Child Behavior Disorders https://greenmedinfo.com/taxonomy/term/1297/all en Cannabidiol could reduce severe behavioural problems in children and adolescents with intellectual disability. https://greenmedinfo.com/article/cannabidiol-could-reduce-severe-behavioural-problems-children-and-adolescents- PMID:  Br J Clin Pharmacol. 2020 Jun 1. Epub 2020 Jun 1. PMID: 32478863 Abstract Title:  A pilot randomised placebo-controlled trial of cannabidiol to reduce severe behavioural problems in children and adolescents with intellectual disability. Abstract:  INTRODUCTION: Severe Behavioural Problems (SBP) are a major contributor to morbidity in children with Intellectual Disability (ID). Medications used to treat SBP in ID are associated with a high risk of side effects. Cannabidiol has potential therapeutic effects in SBP. This pilot study aimed to investigate the feasibility of conducting a randomized placebo-controlled trial of cannabidiol to reduce SBP in children with ID.METHODS: Double-blind, placebo-controlled, two-armed, parallel-design, randomised controlled trial of cannabidiol in children aged 8 - 16 years with ID and SBP. Participants were randomized 1:1 to receive either 98% cannabidiol in oil (Tilray, Canada) or placebo orally for 8 weeks. The dose was up-titrated over 9 days to 20mg/kg/day in two divided doses, with a maximum dose of 500mg twice/day. The feasibility and acceptability of all study components were assessed.RESULTS: Eight children were randomised, and all completed the full study protocol. There were no Serious Adverse Events or drop-outs. Protocol adherence for key study components was excellent: study visits 100%, medication adherence 100%, blood tests 92%, and questionnaire completion 88%. Parents reported a high degree of acceptability with the study design. All parents reported they would recommend the study to other families with children with similar problems. There was an efficacy signal in favour of active drug.CONCLUSIONS: The findings suggest that the study protocol is feasible and acceptable to patients with ID and SBP and their families. <p><a href="https://greenmedinfo.com/article/cannabidiol-could-reduce-severe-behavioural-problems-children-and-adolescents-" target="_blank">read more</a></p> https://greenmedinfo.com/article/cannabidiol-could-reduce-severe-behavioural-problems-children-and-adolescents-#comments Cannabidiol Child Behavior Disorders Learning disorders Neuroprotective Agents Human Study Tue, 09 Jun 2020 19:51:40 +0000 greenmedinfo 221676 at https://greenmedinfo.com Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children. https://greenmedinfo.com/article/effects-prenatal-exposure-particulate-matter-air-pollution-corpus-callosum-and PMID:  Environ Res. 2019 Nov ;178:108734. Epub 2019 Sep 7. PMID: 31539824 Abstract Title:  Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children. Abstract:  OBJECTIVE: Air pollution (AP) may affect neurodevelopment, but studies about the effects of AP on the growing human brain are still scarce. We aimed to investigate the effects of prenatal exposure to AP on lateral ventricles (LV) and corpus callosum (CC) volumes in children and to determine whether the induced brain changes are associated with behavioral problems.METHODS: Among the children recruited through a set of representative schools of the city of Barcelona, (Spain) in the Brain Development and Air Pollution Ultrafine Particles in School Children (BREATHE) study, 186 typically developing participants aged 8-12 years underwent brain MRI on the same 1.5 T MR unit over a 1.5-year period (October 2012-April 2014). Brain volumes were derived from structural MRI scans using automated tissue segmentation. Behavioral problems were assessed using the Strengths and Difficulties Questionnaire (SDQ) and the criteria of the Attention Deficit Hyperactivity Disorder DSM-IV list. Prenatal fine particle (PM) levels were retrospectively estimated at the mothers&#039; residential addresses during pregnancy with land use regression (LUR) models. To determine whether brain structures might be affected by prenatal PMexposure, linear regression models were run and adjusted for age, sex, intracranial volume (ICV), maternal education, home socioeconomic vulnerability index, birthweight and mothers&#039; smoking status during pregnancy. To test for associations between brain changes and behavioral outcomes, negative binomial regressions were performed and adjusted for age, sex, ICV.RESULTS: Prenatal PMlevels ranged from 11.8 to 39.5 μg/mduring the third trimester of pregnancy. An interquartile range increase in PMlevel (7 μg/m) was significantly linked to a decrease in the body CC volume (mm) (β = -53.7, 95%CI [-92.0, -15.5] corresponding to a 5% decrease of the mean body CC volume) independently of ICV, age, sex, maternal education, socioeconomic vulnerability index at home, birthweight and mothers&#039; smoking status during the third trimester of pregnancy. A 50 mmdecrease in the body CC was associated with a significant higher hyperactivity subscore (Rate Ratio (RR) = 1.09, 95%CI [1.01, 1.17) independently of age, sex and ICV. The statistical significance of these results did not survive to False Discovery Rate correction for multiple comparisons.CONCLUSIONS: Prenatal exposure to PMmay be associated with CC volume decrease in children. The consequences might be an increase in behavioral problems. <p><a href="https://greenmedinfo.com/article/effects-prenatal-exposure-particulate-matter-air-pollution-corpus-callosum-and" target="_blank">read more</a></p> https://greenmedinfo.com/article/effects-prenatal-exposure-particulate-matter-air-pollution-corpus-callosum-and#comments Air Pollution Linked Toxicity Child Behavior Disorders Prenatal Chemical Exposures Risk Factors Human Study Thu, 02 Jan 2020 12:25:04 +0000 greenmedinfo 206882 at https://greenmedinfo.com Exposure to cell phones prenatally-and, to a lesser degree, postnatally-was associated with behavioral difficulties such as emotional and hyperactivity problems around the age of school entry. https://greenmedinfo.com/article/exposure-cell-phones-prenatally-and-lesser-degree-postnatally-was-associated-b PMID:  Epidemiology. 2008 Jul ;19(4):523-9. PMID: 18467962 Abstract Title:  Prenatal and postnatal exposure to cell phone use and behavioral problems in children. Abstract:  BACKGROUND: The World Health Organization has emphasized the need for research into the possible effects of radiofrequency fields in children. We examined the association between prenatal and postnatal exposure to cell phones and behavioral problems in young children.METHODS: Mothers were recruited to the Danish National Birth Cohort early in pregnancy. When the children of those pregnancies reached 7 years of age in 2005 and 2006, mothers were asked to complete a questionnaire regarding the current health and behavioral status of children, as well as past exposure to cell phone use. Mothers evaluated the child&#039;s behavior problems using the Strength and Difficulties Questionnaire.RESULTS: Mothers of 13,159 children completed the follow-up questionnaire reporting their use of cell phones during pregnancy as well as current cell phone use by the child. Greater odds ratios for behavioral problems were observed for children who had possible prenatal or postnatal exposure to cell phone use. After adjustment for potential confounders, the odds ratio for a higher overall behavioral problems score was 1.80 (95% confidence interval = 1.45-2.23) in children with both prenatal and postnatal exposure to cell phones.CONCLUSIONS: Exposure to cell phones prenatally-and, to a lesser degree, postnatally-was associated with behavioral difficulties such as emotional and hyperactivity problems around the age of school entry. These associations may be noncausal and may be due to unmeasured confounding. If real, they would be of public health concern given the widespread use of this technology. <p><a href="https://greenmedinfo.com/article/exposure-cell-phones-prenatally-and-lesser-degree-postnatally-was-associated-b" target="_blank">read more</a></p> https://greenmedinfo.com/article/exposure-cell-phones-prenatally-and-lesser-degree-postnatally-was-associated-b#comments Child Behavior Disorders Cell Phone Exposure EMF Pregnancy Pregnancy And Fetal Growth Human Study Sun, 11 Aug 2019 00:41:44 +0000 greenmedinfo 193500 at https://greenmedinfo.com Exposure to certain pyrethroids may negatively affect neurobehavioral development by 6 years of age. https://greenmedinfo.com/article/exposure-certain-pyrethroids-may-negatively-affect-neurobehavioral-development PMID:  Occup Environ Med. 2017 Mar ;74(4):275-281. Epub 2017 Mar 1. PMID: 28250046 Abstract Title:  Behavioural disorders in 6-year-old children and pyrethroid insecticide exposure: the PELAGIE mother-child cohort. Abstract:  OBJECTIVE: The potential impact of environmental exposure to pyrethroid insecticides on child neurodevelopment has only just started to receive attention despite their widespread use. We investigated the associations between prenatal and childhood exposure to pyrethroid insecticides and behavioural skills in 6-year-olds.METHODS: The PELAGIE cohort enrolled 3421 pregnant women from Brittany, France between 2002 and 2006. 428 mothers were randomly selected for the study when their children turned 6, and 287 (67%) agreed to participate. Children&#039;s behaviour was assessed using the Strengths and Difficulties Questionnaire (SDQ). Three subscales (prosocial behaviour, internalising disorders and externalising disorders) were considered. Five pyrethroid metabolites were measured in maternal and child urine samples collected between 6 and 19 gestational weeks and at 6 years of age, respectively. Logistic regression and reverse-scale Cox regression models were used to estimate the associations between SDQ scores and urinary pyrethroid metabolite concentrations, adjusting for organophosphate metabolite concentrations and potential confounders.RESULTS: Increased prenatal cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (DCCA) concentrations were associated with internalising difficulties (Cox p value=0.05). For childhood 3-phenoxybenzoic acid (PBA) concentrations, a positive association was observed with externalising difficulties (Cox p value=0.04) and high ORs were found for abnormal or borderline social behaviour (OR 2.93, 95% CI 1.27 to 6.78, and OR 1.91, 95% CI 0.80 to 4.57, for the intermediate and highest metabolite categories, respectively). High childhood trans-DCCA concentrations were associated with reduced externalising disorders (Cox p value=0.03).CONCLUSIONS: The present study suggests that exposure to certain pyrethroids, at environmental levels, may negatively affect neurobehavioral development by 6 years of age. <p><a href="https://greenmedinfo.com/article/exposure-certain-pyrethroids-may-negatively-affect-neurobehavioral-development" target="_blank">read more</a></p> https://greenmedinfo.com/article/exposure-certain-pyrethroids-may-negatively-affect-neurobehavioral-development#comments Child Behavior Disorders Pyrethroid insecticide Human Study Fri, 18 Aug 2017 19:54:42 +0000 greenmedinfo 151881 at https://greenmedinfo.com Findings provide initial evidence that omega-3 supplementation can produce sustained reductions in externalizing and internalizing behavior problems. https://greenmedinfo.com/article/findings-provide-initial-evidence-omega-3-supplementation-can-produce-sustaine PMID:  J Child Psychol Psychiatry. 2015 May ;56(5):509-20. Epub 2014 Aug 22. PMID: 25146492 Abstract Title:  Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Abstract:  BACKGROUND: While limited evidence suggests that omega-3 supplementation may reduce antisocial behavior in children, studies have not reported on posttreatment follow-up and most treatment periods have been of short duration. This study tests the hypothesis that omega-3 supplementation over 6 months will reduce behavior problems in children both at the end of treatment and at 6 months post treatment.METHODS: In this randomized, double-blind, placebo-controlled, stratified, parallel-group trial, a community sample of 8-16 year old children were randomized into a treatment group (N = 100) and a placebo-control group (N = 100). The supplementation consisted of a fruit drink containing 1 g/day of omega-3 or a placebo consisting of the same fruit drink without omega-3. Participants, caregivers, and research assistants were blinded to group assignment. The primary outcome measures of externalizing and internalizing behavior problems were reported by both caregivers and their children in a laboratory setting at 0 months (baseline), 6 months (end of treatment) and 12 months (6 months post treatment), together with the secondary outcome measures of parental antisocial behavior. Data were analyzed on an intention-to-treat basis including all participants.TRIAL REGISTRATION: ClinicalTrials.gov: http://clinicaltrials.gov/ct2/show/NCT02016079?term=mauritius&amp;rank=2 RESULTS: Significant group × time interactions were observed with the treatment group showing long-term improvements in child behavior problems. The average posttreatment effect size was d = -.59. Effects were documented for parent reports, but with the exception of proactive and reactive aggression, child-report data were nonsignificant. Parents whose children took omega-3 showed significant posttreatment reductions in their own antisocial and aggressive behavior. This improvement in caregiver behavior partly mediated the improvements observed in child behavior.CONCLUSIONS: Findings provide initial evidence that omega-3 supplementation can produce sustained reductions in externalizing and internalizing behavior problems. Results are the first to report improvements in caregiver behavior, and to establish this improvement as a part-mechanism for the efficacy of omega-3. https://greenmedinfo.com/article/findings-provide-initial-evidence-omega-3-supplementation-can-produce-sustaine#comments Anti-Social Behavior Child Behavior Disorders Omega-3 Fatty Acids Behavioral Treatment Human Study Sun, 10 May 2015 15:32:12 +0000 greenmedinfo 117304 at https://greenmedinfo.com Govt Exposed for Forcing Foster Kids, Even Toddlers to Take Dangerous Psychotropic Drugs https://greenmedinfo.com/blog/govt-exposed-forcing-foster-kids-even-toddlers-take-dangerous-psychotropic-drugs <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2017<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Govt Exposed for Forcing Foster Kids, Even Toddlers to Take Dangerous Psychotropic Drugs" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/lrossi/images/foster_psychotropic_drugs_greenmedinfo.jpg" style="width: 615px; height: 407px;" title="Govt Exposed for Forcing Foster Kids, Even Toddlers to Take Dangerous Psychotropic Drugs" /></p> <p class="rtecenter">Originally published on <strong><a href="http://thefreethoughtproject.com/state-drug-foster-kids-psychotropic/" target="_blank" title="Govt Exposed for Forcing Foster Kids, Even Toddlers to Take Dangerous Psychotropic Drugs">TheFreeThoughtProject.com</a></strong>.</p> <p class="rtecenter"><strong>Author: Justin Gardner</strong></p><p><a href="https://greenmedinfo.com/blog/govt-exposed-forcing-foster-kids-even-toddlers-take-dangerous-psychotropic-drugs" target="_blank">read more</a></p> https://greenmedinfo.com/blog/govt-exposed-forcing-foster-kids-even-toddlers-take-dangerous-psychotropic-drugs#comments Child Behavior Disorders Depression Antidepressants Antipsychotic Drugs Childhood Trauma Health Guide: Mental Health antidepressants Antipsychotic Drugs Child Behavior Disorders Depression Even Toddlers to Take Dangerous Psychotropic Drugs Govt Exposed for Forcing Foster Kids Tue, 30 Aug 2016 22:18:29 +0000 GMI reporter 134400 at https://greenmedinfo.com Maternal intake of vegetables, fruit, and vitamin C during pregnancy may be preventive against any of the behavioral problems. https://greenmedinfo.com/article/maternal-intake-vegetables-fruit-and-vitamin-c-during-pregnancy-may-be-prevent PMID:  Nutrition. 2019 Aug 24 ;69:110572. Epub 2019 Aug 24. PMID: 31563826 Abstract Title:  Maternal consumption of vegetables, fruit, and antioxidants during pregnancy and risk for childhood behavioral problems. Abstract:  OBJECTIVE: The aim of this pre-birth cohort study was to examine the associations between maternal intake of vegetables, fruit, and antioxidants during pregnancy and behavioral problems in Japanese children 5 y of age.METHODS: Participants were 1199 mother-child pairs. Dietary intake was assessed using a diet history questionnaire. Emotional, conduct, hyperactivity, and peer problems, as well as low prosocial behavior were assessed using the parent version of the Strengths and Difficulties Questionnaire. Adjustment was made for maternal age, gestation at baseline, region of residence, number of children, maternal and paternal education, household income, maternal depressive symptoms during pregnancy, maternal alcohol intake during pregnancy, maternal smoking during pregnancy, child&#039;s birth weight, child&#039;s sex, breastfeeding duration, and smoking in the household during the child&#039;s first year of life.RESULTS: Maternal intake of total vegetables and green and yellow vegetables during pregnancy was independently inversely associated with childhood low prosocial behavior. Maternal intake of other vegetables during pregnancy was independently inversely related to childhood hyperactivity problems and low prosocial behavior. Maternal intake of fruit and apples during pregnancy was independently inversely related to childhood hyperactivity problems. Maternal intake of citrus fruits during pregnancy was independently inversely related to childhood emotional, conduct, and hyperactivity problems. Maternal vitamin C intake during pregnancy was independently inversely associated with childhood conduct and hyperactivity problems and low prosocial behavior.CONCLUSIONS: Maternal intake of vegetables, fruit, and vitamin C during pregnancy may be preventive against any of the behavioral problems assessed here except for peer problems in Japanese children 5 y of age. <p><a href="https://greenmedinfo.com/article/maternal-intake-vegetables-fruit-and-vitamin-c-during-pregnancy-may-be-prevent" target="_blank">read more</a></p> https://greenmedinfo.com/article/maternal-intake-vegetables-fruit-and-vitamin-c-during-pregnancy-may-be-prevent#comments Child Behavior Disorders Fruit: All Vegetables: All Vitamin C Risk Reduction Human Study Wed, 02 Oct 2019 19:28:02 +0000 greenmedinfo 197824 at https://greenmedinfo.com Microbial regulation of microRNA expression in the brain-gut axis. https://greenmedinfo.com/article/microbial-regulation-microrna-expression-brain-gut-axis PMID:  Curr Opin Pharmacol. 2019 Oct 4 ;48:120-126. Epub 2019 Oct 4. PMID: 31590111 Abstract Title:  Microbial regulation of microRNA expression in the brain-gut axis. Abstract:  The gut microbiome facilitates a consistent transfer of information between the gut and the brain and microRNAs may now represent a key signalling molecule that facilitates this relationship. This review will firstly examine how these small non-coding RNAs influence the gut microbiome, and secondly how the microbiome, when disturbed, may influence miRNA expression in the brain. In addition, we will examine the consequence that microbiome-related changes in miRNA expression have on neurodevelopment, behaviour and cognition. We will also discuss novel data that suggests miRNAs contained in our diet may influence our immune system in a positive manner, offering a further potential pathway for treatment of disorders of the gut-brain axis that are influenced by the microbiome. <p><a href="https://greenmedinfo.com/article/microbial-regulation-microrna-expression-brain-gut-axis" target="_blank">read more</a></p> https://greenmedinfo.com/article/microbial-regulation-microrna-expression-brain-gut-axis#comments Child Behavior Disorders Cognitive Decline/Dysfunction Neurodevelopmental Disorders Gut-brain Axis Review Wed, 09 Oct 2019 19:23:12 +0000 greenmedinfo 198525 at https://greenmedinfo.com Repeated exposure to pulsed LTE radiofrequency fields in early life may have a long-term effect on adult behavior. https://greenmedinfo.com/article/repeated-exposure-pulsed-lte-radiofrequency-fields-early-life-may-have-long-te n/a PMID:  Bioelectromagnetics. 2019 Oct ;40(7):498-511. Epub 2019 Sep 15. PMID: 31522469 Abstract Title:  Early-Life Exposure to Pulsed LTE Radiofrequency Fields Causes Persistent Changes in Activity and Behavior in C57BL/6 J Mice. Abstract:  Despite much research, gaps remain in knowledge about the potential health effects of exposure to radiofrequency (RF) fields. This study investigated the effects of early-life exposure to pulsed long term evolution (LTE) 1,846 MHz downlink signals on innate mouse behavior. Animals were exposed for 30 min/day, 5 days/week at a whole-body average specific energy absorption rate (SAR) of 0.5 or 1 W/kg from late pregnancy (gestation day 13.5) to weaning (postnatal day 21). A behavioral tracking system measured locomotor, drinking, and feeding behavior in the home cage from 12 to 28 weeks of age. The exposure caused significant effects on both appetitive behaviors and activity of offspring that depended on the SAR. Compared with sham-exposed controls, exposure at 0.5 W/kg significantly decreased drinking frequency (P ≤ 0.000) and significantly decreased distance moved (P ≤ 0.001). In contrast, exposure at 1 W/kg significantly increased drinking frequency (P ≤ 0.001) and significantly increased moving duration (P ≤ 0.005). In the absence of other plausible explanations, it is concluded that repeated exposure to low-level RF fields in early life may have a persistent and long-term effect on adult behavior. Bioelectromagnetics. 2019;40:498-511. © 2019 The Authors. Bioelectromagnetics Published by Wiley Periodicals, Inc. https://greenmedinfo.com/article/repeated-exposure-pulsed-lte-radiofrequency-fields-early-life-may-have-long-te#comments Child Behavior Disorders Cell Phone Exposure Electromagnetic Field Harms Electromagnetic Radiation Mobile Phone Radiation activity behavioral issues brain Cell Phones Electromagnetic Hypersensitivity EMF radiation locomotion rodent WiFi Animal Study Mon, 30 Sep 2019 23:29:33 +0000 greenmedinfo 197669 at https://greenmedinfo.com This study replicates the findings of a previous study that indicate cell phone use may be associated with behavioral problems in young children. https://greenmedinfo.com/article/study-replicates-findings-previous-study-indicate-cell-phone-use-may-be-associ PMID:  J Epidemiol Community Health. 2012 Jun ;66(6):524-9. Epub 2010 Dec 7. PMID: 21138897 Abstract Title:  Cell phone use and behavioural problems in young children. Abstract:  BACKGROUND: Potential health effects of cell phone use in children have not been adequately examined. As children are using cell phones at earlier ages, research among this group has been identified as the highest priority by both national and international organisations. The authors previously reported results from the Danish National Birth Cohort (DNBC), which looked at prenatal and postnatal exposure to cell phone use and behavioural problems at age 7 years. Exposure to cell phones prenatally, and to a lesser degree postnatally, was associated with more behavioural difficulties. The original analysis included nearly 13 000 children who reached age 7 years by November 2006.METHODS: To see if a larger, separate group of DNBC children would produce similar results after considering additional confounders, children of mothers who might better represent current users of cell phones were analysed. This &#039;new&#039; dataset consisted of 28 745 children with completed Age-7 Questionnaires to December 2008.RESULTS: The highest OR for behavioural problems were for children who had both prenatal and postnatal exposure to cell phones compared with children not exposed during either time period. The adjusted effect estimate was 1.5 (95% CI 1.4 to 1.7).CONCLUSIONS: The findings of the previous publication were replicated in this separate group of participants demonstrating that cell phone use was associated with behavioural problems at age 7 years in children, and this association was not limited to early users of the technology. Although weaker in the new dataset, even with further control for an extended set of potential confounders, the associations remained. <p><a href="https://greenmedinfo.com/article/study-replicates-findings-previous-study-indicate-cell-phone-use-may-be-associ" target="_blank">read more</a></p> https://greenmedinfo.com/article/study-replicates-findings-previous-study-indicate-cell-phone-use-may-be-associ#comments Child Behavior Disorders Cell Phone Exposure Electromagnetic Field Harms Electromagnetic Radiation Microwave Radiation Mobile Phone Radiation EMF Human Study Sun, 11 Aug 2019 00:46:53 +0000 greenmedinfo 193501 at https://greenmedinfo.com