Furan Toxicity https://greenmedinfo.com/taxonomy/term/10821/all en A variety of vegetables reduce the absorption and enhance excretion of dioxin and furan toxins. https://greenmedinfo.com/article/variety-vegetables-reduce-absorption-and-enhance-excretion-dioxin-and-furan-to PMID:  Fukuoka Igaku Zasshi. 1999 May;90(5):171-83. PMID: 10396873 Abstract Title:  [Effect of green vegetable on digestive tract absorption of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in rats]. Abstract:  The effect green vegetable on fecal excretion of polychlorinated dibenzo-p-dioxin (PCDD) congeners and polychlorinated dibenzofuran (PCDF) congeners was examined in male rats. The rats were administered 10% vegetable diets or a basal diet containing 0.2 ml of the causal rice-bran oil of Yusho that had occurred in the Southwest part of Japan in 1968 and kept on the same diet for five days. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with Komatsuna, Mitsuba, Spinach and Perilla were 7.6-11.6 and 6.5-9.4 times higher, respectively, than that in the group fed with a basal diet. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with Kale, Chinese chive, Shungiku, Chingentsuai, Green lettus and Sweet pepper were 3.3-4.8 and 4.3-4.5 times higher, respectively, than that in the basal group. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with Chinese cabbage, Broccoli, Onion, Welsh onion, Cabbage and Celery were 1.6-3.0 and 1.2-1.3 times higher, respectively, than that in the basal group. A correlation between Chllophyll consumption and fecal excretion of PCDD and PCDF congeners was highly significant (p &lt; 0.01). Next, we investigated the fecal excretion of PCDD and PCDF congeners from day 8 to day 35 in rats administered with 0.5 ml of the rice oil. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with Perilla, Kale and Spinach were 3.1-4.9 and 3.0-3.6 times higner, respectively, than that in the basal group. The presents results suggest that the green vegetables might be useful in treatment of humans exposed to PCDD and PCDF congeners. https://greenmedinfo.com/article/variety-vegetables-reduce-absorption-and-enhance-excretion-dioxin-and-furan-to#comments Broccoli Cabbage Chives Dioxin Toxicity Furan Toxicity Kale Onion Perilla Spinach Vegetables: All Animal Study Fri, 08 Jan 2010 03:38:46 +0000 greenmedinfo 48704 at https://greenmedinfo.com Matcha green tea was able to lower gastrointestinal tract absorption of PCB, PCDF and PCDD in this animal study. https://greenmedinfo.com/article/matcha-green-tea-was-able-lower-gastrointestinal-tract-absorption-pcb-pcdf-and PMID:  Fukuoka Igaku Zasshi. 1997 May ;88(5):162-8. PMID: 9194336 Abstract Title:  [Effect of green tea (matcha) on gastrointestinal tract absorption of polychlorinated biphenyls, polychlorinated dibenzofurans and polychlorinated dibenzo-p-dioxins in rats]. Abstract:  This paper presents the liver distribution and fecal excretion of polychlorinated biphenyls (PCB), polychlorinated dibenzofurans (PCDF) congeners and polychlorinated dibenzo-p-dioxins (PCDD) congeners, in male rats fed with powdered green tea (matcha). The rats were given a treatment diet containing 10% matcha for the first five days. Then, the animals were administered 4 g of 10% matcha diet containing 0.5 ml of the casual rice-bran oil of Yusho that had occurred in the Southwest part of Japan in 1968 and kept on the same diet for another five days. The fecal excretion of PCB, PCDF and PCDD in the group fed with 10% matcha were 4.4, 2.4-9.1 and 2.5-4.7 times higher (p https://greenmedinfo.com/article/matcha-green-tea-was-able-lower-gastrointestinal-tract-absorption-pcb-pcdf-and#comments Dioxin Toxicity Furan Toxicity Green Tea Detoxifier Polychlorinated biphenyls (PCBs) Macha Animal Study Wed, 18 Feb 2015 21:11:35 +0000 greenmedinfo 116309 at https://greenmedinfo.com Propolis exhibits good hepatoprotective and antioxidant potential against furan-induced hepatocellular damage. https://greenmedinfo.com/article/propolis-exhibits-good-hepatoprotective-and-antioxidant-potential-against-fura PMID:  J Vet Res. 2019 Sep ;63(3):423-431. Epub 2019 Sep 13. PMID: 31572824 Abstract Title:  Protective Role of Propolis on Low and High Dose Furan-induced Hepatotoxicity and Oxidative Stress in Rats. Abstract:  Introduction: The aim of this study was to evaluate potential protective effects of propolis on furan-induced hepatic damage by assessing the levels of malondialdehyde (MDA) and reduced glutathione (GSH), antioxidant enzyme activities, and histopathological changes in the liver.Material and Methods: Albino Wistar rats were divided into six groups: a control, propolis-treated (100 mg/kg b.w./day), low-dose furan-treated (furan-L group; 2 mg/kg b.w./day), high-dose furan-treated (furan-H group; 16 mg/kg b.w./day), furan-L+propolis treated, and furan-H+propolis treated group. Propolis and furan were applied by gavage; propolis for 8 days, and furan for 20 days in furan-L groups and 10 days in furan-H groups.Results: While MDA levels were elevated in furan-treated groups, levels of GSH and activities of antioxidant enzymes decreased (p<p><a href="https://greenmedinfo.com/article/propolis-exhibits-good-hepatoprotective-and-antioxidant-potential-against-fura" target="_blank">read more</a></p> https://greenmedinfo.com/article/propolis-exhibits-good-hepatoprotective-and-antioxidant-potential-against-fura#comments Bee Propolis Chemically-Induced Liver Damage Furan Toxicity Oxidative Stress Antioxidants Furan Hepatoprotective Animal Study Mon, 09 Dec 2019 21:14:15 +0000 greenmedinfo 204286 at https://greenmedinfo.com Protective effect of Spirulina platensis against physiological, ultrastructural and cell proliferation damage induced by furan in kidney and liver. https://greenmedinfo.com/article/protective-effect-spirulina-platensis-against-physiological-ultrastructural--0 PMID:  Ecotoxicol Environ Saf. 2020 Jan 31 ;192:110256. Epub 2020 Jan 31. PMID: 32014724 Abstract Title:  Protective effect of Spirulina platensis against physiological, ultrastructural and cell proliferation damage induced by furan in kidney and liver of rat. Abstract:  The modulatory role of the Spirulina platensis (SP) against furan-induced (FU) hepatic and renal damage was assessed in this study. For achieving this, sixty rats were distributed into six groups: control group, SP-administered group (300 mg/kg b.wt orally for 28 days), a FU-intoxicated group (16 mg/kg b.wt, orally, daily for 28 days), protective co-treated group SP/F (administered SP 300 mg/kg b.wt, one week before, and concurrently with FU intoxication), therapeutic co-treated group FU/SP (administered SP 300 mg/kg b.wt, one week after FU intoxication for 28 days) and protective/therapeutic co-treated group SP/FU/SP (administered SP one week before and after, concurrently with FU intoxication). Subsequently, the biochemical responses and the histology of hepatic and renal tissues in treated rats were assessed. The results indicated that FU intoxication induced a significant hepato- and nephropathy represented by the elevation in the values of tissue injury biomarkers and reduction in protein levels. Histologically, a wide range of morphological, cytotoxic, inflammatory, and vascular alterations as well as downregulation in the immunoexpression of the proliferating cell nuclear antigen (PCNA) and the proliferation-associated nuclear antigen (Ki-67) were induced by FU intoxication. Oral SP administration, particularly in the protective/therapeutic co-treated group, markedly supressed the serum levels of the tissue injury biomarkers, diminished the inflammatory response, restored the cytotoxic alterations, upregulated the immunoexpression of PCNA and Ki-67, and restored the perturbed morphology of the hepatic and renal tissues. In conclusion, the obtained data demonstrated that SP co-administration elicitsboth protective and therapeutic potential against the FU-induced hepato- and nephropathy. <p><a href="https://greenmedinfo.com/article/protective-effect-spirulina-platensis-against-physiological-ultrastructural--0" target="_blank">read more</a></p> https://greenmedinfo.com/article/protective-effect-spirulina-platensis-against-physiological-ultrastructural--0#comments Chemically-Induced Liver Damage Furan Toxicity Kidney Damage: Chemically-Induced Spirulina Furan Hepatoprotective Renoprotective Animal Study Wed, 12 Feb 2020 17:45:52 +0000 greenmedinfo 211432 at https://greenmedinfo.com Quercetin possesses antioxidant protective activity against furan induced oxidative damage and stimulates the immune function. https://greenmedinfo.com/article/quercetin-possesses-antioxidant-protective-activity-against-furan-induced-oxid PMID:  Environ Sci Pollut Res Int. 2016 Nov 26. Epub 2016 Nov 26. PMID: 27889890 Abstract Title:  Protective role of quercetin against hematotoxic and immunotoxic effects of furan in rats. Abstract:  Furan (Fu) is a liver carcinogen produced during heating process of food and concerns a public health problem. The current study was undertaken to evaluate the protective role of quercetin (Que) on Fu-induced hematological, immunological, and histopathological alterations in rats. Fifty male Sprague Dawley rats were divided into five equal groups. Group I (Cont) received distilled water, group II (CO) received corn oil, group III (Que) received Que at 50 mg/kg BW, group IV (Fu) received Fu at 16 mg/kg BW, and group V received Que + Fu simultaneously; all groups gavaged daily for 30 days. Our results revealed that Fu administration significantly elevated RBCs, Hb, PCV, WBCs, lymphocytes, and granulocytes and reduced phagocytic percent (Ph%) andindex (PhI). Fu decreased the serum total protein, albumin, globulin, IgM, IgG, and IL4, with a significant increase in the TNFα and 8-OHdG. Moreover, it decreased the GSH content and GST activity and increased the MDA levels in the splenic tissue. Histopathologically, Fu led to a moderate depletion in the lymphoid cells and weak immunostaining of CD20 antigen of few lymphocytes appeared in the spleen. Meanwhile, Que co-administration ameliorated the altered hematological parameters and improved the Ph% and PhI. It modulated the serum biochemical parameters and immunoglobulins. Moreover, it decreased lipid peroxidation and enhanced antioxidant status in the spleen. The results indicated that Que possesses antioxidant protective activity against Fu-induced oxidative damage and stimulates the immune function. <p><a href="https://greenmedinfo.com/article/quercetin-possesses-antioxidant-protective-activity-against-furan-induced-oxid" target="_blank">read more</a></p> https://greenmedinfo.com/article/quercetin-possesses-antioxidant-protective-activity-against-furan-induced-oxid#comments Furan Toxicity Quercetin Antioxidants Furan Immunomodulatory Animal Study Tue, 06 Dec 2016 17:03:11 +0000 greenmedinfo 139969 at https://greenmedinfo.com