Exophthalmic Goiter https://greenmedinfo.com/taxonomy/term/2020/all en 3,3'-Diindolylmethane, a compound found in cruciferous vegetables has an anti-proliferative effects in thyroid proliferative disease. https://greenmedinfo.com/article/33-diindolylmethane-compound-found-cruciferous-vegetables-has-anti-proliferati PMID:  Biochem Biophys Res Commun. 2005 Nov 25;337(3):1019-25. Epub 2005 Oct 3. PMID: 16219298 Abstract Title:  3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease. Abstract:  Considerable epidemiological evidence exists to link thyroid disease with differing patterns of dietary consumption, in particular, cruciferous vegetables. We have been studying the anti-thyroid cancer (TCa) activity of indole-3-carbinol (I3C) found in cruciferous vegetables and its acid catalyzed dimer, 3,3'-diindolylmethane (DIM). There are no studies as yet to elucidate the effect of these compounds on the altered proliferative patterns in goiter or thyroid neoplasia. In this study, we tested the anti-proliferative effects of I3C and DIM on four different thyroid cancer cell lines representative of papillary (B-CPAP and 8505-C) and follicular carcinoma of the thyroid (CGTH-W-1 and ML-1), and primary human goiter cells. Cell survival and IC50 values for I3C and DIM were calculated by the XTT assay and cell cycle distribution analysis was done by flow cytometry. DIM was found to be a better anti-proliferative agent than I3C in both papillary and follicular TCa resulting in a greater cytotoxic effect at a concentration over three fold lower than predicted by the molar ratio of DIM and I3C. The anti-proliferative activity of DIM in follicular TCa was mediated by a G1 arrest followed by induction of apoptosis. DIM also inhibited the growth of primary goiter cells by 70% compared to untreated controls. Contrary to traditional belief that cruciferous vegetables are "goitrogenic", DIM has anti-proliferative effects in glandular thyroid proliferative disease. Our preclinical studies provide a strong rationale for the clinical exploration of DIM as an adjuvant to surgery in thyroid proliferative disease.   https://greenmedinfo.com/article/33-diindolylmethane-compound-found-cruciferous-vegetables-has-anti-proliferati#comments DMSO (Dimethyl sulphoxide) Exophthalmic Goiter Goiter: Exophthalmic Thyroid Cancer Papillary Carcinoma In Vitro Study Sat, 16 May 2009 03:44:20 +0000 greenmedinfo 44269 at https://greenmedinfo.com There is a significant relationship between serum zinc levels and thyroid volume in patients with nodular goiter. https://greenmedinfo.com/article/there-significant-relationship-between-serum-zinc-levels-and-thyroid-volume-pa PMID:  Hormones (Athens). 2010 Jul-Sep;9(3):263-8. PMID: 20688624 Abstract Title:  Relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation. Abstract:  OBJECTIVE: Zinc is essential for many biochemical processes and also for cell proliferation. Thyroid hormones influence zinc metabolism by affecting zinc absorption and excretion. Additionally, zinc deficiency affects thyroid function. The aim of the present study was to evaluate a possible association of zinc levels with thyroid volume, thyroid hormones and thyroid autoantibody levels in healthy subjects, patients with autoimmune thyroid disease (AITD) and patients with nodular goitre following successful iodine supplementation. This is a cross-sectional study in which 201 subjects who were not under medical treatment and did not have previous thyroid surgery or radio-iodine treatment were evaluated. Seventy patients had nodular goitre, 67 AITD and 64 had normal thyroid. Thyroid volume was calculated by ultrasonographic measurements. Serum free T4, T3, TSH, anti-thyroglobulin and anti-thyroid peroxidase levels were determined by appropriate methodology.RESULTS: In patients with normal thyroid, zinc levels were significantly positively correlated with free T3 levels (p https://greenmedinfo.com/article/there-significant-relationship-between-serum-zinc-levels-and-thyroid-volume-pa#comments Exophthalmic Goiter Thyroid Nodule Zinc Zinc Deficiency Human Study Sun, 15 May 2011 04:39:58 +0000 greenmedinfo 63820 at https://greenmedinfo.com