Muscular Atrophy: Spinal https://greenmedinfo.com/taxonomy/term/1116/all en Bulbospinal Neuronopathy https://greenmedinfo.com/disease/bulbospinal-neuronopathy <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/NervousSystem_28.jpg?1472072238" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_pixologic&#039;&gt;pixologic / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Muscular Atrophy: Spinal Tue, 14 Apr 2009 07:15:00 +0000 greenmedinfo 19261 at https://greenmedinfo.com Kennedy Syndrome https://greenmedinfo.com/disease/kennedy-syndrome <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="338" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Genes_144.jpg?1478886506" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_nobeastsofierce&#039;&gt;nobeastsofierce / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Muscular Atrophy: Spinal Tue, 14 Apr 2009 07:20:38 +0000 greenmedinfo 20682 at https://greenmedinfo.com Loganin can be therefore a valuable complementary candidate for treatment of neuromuscular diseases. https://greenmedinfo.com/article/loganin-can-be-therefore-valuable-complementary-candidate-treatment-neuromuscu PMID:  Pharmacol Res. 2016 09 ;111:58-75. Epub 2016 May 27. PMID: 27241020 Abstract Title:  Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy. Abstract:  Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by motor neurons degeneration and muscular atrophy. There is no effective SMA treatment. Loganin is a botanical candidate with anti-inflammatory, anti-oxidant, glucose-lowering and anti-diabetic nephropathy activities. The aim of this study is to investigate the potential protective effects of loganin on SMA using two cellular models, SMN-deficient NSC34 cells and SMA patient fibroblasts, and an animal disease model, SMAΔ7 mice. In SMN-deficient NSC34 cells, loganin increased cell viability, neurite length, and expressions of SMN, Gemin2, SMN-Gemin2 complex, p-Akt, p-GSK-3β, p-CREB, BDNF and Bcl-2. However, both AG1024 (IGF-1 R antagonist) and IGF-1 R siRNA attenuated the protective effects of loganin on SMN level and cell viability in SMN-deficient NSC34 cells. In SMA patient fibroblasts, loganin up-regulated levels of SMN, FL-SMN2, and Gemins, increased numbers of SMN-containing nuclear gems, modulated splicing factors, and up-regulated p-Akt. Furthermore, in the brain, spinal cord and gastrocnemius muscle of SMAΔ7 mice, loganin up-regulated the expressions of SMN and p-Akt. Results from righting reflex and hind-limb suspension tests indicated loganin improved muscle strength of SMAΔ7 mice; moreover, loganin activated Akt/mTOR signal and inhibited atrogin-1/MuRF-1 signal in gastrocnemius muscle ofSMAΔ7 mice. Loganin also increased body weight, but the average lifespan of loganin (20mg/kg/day)-treated SMA mice was 16.80±0.73 days, while saline-treated SMA mice was 10.91±0.96 days. In conclusion, the present results demonstrate that loganin provides benefits to SMA therapeutics via improving SMN restoration, muscle strength and body weight. IGF-1 plays an important role in loganin neuroprotection. Loganin can be therefore a valuable complementary candidate for treatment of neuromuscular diseases via regulation of muscle protein synthesis and neuroprotection. <p><a href="https://greenmedinfo.com/article/loganin-can-be-therefore-valuable-complementary-candidate-treatment-neuromuscu" target="_blank">read more</a></p> https://greenmedinfo.com/article/loganin-can-be-therefore-valuable-complementary-candidate-treatment-neuromuscu#comments Dogwood Muscular Atrophy: Spinal Anti-Apoptotic Neuroprotective Agents Animal Study Fri, 26 Feb 2021 15:52:55 +0000 greenmedinfo 235163 at https://greenmedinfo.com Oculopharyngeal Spinal Muscular Atrophy https://greenmedinfo.com/disease/oculopharyngeal-spinal-muscular-atrophy <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="360" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Spine_19.jpg?1483227297" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_pixologic&#039;&gt;pixologic / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Muscular Atrophy: Spinal Tue, 14 Apr 2009 07:23:21 +0000 greenmedinfo 21290 at https://greenmedinfo.com Progressive Muscular Atrophy https://greenmedinfo.com/disease/progressive-muscular-atrophy <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="354" alt="" src="//cdn.greenmedinfo.com/sites/default/files/MuscularSystem_60.jpg?1485458852" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_elenabsl&#039;&gt;elenabsl / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Muscular Atrophy: Spinal Tue, 14 Apr 2009 07:24:59 +0000 greenmedinfo 21688 at https://greenmedinfo.com Scapuloperoneal Form of Spinal Muscular Atrophy https://greenmedinfo.com/disease/scapuloperoneal-form-spinal-muscular-atrophy <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="360" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Spine_22.jpg?1486417991" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_pixologic&#039;&gt;pixologic / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Muscular Atrophy: Spinal Tue, 14 Apr 2009 07:25:56 +0000 greenmedinfo 21930 at https://greenmedinfo.com