Esophageal Diseases https://greenmedinfo.com/taxonomy/term/1986/all en Alendronate users have an increased rate of esophageal and gastric events. https://greenmedinfo.com/article/alendronate-users-have-increased-rate-esophageal-and-gastric-events PMID:  Pharmacoepidemiol Drug Saf. 2000 Sep;9(5):371-6. PMID: 19025842 Abstract Title:  Incidence of adverse oesophageal and gastric events in alendronate users. Abstract:  Purpose- To estimate the incidence of adverse gastrointestinal events in alendronate users.Methods- The computerized pharmacy claims of 12 geographically dispersed United Health Group-affiliated health plans were used to identify 1421 persons who received alendronate prescriptions. The medical claims data of these individuals were searched for subsequent diagnoses of oesophagitis, ulcer of the oesophagus, oesophageal perforation, gastric ulcer, and gastritis/duodenitis. The incidence level was estimated as cumulative incidence and incidence density and their 95% confidence intervals.Results- Thirty-nine persons had a diagnostic code indicating an incident oesophageal or gastric diagnosis of interest, including 22 with oesophagitis, two with oesophageal ulcer, one with gastric ulcer, and 15 with gastritis/duodenitis. Thirteen cases (33.3%) underwent upper endoscopic examination. Five (12.8%) patients were hospitalized. Reflecting alendronate use, 95% of patients were female. The cumulative incidence of oesophageal and gastric events for alendronate users was 3.1% in females, 2.0% in males, and 3.0% overall. The incidence density of a diagnosis of oesophageal or gastric events was 9.0 per 100 woman-years of exposure. There was no significant variation in the cumulative incidence among different age groups.Conclusions- These results suggest the incidence of oesophageal and gastric diagnostic codes is high among alendronate users. Further research is needed to assess the possible association between alendronate and adverse upper gastrointestinal events. Copyright (c) 2000 John Wiley&amp;Sons, Ltd. https://greenmedinfo.com/article/alendronate-users-have-increased-rate-esophageal-and-gastric-events#comments Esophageal Diseases Gastric Ulcer Alendronate (trade name Fosamax) Ulcerogenic Human Study Tue, 09 Nov 2010 22:40:01 +0000 greenmedinfo 58524 at https://greenmedinfo.com Anti-inflammation and protective effects of Anethum graveolens on esophageal mucosa damages. https://greenmedinfo.com/article/anti-inflammation-and-protective-effects-anethum-graveolens-esophageal-mucosa- PMID:  Foods. 2021 Oct 18 ;10(10). Epub 2021 Oct 18. PMID: 34681549 Abstract Title:  Anti-Inflammation and Protective Effects ofL. (Dill Seeds) on Esophageal Mucosa Damages in Reflux Esophagitis-Induced Rats. Abstract:  L. (dill seeds) are important medicinal and functional foods in Europe and central and south Asia, often used as a seasoning in daily diets.L. seeds (AGS) are used to treat indigestion and have shown physiological activities such as those against hypoglycemia and gastroesophageal disease. This study explored the protective effects of AGS extract on mucosal damages and inflammation in reflux esophagitis rats. AGS inhibited cellular inflammation including NO production and the expression of inflammatory proteins (iNOS and COX2 etc.), cytokines (IL-1β and TNF-α) and nuclear transfer factor related to NF-κB signaling caused by LPS stimulation in vitro. Furthermore, reflux esophagitis-induced rats were used to observe the anti-inflammatory effect of AGS. Tissue staining and inflammation-related protein expression of rats with acute reflux esophagitis indicated that AGS improved this inflammatory response, such as COX-2 and TNF-α in mucosa. In conclusion, AGS have good physiological activity and the possibility of being used as a medicinal food and a functional resource for the prevention and therapy of gastroesophageal diseases. <p><a href="https://greenmedinfo.com/article/anti-inflammation-and-protective-effects-anethum-graveolens-esophageal-mucosa-" target="_blank">read more</a></p> https://greenmedinfo.com/article/anti-inflammation-and-protective-effects-anethum-graveolens-esophageal-mucosa-#comments Dill Esophageal Diseases Esophageal Reflux Anti-Inflammatory Agents Gastrointestinal Agents Animal Study Mon, 10 Jan 2022 20:31:44 +0000 greenmedinfo 251485 at https://greenmedinfo.com