Diabetes: Gestational https://greenmedinfo.com/taxonomy/term/1662/all en Adherence to the Mediterranean diet prior to pregnancy should be considered as a preventive tool against the development of gestational diabetes mellitus. https://greenmedinfo.com/article/adherence-mediterranean-diet-prior-pregnancy-should-be-considered-preventive-t PMID:  Nutrients. 2019 May 1 ;11(5). Epub 2019 May 1. PMID: 31052474 Abstract Title:  Pre-Pregnancy Adherence to the Mediterranean Diet and Gestational Diabetes Mellitus: A Case-Control Study. Abstract:  Gestational diabetes mellitus (GDM), an important public health problem that affects mothers and offspring, is a common metabolic disorder. We evaluated the effect of the pre-pregnancy Mediterranean diet (MD) level of exposure on the odds of GDM development. A case-control study (291 GDM cases and 1175 controls without GDM) was conducted in pregnant women. Pre-pregnancy dietary intake was assessed using a validated food frequency questionnaire to calculate an MD adherence index (range score 0-9: low≤ 2; middle 3-4; high 5-6; very high ≥ 7). Adjusted odds ratios (aOR) and their 95% confidence intervals (CI) were estimated using multivariable logistic regression models including age, BMI, family history of diabetes mellitus, previous GDM, miscarriages, and gravidity. Overall, middle-high MDadherence was 216/291 (74.2%) and very high adherence was 17/291 (5.8%) in cases. In controls the corresponding figures were 900/1175 (76.6%) and 73/1175 (6.2%), respectively. Compared to low adherence, high MD adherence was associated with GDM reduction (aOR 0.61, 95% CI 0.39,0.94;= 0.028), and very high MD adherence was even more strongly associated (aOR 0.33, 95% CI 0.15, 0.72;= 0.005). The protective effect of adherence to the MD prior to pregnancy should be considered as a preventive tool against the development of GDM. <p><a href="https://greenmedinfo.com/article/adherence-mediterranean-diet-prior-pregnancy-should-be-considered-preventive-t" target="_blank">read more</a></p> https://greenmedinfo.com/article/adherence-mediterranean-diet-prior-pregnancy-should-be-considered-preventive-t#comments Diabetes: Gestational Dietary Modification: Mediterranean Diet Risk Reduction Human Study Sat, 11 May 2019 00:51:30 +0000 greenmedinfo 187356 at https://greenmedinfo.com Ambient PM2.5 exposure during the second trimester was associated with higher odds of GDM and higher blood glucose levels. https://greenmedinfo.com/article/ambient-pm25-exposure-during-second-trimester-was-associated-higher-odds-gdm-a PMID:  Environ Res. 2022 Aug 3 ;214(Pt 3):114008. Epub 2022 Aug 3. PMID: 35931192 Abstract Title:  Association of ambient fine particulate matter exposure with gestational diabetes mellitus and blood glucose levels during pregnancy. Abstract:  BACKGROUND: Previous studies have examined the associations between ambient fine particulate matter (PM) exposure and gestational diabetes mellitus (GDM). However, limited studies explored the relationships between PMexposure and blood glucose levels during pregnancy, especially in highly polluted areas.OBJECTIVES: To examine the associations of prenatal ambient PMexposure with GDM and blood glucose levels, and to identify the sensitive exposure windows in a highly air-polluted area.METHODS: From July 2016 to October 2017, a birth cohort study was conducted in Beijing, China. Participants were interviewed in each trimester regarding demographics, lifestyle, living and working environment, and medical conditions. Participant&#039;s daily ambient PMlevels from 3 m before last menstrual period (LMP) to the third trimester was estimated by a hybrid spatiotemporal model. Indoor air quality index was calculated based on environmental tobacco smoke, ventilation, cooking, painting, pesticide, and herbicide use. Distributed lag non-linear model was applied to explore the sensitive weeks of PMexposure.RESULTS: Of 165 pregnant women, 23 (13.94%) developed GDM. After adjusting for potential confounders, PMexposure during the 1trimester was associated with higher odds of GDM (10 μg/mincrease: OR = 1.89, 95% CI: 1.04-3.49). Each 10 μg/mincrease in PMduring the 2trimester was associated with 17.70% (2.21-33.20), 15.99% (2.96-29.01), 18.82% (4.11-33.52), and 17.10% (3.28-30.92) increase in 1-h, 2-h,Δ1h-fasting (1-h minus fasting), and Δ2h-fasting (2-h minus fasting) blood glucose levels, respectively. PMexposure at 24-27weeks after LMP was associated with increased GDM risk. We identified sensitive exposure windows of 21-24weeks for higher 1-h and 2-h blood glucose levels and of 20-22weeks for increasedΔ1h-fasting and Δ2h-fasting.CONCLUSIONS: Ambient PMexposure during the second trimester was associated with higher odds of GDM and higher blood glucose levels. Avoiding exposure to high air pollution levels during the sensitive windows might prevent women from developing GDM. <p><a href="https://greenmedinfo.com/article/ambient-pm25-exposure-during-second-trimester-was-associated-higher-odds-gdm-a" target="_blank">read more</a></p> https://greenmedinfo.com/article/ambient-pm25-exposure-during-second-trimester-was-associated-higher-odds-gdm-a#comments Air Pollution Linked Toxicity Diabetes: Gestational Increased Risk Human Study Sat, 27 Aug 2022 21:45:57 +0000 greenmedinfo 262542 at https://greenmedinfo.com Cumin has blood sugar lowering and anti-glycation properties supeior to the drug glibenclamide. https://greenmedinfo.com/article/cumin-has-blood-sugar-lowering-and-anti-glycation-properties-supeior-drug-glib PMID:  Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2030-6. Epub 2010 May 6. PMID: 20451573 Abstract Title:  Antihyperglycemic activity and inhibition of advanced glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats. Abstract:  Cuminum cyminum is widely used as a spice in many countries. The aim of the present study was to investigate the effect of methanolic extract of seeds of C. cyminum (CC) on diabetes, oxidative stress and formation of advanced glycated end products (AGE) and obtain comparison with glibenclamide. In vitro studies indicated that CC inhibited free radicals and AGE formation. Treatment of streptozotocin-diabetic rats with CC and glibenclamide for 28 days caused a reduction in blood glucose, glycosylated hemoglobin, creatinine, blood urea nitrogen and improved serum insulin and glycogen (liver and skeletal muscle) content when compared to diabetic control rats. Significant reduction in renal oxidative stress and AGE was observed with CC when compared to diabetic control and glibenclamide. CC and glibenclamide improved antioxidant status in kidney and pancreas of diabetic rats. Diabetic rats showed increase in rat tail tendon collagen, glycated collagen, collagen linked fluorescence and reduction in pepsin digestion. Treatment with CC significantly improved these parameters when compared to diabetic control and glibenclamide group. Though the antidiabetic effect of CC was comparable to glibenclamide it had better effect in controlling oxidative stress and inhibiting the AGE formation, which are implicated in the pathogenesis of diabetic microvascular complications. https://greenmedinfo.com/article/cumin-has-blood-sugar-lowering-and-anti-glycation-properties-supeior-drug-glib#comments Advanced Glycation End products (AGE) Cumin Diabetes Mellitus: Type 2 Diabetes: Gestational Diabetes: Oxidative Stress Antioxidants Hypoglycemic Agents Drug: Glibenclamide Natural Substances Versus Drugs Plant Extracts Animal Study Tue, 16 Aug 2011 12:47:50 +0000 greenmedinfo 68134 at https://greenmedinfo.com Diabetes: Pregnancy-Induced https://greenmedinfo.com/disease/diabetes-pregnancy-induced <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="300" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Diabetes_12.jpg?1473978915" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_kzenon&#039;&gt;kzenon / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> Diabetes: Gestational Tue, 14 Apr 2009 07:16:38 +0000 greenmedinfo 19676 at https://greenmedinfo.com First trimester exposure to sulfur dioxide was associated with increased gestational diabetes mellitus risk. https://greenmedinfo.com/article/first-trimester-exposure-sulfur-dioxide-was-associated-increased-gestational-d PMID:  Sci Total Environ. 2020 Jan 10 ;699:134390. Epub 2019 Sep 10. PMID: 31525546 Abstract Title:  Ambient air pollution exposure and gestational diabetes mellitus in Guangzhou, China: A prospective cohort study. Abstract:  BACKGROUND: Evidence concerning the effect of ambient air pollution exposure on gestational diabetes mellitus (GDM) is limited. No published studies have examined maternal weekly air pollution exposure and GDM, and the possible effect modification by folic acid supplementation has not been assessed.OBJECTIVES: To evaluate the association between air pollution exposure and GDM at trimester and weekly levels, and to explore the potential effect modification by folic acid supplementation.METHODS: A total of 5421 pregnant women were recruited during 2011-2014 in Guangzhou, China. Daily PM, PM, SOand NOlevels were collected from 10 monitoring stations. Individual&#039;s exposure during pregnancy was estimated using inverse-distance weighting approach. Binary logistic regression was used to examine the trimester-specific association between air pollution exposure and GDM. Distributed lag models (DLMs) were applied to estimate maternal weekly air pollution exposure and GDM. Stratified analyses by folic acid supplementation and interaction test were performed.RESULTS: The GDM incidence was 11.69%. An interquartile range (IQR) increase in first trimester SOwas associated with increased GDM risk in the single pollutant model, the adjusted odds ratio (aOR) and 95% confidence interval (CI) was 1.22 (1.02-1.47). In DLMs, an IQR increase in SOduring 4th to 10th gestational weeks was associated with increased GDM risk, with the strongest effect in the 7th gestational week. When stratified by maternal folic acid supplementation, first trimester exposure to SOwas associated with increased GDM risk among women taking folic acid supplements (aOR = 1.25, 95% CI: 1.03-1.53) and P value for interaction was 0.13. No significant effects were observed for PM, PMand NO.CONCLUSION: First trimester exposure to SOwas associated with increased GDM risk, especially during the 4th to 10th gestational weeks. The effect might be stronger among women taking folic acid supplements. <p><a href="https://greenmedinfo.com/article/first-trimester-exposure-sulfur-dioxide-was-associated-increased-gestational-d" target="_blank">read more</a></p> https://greenmedinfo.com/article/first-trimester-exposure-sulfur-dioxide-was-associated-increased-gestational-d#comments Air Pollution Linked Toxicity Diabetes: Gestational Increased Risk Human Study Thu, 02 Jan 2020 13:08:11 +0000 greenmedinfo 206888 at https://greenmedinfo.com Fish oil supplementation for 6 weeks in women with gestational diabetes significantly improved gene expression of PPAR-γ, IL-1, and TNF-α. https://greenmedinfo.com/article/fish-oil-supplementation-6-weeks-women-gestational-diabetes-significantly-impr PMID:  Nutrients. 2018 Jan 31 ;10(2). Epub 2018 Jan 31. PMID: 29385062 Abstract Title:  Placebo-Controlled Trial Investigating the Effect of Fish Oil Supplementation on Gene Expression Related to Insulin Action, Blood Lipids, and Inflammation in Gestational Diabetes Mellitus-Fish Oil Supplementation and Gestational Diabetes. Abstract:  Gestational diabetes mellitus (GDM) is a common complication of pregnancy, and it is mostly associated with postpartum diabetes, insulin resistance, and dyslipidemia. Fish oil (omega-3) supplementation has been shown to reduce the risk of different chronic diseases such as cardiovascular disease, type 2 diabetes, and cancers, though the evidence of its impact on gestational diabetes is scarce. Our goal in this study was to determine the effect of fish oil administration on gene expression related to insulin action, blood lipids, and inflammation in women with GDM. Participants with GDM (n = 40), aged 18-40 years, were randomized to take either 1000 mg fish oil capsules, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid (n = 20), or placebo (n = 20) twice a day for 6 weeks. Gene expression related to insulin, lipids, and inflammation was quantified in peripheral blood mononuclear cells (PBMCs) of GDM women using Reverse Transcription Polymerase Chain Reaction (RT-PCR) method. Results of RT-PCR indicated that omega-3 supplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) (P = 0.04) in PBMCs of patients with GDM, compared with the placebo. In addition, gene expression of the low-density lipoprotein receptor (LDLR) (P<p><a href="https://greenmedinfo.com/article/fish-oil-supplementation-6-weeks-women-gestational-diabetes-significantly-impr" target="_blank">read more</a></p> https://greenmedinfo.com/article/fish-oil-supplementation-6-weeks-women-gestational-diabetes-significantly-impr#comments Diabetes: Gestational Fish Oil Gestational Diabetes Anti-Inflammatory Agents Tumor Necrosis Factor (TNF) Alpha Inhibitor Gene Expression Regulation Human Study Thu, 08 Feb 2018 21:40:38 +0000 greenmedinfo 159522 at https://greenmedinfo.com Increasing physical activity may lower the risk of progression from gestational diabetes mellitus to type 2 diabetes. https://greenmedinfo.com/article/increasing-physical-activity-may-lower-risk-progression-gestational-diabetes-m PMID:  JAMA Intern Med. 2014 Jul ;174(7):1047-55. PMID: 24841449 Abstract Title:  Physical activity and sedentary behaviors associated with risk of progression from gestational diabetes mellitus to type 2 diabetes mellitus: a prospective cohort study. Abstract:  IMPORTANCE: Women with a history of gestational diabetes mellitus (GDM) are at substantially increased risk of type 2 diabetes mellitus (T2DM). The identification of important modifiable factors could help prevent T2DM in this high-risk population.OBJECTIVE: To examine the role of physical activity and television watching and other sedentary behaviors, and changes in these behaviors in the progression from GDM to T2DM.DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of 4554 women from the Nurses&#039; Health Study II who had a history of GDM, as part of the ongoing Diabetes&amp;Women&#039;s Health Study. These women were followed up from 1991 to 2007.EXPOSURES: Physical activity and television watching and other sedentary behaviors were assessed in 1991, 1997, 2001, and 2005.MAIN OUTCOMES AND MEASURE: Incident T2DM identified through self-report and confirmed by supplemental questionnaires.RESULTS: We documented 635 incident T2DM cases during 59,287 person-years of follow-up. Each 5-metabolic equivalent hours per week (MET-h/wk) increment of total physical activity, which is equivalent to 100 minutes per week of moderate-intensity physical activity, was related to a 9% lower risk of T2DM (adjusted relative risk [RR], 0.91; 95% CI, 0.88-0.94); this inverse association remained significant after additional adjustment for body mass index (BMI). Moreover, an increase in physical activity was associated with a lower risk of developing T2DM. Compared with women who maintained their total physical activity levels, women who increased their total physical activity levels by 7.5 MET-h/wk or more (equivalent to 150 minutes per week of moderate-intensity physical activity) had a 47% lower risk of T2DM (RR, 0.53; 95% CI, 0.38-0.75); the association remained significant after additional adjustment for BMI. The multivariable adjusted RRs (95% CIs) for T2DM associated with television watching of 0 to 5, 6 to 10, 11 to 20, and 20 or more hours per week were 1 (reference), 1.28 (1.04-1.59), 1.41 (1.11-1.79), and 1.77 (1.28-2.45), respectively (P value for trend<p><a href="https://greenmedinfo.com/article/increasing-physical-activity-may-lower-risk-progression-gestational-diabetes-m" target="_blank">read more</a></p> https://greenmedinfo.com/article/increasing-physical-activity-may-lower-risk-progression-gestational-diabetes-m#comments Diabetes Mellitus: Type 2: Prevention Diabetes: Gestational Exercise Physical Activity Risk Factors Risk Reduction Human Study Fri, 27 Jan 2017 16:26:20 +0000 greenmedinfo 142725 at https://greenmedinfo.com Iron supplementation is associated with glucose impairment and hypertension in midpregnancy. https://greenmedinfo.com/article/iron-supplementation-associated-glucose-impairment-and-hypertension-midpregnan PMID:  Am J Obstet Gynecol. 2009 Aug ;201(2):158.e1-6. Epub 2009 Jun 13. PMID: 19527900 Abstract Title:  Iron supplementation and gestational diabetes in midpregnancy. Abstract:  OBJECTIVE: Iron supplementation in pregnancy seems beneficial for neonatal/maternal outcomes, but it was associated with diabetes and hypertension in the general population.STUDY DESIGN: We investigated the association between iron supplementation during midpregnancy and metabolic/hypertensive abnormalities in 500 consecutive gestational diabetes mellitus (GDM) and 500 normoglycemic women.RESULTS: Iron-supplement users (n = 212/1000) showed significantly higher values of prepregnancy body mass index (BMI), actual BMI, waist circumference, blood pressure, fasting glucose, Homeostasis-Model-Assessment-Insulin-Resistance, and lower high-density lipoprotein-cholesterol than nonusers. The prevalence of GDM (70.8% vs 44.4%), hypertension (25.9% vs 9.8%), metabolic syndrome (25.9% vs 10.4%) was significantly higher in the former with a 2- to 3-fold-increased risk at multiple regression analyses. Most glucose values of the oral glucose tolerance test were significantly higher in iron supplemented women, both in GDM and normoglycemic individuals.CONCLUSION: Iron supplementation is associated with glucose impairment and hypertension in midpregnancy; its potential harmful effects might be carefully debated regarding its effectiveness. https://greenmedinfo.com/article/iron-supplementation-associated-glucose-impairment-and-hypertension-midpregnan#comments Diabetes: Gestational Gestational Diabetes Hypertension: Pre-Eclampsia Induced Metabolic Syndrome X Prenatal Nutrition: Prevention of Problems Industrial Iron Human Study Sun, 30 Oct 2011 00:04:48 +0000 greenmedinfo 69468 at https://greenmedinfo.com Results of this study reveal a higher risk of development of gestational diabetes mellitus among pregnant women having deficient vitamin D status. https://greenmedinfo.com/article/results-study-reveal-higher-risk-development-gestational-diabetes-mellitus-amo PMID:  BMC Pregnancy Childbirth. 2018 Apr 10 ;18(1):86. Epub 2018 Apr 10. PMID: 29631547 Abstract Title:  Lower vitamin D levels in Saudi pregnant women are associated with higher risk of developing GDM. Abstract:  BACKGROUND: Gestational diabetes mellitus (GDM) has serious consequences such as increased risks of preeclampsia, macrosomia and cesarean delivery. Even though the mechanistic basis of GDM has not been completely understood, several risk factors have been identified and one of these is vitamin D. However, the link between vitamin D deficiency and development of GDM is yet to be proven with certainty.METHODS: This study aimed to investigate the link between the incidence of GDM and serum vitamin D level in pregnant women of Saudi Arabia. 515 Saudi women (ages 18-46) in their 24-28th week of pregnancy, visiting various hospitals of Riyadh, participated in this study. Serum vitamin D and various biochemical and anthropometric parameters were determined in the first trimester and the recruits were screened for GDM by OGTT according to IADPSG criteria in their 2nd trimester. The association between vitamin D deficiency and development of GDM was calculated based on odds ratio of the incidence of GDM among vitamin D deficient and normal women.RESULTS: In this study cohort of 515 pregnant women, in the first trimester vitamin D deficiency (<p><a href="https://greenmedinfo.com/article/results-study-reveal-higher-risk-development-gestational-diabetes-mellitus-amo" target="_blank">read more</a></p> https://greenmedinfo.com/article/results-study-reveal-higher-risk-development-gestational-diabetes-mellitus-amo#comments Diabetes: Gestational Vitamin D Deficiency Increased Risk Human Study Mon, 02 Jul 2018 12:47:46 +0000 greenmedinfo 166677 at https://greenmedinfo.com These findings suggested that exposure to BPA might affect glucose homeostasis and the middle term of pregnancy. https://greenmedinfo.com/article/these-findings-suggested-exposure-bpa-might-affect-glucose-homeostasis-and-mid PMID:  Environ Sci Pollut Res Int. 2020 Oct 20. Epub 2020 Oct 20. PMID: 33083951 Abstract Title:  Serum Bisphenol A, glucose homeostasis, and gestational diabetes mellitus in Chinese pregnant women: a prospective study. Abstract:  Lab studies have suggested that exposure to Bisphenol A (BPA) could disturb glucose homeostasis, but epidemiologic studies are limited and show inconsistent results for pregnant women. For this, 535 pregnant women were selected from a pregnant women cohort established in Tangshan City in North China between 2013 and 2014. Serum concentrations of BPA were measured in the early term of pregnancy, and fasting glucose and insulin levels were repeatedly measured in each of three terms of pregnancy (early, middle, and late). Gestational diabetes mellitus (GDM) were examined by Oral Glucose Tolerance Test (OGTT) in the middle and late terms of pregnancy. BPA was detected in 97.5% of pregnant women with a median of 6.50 ng/ml. Natural log-transformed BPA (Ln BPA) was positively associated with fasting glucose level (β (95% CI): 0.038 (0.015~0.061)), fasting insulin level (0.195 (0.069~0.321)), and homeostasis model insulin resistance index (HOMA-IR) (0.226 (0.087~0.364)) in the middle term of pregnancy by multiple linear regression model after adjusting for potential confounders. After serum BPA levels were divided into three groups (low, middle, and high), BPA showed a positive dose-response relationship with blood glucose, insulin, and HOMA-IR in the middle term of pregnancy. Increased BPA concentrationtended to increase the RR of GDM although not statistically significant (risk ratio: 2.51 (95% CI: 0.68~9.30) for high vs low tertile of BPA concentrations). These findings suggested that exposure to BPA might affect glucose homeostasis and the middle term of pregnancy was a potentially sensitive period. <p><a href="https://greenmedinfo.com/article/these-findings-suggested-exposure-bpa-might-affect-glucose-homeostasis-and-mid" target="_blank">read more</a></p> https://greenmedinfo.com/article/these-findings-suggested-exposure-bpa-might-affect-glucose-homeostasis-and-mid#comments Bisphenol Toxicity Diabetes: Gestational Bisphenol A Risk Factors Human Study Fri, 20 Nov 2020 01:37:20 +0000 greenmedinfo 229870 at https://greenmedinfo.com This meta-analysis indicates a consistent association between vitamin D deficiency and an increased risk of gestational diabetes mellitus. https://greenmedinfo.com/article/meta-analysis-indicates-consistent-association-between-vitamin-d-deficiency-an PMID:  Nutrients. 2015 Oct 1 ;7(10):8366-75. Epub 2015 Oct 1. PMID: 26437429 Abstract Title:  Vitamin D Deficiency Increases the Risk of Gestational Diabetes Mellitus: A Meta-Analysis of Observational Studies. Abstract:  The results investigating the relationship between vitamin D levels and gestational diabetes mellitus (GDM) are inconsistent. Thus, we focused on evaluating the association of vitamin D deficiency with GDM by conducting a meta-analysis of observed studies. A systematic literature search was conducted via PubMed, MEDLINE, and Cochrane library to identify eligible studies before August 2015. The meta-analysis of 20 studies including 9209 participants showed that women with vitamin D deficiency experienced a significantly increased risk for developing GDM (odds ratio (OR) = 1.53; 95% confidence intervals (CI), 1.33, 1.75) with a little heterogeneity (I² = 16.20%, p = 0.252). A noteworthy decrease of 4.93 nmol/L (95% CI, -6.73, -3.14) in serum 25(OH)D was demonstrated in the participants with GDM, and moderate heterogeneity was observed (I² = 61.40%, p = 0.001). Subgroup analysis with study design showed that there were obvious heterogeneities in nested case-control studies (I²&gt;52.5%, p<p><a href="https://greenmedinfo.com/article/meta-analysis-indicates-consistent-association-between-vitamin-d-deficiency-an" target="_blank">read more</a></p> https://greenmedinfo.com/article/meta-analysis-indicates-consistent-association-between-vitamin-d-deficiency-an#comments Diabetes: Gestational Vitamin D Vitamin D Deficiency Increased Risk Meta Analysis Mon, 02 Jul 2018 13:01:31 +0000 greenmedinfo 166685 at https://greenmedinfo.com This meta-analysis showed that the serum selenium level of patients with GDM was lower than that in healthy pregnant women. https://greenmedinfo.com/article/meta-analysis-showed-serum-selenium-level-patients-gdm-was-lower-healthy-pregn PMID:  Diabetes Metab Res Rev. 2022 Jan 26:e3522. Epub 2022 Jan 26. PMID: 35080114 Abstract Title:  The association between serum selenium level and gestational diabetes mellitus: A systematic review and meta-analysis. Abstract:  BACKGROUND: The relationship between serum selenium level and gestational diabetes mellitus (GDM) is controversial. The purpose is to update and summarize previous studies to understand the relationship in more detail.METHODS: PubMed, The Cochrane Library, EMBASE, Web of science, CNKI, WANFANG DATA and Cqvip were searched for studies published up to 3 September 2021. The random-effects model was used to measure the combined estimation. The overall effect was reported in a standard mean difference (SMD) and 95% confidence interval (95% CI). All data were analysed by Review Manager 5.4.RESULTS: Twenty-seven studies involving 1588 patients with GDM and 2450 healthy pregnant women contributed to this meta-analysis. Selenium level was significantly lower in women with GDM than those without GDM (SMD = -1.29; 95% CI: -1.60 to -0.97, p <p><a href="https://greenmedinfo.com/article/meta-analysis-showed-serum-selenium-level-patients-gdm-was-lower-healthy-pregn" target="_blank">read more</a></p> https://greenmedinfo.com/article/meta-analysis-showed-serum-selenium-level-patients-gdm-was-lower-healthy-pregn#comments Diabetes: Gestational Mineral Deficiencies: Selenium Selenium Meta Analysis Risk Factors Review Fri, 04 Feb 2022 18:28:53 +0000 greenmedinfo 252762 at https://greenmedinfo.com