Celiac Disease https://greenmedinfo.com/taxonomy/term/1207/all en Consumption of oats does not induce TG2 autoantibody production at mucosal level in children with celiac disease. https://greenmedinfo.com/article/consumption-oats-does-not-induce-tg2-autoantibody-production-mucosal-level-chi PMID:  BMC Res Notes. 2008 Jun 27;1:37. PMID: 19412007 Abstract Title:  Oats do not induce systemic or mucosal autoantibody response in children with coeliac disease. Abstract:  OBJECTIVES: A gluten-free diet omitting wheat, rye, and barley is the only effective treatment for coeliac disease. The necessity of excluding oats from the diet has remained controversial. We studied the toxicity of oats in children with coeliac disease during a 2-year follow-up by investigating jejunal transglutaminase 2 (TG2)-targeted IgA-class autoantibody deposits, a potentially more sensitive disease marker than serum antibodies or conventional histology. PATIENTS AND METHODS: Twenty-three coeliac children in remission were randomized to undergo oat or gluten challenge with wheat, rye, barley, and oats. When jejunal histological relapse was evident after gluten challenge, patients excluded wheat, rye, and barley but continued with oats. Mucosal morphology and TG2-targeted autoantibody deposits were studied in jejunal biopsies taken at baseline and after 6 and 24 months. Furthermore, serum IgA-class TG2 antibodies were measured. RESULTS: At baseline, serum TG2 antibodies were negative in all 23 patients, but 7 of them had minor mucosal deposits. In the oats group, there was no significant change in the intensity of the deposits within 2 years. In contrast, during the gluten challenge, the intensity of the deposits clearly increased and decreased again when wheat, rye, and barley were excluded but consumption of oats was continued; this was in line with serum autoantibodies. The intensity of the mucosal deposits correlated well with both villous morphology and serum autoantibody levels. CONCLUSIONS: Consumption of oats does not induce TG2 autoantibody production at mucosal level in children with coeliac disease. Measurement of small-intestinal mucosal autoantibody deposits is suitable for monitoring treatment in coeliac patients. https://greenmedinfo.com/article/consumption-oats-does-not-induce-tg2-autoantibody-production-mucosal-level-chi#comments Celiac Disease Oats Human Study Sun, 07 Nov 2010 13:06:30 +0000 greenmedinfo 58474 at https://greenmedinfo.com "Frequency of celiac disease and irritable bowel syndrome coexistance and its influence on the disease course" https://greenmedinfo.com/article/frequency-celiac-disease-and-irritable-bowel-syndrome-coexistance-and-its-infl PMID:  Przegl Lek. 2009 ;66(3):126-9. PMID: 19689036 Abstract Title:  [Frequency of celiac disease and irritable bowel syndrome coexistance and its influence on the disease course]. Abstract:  Celiac disease is increasingly recognized autoimmune enteropathy caused by a permanent gluten intolerance. Gluten is the main storage protein of wheat, in genetically predisposed individuals. Celiac disease risk in first degree relatives is about 10%. Diarrhea and changes of bowel movement, observed as well in celiac disease as in IBS, may lead to misdiagnosis of IBS basing on the Rome criteria or may be associated with coexistence of both diseases. The aim of the study was to assess the celiac disease prevalence in patients with irritable bowel syndrome. The study group comprised 200 patients (120 women and 80 men) aged 18-78 years (mean: 46.7 years) with diarrhoeal form of irritable bowel syndrome (IBS), according to the Rome criteria II. At the beginning and after a three month period anti tissue transglutaminase antibodies (IgA tTG) were estimated. Gastroscopy with biopsy where performed in those with IgA tTG titre above 1/200. 40 patients were immunologically positive and 14 of them have histopathologically proven celiac disease. In the group of patients with detected celiac disease, gluten free diet was applied besides the treatment with trimebutin or mebewerin, recommended for IBS. After 6 months the decrease of IgA tTG titre in the serum was observed. In 5 of these patients IgA tTG level was negative. It was associated with the significant decrease of clinical symptoms, such as diarrhea and flatulence. The remaining symptoms, such as abdominal pain, feeling of incomplete defecation demanded continuation of IBS treatment. With regard to often atypical celiac disease symptoms--adult active searching should be performed to differentiate from irritable bowel syndrome. https://greenmedinfo.com/article/frequency-celiac-disease-and-irritable-bowel-syndrome-coexistance-and-its-infl#comments Celiac Disease Irritable Bowel Syndrome Dietary Modification: Wheat/Gluten Free Wheat Human Study Fri, 23 Mar 2012 04:34:20 +0000 greenmedinfo 73550 at https://greenmedinfo.com "Glutenfree" Fallacy Reveals Widespread Grain Addiction https://greenmedinfo.com/blog/glutenfree-fallacy-reveals-widespread-grain-addiction <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2018<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="glutenfree_fallacy" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/greenmedinfo/images/12871809_s.jpg" /></p> <p><em><strong><span style="font-size:18px;"><span style="font-family:verdana,geneva,sans-serif;">When names become labels, their meanings often become misleading or are forgotten</span></span></strong></em></p> <p><span style="font-size:14px;"><span style="font-family:verdana,geneva,sans-serif;">In my blog <strong><a href="/blog/naming-convention-when-celiac-becomes-disease" rel="dofollow" target="_blank">Naming Convention: When Celiac becomes a Disease</a></strong> I discussed the controversies and confusions surrounding the definitions of gluten sensitivity and celiac disease. I also detailed why I prefer to use the terms non-celiac and/or celiac gluten sensitivity.</span></span></p><p><a href="https://greenmedinfo.com/blog/glutenfree-fallacy-reveals-widespread-grain-addiction" target="_blank">read more</a></p> https://greenmedinfo.com/blog/glutenfree-fallacy-reveals-widespread-grain-addiction#comments Celiac Disease Food Allergies: Wheat Gluten Sensitivity Hemorrhoids Irritable Bowel Syndrome Dietary Modification: Wheat/Gluten Free Gliadin Wheat Wheat Germ Agglutinin (WGA) Sat, 21 Apr 2012 13:03:13 +0000 ndocroth 74443 at https://greenmedinfo.com 2-5% of celiac disease does not respond to a gluten-free diet and may lead to the development of enteropathy-associated T-cell lymphoma. https://greenmedinfo.com/article/2-5-celiac-disease-does-not-respond-gluten-free-diet-and-may-lead-development- PMID:  Nat Rev Gastroenterol Hepatol. 2010 Apr;7(4):204-13. Epub 2010 Mar 9. PMID: 20212505 Abstract Title:  The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Abstract:  Celiac disease is a gluten-sensitive enteropathy that affects people of all ages worldwide. This disease has emerged as a major health-care problem, as advances in diagnostic and screening methods have revealed its global prevalence. Environmental factors such as gluten introduction at childhood, infectious agents and socioeconomic features, as well as the presence of HLA-DQ2 and/or HLA-DQ8 haplotypes or genetic variations in several non-HLA genes contribute to the development of celiac disease. Growing insight into the variable clinical and histopathological presentation features of this disease has opened new perspectives for future research. A strict life-long gluten-free diet is the only safe and efficient available treatment, yet it results in a social burden. Alternative treatment modalities focus on modification of dietary components, enzymatic degradation of gluten, inhibition of intestinal permeability and modulation of the immune response. A small group of patients with celiac disease (2-5%), however, fail to improve clinically and histologically upon elimination of dietary gluten. This complication is referred to as refractory celiac disease, and imposes a serious risk of developing a virtually lethal enteropathy-associated T-cell lymphoma. https://greenmedinfo.com/article/2-5-celiac-disease-does-not-respond-gluten-free-diet-and-may-lead-development-#comments Celiac Disease Celiac Disease: Refractory Lymphoma Lymphoma: T-cell Diseases that are Linked Human Study Wed, 10 Nov 2010 00:58:49 +0000 greenmedinfo 58551 at https://greenmedinfo.com 5 Foods That Can Cause Depression https://greenmedinfo.com/blog/5-foods-can-cause-depression <p class="rtecenter"><br /> <span style="font-size:12px;"><span style="font-family:verdana,geneva,sans-serif;"><strong>Originally published on <a href="https://kellybroganmd.com/5-foods-that-can-cause-depression/" rel="dofollow" target="_blank">www.kellybroganmd.com</a></strong></span></span></p> <p class="rtecenter"><span style="font-size:14px;"><span style="font-family:verdana,geneva,sans-serif;"><iframe allow="accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" frameborder="0" height="315" src="https://www.youtube.com/embed/879rgUbp1FY" width="560"></iframe></span></span></p> <p><em><span style="font-size: 18px;"><strong><span style="font-family: verdana, geneva, sans-serif;">The food you eat directly affects your brain</span></strong></span></em></p><p><a href="https://greenmedinfo.com/blog/5-foods-can-cause-depression" target="_blank">read more</a></p> https://greenmedinfo.com/blog/5-foods-can-cause-depression#comments ADHD Anxiety Celiac Disease Depression Gluten Sensitivity Headache Inflammation Leaky Gut Syndrome Seizures Artificial Sweeteners Blood Sugar Problems Gluten GMOs Health Guide: Farm/Pharma Face Off Health Guide: Food-Brain Connection Health Guide: Herbs and Traditional Knowledge Health Guides: Healing Foods Roundup Sugar Depression mental health natural health Sat, 02 Feb 2019 20:58:45 +0000 GMI reporter 178877 at https://greenmedinfo.com 6 months of a gluten free diet result in improvements in celiac disease patients with hypertransaminasemia liver involvement https://greenmedinfo.com/article/6-months-gluten-free-diet-result-improvements-celiac-disease-patients-hypertra PMID:  Scand J Gastroenterol. 2012 Apr 19. Epub 2012 Apr 19. PMID: 22512436 Abstract Title:  Transient elastography in patients with celiac disease: A noninvasive method to detect liver involvement associated with celiac disease. Abstract:  Abstract Background. Liver involvement in celiac disease (CD) is clinically relevant and could require specific treatment in addition to gluten-free diet (GFD). Transient elastography (TE), a noninvasive tool for assessing liver stiffness (LS), has widely been reported as an accurate surrogate marker of liver fibrosis. Aims. To prospectively identify celiac patients with liver involvement by TE and to assess the effect of GFD. Material and methods. Ninety-five histologically confirmed CD patients (24 newly diagnosed) were consecutively evaluated by TE and compared with 146 patients with chronic hepatitis C (HCV) and 54 healthy subjects. Results. LS ranged between 2.8 and 6.7 kPa (median 4.9) in healthy subjects, defining 6.9 kPa as the upper reference limit (2 SD above the mean levels). TE was above 6.9 kPa in 10 (10.5%) CD patients. Median TE values resulted significantly higher in CD patients with hypertransaminasemia than those without [6.1 vs. 4.2 kPa (p&lt;0.01)]. Among the 24 newly diagnosed patients with CD, median TE values declined from 4.4 to 4 kPa, after 6 months of GFD, resulting below 6.9 kPa in 100% of the patients. Conclusions. A subset of CD patients with hypertransaminasemia showed liver involvement by TE. Accordingly, based on its accuracy in predicting liver fibrosis, TE could be used to identify those CD patients suitable for liver biopsy. https://greenmedinfo.com/article/6-months-gluten-free-diet-result-improvements-celiac-disease-patients-hypertra#comments Celiac Disease Hypertransaminasemia Liver Fibrosis Dietary Modification: Wheat/Gluten Free Gluten Transient Elastography (TE) Human Study Sun, 22 Apr 2012 02:25:28 +0000 greenmedinfo 74620 at https://greenmedinfo.com 8 Ways Microbes Can Save Us From Ourselves https://greenmedinfo.com/blog/8-ways-microbes-can-save-us-ourselves1 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="8 Ways Microbes Can Save Us From Ourselves" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/sayerji/images/microbes_poisoning.jpg" style="width: 400px; height: 300px;" /></p> <p><span style="font-size:24px;"><strong><em>Could bacteria and related microbes, widely believed to be a primary cause of disease, explain how we are capable of surviving through the self-created chemical nightmare of industrialized society? </em></strong></span></p><p><a href="https://greenmedinfo.com/blog/8-ways-microbes-can-save-us-ourselves1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/8-ways-microbes-can-save-us-ourselves1#comments Bifidobacterium Bisphenol-A Toxicity Celiac Disease Gluten Sensitivity Perchlorate Toxicity Probiotics Saccharomyces Boulardii Bisphenol A Chemotherapy Wheat Thu, 07 Mar 2019 11:39:46 +0000 Sayer Ji 87375 at https://greenmedinfo.com A case of uveitis in a girl with with celiac disease and diabetes mellitus type 1 responded to a gluten free diet. https://greenmedinfo.com/article/case-uveitis-girl-celiac-disease-and-diabetes-mellitus-type-1-responded-gluten PMID:  Gastroenterol Clin Biol. 2010 Apr-May;34(4-5):319-20. Epub 2010 Apr 28. PMID: 20427138 Abstract Title:  Uveitis responding on gluten free diet in a girl with celiac disease and diabetes mellitus type 1. Abstract:  A 9-year old girl with a history of diabetes mellitus type 1, presented with visual loss of the left eye. The right eye examination was unremarkable. Slit-lamp examination revealed few small and fine keratic precipitates. We noted 2+ flare in the vitreous. There was no choroiditis, papillitis or retinal vasculitis. No aetiology was found. The patient was treated by topical and systemic corticosteroids without any improvement. Celiac disease was discovered by the presence of celiac antibodies in the work-up of joint pain and diabetes mellitus type 1. Antiendomysium antibodies and anti-transglutaminase antibodies were both positive. A small bowel biopsy confirmed celiac disease. A gluten free diet was set up and corticosteroids were tapered off. Recovery of the uveitis was obvious during gluten free diet and normalized within two months. https://greenmedinfo.com/article/case-uveitis-girl-celiac-disease-and-diabetes-mellitus-type-1-responded-gluten#comments Celiac Disease Uveitis Human: Case Report Tue, 08 Feb 2011 21:21:39 +0000 greenmedinfo 60886 at https://greenmedinfo.com A Gluten for Punishment: the Whole Grain Assault on Health https://greenmedinfo.com/blog/gluten-punishment-whole-grain-assault-health <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2012<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="A Gluten for Punishment: the Whole Grain Assault on Health" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/sayerji/images/gluten_punishment(1).jpg" style="width: 400px; height: 267px;" /></p> <h1> <span style="font-size:14px;"><strong>From Few to You</strong></span></h1> <p>Among thoughtful and informed medical providers and public alike, there is an ongoing transition toward recognizing adverse health effects from grains as being common and normal rather than rare and abnormal.&nbsp; Not all medical providers, of course, support this change in perspective and some are downright hostile toward it.&nbsp; Likewise, a segment of the public seems to be irritated by the gluten free trend and consider it just a silly fad.&nbsp;</p> <p>Yet, if medicine is to be science based, no credible medical provider can dismiss the possibility that a large proportion of the U.S. (and possibly world) population may be sensitive to certain molecules present in most grains.&nbsp; Similarly, those that belittle the gluten free movement as a fad might, in fact, be an unknowing victim of grain sensitivity.</p> <p>Celiac disease may have been described by the ancient physician Aretaeus of Cappadocia in the first century CE.&nbsp; It was not until the 1940's, however, that the Dutch physician Willem Karel Dicke connected the disease to wheat as a result of the Dutch famine of 1944, in which wheat was scarce and those suffering from the disease seemed to dramatically improve.&nbsp; Since that time, modern medicine has narrowly defined the disease as an autoimmune disease resulting from the ingestion of <strong><a href="/toxic-ingredient/gliadin">gliadin</a></strong>, a component of wheat gluten.</p> <p><a href="https://greenmedinfo.com/blog/gluten-punishment-whole-grain-assault-health" target="_blank">read more</a></p> https://greenmedinfo.com/blog/gluten-punishment-whole-grain-assault-health#comments Celiac Disease Dietary Modification: Wheat/Gluten Free Food Allergies: Wheat Gluten Enteropathy Gluten Sensitivity Agglutinizing Benzoxazinoids (BAs) Bowel/Colon Health Carcinogenic (suspected) Dark Side of Wheat Dietary Modification: Wheat/Gluten Free Food Freedom Gastrotoxic Gliadin Gluten Health Guide: Food-Brain Connection Immunoreactive Inflammatory Lectin Toxicity Lectins Mutagenic Nephrotoxic Neurotoxic Western Diet Wheat Wheat Germ Agglutinin (WGA) HLA-DQ2/DQ8 Wed, 05 Dec 2012 13:00:00 +0000 ndaleymail 86091 at https://greenmedinfo.com A gluten free diet could be a useful approach in reducing GERD symptoms in adult celiac patients. https://greenmedinfo.com/article/gluten-free-diet-could-be-useful-approach-reducing-gerd-symptoms-adult-celiac- PMID:  J Gastroenterol Hepatol. 2008 Sep ;23(9):1368-72. PMID: 18853995 Abstract Title:  Effect of gluten-free diet on preventing recurrence of gastroesophageal reflux disease-related symptoms in adult celiac patients with nonerosive reflux disease. Abstract:  BACKGROUND AND AIM: In celiac disease (CD) the role of a gluten-free diet (GFD) on gastroesophageal reflux disease-related symptoms (GERD-rs) is unclear. The aim of this study was to establish the recurrence of GERD-rs, in CD patients with nonerosive reflux disease (NERD).METHODS: From a total of 105 adult CD patients observed, 29 who presented with the NERD form were enrolled in the study. Thirty non-CD patients with NERD were studied as controls. Recurrence of GERD-rs was clinically assessed at 6, 12, 18, and 24 months follow-up (FU) after withdrawal of initial proton-pump inhibitor (PPI) treatment for 8 weeks.RESULTS: GERD-rs were resolved in 25 (86.2%) CD patients and in 20 (66.7%) controls after 8 weeks of PPI treatment. In the CD group, recurrence of GERD-rs was found in five cases (20%) at 6 months but in none at 12, 18, and 24 months while in the control group recurrence was found in six of 20 controls (30%), in another six (12/20, 60%), in another three (15/20, 75%), and in another two (17/20, 85%) at 6, 12, 18, and 24 months FU respectively.CONCLUSIONS: The present study is the first to have evaluated the effect of a GFD in the nonerosive form of GERD in CD patients, by means of clinical long-term follow-up, suggesting that GFD could be a useful approach in reducing GERD symptoms and in the prevention of recurrence. https://greenmedinfo.com/article/gluten-free-diet-could-be-useful-approach-reducing-gerd-symptoms-adult-celiac-#comments Celiac Disease Gastroesophageal Reflux Dietary Modification: Wheat/Gluten Free Gluten Wheat Human Study Thu, 03 May 2012 14:06:01 +0000 greenmedinfo 75250 at https://greenmedinfo.com A Glutenfree diet improves osteogenesis imperfecta associated with celiac disease and type II diabetes https://greenmedinfo.com/article/glutenfree-diet-improves-osteogenesis-imperfecta-associated-celiac-disease-and PMID:  Case Report Med. 2012 ;2012:813461. Epub 2012 Mar 5. PMID: 22481956 Abstract Title:  Osteogenesis Imperfecta with Celiac Disease and Type II Diabetes Mellitus Associated: Improvement with a Gluten-Free Diet. Abstract:  Osteogenesis imperfecta (OI) is a genetic disease, with a connective tissue alteration, consisting in the presence of multiple spontaneous fractures or after minimal traumatism. Its association with other metabolic processes is rarely described. We present the clinical case of a female adult patient of 43 years. From her infancy, she has had multiple fractures, needing several surgical interventions, and she was diagnosed of OI type 2 at adolescence age. Due mainly to difficulties in walking remaining in wheel-chair in the last three years, she was overweight with morbid obesity (BMI = 45.4) and had a type-II DM associated. She suffered from recurrent abdominal pain and chronic diarrhea and was diagnosed of celiac disease (CD) with increased intraepithelial duodenal infiltration, being classified as lymphocytic enteritis, Marsh I type. She was put on a gluten-free diet (GFD), having lost 6 kg of weight after 6 months, with a good control of DM-II and presenting a significant clinical improvement. It is rewarding to search the presence of two coincidental metabolic diseases associated to OI, specially CD, because of the dramatic clinical benefit in the general found after putting on a GFD. https://greenmedinfo.com/article/glutenfree-diet-improves-osteogenesis-imperfecta-associated-celiac-disease-and#comments Celiac Disease Diabetes Mellitus: Type 2 Diarrhea Osteogenesis Imperfecta Dietary Modification: Wheat/Gluten Free Gluten Multiple Fractures Human: Case Report Wed, 11 Apr 2012 01:42:19 +0000 greenmedinfo 74132 at https://greenmedinfo.com A glutenfree diet showed short-term benefits by reducing GI symptoms and severe hypoglycaemia in T1D and CD https://greenmedinfo.com/article/glutenfree-diet-showed-short-term-benefits-reducing-gi-symptoms-and-severe-hyp PMID:  Pediatr Diabetes. 2011 Jun ;12(4 Pt 1):322-5. Epub 2011 Mar 29. PMID: 21615651 Abstract Title:  Clinical and metabolic effects of gluten free diet in children with type 1 diabetes and coeliac disease. Abstract:  BACKGROUND: Following the recommendations of The International Society for Pediatric and Adolescent Diabetes (ISPAD) in 2000, our clinic started routine screening of children with type 1 diabetes (T1D) for coeliac disease (CD). OBJECTIVES: To determine the short-term clinical and metabolic effects of gluten free diet (GFD) in a group of children with T1D and confirmed CD. METHODS: Data were collected on all children with T1D and CD between November 2000 and November 2007 before and 12 months after commencement of GFD. Data included the presence of gastrointestinal (GI) symptoms, episodes of severe hypoglycaemia, daily insulin requirements, height, weight, body mass index (BMI), glycosylated haemoglobin (HbA1c), haemoglobin, and persistence of autoantibodies. The effects of GFD on these parameters were studied and compared with those from the revised ISPAD Guidelines in 2007. RESULTS: Four hundred and sixty-eight children with T1D were screened, of whom 23 patients were diagnosed with CD. The mean age at diagnosis of T1D and CD was 6.8 years and 11.1 years, respectively. Ten out of 11 children showed improvement in their GI symptoms, while 6 out of 8 patients had no further severe hypoglycaemic episodes. Nine patients remained positive for antiendomysial antibodies after GFD. There was no significant change in the standard deviation score for height, weight, and BMI or the mean HbA1c and Hb before and after GFD. However the mean insulin requirement increased from 0.88 to 1.1 units/kg/day, which was statistically significant (p&lt;0.005). CONCLUSION: In our experience, GFD showed short-term benefits by reducing GI symptoms and severe hypoglycaemia while the insulin requirement increased significantly. https://greenmedinfo.com/article/glutenfree-diet-showed-short-term-benefits-reducing-gi-symptoms-and-severe-hyp#comments Celiac Disease Diabetes Mellitus: Type 1: Prevention Gluten Insulin Autoantibodies Body Mass Index (BMI) Glycosylated Haemoglobin (HbA1c) Hypoglycemia Human Study Sat, 14 Apr 2012 01:13:47 +0000 greenmedinfo 74272 at https://greenmedinfo.com A high frequency of celiac disease was found in patients with lymphoma in the southeast region of Turkey. https://greenmedinfo.com/article/high-frequency-celiac-disease-was-found-patients-lymphoma-southeast-region-tur PMID:  Turk J Gastroenterol. 2009 Jun ;20(2):87-92. PMID: 19530040 Abstract Title:  Screening for Celiac disease in Hodgkin and non-Hodgkin lymphoma patients. Abstract:  BACKGROUND/AIMS: Celiac disease is an abnormal T cell-mediated immune response against dietary gluten in genetically predisposed individuals. The aim of our prospective study was to evaluate the frequency of Celiac disease in patients with lymphoma and to determine the usefulness of the anti-gliadin and anti-endomysial antibodies (EMA) for diagnosis of Celiac disease in this patient group.METHODS: We studied 119 patients with previously or newly diagnosed non-Hodgkin&#039;s lymphoma and 60 patients with Hodgkin&#039;s lymphoma who presented at the hematology and medical oncology divisions of Dicle University Hospital in Turkey between December 2002 and January 2006. Serological screening for Celiac disease was performed in all patients by searching for serum anti-gliadin immunoglobulin A and immunoglobulin G, and EMA immunoglobulin A and immunoglobulin G.RESULTS: In the Hodgkin&#039;s lymphoma group, anti-gliadin immunoglobulin A was detected in 9 (15%) patients (3 male, 6 female), and antigliadin immunoglobulin G was detected in 21 (35%) patients (15 male, 6 female). In the non-Hodgkin&#039;s lymphoma group, antigliadin immunoglobulin A was detected in 6 (5%) patients (2 M male 4 female), and anti-gliadin immunoglobulin G was detected in 30 (25.2%) patients (18 male, 12 female). EMA immunoglobulin A and immunoglobulin G were not detected in the Hodgkin&#039;s lymphoma and non-Hodgkin&#039;s lymphoma groups.CONCLUSIONS: Our report is the first to describe the frequency of Celiac disease in patients with lymphoma in the southeast region of Turkey. In our study, there was no evidence that Celiac disease is a pre-malignant condition for lymphoma. Serological screening for Celiac disease in lymphoma patients does not seem to be necessary. https://greenmedinfo.com/article/high-frequency-celiac-disease-was-found-patients-lymphoma-southeast-region-tur#comments Celiac Disease Lymphoma Non-Hodgkin Lymphoma Gliadin Human Study Fri, 30 Mar 2012 21:20:44 +0000 greenmedinfo 73750 at https://greenmedinfo.com A remarkable preventive role of many vitamins like B6, B9, B12 and D on the risk of developing CRC was suggested by a large number of observational studies. https://greenmedinfo.com/article/remarkable-preventive-role-many-vitamins-b6-b9-b12-and-d-risk-developing-crc-w PMID:  World J Gastroenterol. 2015 May 7 ;21(17):5191-5209. PMID: 25954093 Abstract Title:  Role of vitamins in gastrointestinal diseases. Abstract:  A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases. For instance, most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials, however interventional trials failed to prove a clear beneficial preventive role. On the other hand, more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities. Examples for this include the therapeutic role of vitamin E in patients with non-alcoholic steatohepatitis, the additive role of vitamins B12 and D to the standard therapy of chronic hepatitis C virus, the role of vitamin C in reducing the risk of gallstones, the positive outcome with vitamin B12 in patients with aphthous stomatitis, and the beneficial effect of vitamin D and B1 in patients with inflammatory bowel disease. Other potential uses are yet to be elaborated, like those on celiac disease, pancreatic cancer, pancreatitis, cholestasis and other potential fields. Data from several ongoing interventional trials are expected to add to the current knowledge over the coming few years. Given that vitamin supplementation is psychologically accepted by patients as a natural compound with relative safety and low cost, their use should be encouraged in the fields where positive data are available. https://greenmedinfo.com/article/remarkable-preventive-role-many-vitamins-b6-b9-b12-and-d-risk-developing-crc-w#comments Celiac Disease Colorectal Cancer Colorectal Cancer: Prevention Folate Gastrointestinal Diseases Vitamin B-12 Vitamin B-6 Vitamin C Vitamin D Vitamin E Gastrointestinal Agents Review Thu, 14 May 2015 21:36:38 +0000 greenmedinfo 117412 at https://greenmedinfo.com A rhesus monkey model of gluten sensitivity for histopathology of CD, intestinal permeability, and states of epithelial integrity and disrepair. https://greenmedinfo.com/article/rhesus-monkey-model-gluten-sensitivity-histopathology-cd-intestinal-permeabili PMID:  PLoS One. 2010 ;5(4):e10228. Epub 2010 Apr 19. PMID: 20419103 Abstract Title:  Visualization of transepithelial passage of the immunogenic 33-residue peptide from alpha-2 gliadin in gluten-sensitive macaques. Abstract:  BACKGROUND: Based on clinical, histopathological and serological similarities to human celiac disease (CD), we recently established the rhesus macaque model of gluten sensitivity. In this study, we further characterized this condition based on presence of anti-tissue transglutaminase 2 (TG2) antibodies, increased intestinal permeability and transepithelial transport of a proteolytically resistant, immunotoxic, 33-residue peptide from alpha(2)-gliadin in the distal duodenum of gluten-sensitive macaques. METHODOLOGY/PRINCIPAL FINDINGS: Six rhesus macaques were selected for study from a pool of 500, including two healthy controls and four gluten-sensitive animals with elevated anti-gliadin or anti-TG2 antibodies as well as history of non-infectious chronic diarrhea. Pediatric endoscope-guided pinch biopsies were collected from each animal&#039;s distal duodenum following administration of a gluten-containing diet (GD) and again after remission by gluten-free diet (GFD). Control biopsies always showed normal villous architecture, whereas gluten-sensitive animals on GD exhibited histopathology ranging from mild lymphocytic infiltration to villous atrophy, typical of human CD. Immunofluorescent microscopic analysis of biopsies revealed IgG+ and IgA+ plasma-like cells producing antibodies that colocalized with TG2 in gluten-sensitive macaques only. Following instillation in vivo, the Cy-3-labeled 33-residue gluten peptide colocalized with the brush border protein villin in all animals. In a substantially enteropathic macaque with&quot;leaky&quot;duodenum, the peptide penetrated beneath the epithelium into the lamina propria. CONCLUSIONS/SIGNIFICANCE: The rhesus macaque model of gluten sensitivity not only resembles the histopathology of CD but it also may provide a model for studying intestinal permeability in states of epithelial integrity and disrepair. https://greenmedinfo.com/article/rhesus-monkey-model-gluten-sensitivity-histopathology-cd-intestinal-permeabili#comments Celiac Disease Gliadin Gluten Animal Study Mon, 09 Apr 2012 17:16:56 +0000 greenmedinfo 74066 at https://greenmedinfo.com