015 ;19(1):418. Epub 2015 Nov 27. PMID:
26612352
Article Published Date
: Dec 31, 2014
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Sepsis
,
Septic Shock
,
Vitamin C Deficiency
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs.
Apr 30, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Chemother Pharmacol. 2011 May ;67(5):1157-66. Epub 2010 Aug 8. PMID:
20694726
Article Published Date
: Apr 30, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
,
Chemotherapeutic Synergy: Docetaxel
[+]
Ascorbate is a critical mediator of the interface between our genomes and our environment.
May 09, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biol Chem. 2013 May 10 ;288(19):13669-74. Epub 2013 Apr 2. PMID:
23548903
Article Published Date
: May 09, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Pharmacological Actions
:
Gene Protective
Additional Keywords
:
Environmental Factors
,
Epigenetic Modification
,
Gene Environment
[+]
Ascorbate may exert significant protection by reducing reactive oxygen species and renal oxidative damage via its antioxidant activity
Jul 06, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Jul 7 ;9(7). Epub 2017 Jul 7. PMID:
28686196
Article Published Date
: Jul 06, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Kidney Diseases
Pharmacological Actions
:
Antioxidants
,
Renoprotective
[+]
Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells.
Feb 29, 2004
Click here to read the entire abstract
Pubmed Data
: Apoptosis. 2004 Mar ;9(2):223-33. PMID:
15004519
Article Published Date
: Feb 29, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antioxidants
,
Chemotherapeutic
,
Cytotoxicity
[+]
Ascorbic acid and β-carotene have an anti-cancer effect against a human hepatocellular carcinoma cell line.
Oct 01, 2011
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2011 Oct ;38(7):4265-72. Epub 2010 Nov 30. PMID:
21116852
Article Published Date
: Oct 01, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
beta-Carotene
,
Vitamin C
Diseases
:
DNA damage
,
Lipid Peroxidation
,
Liver Cancer
Pharmacological Actions
:
Apoptotic
[+]
Ascorbic acid as DNase I inhibitor in prevention of male infertility.
Mar 14, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 Mar 15. Epub 2018 Mar 15. PMID:
29551685
Article Published Date
: Mar 14, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
DNA damage
,
Infertility: Male
Pharmacological Actions
:
Antioxidants
[+]
Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 01 1 ;495(1):433-437. Epub 2017 Nov 9. PMID:
29129689
Article Published Date
: Dec 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Endothelial Dysfunction
,
Sepsis
Pharmacological Actions
:
Antioxidants
[+]
Ascorbic acid attenuates senescence of human osteoarthritic osteoblasts.
Jan 23, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2017 11 24 ;18(12). Epub 2017 Nov 24. PMID:
29186811
Article Published Date
: Jan 23, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Osteoprotective
[+]
Ascorbic acid efficiently protected human chondrocytes against damage induced by H2O2 by regulating multiple regulatory pathways.
Aug 19, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2015 Aug 20. Epub 2015 Aug 20. PMID:
26300283
Article Published Date
: Aug 19, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Osteoarthritis
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
NF-kappaB Inhibitor
[+]
Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells.
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Res. 2012 Jan ;22(1):219-36. Epub 2011 Dec 6. PMID:
22143566
Article Published Date
: Dec 31, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Pharmacological Actions
:
Cardioprotective
Additional Keywords
:
Myocardial Regeneration
[+]
Ascorbic acid has a great therapeutic potential for amyloid disorders.
Mar 26, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2018 Mar 27 ;114:666-678. Epub 2018 Mar 27. PMID:
29596935
Article Published Date
: Mar 26, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Alzheimer's Disease
,
Neurodegenerative Diseases
[+]
Ascorbic acid induces growth inhibition and redifferentiation of human gastric cancer cells through the production of hydrogen peroxide.
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: Biomed Environ Sci. 2006 Oct;19(5):385-91. PMID:
17190193
Article Published Date
: Oct 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Hydrogen Peroxide
,
Vitamin C
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell Differentiation Inducer
[+]
Ascorbic acid induces necrotic cell death through ROS generation, PKC activation, and cytosolic calcium signalling.
May 21, 2016
Click here to read the entire abstract
Pubmed Data
: J Cell Physiol. 2016 May 22. Epub 2016 May 22. PMID:
27211910
Article Published Date
: May 21, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Laryngeal Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Cytotoxic
[+]
Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity.
Apr 11, 2017
Click here to read the entire abstract
Pubmed Data
: Arch Biochem Biophys. 2017 Apr 12 ;621:54-62. Epub 2017 Apr 12. PMID:
28412155
Article Published Date
: Apr 11, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Pharmacological Actions
:
Neuroprotective Agents
[+]
Ascorbic acid prevents zinc oxide nanoparticle-induced intracellular oxidative stress and inflammatory responses.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Toxicol Ind Health. 2017 Jan 1:748233717707361. Epub 2017 Jan 1. PMID:
28854869
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
Problem Substances
:
Nanoparticles
[+]
Ascorbic acid serum levels are reduced in patients with hematological malignancies.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Results Immunol. 2016 ;6:8-10. Epub 2016 Jan 12. PMID:
27014565
Article Published Date
: Dec 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Liver Diseases
,
Vitamin C Deficiency
[+]
Ascorbic acid synergistically potentiates phloxine b-induced photocytotoxicity in human acute promyelocytic leukemia cells.
Mar 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2014 Apr ;28(4):167-73. Epub 2014 Jan 31. PMID:
24488945
Article Published Date
: Mar 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Oxidative Stress
,
Promyelocytic leukemia
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Ascorbic acid, various amino acids and green tea have anti-atherogenic effects.
Mar 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol. 2007 Mar;49(3):140-5. PMID:
17414225
Article Published Date
: Mar 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Amino Acids
,
Green Tea
,
Vitamin C
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Interleukin-6 Downregulation
[+]
Ascorbic decreases hypoxia inducible factor -1 alpha activity and reduce malignant potential in human melanoma.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Feb ;86:502-513. Epub 2016 Dec 23. PMID:
28012930
Article Published Date
: Jan 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Melanoma
Pharmacological Actions
:
Chemotherapeutic
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
Astaxanthin reduces iron-induced oxidative damage.
Oct 19, 2001
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2001 Oct 19;288(1):225-32. PMID:
11594777
Article Published Date
: Oct 19, 2001
Study Type
: In Vitro Study
Additional Links
Substances
:
Astaxanthin
,
beta-Carotene
,
Carotenoids
,
Vitamin C
Diseases
:
Iron Overload
,
Iron Poisoning
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Beta-carotene, curcumin, and ascorbic acid prevent hydrocortisone-induced genotoxicity.
Jan 01, 2002
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):212-23. PMID:
15586444
Article Published Date
: Jan 01, 2002
Study Type
: In Vitro Study
Additional Links
Substances
:
beta-Carotene
,
Curcumin
,
Vitamin C
Diseases
:
Corticosteroid-Induced Toxicity
,
DNA damage
Pharmacological Actions
:
Antimutagenic Agents
,
Antioxidants
,
Cell cycle arrest
,
Genoprotective
Additional Keywords
:
Drug: Hydrocortisone
[+]
Blueberry juice shows similar anti-oxidative or anti-premutagenic activity to vitamin C.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Cancer Prev. 2017 Sep ;22(3):174-181. Epub 2017 Sep 30. PMID:
29018782
Article Published Date
: Aug 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Blueberry
,
Vitamin C
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antimutagenic Agents
,
Antioxidants
[+]
Coffee and vitamin C supplementation could be considered as preventive measures in patients with hyperuricemia and gout.
Dec 01, 2008
Click here to read the entire abstract
Pubmed Data
: Biosci Biotechnol Biochem. 2008 Dec;72(12):3148-57. Epub 2008 Dec 7. PMID:
20035225
Article Published Date
: Dec 01, 2008
Study Type
: Commentary
Additional Links
Substances
:
Coffee
,
Vitamin C
Diseases
:
Gout
,
Hyperuricemia
[+]
Combination therapy with sulindac and vitamin C could be a novel anti-cancer therapeutic strategy for p53 wild type colon cancers.
Jun 19, 2016
Click here to read the entire abstract
Pubmed Data
: Toxicol Lett. 2016 Jun 20. Epub 2016 Jun 20. PMID:
27339904
Article Published Date
: Jun 19, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Combined ascorbic acid and hyperthermic treatment synergistically inhibits ehrlich ascites tumor cell growth and induced apoptosis.
May 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Oncol. 2015 Jun ;37(2):94-9. PMID:
26112934
Article Published Date
: May 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Tumors
Therapeutic Actions
:
Integrative Medicine
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Dose Response
[+]
Combined use of doxycycline and vitamin C could represents a new synthetic-lethal metabolic strategy for eradicating CSCs.
Sep 14, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Sep 15 ;8(40):67269-67286. Epub 2017 Jun 9. PMID:
28978032
Article Published Date
: Sep 14, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Cancers: All
Pharmacological Actions
:
Chemotherapeutic
Additional Keywords
:
Cancer Stem Cells
,
Natural Substance/Drug Synergy
[+]
Curcumin and ascorbic acid exhibit antioxidant and anticarcinogenic properties.
Apr 30, 1992
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 1992 Apr 30;63(3):237-41. PMID:
1576592
Article Published Date
: Apr 30, 1992
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Vitamin C
Diseases
:
Cancers: All
,
DNA damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Chemopreventive
[+]
Curcumin works synergistically with antifungal drugs.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: FEMS Yeast Res. 2010 Aug 1;10(5):570-8. Epub 2010 Apr 23. PMID:
20528949
Article Published Date
: Aug 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Flavonoids
,
Polyphenols
,
Vitamin C
Diseases
:
Candida Infection
Pharmacological Actions
:
Antifungal Agents
,
Antioxidants
,
Apoptotic
Additional Keywords
:
Drug Synergy
[+]
Daily supplementation with 500mg of vitamin C per day for 50 days decreases the 1-year risk of CRPS-I after wrist fracture.
Mar 04, 2017
Click here to read the entire abstract
Pubmed Data
: Orthop Traumatol Surg Res. 2017 Mar 5. Epub 2017 Mar 5. PMID:
28274883
Article Published Date
: Mar 04, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Bone Fractures
,
Complex Regional Pain Syndrome: Type I
Additional Keywords
:
Risk Reduction
[+]
Deficiency of vitamin D and vitamin C could alter the pathogenesis of bronchial asthma.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Bratisl Lek Listy. 2016 ;117(6):305-7. PMID:
27546360
Article Published Date
: Dec 31, 2015
Study Type
: Review
Additional Links
Substances
:
Vitamin C
,
Vitamin D
Diseases
:
Bronchial Asthma
,
Vitamin C Deficiency
,
Vitamin D Deficiency
Additional Keywords
:
Risk Factors
[+]
Dietary supplements and nutraceuticals could help with hypertension.
Mar 18, 2015
Click here to read the entire abstract
Pubmed Data
: High Blood Press Cardiovasc Prev. 2015 Mar 19. Epub 2015 Mar 19. PMID:
25788027
Article Published Date
: Mar 18, 2015
Study Type
: Review
Additional Links
Substances
:
Arginine
,
Beet
,
Cocoa
,
Coenzyme Q10
,
Garlic: Aged
,
Melatonin
,
Potassium
,
Vitamin C
Diseases
:
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
[+]
Diuretics used to treat chronic congestive heart failure may cause deficiencies in magnesium, thimaine and vitamin c, worsening the conditiion.
Jan 01, 1999
Click here to read the entire abstract
Pubmed Data
: Cardiology. 1999;92(3):156-61. PMID:
10754345
Article Published Date
: Jan 01, 1999
Study Type
: Commentary
Additional Links
Substances
:
Magnesium
,
Thiamine (B-1)
,
Vitamin C
Diseases
:
Congestive Heart Failure
Additional Keywords
:
Problems with Diuretics
[+]
Doxycycline and vitamin C may represent a new synthetic lethal drug combination for eradicating cancer stem cells.
Jun 08, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Jun 9. Epub 2017 Jun 9. PMID:
28622697
Article Published Date
: Jun 08, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
,
Vitamin C
Diseases
:
Breast Cancer
,
Breast Cancer Stem Cells
,
Cancers: All
Pharmacological Actions
:
Antiproliferative
Additional Keywords
:
Cancer Stem Cells
,
Natural Substance/Drug Synergy
[+]
Emerging evidence provides data in support of the administration of vitamin C in addition to standard therapy to ameliorate sepsis and septic shock.
Sep 17, 2017
Click here to read the entire abstract
Pubmed Data
: J Crit Care. 2017 Sep 18 ;43:230-234. Epub 2017 Sep 18. PMID:
28934705
Article Published Date
: Sep 17, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Sepsis
,
Septic Shock
[+]
Exogenous ascorbic acid improves defence responses of sunflower exposed to multiple stresses.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Acta Biol Hung. 2017 Sep ;68(3):290-299. PMID:
28901807
Article Published Date
: Aug 31, 2017
Study Type
: Plant Study
Additional Links
Substances
:
Vitamin C
[+]
Food synergies for improving bioavailability of micronutrients from plant foods.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Food Chem. 2018 Jan 1 ;238:180-185. Epub 2016 Sep 19. PMID:
28867091
Article Published Date
: Dec 31, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin A
,
Vitamin C
,
Vitamin D
,
Zinc
Additional Keywords
:
Natural Substance Synergy
[+]
Gold nanoparticles could enhance the antioxidant activity of vitamin C.
Apr 08, 2016
Click here to read the entire abstract
Pubmed Data
: J Photochem Photobiol B. 2016 Apr 9 ;161:266-272. Epub 2016 Apr 9. PMID:
27288656
Article Published Date
: Apr 08, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Gold (nanoparticles)
,
Vitamin C
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Bioenhancer
[+]
Grifola frondosa and Vitamin C had a synergistic apoptotic effect on SMMC-7721 liver cancer cells.
May 04, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Integr Cancer Ther. 2016 May 5. Epub 2016 May 5. PMID:
27151580
Article Published Date
: May 04, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Maitake Mushroom
,
Vitamin C
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
Additional Keywords
:
Natural Substance Synergy
[+]
Herbs provide protection against harmful UV radiation due to their antioxidant activity.
Jul 01, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacogn Rev. 2011 Jul ;5(10):164-73. PMID:
22279374
Article Published Date
: Jul 01, 2011
Study Type
: Review
Additional Links
Substances
:
Coconut oil: topical
,
Flavonoids
,
Krameria lappacea: topical
,
Olive oil: topical
,
Peanut oil: topical
,
Sesame oil: topical
,
Vitamin C
,
Vitamin E
Diseases
:
Skin Diseases: Photo-Aging
,
Sunburn
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Antioxidants
,
Photoprotective
[+]
High dose of ascorbic acid induces cell death in mesothelioma cells.
Apr 02, 2010
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2010 Apr 2;394(2):249-53. Epub 2010 Feb 19. PMID:
20171954
Article Published Date
: Apr 02, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Mesothelioma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
High dose of vitamin C in combination with 5-FU chemotherapy enhances the chemoresponsiveness of cancer cells.
Apr 30, 2003
Click here to read the entire abstract
Pubmed Data
: In Vivo. 2003 May-Jun;17(3):289-92. PMID:
12929582
Article Published Date
: Apr 30, 2003
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Cancers: Multi-Drug Resistant
,
Liver Cancer
,
Lymphoma
Pharmacological Actions
:
Antiproliferative
,
Chemosensitizer
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
[+]
High tumor tissue ascorbate level could limit the expression of HIF-1α and its targets in thyroid lesions.
Oct 29, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Biomed Sci. 2017 Oct 30 ;24(1):83. Epub 2017 Oct 30. PMID:
29084538
Article Published Date
: Oct 29, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Thyroid Cancer
Pharmacological Actions
:
Chemotherapeutic
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
High-dose vitamin C selectively induces DNA damage on cancer stem cells rather than differentiated tumor cells.
Jan 25, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 02 26 ;497(1):347-353. Epub 2018 Feb 9. PMID:
29432735
Article Published Date
: Jan 25, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Cancers: All
Additional Keywords
:
Cancer Stem Cells
,
Cancers: All
,
Selective Cytotoxicity
,
Vitamin C
[+]
Highl doses of ascorbate up regulated 32 miRNAs 4-fold, mainly involved in tumor suppression and drug resistance.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Oncol. 2014 ;4:227. Epub 2014 Aug 25. PMID:
25202679
Article Published Date
: Dec 31, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Melanoma
,
Melanoma: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Cell cycle arrest
,
MicroRNA modulator
Additional Keywords
:
DNA Methyltransferase
,
Epigenetic Modification
[+]
In vitro treatment of HSV-2 with ascorbate-Cu(II) is not only able to inactivate the virus, but also suggested that the viral particles induced a protective response against herpes encephalitis.
Sep 14, 2004
Click here to read the entire abstract
Pubmed Data
: J Virol Methods. 2004 Sep 15 ;120(2):161-5. PMID:
15288958
Article Published Date
: Sep 14, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Encephalitis: Herpes Simplex
,
Herpes Simplex Virus Type 2
Pharmacological Actions
:
Antiviral Agents
Additional Keywords
:
Significant Treatment Outcome
[+]
In-vitro evidence supports a critical role for vitamin C in cellular mechanisms relevant to the pathophysiology of sepsis.
Nov 14, 2017
Click here to read the entire abstract
Pubmed Data
: Curr Opin Anaesthesiol. 2017 Nov 15. Epub 2017 Nov 15. PMID:
29176375
Article Published Date
: Nov 14, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Sepsis
[+]
Influence of temperature and brewing time of nettle infusions on vitamin C content.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Rocz Panstw Zakl Hig. 2016 ;67(4):367-371. PMID:
27925706
Article Published Date
: Dec 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Nettle
,
Vitamin C
Additional Keywords
:
Herbal Teas
[+]
L-ascorbic acid exhibited an additive effect on cell proliferation in all gefitinib-sensitive and gefitinib-resistant cell lines.
Jun 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2017 Jul ;14(1):276-282. Epub 2017 May 2. PMID:
28693165
Article Published Date
: Jun 30, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Cancers: Drug Resistant
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemosensitizer
,
Chemotherapeutic
Additional Keywords
:
Chemotherapeutic Synergy: Gefitinib
[+]
Limited vitamin C availability resulted in a functional type II cell but a cell more sensitive to oxidant-induced injury.
Sep 30, 1997
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Physiol Lung Cell Mol Physiol. 1997 Oct 1 ;273(4):L782-L788. PMID:
29585842
Article Published Date
: Sep 30, 1997
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Oxidative Stress
,
Vitamin C Deficiency
Pharmacological Actions
:
Antioxidants
[+]
Low dose ascorbic acid inactivates the ERK phosphorylation pathway, which inhibited HL 60 cell differentiation.
Sep 30, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2015 Oct ;12(4):5501-7. Epub 2015 Jul 20. PMID:
26238149
Article Published Date
: Sep 30, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Promyelocytic leukemia
Pharmacological Actions
:
Antiproliferative
[+]
Low levels of vitamin C (ascorbic acid) may contribute to the formation of cholesterol gallstones.
Feb 01, 1993
Click here to read the entire abstract
Pubmed Data
: Med Hypotheses. 1993 Feb;40(2):81-4. PMID:
8455479
Article Published Date
: Feb 01, 1993
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Gallstones
[+]
Low red blood cell vitamin C concentrations induce red blood cell fragility.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: EBioMedicine. 2015 Nov ;2(11):1735-50. Epub 2015 Oct 3. PMID:
26870799
Article Published Date
: Oct 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Diabetes Mellitus: Type 2: Prevention
,
Hyperglycemia
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Risk Reduction
[+]
Low tumor tissue ascorbate levels were associated with high HIF-1 activation and tumor growth.
Jul 14, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Res. 2010 Jul 15 ;70(14):5749-58. Epub 2010 Aug 22. PMID:
20570889
Article Published Date
: Jul 14, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Endometrial Cancer
,
Vitamin C Deficiency
Pharmacological Actions
:
Hypoxia-inducible factor-1 (HIF-1) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Microwave cooking results in the decrease of a broad range of nutrients, including vitamin C and phenolic compounds.
Nov 28, 2007
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2007 Nov 28;55(24):10001-7. Epub 2007 Nov 3. PMID:
17979232
Article Published Date
: Nov 28, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Nutritional Deficiencies
Anti Therapeutic Actions
:
Microwave Cooking
[+]
Natural immunomodulators represent a potentially important way of blocking or partly restoring the immunosuppression of toxins such as mercury.
Oct 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Toxins (Basel). 2012 Nov ;4(11):1301-8. Epub 2012 Nov 9. PMID:
23202317
Article Published Date
: Oct 31, 2012
Study Type
: Review
Additional Links
Substances
:
Resveratrol
,
Stilbenes
,
Vitamin C
Pharmacological Actions
:
Cytoprotective
Problem Substances
:
Thimerosal
Adverse Pharmacological Actions
:
Immunotoxic
[+]
Oral sodium bicarbonate and intravenous DHA may have the potential to blunt the aggressiveness of certain cancers.
Sep 30, 2013
Click here to read the entire abstract
Pubmed Data
: Med Hypotheses. 2013 Oct ;81(4):664-70. Epub 2013 Aug 2. PMID:
23916956
Article Published Date
: Sep 30, 2013
Study Type
: Commentary
Additional Links
Substances
:
Sodium Bicarbonate
,
Vitamin C
Diseases
:
Breast Cancer
,
Cancers: All
Pharmacological Actions
:
Anti-metastatic
[+]
Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease.
Feb 01, 1998
Click here to read the entire abstract
Pubmed Data
: Mol Chem Neuropathol. 1998 Feb;33(2):139-48. PMID:
9565971
Article Published Date
: Feb 01, 1998
Study Type
: Commentary
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Alzheimer's Disease
,
Cholesterol: Oxidation
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Neuroprotective Agents
Additional Keywords
:
Diseases that are Linked
[+]
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
Sep 20, 2005
Click here to read the entire abstract
Pubmed Data
: Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9. Epub 2005 Sep 12. PMID:
16157892
Article Published Date
: Sep 20, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Hydrogen Peroxide
,
Vitamin C
Diseases
:
Cancers: All
[+]
Pharmacological concentrations of AA induce anti-proliferative, cytotoxic and genotoxic effects on three colon cancer cell lines under study.
Apr 05, 2016
Click here to read the entire abstract
Pubmed Data
: Eur J Cell Biol. 2016 Apr 6. Epub 2016 Apr 6. PMID:
27083410
Article Published Date
: Apr 05, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Cytotoxic
Additional Keywords
:
Selective Cytotoxicity
[+]
Pharmacological doses of ascorbate (vitamin C) induces oxidative stress which kills breast cancer cells.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Int J Toxicol. 2009 Jan-Feb;28(1):33-42. PMID:
19482829
Article Published Date
: Jan 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Breast Cancer
[+]
Phytochemicals and micronutrients may enhance efficacy of doxycycline in combating all the morphological forms of studied Borrelia sp.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Biol Sci. 2016 ;12(9):1093-103. Epub 2016 Jul 22. PMID:
27570483
Article Published Date
: Dec 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Baicalein
,
Iodine
,
Luteolin
,
Rosmarinic acid
,
Vitamin C
,
Vitamin D
Diseases
:
Lyme Borreliosis
,
Lyme Disease
Pharmacological Actions
:
Antimicrobial
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Potassium potentiated the anti-tumoral effects of vitamin C in breast cancer cells in vitro.
May 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2016 Jun ;11(6):4224-4234. Epub 2016 Apr 27. PMID:
27313770
Article Published Date
: May 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Potassium
,
Vitamin C
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
NF-kappaB Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Resveratrol exhibits antioxidant properties.
Apr 01, 2010
Click here to read the entire abstract
Pubmed Data
: Toxicol In Vitro. 2010 Apr;24(3):916-20. Epub 2009 Nov 27. PMID:
19945524
Article Published Date
: Apr 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol
,
Stilbenes
,
Vitamin C
Diseases
:
DNA damage
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Resveratrol, vitamin C and/or vitamin E are effective in protecting cells against oxidative damage.
Apr 14, 1997
Click here to read the entire abstract
Pubmed Data
: Neuroreport. 1997 Apr 14;8(6):1499-502. PMID:
9172162
Article Published Date
: Apr 14, 1997
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol
,
Stilbenes
,
Vitamin C
,
Vitamin E
Diseases
:
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Review of essential nutrients for bone health and their availability in the average North American diet.
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Open Orthop J. 2012 ;6:143-9. Epub 2012 Apr 5. PMID:
22523525
Article Published Date
: Dec 31, 2011
Study Type
: Review
Additional Links
Substances
:
Boron
,
Calcium
,
Vitamin C
,
Vitamin D
,
Vitamin K
Diseases
:
Mineral Imbalances
[+]
Review: vitamin C requirements in surgical patients are higher.
Aug 01, 2009
Click here to read the entire abstract
Pubmed Data
: Toxicol In Vitro. 2009 Aug;23(5):763-71. Epub 2009 Apr 9. PMID:
20689415
Article Published Date
: Aug 01, 2009
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Oxidative Stress
,
Surgery: All
[+]
Salvianolic acid B, a compound found within red sage, and vitamin C work synergistically to enhance embyronic stem cell differentiation into cardiomyocytes.
Oct 02, 2009
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2009 Oct 2;387(4):723-8. Epub 2009 Jul 28. PMID:
19643081
Article Published Date
: Oct 02, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Red Sage
,
Vitamin C
Diseases
:
Myocardial Infarction
,
Stem Cell Transplant
Additional Keywords
:
Drug Synergy
,
Myocardial Regeneration
[+]
Selected antioxidants could be used to treat endometriosis by reducing oxidative stress.
Aug 09, 2015
Click here to read the entire abstract
Pubmed Data
: Expert Opin Ther Targets. 2015 Aug 10:1-18. Epub 2015 Aug 10. PMID:
26256952
Article Published Date
: Aug 09, 2015
Study Type
: Review
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Melatonin
,
Resveratrol
,
Vitamin C
,
Vitamin E
,
Xanthohumol
Diseases
:
Endometriosis
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Silencing HIF-1α induces TET2 expression and augments ascorbic acid induced 5-hydroxymethylation of DNA in human metastatic melanoma cells.
Jun 07, 2017
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2017 Jun 8. Epub 2017 Jun 8. PMID:
28601635
Article Published Date
: Jun 07, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Melanoma: Metastatic
Additional Keywords
:
Reactivation Of Tumor Suppressor Gene
[+]
Six dietary constituents inhibit nicotine-DNA adduct formation.
Jul 01, 2003
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2003 Jul;41(7):1045-50. PMID:
12804663
Article Published Date
: Jul 01, 2003
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Garlic
,
Grape Seed Extract
,
Tea
,
Vitamin C
,
Vitamin E
Diseases
:
DNA damage
,
Nicotine/Tobacco Toxicity
Pharmacological Actions
:
Genoprotective
Additional Keywords
:
Plant Extracts
[+]
Skin aging can be decelerated with a nutrient complex containing soy, tomato, grape seed, and white tea extracts, and sodium ascorbate (vitamin C), tocopherol acetate (vitamin E), zinc, and Biomarine complex.
Apr 01, 1997
Click here to read the entire abstract
Pubmed Data
: Gastroenterol Hepatol. 1997 Apr;20(4):172-4. PMID:
17028931
Article Published Date
: Apr 01, 1997
Study Type
: In Vitro Study
Additional Links
Substances
:
Grape Seed Extract
,
Soy
,
Tomato
,
Vitamin C
,
Vitamin E
,
White Tea
,
Zinc
Diseases
:
Aging
,
Aging Skin
[+]
Sprouting buckwheat triggers a variety of nutritional changes increasing hypocholesterolemic, hypotriglyceridemic, and antioxidative activities.
Feb 27, 2008
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2008 Feb 27;56(4):1216-23. Epub 2008 Jan 24. PMID:
18217700
Article Published Date
: Feb 27, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Buckwheat
,
Flavonoids
,
Polyphenols
,
Quercetin
,
Rutin
,
Sprouts
,
Vitamin C
Diseases
:
High Cholesterol
,
Hyperlipidemia
,
Triglycerides: Elevated
Pharmacological Actions
:
Antioxidants
,
Hypolipidemic
Additional Keywords
:
Plant Extracts
[+]
Storage of human corenea with anti-oxidative vitamins prior to transplantation may prolong the survival of corneal grafts.
Jun 01, 2005
Click here to read the entire abstract
Pubmed Data
: Cell Tissue Res. 2005 Jun;320(3):465-75. Epub 2005 Apr 19. PMID:
15838641
Article Published Date
: Jun 01, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
Diseases
:
Organ Transplantation: Cornea
Pharmacological Actions
:
Antioxidants
,
Apoptotic
[+]
Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions.
Jun 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Blood Transfus. 2014 Jul ;12(3):376-87. Epub 2014 Jun 5. PMID:
25074788
Article Published Date
: Jun 30, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
NAC (N-acetyl-L-cysteine)
,
Vitamin C
Diseases
:
Blood Storage Problems
Pharmacological Actions
:
Antioxidants
[+]
Strategies to reduce oxidative stress in glaucoma patients.
Jan 04, 2017
Click here to read the entire abstract
Pubmed Data
: Curr Neuropharmacol. 2017 07 5. Epub 2017 Jul 5. PMID:
28677495
Article Published Date
: Jan 04, 2017
Study Type
: Review
Additional Links
Substances
:
Coenzyme Q10
,
Ginkgo biloba
,
Green Tea
,
Melatonin
,
Omega-3 Fatty Acids
,
Omega-6 Fatty Acids
,
Vitamin B-3 (Niacin)
,
Vitamin C
,
Vitamin E
Diseases
:
Glaucoma
Pharmacological Actions
:
Antioxidants
[+]
Sub-apoptotic dosages of pro-oxidant vitamin cocktails sensitize human melanoma cells to NK cell lysis.
Sep 04, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2015 Sep 5. Epub 2015 Sep 5. PMID:
26427039
Article Published Date
: Sep 04, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
,
Vitamin E
,
Vitamin K
Diseases
:
Melanoma
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Natural Substance Synergy
[+]
Supplementation with vitamin C can boost the outcome of DNMTi treatment of cancer cells in vitro.
Jan 12, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Proc Natl Acad Sci U S A. 2016 09 13 ;113(37):10238-44. Epub 2016 Aug 29. PMID:
27573823
Article Published Date
: Jan 12, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Cancers: All
Pharmacological Actions
:
Chemotherapeutic
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Synergistic effects were observed between rifampin or isoniazid and vitamin C against all tested strains.
Nov 18, 2015
Click here to read the entire abstract
Pubmed Data
: Microb Pathog. 2015 Nov 19. Epub 2015 Nov 19. PMID:
26602814
Article Published Date
: Nov 18, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Mycobacterium tuberculosis
,
Staphylococcus aureus infection
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Synergistic enhancement of topotecan-induced cell death by ascorbic acid in human breast MCF-7 tumor cells.
Oct 23, 2017
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2017 Oct 24 ;113:406-412. Epub 2017 Oct 24. PMID:
29079526
Article Published Date
: Oct 23, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
The antioxidants glutathione and ascorbic acid increase the survival of dopaminergic grafts in the rat model of Parkinson's disease
Dec 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Chem Neuroanat. 2004 Dec;28(4):253-64. PMID:
15531136
Article Published Date
: Dec 01, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Glutathione
,
Vitamin C
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
The antiviral property of vitamin C may be due to the fact that it inhibits the viral enzyme neuraminidase.
Jan 01, 1978
Click here to read the entire abstract
Pubmed Data
: Med Hypotheses. 1978 Jan-Feb;4(1):40-3. PMID:
634178
Article Published Date
: Jan 01, 1978
Study Type
: Commentary
Additional Links
Substances
:
Vitamin C
Diseases
:
Human Influenza
,
Influenza A
Pharmacological Actions
:
Antiviral Agents
,
Neurominidase Inhibitor
[+]
The bioavailability of ascorbate has a profound impact on the epigenome.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Annu Rev Nutr. 2015 ;35:545-64. Epub 2015 May 6. PMID:
25974700
Article Published Date
: Dec 31, 2014
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Additional Keywords
:
Epigenetic Modification
[+]
The broad spectrum of actions of VitC highlights its relevance for stem cell biology in both physiology and disease.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Stem Cells Int. 2017 ;2017:8936156. Epub 2017 Apr 20. PMID:
28512473
Article Published Date
: Dec 31, 2016
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Additional Keywords
:
Mesenchymal Stem Cells
[+]
The combination of polydatin and vitamin C has the ability to enhance the myocardial protective effects.
Nov 27, 2016
Click here to read the entire abstract
Pubmed Data
: Fundam Clin Pharmacol. 2016 Nov 28. Epub 2016 Nov 28. PMID:
27891661
Article Published Date
: Nov 27, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Chemoprotective Agents
Additional Keywords
:
Chemotherapy
,
Chemotherapy-Induced Toxicity: Doxorubicin
,
Natural Substance Synergy
,
Vitamin C
[+]
The combination of vitamin K3 and vitamin C has synergic activity against three forms of Trypanosoma cruzi.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(12):e0144033. Epub 2015 Dec 7. PMID:
26641473
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
,
Vitamin K
Diseases
:
Chagas Disease
Pharmacological Actions
:
Antiprotozoal Agents
Additional Keywords
:
Natural Substance Synergy
[+]
The current study suggests that a high dose of vitamin C may induce gastric cancer cell apoptosis.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Oncol Lett. 2016 Nov ;12(5):4270-4276. Epub 2016 Sep 29. PMID:
27895802
Article Published Date
: Oct 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Apoptotic
Additional Keywords
:
alternative cancer treatments
,
Cancer
,
gastric cancer
,
Vitamin C
[+]
The extent of benzene-induced toxicity may be dependent on the nutritional status of the person exposed.
May 01, 1980
Click here to read the entire abstract
Pubmed Data
: Med Hypotheses. 1980 May;6(5):535-44. PMID:
7412643
Article Published Date
: May 01, 1980
Study Type
: Commentary
Additional Links
Substances
:
B-complex
,
Methionine
,
Selenium
,
Vitamin C
Diseases
:
Benzene Toxicity
,
Leukemia
[+]
The ketogenic diet and vitamin C have a potential role in the management of advanced differentiated thyroid cancer.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Oncol. 2017 ;7:160. Epub 2017 Jul 25. PMID:
28791253
Article Published Date
: Dec 31, 2016
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Thyroid Cancer
Therapeutic Actions
:
Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions
:
Chemotherapeutic
[+]
The present review illustrates the effect of vitamin D and ascorbic acid intake on preventing cancer.
Oct 18, 2015
Click here to read the entire abstract
Pubmed Data
: Crit Rev Food Sci Nutr. 2015 Oct 19:0. Epub 2015 Oct 19. PMID:
26479551
Article Published Date
: Oct 18, 2015
Study Type
: Review
Additional Links
Substances
:
Vitamin C
,
Vitamin D
Diseases
:
Cancers: All
Pharmacological Actions
:
Chemopreventive
[+]
The results of this study show the anti-proliferative effects of ascorbic acid against leukemic cells.
Dec 31, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Anticancer Res. 2007 Jan-Feb;27(1A):289-98. PMID:
17352246
Article Published Date
: Dec 31, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Acute T cell Leukemias
,
Human T-cell leukemia virus type I (HTLV-I)
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
The results of this study suggests a positive role for ascorbic acid in regulating HIF-1α in melanoma.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Cancer. 2015 ;15(1):867. Epub 2015 Nov 7. PMID:
26547841
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Melanoma
,
Melanoma: Metastasis
Pharmacological Actions
:
Anti-metastatic
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
These data indicate that ascorbic acid has the potential to modify TET function in lymphoma and enhance chemosensitivity.
Jul 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Blood Cancer J. 2017 Jul 21 ;7(7):e587. Epub 2017 Jul 21. PMID:
28731456
Article Published Date
: Jul 20, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Lymphoma
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
These findings show that chronic alcohol exposure inhibits the ascorbic acid uptake of pancreatic acinar cells.
Jun 30, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Physiol Cell Physiol. 2016 Jul 1 ;311(1):C129-35. Epub 2016 Apr 27. PMID:
27122159
Article Published Date
: Jun 30, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Alcohol Toxicity
Additional Keywords
:
Epigenetic Modification
[+]
These findings together indicate an epigenetic role of vitamin C in midbrain DA neuron development.
Mar 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Stem Cells. 2015 Apr ;33(4):1320-32. PMID:
25535150
Article Published Date
: Mar 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Parkinson's Disease
Additional Keywords
:
Epigenetic Modification
[+]
These results identified some genes which were downregulated by vitamin C and curcumin.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2017 ;8:38. Epub 2017 Feb 2. PMID:
28210221
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
Vitamin C
Diseases
:
Cancers: Drug Resistant
,
Colon Cancer
,
Glioblastoma
,
Leukemia
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Gene Expression Regulation
[+]
This review aims to provide an overview of the links between oxidative stress, vascular inflammation, endothelial dysfunction and cardiovascular risk factors.
Apr 10, 2015
Click here to read the entire abstract
Pubmed Data
: Vascul Pharmacol. 2015 Apr 11. Epub 2015 Apr 11. PMID:
25869516
Article Published Date
: Apr 10, 2015
Study Type
: Review
Additional Links
Substances
:
Antioxidants: Fat Soluble
,
Polyphenols
,
Vitamin C
,
Vitamin E
Diseases
:
Cardiovascular Diseases
,
Endothelial Dysfunction
,
Inflammation
Pharmacological Actions
:
Antioxidants
[+]
This review examines the functional importance of vitamin C as it relates to the development and maintenance of bone tissues.
Sep 10, 2015
Click here to read the entire abstract
Pubmed Data
: J Bone Miner Res. 2015 Sep 11. Epub 2015 Sep 11. PMID:
26358868
Article Published Date
: Sep 10, 2015
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Bone Diseases
,
Bone Fractures
,
Osteoporosis
Additional Keywords
:
Epigenetic Modification
,
Gene Expression Regulation
[+]
This review will focus on the potential of vitamin C to optimize the outcome of epigenetic therapy in cancer patients.
Oct 31, 2017
Click here to read the entire abstract
Pubmed Data
: Semin Cancer Biol. 2017 Nov 1. Epub 2017 Nov 1. PMID:
29102482
Article Published Date
: Oct 31, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Cancers: All
Pharmacological Actions
:
Chemotherapeutic
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
This reviews the beneficial effects of ascorbic acid for the management of psychiatric disorders.
Jun 08, 2017
Click here to read the entire abstract
Pubmed Data
: CNS Drugs. 2017 Jun 9. Epub 2017 Jun 9. PMID:
28600627
Article Published Date
: Jun 08, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin C
Diseases
:
Psychiatric Disorders
[+]
This synergistic action of vitamins with the antibiotics can be used as a tool to treat multiple drug resistant super bugs.
Feb 01, 2018
Click here to read the entire abstract
Pubmed Data
: J Glob Antimicrob Resist. 2018 Feb 2. Epub 2018 Feb 2. PMID:
29408383
Article Published Date
: Feb 01, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Riboflavin (Vitamin B-2)
,
Thiamine (B-1)
,
Vitamin A
,
Vitamin B-12
,
Vitamin B-6
,
Vitamin C
,
Vitamin D
,
Vitamin K
Diseases
:
Acinetobacter baumannii infection
,
Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions
:
Antimicrobial
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Trichostatin A works synergistically with curcumin to inhibit human leukemia cells.
Aug 01, 2006
Click here to read the entire abstract
Pubmed Data
: Pharmazie. 2006 Aug;61(8):710-6. PMID:
16964716
Article Published Date
: Aug 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
NAC (N-acetyl-L-cysteine)
,
Vitamin C
Diseases
:
Promyelocytic leukemia
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
Additional Keywords
:
Drug Synergy
[+]
Vitamin A and C cosupplementation synergistically enhances reprogramming of differentiated cells to the naive state.
May 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Epigenomics. 2017 Jun ;9(6):863-871. Epub 2017 May 30. PMID:
28554227
Article Published Date
: May 31, 2017
Study Type
: Review
Additional Links
Substances
:
Vitamin A
,
Vitamin C
Diseases
:
Cancers: All
Pharmacological Actions
:
Regenerative
Additional Keywords
:
Cancers: All
,
Epigenetic Modification
,
Regenerative
,
Vitamin A
,
Vitamin C
[+]
Vitamin B2 is a promising sensitizer for improving the efficacy of vitamin C based cancer chemoprevention and chemotherapy.
Jul 12, 2015
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2015 Jul 13. Epub 2015 Jul 13. PMID:
26165392
Article Published Date
: Jul 12, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Riboflavin (Vitamin B-2)
,
Vitamin C
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
,
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Chemopreventive
,
Chemosensitizer
Additional Keywords
:
Natural Substance Synergy
[+]
Vitamin C (ascorbic acid) reverses chemoresistance of human non-small lung-cancer cells.
Aug 01, 1994
Click here to read the entire abstract
Pubmed Data
: Biochem J. 1994 Aug 1;301 ( Pt 3):759-64. PMID:
7914401
Article Published Date
: Aug 01, 1994
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Cancers: Multi-Drug Resistant
,
Lung Cancer
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Vitamin C (dehydroascorbic acid) and mixtures of vitamin E and beta-carotene possess antitumor properties upon radiation and increase the chemotherapeutic activity of mitomycin C.
Nov 01, 2004
Click here to read the entire abstract
Pubmed Data
: In Vivo. 2004 Nov-Dec;18(6):795-8. PMID:
15646822
Article Published Date
: Nov 01, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
beta-Carotene
,
Vitamin C
,
Vitamin E
Diseases
:
Cancers: All
,
Tumors
Pharmacological Actions
:
Chemosensitizer
,
Radiosensitizer
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Vitamin C administration may provide a potentially effective technique in periodontal therapy.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2015 Jan ;11(1):242-8. Epub 2014 Oct 21. PMID:
25333298
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Hydrogen Peroxide Induced Toxicity
,
Oxidative Stress
,
Periodontal Diseases
,
Periodontitis
Pharmacological Actions
:
Antioxidants
[+]
Vitamin C and B6 can reduce benzo(a)pyrene-induced DNA methylation alterations and may be used as chemopreventive agents.
Nov 24, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Nov 25. Epub 2016 Nov 25. PMID:
27901495
Article Published Date
: Nov 24, 2016
Study Type
: In Vitro Study, Review
Additional Links
Substances
:
Vitamin B-6
,
Vitamin C
Diseases
:
Air Pollution Linked Toxicity
,
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Additional Keywords
:
DNA Methylation
,
Hypomethylation
Problem Substances
:
Benzo(a)pyrene
[+]
Vitamin C and E have a protective against against B(a)P-induced genotoxicity in human lymphocytes.
Jan 01, 1999
Click here to read the entire abstract
Pubmed Data
: J Environ Pathol Toxicol Oncol. 1999;18(3):159-67. PMID:
15281228
Article Published Date
: Jan 01, 1999
Study Type
: In Vitro Study
Additional Links
Substances
:
Vitamin C
,