Complex Regional Pain Syndrome: Type I https://greenmedinfo.com/taxonomy/term/1416/all en A routine, daily administration of vitamin C may be beneficial in foot and ankle surgery or injury to avoid CRPS. https://greenmedinfo.com/article/routine-daily-administration-vitamin-c-may-be-beneficial-foot-and-ankle-surger PMID:  J Foot Ankle Surg. 2013 Jan-Feb;52(1):62-6. Epub 2012 Sep 15. PMID: 22985495 Abstract Title:  Efficacy and safety of high-dose vitamin C on complex regional pain syndrome in extremity trauma and surgery--systematic review and meta-analysis. Abstract:  Complex regional pain syndrome (CRPS) is a devastating condition often seen after foot and ankle injury and surgery. Prevention of this pathology is attractive not only to patients but also to surgeons, because the treatment of this condition can be difficult. We evaluated the effectiveness of vitamin C in preventing occurrence of CRPS in extremity trauma and surgery by systematically reviewing relevant studies. The databases used for this review included: Ovid EMBASE, Ovid MEDLINE, CINAHL, and the Cochrane Database. We searched for comparative studies that evaluated the efficacy of more than 500 mg of daily vitamin C. After screening for inclusion and exclusion criteria, we identified 4 studies that were relevant to our study question. Only 1 of these 4 studies was on foot and ankle surgery; the rest concerned the upper extremities. All 4 studies were in favor of this intervention with minimal heterogeneity (Tau(2) = 0.00). Our quantitative synthesis showed a relative risk of 0.22 (95% confidence interval = 0.12, 0.39) when daily vitamin C of at least 500 mg was initiated immediately after the extremity surgery or injury and continued for 45 to 50 days. A routine, daily administration of vitamin C may be beneficial in foot and ankle surgery or injury to avoid CRPS. Further foot and ankle specific and dose-response studies are warranted. <p><a href="https://greenmedinfo.com/article/routine-daily-administration-vitamin-c-may-be-beneficial-foot-and-ankle-surger" target="_blank">read more</a></p> https://greenmedinfo.com/article/routine-daily-administration-vitamin-c-may-be-beneficial-foot-and-ankle-surger#comments Complex Regional Pain Syndrome: Type I Vitamin C Meta Analysis Mon, 02 Mar 2020 17:40:41 +0000 greenmedinfo 215109 at https://greenmedinfo.com A case report of complex regional pain syndrome symptom reduction after high frequency spinal cord stimulation. https://greenmedinfo.com/article/case-report-complex-regional-pain-syndrome-symptom-reduction-after-high-freque PMID:  Pain Physician. 2017 Jan-Feb;20(1):E177-E182. PMID: 28072810 Abstract Title:  High Frequency Spinal Cord Stimulation for Complex Regional Pain Syndrome: A Case Report. Abstract:  Complex regional pain syndrome (CRPS) is a chronic, debilitating, neuropathic pain condition which is often misdiagnosed, difficult to manage, and lacks proven methods for remission. Most available methods provide some relief to a small percentage of patients. Recent FDA approval and superiority of the Nevro Senza 10-kHz high frequency (HF10) spinal cord stimulation (SCS) therapy over traditional low-frequency spinal cord stimulation for treatment of chronic back and leg pain may provide a new interventional therapeutic option for patients suffering from CRPS. We provide a case report of a 53-year-old Caucasian woman who suffered with CRPS in the right knee and thigh for over 7 years. Implantation of the HF10 device provided over 75% relief of pain, erythema, heat, swelling, and tissue necrosis to the entire region within 1 month of treatment. Because the HP10 therapy provides pain relief without paresthesia typical of traditional low-frequency, this system may provide relief for patients suffering from chronic pain.Key words: Complex regional pain syndrome, spinal cord stimulation, Nevro Senza HF10, erythema, knee, thigh. <p><a href="https://greenmedinfo.com/article/case-report-complex-regional-pain-syndrome-symptom-reduction-after-high-freque" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-complex-regional-pain-syndrome-symptom-reduction-after-high-freque#comments Complex Regional Pain Syndrome: Type I Complex Regional Pain Syndrome: Type II Electrotherapy Human: Case Report Mon, 02 Mar 2020 17:30:30 +0000 greenmedinfo 215094 at https://greenmedinfo.com A case report of complex regional pain syndrome type-I after rubella vaccination. https://greenmedinfo.com/article/case-report-complex-regional-pain-syndrome-type-i-after-rubella-vaccination PMID:  Coll Antropol. 2013 Sep ;37(3):1015-8. PMID: 24308253 Abstract Title:  Complex regional pain syndrome type I after diphtheria-tetanus (Di-Te) vaccination. Abstract:  Complex regional pain syndrome type I (CRPS I) is a disorder of one or more extremities characterized by pain, abnormal sensitivity (allodynia), swelling, limited range of motion, vasomotor instability, fatigue and emotional distress. The symptoms may be aggravated by even minor activity or weather change. It is usually provoked by injury, surgery or injection but in a small proportion of patients CRPS I develops without a clear causative event. There are several literature reports on CRPS after rubella and hepatitis B vaccination. We present a case of CRPS I affecting the left arm after diphtheria and tetanus (Di-Te) vaccination in the left deltoid muscle in a young girl having experienced profound emotional stress before the vaccination procedure. History data on previous minor trauma at the site of vaccination or emotional stress may necessitate temporary vaccination delay due to their proneness to impaired local or systemic immune response and CRPS as a complication of vaccination. If a child or an adult has prominent swelling and severe pain after vaccination, the diagnosis of CRPS I should be considered and if confirmed, the multidisciplinary treatment should start as soon as possible. <p><a href="https://greenmedinfo.com/article/case-report-complex-regional-pain-syndrome-type-i-after-rubella-vaccination" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-complex-regional-pain-syndrome-type-i-after-rubella-vaccination#comments Complex Regional Pain Syndrome: Type I Vaccination: All Vaccination: Mumps-Measles-Rubella (MMR) Human: Case Report Tue, 04 Feb 2020 16:24:48 +0000 greenmedinfo 210479 at https://greenmedinfo.com A case report of concurrent scurvy and complex regional pain syndrome type I and its treatment with vitamin C. https://greenmedinfo.com/article/case-report-concurrent-scurvy-and-complex-regional-pain-syndrome-type-i-and-it PMID:  Indian Pediatr. 2009 Jun ;46(6):529-31. PMID: 19556664 Abstract Title:  Complex regional pain syndrome type 1 and scurvy. Abstract:  A 5 year old female developed features of complex regional pain syndrome (CRPS) i.e excessive pain to touch, decreased sweating and edema of left ankle 2 years after fracture of left tibia. Gum bleeding, petechiae and pseudoparalysis and suggestive radiograph characterized scurvy. Hyperesthesia improved and child walked with support following administration of vitamin C. <p><a href="https://greenmedinfo.com/article/case-report-concurrent-scurvy-and-complex-regional-pain-syndrome-type-i-and-it" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-concurrent-scurvy-and-complex-regional-pain-syndrome-type-i-and-it#comments Complex Regional Pain Syndrome: Type I Vitamin C Human: Case Report Mon, 02 Mar 2020 17:46:28 +0000 greenmedinfo 215116 at https://greenmedinfo.com A case report of reversal of complex regional pain syndrome type 1 with ultrasound-guided dry needling. https://greenmedinfo.com/article/case-report-reversal-complex-regional-pain-syndrome-type-1-ultrasound-guided-d PMID:  Pain Med. 2018 01 1 ;19(1):208-212. PMID: 28637210 Abstract Title:  Improvement in CRPS After Deep Dry Needling Suggests a Role in Myofascial Pain. Abstract:  [n/a] <p><a href="https://greenmedinfo.com/article/case-report-reversal-complex-regional-pain-syndrome-type-1-ultrasound-guided-d" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-reversal-complex-regional-pain-syndrome-type-1-ultrasound-guided-d#comments Complex Regional Pain Syndrome: Type I Acupuncture Human: Case Report Mon, 02 Mar 2020 17:17:15 +0000 greenmedinfo 215090 at https://greenmedinfo.com A case report of reversal of complex regional pain syndrome type 1 with ultrasound-guided dry needling. https://greenmedinfo.com/article/case-report-reversal-complex-regional-pain-syndrome-type-1-ultrasound-guided-0 PMID:  Pain Med. 2018 01 1 ;19(1):208-212. PMID: 28637210 Abstract Title:  Improvement in CRPS After Deep Dry Needling Suggests a Role in Myofascial Pain. Abstract:  [n/a] <p><a href="https://greenmedinfo.com/article/case-report-reversal-complex-regional-pain-syndrome-type-1-ultrasound-guided-0" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-reversal-complex-regional-pain-syndrome-type-1-ultrasound-guided-0#comments Complex Regional Pain Syndrome: Type I Acupuncture Human: Case Report Mon, 02 Mar 2020 17:17:15 +0000 greenmedinfo 215091 at https://greenmedinfo.com A case report of successful treatment of long-standing complex regional pain syndrome with hyperbaric oxygen therapy. https://greenmedinfo.com/article/case-report-successful-treatment-long-standing-complex-regional-pain-syndrome- PMID:  J Neuroimmune Pharmacol. 2019 Dec 14. Epub 2019 Dec 14. PMID: 31838618 Abstract Title:  Successful Treatment of Long Standing Complex Regional Pain Syndrome with Hyperbaric Oxygen Therapy. Abstract:  Complex regional pain syndrome (CRPS) is a devastating posttraumatic neuroinflammatory condition with both autoinflammatory and autoimmune features, characterized by unrelenting severe pain and disability, with the majority of affected patients being unable to function socially or vocationally. Remission is more likely in children than adults, and if treatment is started early. Once established, there are no universally effective treatments, and these are desperately needed. A single limb is often involved, but there can be multi-limb spread, and systemic autonomic manifestations. We describe a case of long-standing CRPS with multi-limb spread and systemic autonomic features, controlled only with very high dose oral corticosteroids, which led to several complications. Multiple other treatment modalities failed or were insufficient to control the CRPS and allow tapering of the corticosteroids, but the patient had a dramatic response to hyperbaric oxygen therapy (HBOT), allowing a reduction in prednisone dose to just over the physiologic range. When symptoms started to increase several months later, a second course of HBOT treatments allowed reduction in prednisone dose into the physiologic range while still controlling CRPS symptoms. This case is unique in that it shows that HBOT can be effective in long-standing CRPS, both initially, and for subsequent flares, and adds to the evidence supporting HBOT as a potential treatment for this condition. Graphical Abstract HBOT effect on prednisone dose for symptom control. <p><a href="https://greenmedinfo.com/article/case-report-successful-treatment-long-standing-complex-regional-pain-syndrome-" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-successful-treatment-long-standing-complex-regional-pain-syndrome-#comments Complex Regional Pain Syndrome: Type I Complex Regional Pain Syndrome: Type II Hyperbaric Treatment Human: Case Report Mon, 02 Mar 2020 16:39:57 +0000 greenmedinfo 215062 at https://greenmedinfo.com A case report of wireless peripheral nerve stimulation in complex regional pain syndrome treatment. https://greenmedinfo.com/article/case-report-wireless-peripheral-nerve-stimulation-complex-regional-pain-syndro PMID:  Scand J Pain. 2018 07 26 ;18(3):555-560. PMID: 29794269 Abstract Title:  Wireless peripheral nerve stimulation for complex regional pain syndrome type I of the upper extremity: a case illustration introducing a novel technology. Abstract:  Background Complex regional pain syndrome (CRPS) is a debilitating painful disorder, cryptic in its pathophysiology and refractory condition with limited therapeutic options. Type I CRPS with its variable relationship to trauma has often no discernible fractures or nerve injuries and remains enigmatic in its response to conservative treatment as well as the other limited interventional therapies. Neuromodulation in the form of spinal cord and dorsal root ganglion stimulation (SCS, DRGS) has shown encouraging results, especially of causalgia or CRPS I of lower extremities. Upper extremity CRPS I is far more difficult. Objective To report a case of upper extremity CRPS I treated by wireless peripheral nerve stimulation (WPNS) for its unique features and minimally invasive technique. The system does not involve implantation of battery or its connections. Case report A 47 year old female patient presented with refractory CRPS I following a blunt trauma to her right forearm. As interventional treatment in the form of local anesthetics (Anesthesia of peripheral branches of radial nerve) and combined infusions of ketamine/lidocaine failed to provide any significant relief she opted for WPNS treatment. Based on the topographic distribution, two electrodes (Stimwave Leads: FR4A-RCV-A0 with tines, Generation 1 and FR4A-RCV-B0 with tines, Generation 1), were placed along the course of radial and median nerves under ultrasonography monitoring and guided by intraoperative stimulation. This procedure did not involve implantation of extension cables or the power source. At a frequency of 60 Hz and 300μs the stimulation induced paresthesia along the distribution of the nerves. Therapeutic relief was observed with high frequency (HF) stimulation (HF 10 kHz/32 μs, 2.0 mA) reducing her pain from a visual analogue scale (VAS) score of 7-4 postoperatively. Three HF stimulations programs were provided at the time of discharge, as she improved in her sensory impairment to touch, pressure and temperature at her first follow up visit. At 5-months she was able to drive, did not require opioids and allodynia disappeared. Conclusions In a case with difficult CRPS I involving upper extremity, a minimally invasive WPNS of radial and median nerves provided good symptomatic relief. The procedure was tolerated well and both electrodes remained in place without any adverse events. Implications In view of the very limited options currently available to manage CRPS, WPNS can be a promising therapeuticmodality. <p><a href="https://greenmedinfo.com/article/case-report-wireless-peripheral-nerve-stimulation-complex-regional-pain-syndro" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-wireless-peripheral-nerve-stimulation-complex-regional-pain-syndro#comments Complex Regional Pain Syndrome: Type I Complex Regional Pain Syndrome: Type II Electrotherapy Human: Case Report Mon, 02 Mar 2020 17:13:05 +0000 greenmedinfo 215087 at https://greenmedinfo.com A case series of beneficial clinical outcomes associated with manual lumbar spine therapy in complex regional pain syndrome. https://greenmedinfo.com/article/case-series-beneficial-clinical-outcomes-associated-manual-lumbar-spine-therap PMID:  Physiother Theory Pract. 2020 Jan ;36(1):241-248. Epub 2018 Jun 6. PMID: 29873592 Abstract Title:  Utilization of manual therapy to the lumbar spine in conjunction with traditional conservative care for individuals with bilateral lower extremity complex regional pain syndrome: A case series. Abstract:  : Conservative therapies for complex regional pain syndrome (CRPS) have traditionally focused on exercise and desensitization techniques targeted at the involved extremity. The primary purpose of this case series is to report on the potential benefit of utilizing manual therapy to the lumbar spine in conjunction with traditional conservative care when treating patients with lower extremity CRPS.: Two patients with the diagnosis of lower extremity CRPS were treated with manual therapy to the lumbar spine in conjunction with education, exercise, desensitization, and soft tissue techniques for the extremity.: Patient 1 received 13 sessions over 6 weeks resulting in a 34-point improvement in oswestry disability index (ODI) and 35-point improvement in lower extremity functional scale (LEFS). Patient 2 received 21 sessions over 12 weeks resulting in a 28-point improvement in ODI and a 41-point improvement in LEFS.: Both patients exhibited reductions in pain and clinically meaningful improvements in function. Manual therapies when applied to the lumbar spine in these patients as part of a comprehensive treatment plan resulted in improved spinal mobility, decreased pain, and reduction is distal referred symptoms. Although one cannot infer a cause and effect relationship from a case series, this report identifies meaningful clinical outcomes potentially associated with manual physical therapy to the lumbar spine for two patients with complex regional pain syndrome type 1. <p><a href="https://greenmedinfo.com/article/case-series-beneficial-clinical-outcomes-associated-manual-lumbar-spine-therap" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-series-beneficial-clinical-outcomes-associated-manual-lumbar-spine-therap#comments Complex Regional Pain Syndrome: Type I Complex Regional Pain Syndrome: Type II Massage/Therapeutic Touch Human: Case Report Mon, 02 Mar 2020 17:10:53 +0000 greenmedinfo 215085 at https://greenmedinfo.com A case series of rapid and substantial symptom relief in complex regional pain syndrome with hirudotherapy. https://greenmedinfo.com/article/case-series-rapid-and-substantial-symptom-relief-complex-regional-pain-syndrom PMID:  J Integr Med. 2019 Sep ;17(5):383-386. Epub 2019 May 23. PMID: 31253578 Abstract Title:  Beneficial effects of hirudotherapy in a chronic case of complex regional pain syndrome. Abstract:  We report about hirudotherapy in a patient with chronic complex regional pain syndrome (CRPS) in the right hand. CRPS is a multifactorial disease associated with disabling pain as well as sensory and motor deficits. The optimal therapeutic management is based on personalized multimodal treatment approaches; however, hirudotherapy has not been described in the available literature. To date, we have completed five medicinal leech treatments. Altogether, hirudotherapy led to rapid and substantial relief of symptoms, especially with respect to pain intensity ratings and skin temperature asymmetries. In addition, the patient&#039;s active and passive agility of the affected limb improved obviously. <p><a href="https://greenmedinfo.com/article/case-series-rapid-and-substantial-symptom-relief-complex-regional-pain-syndrom" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-series-rapid-and-substantial-symptom-relief-complex-regional-pain-syndrom#comments Complex Regional Pain Syndrome: Type I Complex Regional Pain Syndrome: Type II Blood-letting Human: Case Report Mon, 02 Mar 2020 16:43:01 +0000 greenmedinfo 215064 at https://greenmedinfo.com A review of studies suggesting cortical involvement in the pathogenesis of complex regional pain syndrome. https://greenmedinfo.com/article/review-studies-suggesting-cortical-involvement-pathogenesis-complex-regional-p PMID:  Eur J Pain. 2009 Oct ;13(9):902-7. Epub 2008 Dec 19. PMID: 19101181 Abstract Title:  Cortical changes in complex regional pain syndrome (CRPS). Abstract:  Recent research suggests that changes in cortical structures can contribute to the pathophysiology of Complex Regional Pain Syndrome (CRPS). This review provides an overview of studies showing cortical involvement in CRPS, including mislocalizations of tactile stimuli, changes in size and organization of the somatosensory map, changes in motor cortex representation and body perception disturbances. In addition, we review experimental treatment approaches, such as mirror therapy and motor imagery programs, aimed at restoring the integrity of neural processing in the sensory-motor cortex in individuals with CRPS. The intervention effects are promising and can be theoretically motivated on the basis of established principles of neural organization, although important questions concerning the precise neural mechanisms of action remain unanswered. <p><a href="https://greenmedinfo.com/article/review-studies-suggesting-cortical-involvement-pathogenesis-complex-regional-p" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-studies-suggesting-cortical-involvement-pathogenesis-complex-regional-p#comments Complex Regional Pain Syndrome: Type I Complex Regional Pain Syndrome: Type II Review Mon, 02 Mar 2020 17:48:55 +0000 greenmedinfo 215119 at https://greenmedinfo.com Blockage of the TRPV1 channel may ameliorate complex regional pain syndrome type 1. https://greenmedinfo.com/article/blockage-trpv1-channel-may-ameliorate-complex-regional-pain-syndrome-type-1 PMID:  Front Pharmacol. 2019 ;10:453. Epub 2019 Apr 26. PMID: 31105572 Abstract Title:  TRPV1 Channel Contributes to the Behavioral Hypersensitivity in a Rat Model of Complex Regional Pain Syndrome Type 1. Abstract:  Complex regional pain syndrome type 1 (CRPS-I) is a debilitating pain condition that significantly affects life quality of patients. It remains a clinically challenging condition and the mechanisms of CRPS-I have not been fully elucidated. Here, we investigated the involvement of TRPV1, a non-selective cation channel important for integrating various painful stimuli, in an animal model of CRPS-I. A rat model of chronic post-ischemia pain (CPIP) was established to mimic CRPS-I. TRPV1 expression was significantly increased in hind paw tissue and small to medium-sized dorsal root ganglion (DRG) neurons of CPIP rats. CPIP rats showed increased TRPV1 current density and capsaicin responding rate in small-sized nociceptive DRG neurons. Local pharmacological blockage of TRPV1 with the specific antagonist AMG9810, at a dosage that does not produce hyperthermia or affect thermal perception or locomotor activity, effectively attenuated thermal and mechanical hypersensitivity in bilateral hind paws of CPIP rats and reduced the hyperexcitability of DRG neurons induced by CPIP. CPIP rats showed bilateral spinal astrocyte and microglia activations, which were significantly attenuated by AMG9810 treatment. These findings identified an important role of TRPV1 in mediating thermal and mechanical hypersensitivity in a CRPS-I animal model and further suggest local pharmacological blocking TRPV1 may represent an effective approach to ameliorate CRPS-I. <p><a href="https://greenmedinfo.com/article/blockage-trpv1-channel-may-ameliorate-complex-regional-pain-syndrome-type-1" target="_blank">read more</a></p> https://greenmedinfo.com/article/blockage-trpv1-channel-may-ameliorate-complex-regional-pain-syndrome-type-1#comments Complex Regional Pain Syndrome: Type I Animal Study Mon, 02 Mar 2020 16:44:59 +0000 greenmedinfo 215067 at https://greenmedinfo.com Chinese scalp acupuncture relieves pain and restores function in complex regional pain syndrome. https://greenmedinfo.com/article/chinese-scalp-acupuncture-relieves-pain-and-restores-function-complex-regional PMID:  Mil Med. 2012 Oct ;177(10):1231-4. PMID: 23113454 Abstract Title:  Chinese scalp acupuncture relieves pain and restores function in complex regional pain syndrome. Abstract:  Complex Regional Pain Syndrome (CRPS) can result from trauma or after surgery. It is often difficult to manage effectively. If not recognized early, it can result in significant debilitation. Symptoms attributed to CRPS include neuropathic pain, allodynia, sudomotor changes, and decreased range of motion. It can occur with (Type II) or without (Type I) nerve injury. A number of soldiers sustaining extremity injuries during combat have manifested these symptoms. Two subjects were diagnosed with CRPS after sustaining upper extremity injuries during military operations. After failing conservative treatment, Chinese Scalp Acupuncture (CSA) was used once to twice a week for 1 to 4 weeks. CSA resulted in improvement in the pain visual analog scale or numeric rating scale by over 80% in two soldiers with upper extremity CRPS. Additionally, decreased sensory changes and improved function were noted on exam and therapy assessments. Notably, the pain reduction, functional improvement, and normalization of sensation have been fully maintained between treatments. The treatment response had been sustained at 20-month follow-up with no recurrence. CSA provided lasting pain reduction, and improved function and sensation in this group of combatants with upper extremity CRPS. <p><a href="https://greenmedinfo.com/article/chinese-scalp-acupuncture-relieves-pain-and-restores-function-complex-regional" target="_blank">read more</a></p> https://greenmedinfo.com/article/chinese-scalp-acupuncture-relieves-pain-and-restores-function-complex-regional#comments Complex Regional Pain Syndrome: Type I Acupuncture Human: Case Report Mon, 02 Mar 2020 17:39:18 +0000 greenmedinfo 215106 at https://greenmedinfo.com Complex regional pain syndrome type 1 may be associated with menstrual cycle disorders. https://greenmedinfo.com/article/complex-regional-pain-syndrome-type-1-may-be-associated-menstrual-cycle-disord PMID:  Complement Ther Med. 2009 Oct-Dec;17(5-6):262-8. Epub 2009 Nov 7. PMID: 19942105 Abstract Title:  Complex regional pain syndrome type 1 may be associated with menstrual cycle disorders: a case-control study. Abstract:  BACKGROUND: Complex regional pain syndrome type 1 (CRPS1) can develop after severe trauma or surgery in the limbs, and presents with chronic, changes in temperature, edema and dysfunction. Seventy-five percent of CRPS1 patients are female. While neurological and inflammatory components have been proposed, the etiology remains unclear. No consensus on optimal management of CRPS1 exists. In traditional Chinese medicine, menstrual disorders are related to the state of women&#039;s constitution and therefore identify their pain patterns. A classification by constitution might improve the pain management in CRPS1 patients. It is unknown whether associations exist between menstrual-cycle-conditions and CRPS1. AIM: To investigate whether a specified menstrual condition is associated with the risk of developing CRPS1. METHODS: A population-based case-control study of CRPS1 was conducted among Dutch women aged 18-82; i.e. 34 women with CRPS1 and 147 controls. A standard questionnaire consisting of 59 menstrual-cycle-symptom-based questions was administered. From this questionnaire, 15 CRPS1-related questions (DRQ 15) were analyzed. We used multivariate logistic regression to obtain odds ratios and 95% confidence intervals (CI) for specified menstrual disorders adjusting for age, oral contraceptives, hysterectomy and age at menarcheor = 17 years. RESULTS: On the basis of the DRQ 15, women with CRPS1 were 5.3 (95%CI 2.1, 12.9) times more likely to have menstrual disorders than comparable controls. CONCLUSION: Our results suggest that selected menstrual conditions are associated with the risk of developing CRPS1. https://greenmedinfo.com/article/complex-regional-pain-syndrome-type-1-may-be-associated-menstrual-cycle-disord#comments Complex Regional Pain Syndrome: Type I Menstruation Disorders Diseases that are Linked Human Study Wed, 02 Jun 2010 18:09:42 +0000 greenmedinfo 55282 at https://greenmedinfo.com Daily supplementation with 500mg of vitamin C per day for 50 days decreases the 1-year risk of CRPS-I after wrist fracture. https://greenmedinfo.com/article/daily-supplementation-500mg-vitamin-c-day-50-days-decreases-1-year-risk-crps-i PMID:  Orthop Traumatol Surg Res. 2017 Mar 5. Epub 2017 Mar 5. PMID: 28274883 Abstract Title:  Efficacy of Vitamin C in Preventing Complex Regional Pain Syndrome after Wrist Fracture: A Systematic Review and Meta-Analysis. Abstract:  BACKGROUND: Complex regional pain syndrome type I (CRPS-I), previously known as reflex sympathetic dystrophy, is common after conservatively or surgicallytreatedwrist fractures. Several studies support the efficacy of vitamin C in preventing CRPS-I, although the data are somewhat conflicting. The primary objective of this systematic literature review and meta-analysis was to assess the efficacy of vitamin C therapy in preventing CRPS-I after a wrist fracture.METHODS: Randomised, placebo-controlled trials of vitamin C to prevent CRPS-I after wrist fractureswere sought in the three main databases: PubMed (1980 to December 2015), CENTRAL (Central 2015, number 12), andEmbase (1980 to December 2015). Two authors worked independently to select articles. Data from selected articles were collected independently.RESULTS: Three randomisedplacebo-controlled trials in a total of 875 patients were included.Treatment was non-operative in758/890(85.1%)fracturesand operative in 132(14.9%)fractures. Vitamin C supplementation was started on the day of the injury and continued for 50 days. In the group given 500mg of vitamin C daily, the risk ratio for CRPS-I was 0.54 (95%CI, 0.33-0.91;p=0.02).Thus, the risk of developing CRPS-I was significantly decreased by prophylactic treatment with 500mg of vitamin C per day. The heterogeneity rate was 65% (non-significant).CONCLUSION: Daily supplementation with 500mg of vitamin C per day for 50 days decreases the 1-year risk of CRPS-I after wrist fracture.LEVEL OF EVIDENCE: II, systematic review of level I and II studies. <p><a href="https://greenmedinfo.com/article/daily-supplementation-500mg-vitamin-c-day-50-days-decreases-1-year-risk-crps-i" target="_blank">read more</a></p> https://greenmedinfo.com/article/daily-supplementation-500mg-vitamin-c-day-50-days-decreases-1-year-risk-crps-i#comments Bone Fractures Complex Regional Pain Syndrome: Type I Vitamin C Risk Reduction Review Wed, 15 Mar 2017 04:16:58 +0000 greenmedinfo 144827 at https://greenmedinfo.com