Diabetes: Low Immune Function https://greenmedinfo.com/taxonomy/term/11547/all en Laughter up-regulates the genes related to natural killer cell activity in diabetes. https://greenmedinfo.com/article/laughter-regulates-genes-related-natural-killer-cell-activity-diabetes PMID:  Biomed Res. 2007 Dec;28(6):281-5. PMID: 18202517 Abstract Title:  Laughter up-regulates the genes related to NK cell activity in diabetes. Abstract:  To elucidate the sustainable effects of laughter on gene expression, we recruited type 2 diabetic patients who were in-patient for receiving self-management education and examined time-dependent regulation for gene expression by laughter. Two-day experiment was performed. On one day, the patients watched comic video and laughed together with hospital staffs. On the other day, they participated in an inpatient diabetes educational program. Blood samples were collected before and 1.5, 4 h after watching comic video or spending lecture time, and changes in gene expression were comprehensively analyzed by microarray technique. Of the 41,000 genes analyzed, the laughter relatively up-regulated 39 genes, among which, 27 genes were relatively increased in the expression for all the observation period after watching comic video. By functional classification of these genes, 14 genes were found to be related to natural killer cell activity. No genes were included that are directly involved in blood glucose regulation, though successive suppression of postprandial blood glucose levels was observed. These results suggest that the laughter influences the expression of many genes classified into immune responses, and may contribute to amelioration of postprandial blood glucose elevation through a modulation of NK cell activity caused by up-regulation of relating genes. https://greenmedinfo.com/article/laughter-regulates-genes-related-natural-killer-cell-activity-diabetes#comments Diabetes: Low Immune Function Immunomodulatory Laughter/Humor Human Study Sun, 10 Jan 2010 15:14:34 +0000 greenmedinfo 48888 at https://greenmedinfo.com Lutein prevents the effect of high glucose levels on immune system cells in vivo and in vitro. https://greenmedinfo.com/article/lutein-prevents-effect-high-glucose-levels-immune-system-cells-vivo-and-vitro PMID:  J Physiol Biochem. 2008 Jun;64(2):149-57. PMID: 19043985 Abstract Title:  Lutein prevents the effect of high glucose levels on immune system cells in vivo and in vitro. Abstract:  Diabetic patients present an increased susceptibility to frequent and protracted infections. The recognition of an impaired immune system has implications for the diagnosis, treatment and outcome of infections. Nuclear Factor kappa B (NF-kappaB) is a redox sensitive transcription factor involved in immune response, cell proliferation and apoptosis that has been associated to the development of diabetic complications. Herein we study the effects of high glucose on oxidative stress markers (malondialdeyde and glutathione contents) and NF-kappaB activity in U937 cells (a human promonocytic cell line). Furtheremore effects of lutein treatment in lymphocytes from diabetic rats was studied. The results show that high glucose induces oxidative stress in immune system cells, both in vitro and in vivo, as well as an increase in their NF-kappaB activity. It is also showed that lutein, a natural antioxidant without hypoglycemiant properties, is able to prevent all the alterations observed. Thus, this study confirms the role of oxidative stress in the immune system impairment described in diabetes, and allows the proposal of antioxidants for the clinical management of the diabetes-associated susceptibility to infections. https://greenmedinfo.com/article/lutein-prevents-effect-high-glucose-levels-immune-system-cells-vivo-and-vitro#comments Diabetes: Low Immune Function Hyperglycemia Immune Disorders: Low Immune Function Lutein Oxidative Stress Antioxidants NF-kappaB Inhibitor Animal Study Thu, 04 Nov 2010 21:05:14 +0000 greenmedinfo 58400 at https://greenmedinfo.com Regular Tai Chi Chuan exercise improves T cell helper function of patients with type 2 diabetes mellitus. https://greenmedinfo.com/article/regular-tai-chi-chuan-exercise-improves-t-cell-helper-function-patients-type-2 PMID:  Br J Sports Med. 2009 Nov;43(11):845-50. Epub 2008 Apr 2. PMID: 18385192 Abstract Title:  Regular Tai Chi Chuan exercise improves T cell helper function of patients with type 2 diabetes mellitus with an increase in T-bet transcription factor and IL-12 production. Abstract:  BACKGROUND: Exercise has been shown to be beneficial in the treatment of type 2 diabetes mellitus (DM); its benefit to immune function, however, remains to be determined. OBJECTIVE: This study investigated the effect of a 12-week course of Tai Chi Chuan (TCC) exercise on T cell helper (Th) reaction in patients with type 2 DM. METHODS: A case-control study was performed in 30 pairs of patients with type 2 DM and normal age-matched adults. Fasting blood glucose, HbA1c, mediators (interleukin (IL)-12, IL-4 and transforming growth factor (TGF)beta) and transcription factors (T-bet, GATA-3 and FoxP3) of Th1/Th2/T regulatory (Treg) reaction were measured before and after a 12-week TCC exercise programme. RESULTS: Fasting glucose and HbA1c levels in the patients with type 2 DM were significantly higher than in age-matched controls before exercise. After TCC exercise, HbA1c levels in patients with type 2 DM significantly decreased (7.59 (0.32)% vs 7.16 (0.22)%; p = 0.047) and blood levels of IL-12 increased significantly (5.96 (1.10) vs 12.96 (3.07); p = 0.035). To study the molecular Th1/Th2/Treg reaction, patients with type 2 DM were found to have lower T-bet but not GATA-3 or FoxP3 expression than normal controls before TCC exercise. After the 12-week TCC exercise T-bet expression significantly increased in patients with type 2 DM. CONCLUSIONS: A 12-week TCC exercise programme decreases HbA1c levels along with an increase in the Th1 reaction. A combination of TCC with medication may provide an even better improvement in both metabolism and immunity of patients with type 2 DM. https://greenmedinfo.com/article/regular-tai-chi-chuan-exercise-improves-t-cell-helper-function-patients-type-2#comments Diabetes Mellitus: Type 2 Diabetes: Low Immune Function Human Study Thu, 14 Jan 2010 23:20:20 +0000 greenmedinfo 49198 at https://greenmedinfo.com