Low Immune Function: Splenic Dysfunction https://greenmedinfo.com/taxonomy/term/12926/all en Curcumin regresses tumors as well as protects the host from tumor-induced immunosuppression and toxicity. https://greenmedinfo.com/article/curcumin-regresses-tumors-well-protects-host-tumor-induced-immunosuppression-a PMID:  Cancer Detect Prev. 2005;29(5):470-8. Epub 2005 Sep 26. PMID: 16188398 Abstract Title:  Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Abstract:  BACKGROUND: The true therapeutic benefit of the use of natural products, especially acceptable dietary components such as curcumin, which can spare the normal cells and boost host immunity, has opened new horizons in cancer prevention and treatment.METHODS: In our model system we used Ehrlich's ascites carcinoma cells grown in peritoneal carity of Swiss albino mice and curcumin was fed every alternative day.RESULTS: Here, we report that curcumin administration to tumor-bearing mice decreased tumor cell number significantly in a dose-dependent manner. Furthermore, tumor-induced depletion of immune cell number of the host, as was evidenced from the decrease in bone marrow progenitor as well as thymic and splenic mononuclear cell numbers, was reintrated by curcumin. In fact, curcumin inhibited tumor-induced apoptosis of both thymocytes and splenocytes thereby restoring immune cell numbers to normal level in treated Ehrlich's ascites carcinoma-bearing mice. Moreover, curcumin was not toxic to the host; rather in tumor-bearing mice it inhibited hematopoietic toxicity, acted as a hepatoprotective agent and activated depressed anti-oxidant and detoxification systems.CONCLUSION: The ability of curcumin to regress tumor as well as to protect the host from tumor-induced immunosuppression and toxicity strongly supports the candidacy of curcumin as a potential agent for the dietary therapy of cancer. https://greenmedinfo.com/article/curcumin-regresses-tumors-well-protects-host-tumor-induced-immunosuppression-a#comments Curcumin Immune Disorders: Low Immune Function Low Immune Function: Splenic Dysfunction Tumors Apoptotic Immunomodulatory Animal Study Sat, 19 Feb 2011 00:45:52 +0000 greenmedinfo 61810 at https://greenmedinfo.com Dietary beta-carotene and astaxanthin but not canthaxanthin stimulate splenocyte function in mice. https://greenmedinfo.com/article/dietary-beta-carotene-and-astaxanthin-not-canthaxanthin-stimulate-splenocyte-f PMID:  Anticancer Res. 1999 Nov-Dec;19(6B):5223-7. PMID: 10697539 Abstract Title:  Dietary beta-carotene and astaxanthin but not canthaxanthin stimulate splenocyte function in mice. Abstract:  The in vivo modulatory effect of beta-carotene, astaxanthin and canthaxanthin on lymphocyte function was investigated. Female BALB/c mice (8 wk old) were fed a basal diet containing 0, 0.1% or 0.4% beta-carotene, astaxanthin or canthaxanthin for 0, 2 or 4 wk (n = 8/diet/period). Splenic lymphocytes were isolated and mitogen-stimulated proliferation, IL-2 production and lymphocyte cytotoxicity were assessed. Body weight and feed intake were not different among dietary treatments. Plasma carotenoids were undetectable in unsupplemented mice but concentrations of the respective carotenoids were elevated in mice fed 0.1 or 0.4% beta-carotene (0.22 and 0.39 mumol/L), astaxanthin (16.4 and 50.2 mumol/L) and canthaxanthin (5.00 and 7.02 mumol/L) respectively. Mice fed both dietary levels of beta-carotene and astaxanthin had enhanced phytohemagglutinin-induced lymphoblastogenesis compared to unsupplemented mice (P https://greenmedinfo.com/article/dietary-beta-carotene-and-astaxanthin-not-canthaxanthin-stimulate-splenocyte-f#comments Astaxanthin beta-Carotene Low Immune Function: Splenic Dysfunction Immunostimulatory Animal Study Tue, 28 Jun 2011 19:21:15 +0000 greenmedinfo 64972 at https://greenmedinfo.com Echinacea stimulates macrophage function in the lung and spleen of normal rats. https://greenmedinfo.com/article/echinacea-stimulates-macrophage-function-lung-and-spleen-normal-rats PMID:  J Nutr Biochem. 2002 Aug;13(8):487. PMID: 12165361 Abstract Title:  Echinacea stimulates macrophage function in the lung and spleen of normal rats. Abstract:  Echinacea plant extract has been used for immunostimulation for many years but the evidence supporting its therapeutic potential is still controversial. Using male Sprague-Dawley rats (425-475 g), an in vivo study was conducted to examine the immunomodulatory effects of preparations of Echinacea containing its components cichoric acid, polysaccharides and alkylamides in different concentrations. The rats were gavaged orally with these preparations, two times/day for 4 days. Phagocytic activity of alveolar macrophage was increased with increasing concentrations of the Echinacea components. A trend of increase in TNF-alpha and nitric oxide release by the alveolar macrophages following an in vitro stimulation with LPS was also evident. An enhanced release of cytokines (such as TNF-alpha and IFN-gamma) in response to Echinacea components, was also apparent in rat's spleen macrophage, but at higher concentrations. These results suggest that the Echinacea preparations containing optimal concentrations of cichoric acid, polysaccharides and alkylamides are potentially effective in stimulating an in vivo, non-specific immune response in normal rats. https://greenmedinfo.com/article/echinacea-stimulates-macrophage-function-lung-and-spleen-normal-rats#comments Echinacea Immune Disorders: Low Immune Function Low Immune Function: Splenic Dysfunction Immunomodulatory Animal Study Wed, 22 Dec 2010 05:05:00 +0000 greenmedinfo 59786 at https://greenmedinfo.com Hemp seed protein has an immunomodulatory and antifatigue effect in mice. https://greenmedinfo.com/article/hemp-seed-protein-has-immunomodulatory-and-antifatigue-effect-mice PMID:  Wei Sheng Yan Jiu. 2008 Mar;37(2):175-8. PMID: 18589601 Abstract Title:  [Initial study of Hemp seeds protein on antifatigue and the immunomodulation effects in mice]. Abstract:  OBJECTIVE: To study the effects of Hemp seeds protein (HSP) on antifatigue and immunnomodulation effect in mice. METHODS: Female ICR mice at the ages of 6-8 weeks were administered with the HSP for 4 weeks at the dose of 1.32, 2.64 and 7.92 g/kg bw. After four weeks' treatment, the mice swimming time and some hiochemistry indexes were tested, such as blood lactic acid, BUN and hepatic glycogen, as well as the ratio of spleen and thymus organs index, the capacities of lymphocyte proliferation induced by ConA, DTH response, IgM-PFC number, the level of serum HC50, the indexes of the chicken red blood cells phagocytosis and the clearance rate of carbon particles were detected, and the ratio of CD4+ T helper (Th) cell in spleen were determined by the flow cytometer. RESULTS: In comparison with the control group, the HSP could improve the the swimming time and contents of liver hepatin distinctly, and reduced the contents of blood lactic acid. Then the capacities of lymphocyte proliferation induced by ConA, DTH response, IgM-PFC number, the level of serum HC50, the indexes of the clearance rate of carbon particles and the ratio of CD4+ T helper (Th) cell in spleen increased. CONCLUSION: HSP could have the ability of antifatigue and improve the immunomodulation effect in mice. https://greenmedinfo.com/article/hemp-seed-protein-has-immunomodulatory-and-antifatigue-effect-mice#comments Fatigue Hemp Protein Hemp Seed Immune Disorders: Low Immune Function Low Immune Function: Splenic Dysfunction Animal Study Tue, 07 Sep 2010 20:27:54 +0000 greenmedinfo 56108 at https://greenmedinfo.com Maitake stimulates immune function through enhancing the thymus index and splenic function in mice. https://greenmedinfo.com/article/maitake-stimulates-immune-function-through-enhancing-thymus-index-and-splenic- PMID:  Zhong Yao Cai. 2003 Jan;26(1):31-2. PMID: 12858772 Abstract Title:  [Anti-tumor effect of polysaccharide from Grifola frondosa and its influence on immunological function]. Abstract:  When the polysaccharide from Grifola frondosa (PGF) was taken orally by S180 bearing mice at the dosage of 50-150 mg/kg.d for 9 d, the inhibitory rate to S180 was 27.97%-38.46%. The PGF can also enhance thymus index, the ability of splenic lymphocyte proliferation and formation of antibody in splenic cells, and promote the production of IgM hemolysin significantly in S-180 bearing mice. https://greenmedinfo.com/article/maitake-stimulates-immune-function-through-enhancing-thymus-index-and-splenic-#comments Low Immune Function: Splenic Dysfunction Low Immune Function: Thymus Dysfunction Maitake Mushroom Anti-Tumor Immunomodulatory Animal Study Fri, 15 Jan 2010 01:30:14 +0000 greenmedinfo 49237 at https://greenmedinfo.com Piperine, a major component of black pepper, has cyptoprotective and immunomodulating properties. https://greenmedinfo.com/article/piperine-major-component-black-pepper-has-cyptoprotective-and-immunomodulating PMID:  Eur J Pharmacol. 2007 Dec 8;576(1-3):160-70. Epub 2007 Jul 25. PMID: 17706638 Abstract Title:  Cytoprotective and immunomodulating properties of piperine on murine splenocytes: an in vitro study. Abstract:  Piper longum Linn. and Piper nigrum Linn. are conventionally used as immuno-enhancers in Indian system of traditional medicine. The underlying mechanism remains unknown. The present study was therefore, undertaken to delineate the role of piperine (major alkaloid) in cadmium (Cd) induced immuno-compromised murine splenocytes. The various biological determinants such as oxidative stress markers (reactive oxygen species and GSH), Bcl-2 protein expression, mitochondrial membrane potential, caspase-3 activity, DNA damage, splenic B and T cell population, blastogenesis and cytokines (Interleukin-2 and gamma-Interferon) were measured to ascertain its cell protective potential. Cadmium induces apoptosis at 6 h onwards. The oxidative stress markers markedly alter prior to a decline in mitochondrial membrane potential, caspase-3 activation and DNA degradation The splenic cell population was observed to change only at 18 h and the release of two cytokines was affected at 72 h. Addition of piperine in various concentrations (1, 10 and 50 microg/ml) ameliorated the above events. The highest dose of piperine could completely abrogate the toxic manifestations of cadmium and the splenic cells behaved similar to control cells. The reported free radical scavenging property of piperine and its antioxidant potential could be responsible for the modulation of intracellular oxidative stress signals. These in turn appear to mitigate the apoptotic pathway and other cellular responses altered by cadmium. The findings strongly indicate the anti-oxidative, anti-apoptotic and chemo-protective ability of piperine in blastogenesis, cytokine release and restoration of splenic cell population and is suggestive of its therapeutic usefulness in immuno-compromised situations. https://greenmedinfo.com/article/piperine-major-component-black-pepper-has-cyptoprotective-and-immunomodulating#comments Immune Disorders: Low Immune Function Low Immune Function: Splenic Dysfunction Piperidines Antiproliferative Apoptotic Immunomodulatory In Vitro Study Sun, 26 Sep 2010 00:17:14 +0000 greenmedinfo 57211 at https://greenmedinfo.com