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Vitamin K

Vitamin K

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Article Count - 65
Cumulative Knowledge - 562

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Quick Summary: Current access displays 2 out of 56 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Osteoporosis	230	25	Log in \| Sign up
Bone Fractures	106	9	Log in \| Sign up

Quick Summary: Current access displays 2 out of 14 associated Pharmacological Actions

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Cardioprotective	40	2	Log in \| Sign up
Anticarcinogenic Agents	10	1	Log in \| Sign up

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View the Evidence: Substances

Prolonged intake of fermented soybean (natto) diets containing vitamin K2 (menaquinone-7) prevents bone loss in ovariectomized rats.

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Pubmed Data : J Bone Miner Metab. 2000;18(2):71-6. PMID: 10701161

Article Published Date : Jan 01, 2000

Study Type : Human Study

Additional Links

Substances : Natto : CK(121) : AC(21), Vitamin K : CK(550) : AC(65)

Diseases : Osteopenia : CK(207) : AC(41), Osteoporosis : CK(1171) : AC(205)

Supplemention of vitamin K antagonists with 100 mcg of vitamin K improves stability of anticoagulant therapy and reduces side effects.

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Pubmed Data : J Thromb Haemost. 2007 Oct;5(10):2043-8. Epub 2007 Jul 31. PMID: 17666020

Article Published Date : Oct 01, 2007

Study Type : Human Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65)

Diseases : Clotting : CK(177) : AC(36), Thrombosis : CK(657) : AC(74)

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268), Vitamin K Myth : CK(10) : AC(1)

The consumption of vitamin K2 rich fermented soybean food products may contribute to the relatively lower fracture risk of Japanese women.

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Pubmed Data : Nutrition. 2001 Apr;17(4):315-21. PMID: 11369171

Article Published Date : Apr 01, 2001

Study Type : Human Study

Additional Links

Substances : Fermented Foods and Beverages : CK(670) : AC(133), Natto : CK(121) : AC(21), Soy : CK(1672) : AC(347), Vitamin K : CK(550) : AC(65), Vitamin K2: Menaquinone-7 : CK(88) : AC(14)

Diseases : Osteoporosis : CK(1171) : AC(205)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

There is an inverse association between the intake of menaquinones and prostate cancer.

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Pubmed Data : Am J Clin Nutr. 2008 Apr;87(4):985-92. PMID: 18400723

Article Published Date : Apr 01, 2008

Study Type : Human Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65), Vitamin K2 : CK(277) : AC(32), Vitamin K2: Menaquinones (MK-4-14) : CK(149) : AC(19)

Diseases : Prostate Cancer: Prevention : CK(155) : AC(16)

Vitamin D3 and vitamin K2 have a therapeutic effect on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.

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Pubmed Data : J Nutr. 2008 May;138(5):954-63. PMID: 11180916

Article Published Date : May 01, 2008

Study Type : Human Study

Additional Links

Substances : Vitamin D : CK(1682) : AC(238), Vitamin K : CK(550) : AC(65), Vitamin K2: Menaquinone-7 : CK(88) : AC(14)

Diseases : Osteoporosis : CK(1171) : AC(205)

Vitamin K supplementation in postmenopausal women wih osteopenia appears to protect against bone fractures and cancers.

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Pubmed Data : PLoS Med. 2008 Oct 14;5(10):e196. PMID: 18922041

Article Published Date : Oct 14, 2008

Study Type : Human Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65)

Diseases : Bone Fractures : CK(1610) : AC(69), Cancers: All : CK(9062) : AC(2869), Osteopenia : CK(207) : AC(41)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382)

Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Vitamin K supplementation inhibits the progression of coronary artery calcification in oldern men and women.

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Pubmed Data : Am J Clin Nutr. 2009 Jun;89(6):1799-807. Epub 2009 Apr 22. PMID: 19386744

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65)

Diseases : Arterial Calcification : CK(154) : AC(25), Coronary Artery Disease : CK(1305) : AC(136), Ectopic Calcification : CK(792) : AC(113)

Vitamin K2 (MK-4) may be beneficial in the maintenance of bone health in postmenopausal women.

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Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15-21. PMID: 19352059

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Substances : Vitamin K2 : CK(277) : AC(32), Vitamin K2: (MK-4) : CK(21) : AC(3)

Diseases : Bone Fractures : CK(1610) : AC(69), Osteoporosis : CK(1171) : AC(205), Postmenopausal Disorders : CK(285) : AC(35)

Vitamin K2 appears effective in the treatment of myelodysplastic syndrome - Article 1.

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Pubmed Data : Rinsho Ketsueki. 2002 Feb;43(2):117-21. PMID: 11925874

Article Published Date : Feb 01, 2002

Study Type : Human Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65)

Diseases : Myelodysplastic Syndrome : CK(198) : AC(18), Myelodysplastic Syndromes : CK(188) : AC(17)

Vitamin K2 appears effective in the treatment of myelodysplastic syndrome - Article 2

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Pubmed Data : Leukemia. 1998 Sep;12(9):1392-7. PMID: 9737687

Article Published Date : Sep 01, 1998

Study Type : Human Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65)

Diseases : Myelodysplastic Syndrome : CK(198) : AC(18), Myelodysplastic Syndromes : CK(188) : AC(17)

Vitamin K2 improves disease activity in rheumatoid arthritis.

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Pubmed Data : Mod Rheumatol. 2012 Nov 6. Epub 2012 Nov 6. PMID: 23124653

Article Published Date : Nov 05, 2012

Study Type : Human Study

Additional Links

Substances : Vitamin K2 : CK(277) : AC(32)

Diseases : C-Reactive Protein : CK(819) : AC(74), Rheumatoid Arthritis : CK(424) : AC(64)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Matrix metalloproteinase-3 (MMP-3) inhibitor : CK(26) : AC(6)

Vitamin K2 improves hip bone geometry and bone strength indices in postmenopausal women.

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Pubmed Data : Osteoporos Int. 2007 Jul;18(7):963-72. Epub 2007 Feb 8. PMID: 17287908

Article Published Date : Jul 01, 2007

Study Type : Human Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65)

Diseases : Osteoporosis : CK(1171) : AC(205)

Vitamin K2 inhibits glucorticoid-induced bone loss.

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Pubmed Data : J Bone Miner Metab. 2005;23(1):41-7. PMID: 15616893

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65)

Diseases : Osteoporosis: Steroid-Induced : CK(28) : AC(6)

Vitamin K2 plus Vitamin D3 are therapeutic for the treatment of anemia and thyrombocytopenia associated wtih low/intermediate myelodysplastic syndrome.

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Pubmed Data : Leuk Res. 2010 Sep;34(9):1151-7. Epub 2010 Jun 1. PMID: 20569983

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : Vitamin D : CK(1682) : AC(238), Vitamin K : CK(550) : AC(65), Vitamin K2 : CK(277) : AC(32)

Diseases : Anemia: Aplastic : CK(30) : AC(3), Myelodysplastic Syndrome : CK(198) : AC(18), Thrombocytopenia : CK(800) : AC(25)

Vitamin K2 treatment in combination with calcium supplementation increases bone mineral density in the treatment of postmenopausal osteoporosis.

Click here to read the entire abstract

Pubmed Data : J Obstet Gynaecol Res. 2006 Apr;32(2):230-4. PMID: 16594930

Article Published Date : Apr 01, 2006

Study Type : Human Study

Additional Links

Substances : Vitamin K2 : CK(277) : AC(32), Vitamin K2: (MK-4) : CK(21) : AC(3)

Diseases : Osteoporosis : CK(1171) : AC(205)

vitamin Vitamin (2) works synergistically with alendronate on improving both osteocalcin carboxylation and BMD of femoral neck in postmenopausal women with osteoporosis.

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Pubmed Data : J Bone Miner Metab. 2008;26(3):260-4. Epub 2008 May 11. PMID: 18470667

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Vitamin K2 : CK(277) : AC(32)

Diseases : Bone Fractures : CK(1610) : AC(69), Osteoporosis : CK(1171) : AC(205)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

Vitamins K1 and D have a beneficial effect on the elastic properties of the arterial vessel wall.

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Pubmed Data : Thromb Haemost. 2004 Feb;91(2):373-80. PMID: 14961167

Article Published Date : Feb 01, 2004

Study Type : Human Study

Additional Links

Substances : Vitamin D : CK(1682) : AC(238), Vitamin K : CK(550) : AC(65)

Diseases : Arterial Hardening: Elasticity : CK(128) : AC(17), Arteriosclerosis : CK(2154) : AC(123)

Vitamins K2 and D3 have a protective effect on prednisolone-induced loss of bone mineral density in the lumbar spine.

Click here to read the entire abstract

Pubmed Data : Am J Kidney Dis. 2004 Jan;43(1):53-60. PMID: 14712427

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Substances : Vitamin D : CK(1682) : AC(238), Vitamin K : CK(550) : AC(65), Vitamin K2: Menaquinone-7 : CK(88) : AC(14)

Diseases : Corticosteroid-Induced Toxicity : CK(78) : AC(17), Osteoporosis: Steroid-Induced : CK(28) : AC(6)

Additional Keywords : Drug: Prednisolone : CK(20) : AC(2)

Evidence shows that deficiency of Vit. K may contribute to the development of cardiovascular plaque (increased intima media thickness) and supplementation may reverse or forestall the process of calcification.

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Pubmed Data : Blood. 2007 Apr 1;109(7):2823-31. PMID: 17138823

Article Published Date : Apr 01, 2007

Study Type : Animal Study

Additional Links

Substances : Vitamin K : CK(550) : AC(65)

Diseases : Arterial Calcification : CK(154) : AC(25), Arterial Plaque : CK(439) : AC(20)

Menaquinone-7, a form of vitamin K2, has a stimulatory effect on bone formation in the femoral tissues of elderly female rats in vitro.

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Pubmed Data : Int J Mol Med. 2002 Dec;10(6):729-33. PMID: 12429999

Article Published Date : Dec 01, 2002

Study Type : Animal Study

Additional Links

Substances : Genistein : CK(450) : AC(174), Vitamin K : CK(550) : AC(65), Vitamin K2: Menaquinone-7 : CK(88) : AC(14)

Diseases : Aging : CK(1351) : AC(369), Osteopenia : CK(207) : AC(41), Osteoporosis : CK(1171) : AC(205)

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