Gastroschisis https://greenmedinfo.com/taxonomy/term/2241/all en Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model. https://greenmedinfo.com/article/maternal-administration-cannabidiol-promotes-anti-inflammatory-effect-intestin PMID:  Braz J Med Biol Res. 2018 Mar 15 ;51(5):e7132. Epub 2018 Mar 15. PMID: 29561958 Abstract Title:  Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model. Abstract:  Gastroschisis (GS) is an abdominal wall defect that results in histological and morphological changes leading to intestinal motility perturbation and impaired absorption of nutrients. Due to its anti-inflammatory, antioxidant, and neuroprotective effects, cannabidiol (CBD) has been used as a therapeutic agent in many diseases. Our aim was to test the effect of maternal CBD in the intestine of an experimental model of GS. Pregnant rats were treated over 3 days with CBD (30 mg/kg) after the surgical induction of GS (day 18.5 of gestation) and compared to controls. Fetuses were divided into 4 groups: 1) control (C); 2) C+CBD (CCBD); 3) gastroschisis (G), and 4) G+CBD (GCBD). On day 21.5 of gestation, the fetuses were harvested and evaluated for: a) body weight (BW), intestinal weight (IW), and IW/BW ratio; b) histometric analysis of the intestinal wall; c) immunohistochemically analysis of inflammation (iNOS) and nitrite/nitrate level. BW: GCBD was lower than CCBD (P<p><a href="https://greenmedinfo.com/article/maternal-administration-cannabidiol-promotes-anti-inflammatory-effect-intestin" target="_blank">read more</a></p> https://greenmedinfo.com/article/maternal-administration-cannabidiol-promotes-anti-inflammatory-effect-intestin#comments Cannabidiol Gastroschisis Inflammation Anti-Inflammatory Agents Animal Study Fri, 06 Apr 2018 22:47:10 +0000 greenmedinfo 162306 at https://greenmedinfo.com