Lymphoma https://greenmedinfo.com/taxonomy/term/2257/all en Increased sun exposure of children may also be associated with a decreased risk of developing both childhood non Hodgkin and Hodgkin lymphoma. https://greenmedinfo.com/article/increased-sun-exposure-children-may-also-be-associated-decreased-risk-developi PMID:  Cancer Causes Control. 2007 Nov;18(9):1031-7. Epub 2007 Jul 26. PMID: 17653828 Abstract Title:  Sun exposure, birth weight, and childhood lymphomas: a case control study in Greece. Abstract:  OBJECTIVES: To explore whether the inverse association of sun exposure with non Hodgkin lymphoma among adults is also evident among the childhood population and test the specificity of the relation by contrasting the findings to those for Hodgkin lymphoma.METHODS: A total of 87 cases of childhood (0-14 years) with non Hodgkin lymphoma and 71 with Hodgkin lymphoma, diagnosed in Greece through the national network of childhood Hematology-Oncology Units, during a 7-year period, along with 164 age- and gender-matched control children were enrolled in the study. The guardians of all eligible children were interviewed in person on the basis of a structured questionnaire covering socio-demographic, anthropometric, and perinatal characteristics. Average time of sunbathing per year at a seaside resort was used as a proxy variable of exposure to sun controlling for use of sun protection measures.RESULTS: The estimated incidence of 10.2 cases per 1,000,000 children-years {95% Confidence Intervals (CI), 8.4-12.1} for NHL during the study period in Greece is around the average figure in countries of the European Union. There was an inverse association of sun exposure with Non Hodgkin lymphoma, namely, for an increment of 15 days of sunbathing at seaside resorts children had almost 40% lower risk (Odds Ratio: 0.60, 95% CI: 0.43-0.83), whereas no such association was evident for Hodgkin lymphoma. The risk for non Hodgkin lymphoma has been found to be statistically and significantly higher in birth weight (Odds ratio: 1.42 and 95% CI, 1.04-1.92, for every 500 g increment), whereas there was no substantial indication that maternal education or maternal smoking during the child&#039;s life were important risk factors for the disease.CONCLUSIONS: This is the first study to provide epidemiological evidence that increased sun exposure of children may also be associated with a decreased risk of developing childhood non Hodgkin, but not Hodgkin lymphoma. https://greenmedinfo.com/article/increased-sun-exposure-children-may-also-be-associated-decreased-risk-developi#comments Cancer: Childhood Hodgkin Lymphoma Lymphoma Lymphoma: Non-Hodgkin Sunlight exposure Human Study Fri, 18 Feb 2011 17:28:30 +0000 greenmedinfo 61713 at https://greenmedinfo.com Larrea divaricata has an antiproliferative activity on lymphoma cell line: participation of hydrogen peroxide in its action. https://greenmedinfo.com/article/larrea-divaricata-has-antiproliferative-activity-lymphoma-cell-line-participat PMID:  Cancer Invest. 2010 Jan;28(1):13-22. PMID: 20001294 Abstract Title:  Antiproliferative activity of Larrea divaricata Cav. on lymphoma cell line: participation of hydrogen peroxide in its action. Abstract:  Larrea divaricata is a plant used in Argentina. The aim was to analyze the participation of H2O2 in the antiproliferative effect of L divaricata on BW5147 cells. Different studies were performed: proliferation, viability, nitrite production, apoptosis, oxygen reducing activity, NF-kappa B translocation, H2O2 production, H2O2 scavenging activity, and effect on exogenous superoxide dismutase. The extract decreased proliferation and induced apoptosis through P-38 and ERK pathways. The extract activated Mn2+-SOD, increasing H2O2, which was implicated in the antiproliferative mechanism by the increase of Nitric oxide (NO). New drugs, which can increase H2O2, could be a therapeutic strategy for the treatment of cancer. https://greenmedinfo.com/article/larrea-divaricata-has-antiproliferative-activity-lymphoma-cell-line-participat#comments Hydrogen Peroxide Larrea divaricata Lymphoma Antiproliferative In Vitro Study Fri, 01 Jan 2010 00:03:18 +0000 greenmedinfo 48501 at https://greenmedinfo.com The clinical cases presented here reinforce the hypothesis that GcMAF could become part of anticancer immunotherapeutic regimens. https://greenmedinfo.com/article/clinical-cases-presented-here-reinforce-hypothesis-gcmaf-could-become-part-ant PMID:  Oncoimmunology. 2013 Aug 1 ;2(8):e25769. Epub 2013 Jul 29. PMID: 24179708 Abstract Title:  GC protein-derived macrophage-activating factor decreasesα-N-acetylgalactosaminidase levels in advanced cancer patients. Abstract:  α-N-acetylgalactosaminidase (nagalase) accumulates in the serum of cancer patients and its activity correlates with tumor burden, aggressiveness and clinical disease progression. The administration of GC protein-derived macrophage-activating factor (GcMAF) to cancer patients with elevated levels ofnagalase has been associated with a decrease of serum nagalase activity and with significant clinical benefits. Here, we report the results of the administration of GcMAF to a heterogeneous cohort of patients with histologically diverse, advanced neoplasms, generally considered as&quot;incurable&quot;diseases. In most cases, GcMAF therapy was initiated at late stages of tumor progression. As this is an open-label, non-controlled, retrospective analysis, caution must be employed when establishing cause-effect relationships between the administration GcMAF and disease outcome. However, the response to GcMAF was generally robust and some trends emerged. All patients (n = 20) presented with elevated serum nagalase activity, well above normal values. All patients but one showed a significant decrease of serum nagalase activity upon weekly GcMAF injections. Decreased nagalase activity was associated with improved clinical conditions and no adverse side effects were reported. The observations reported here confirm and extend previous results and pave the way to further studies aimed at assessing the precise role and indications for GcMAF-based anticancer immunotherapy. https://greenmedinfo.com/article/clinical-cases-presented-here-reinforce-hypothesis-gcmaf-could-become-part-ant#comments Bladder Cancer Breast Cancer Follicular Lymphoma Gc protein-derived macrophage activating factor (GcMAF) Laryngeal Cancer Lymphoma Ovarian Cancer Prostate Cancer Tongue Cancer Immunomodulatory Nagalase Significant Treatment Outcome Human Study Thu, 06 Aug 2015 01:23:21 +0000 greenmedinfo 119586 at https://greenmedinfo.com 2-5% of celiac disease does not respond to a gluten-free diet and may lead to the development of enteropathy-associated T-cell lymphoma. https://greenmedinfo.com/article/2-5-celiac-disease-does-not-respond-gluten-free-diet-and-may-lead-development- PMID:  Nat Rev Gastroenterol Hepatol. 2010 Apr;7(4):204-13. Epub 2010 Mar 9. PMID: 20212505 Abstract Title:  The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Abstract:  Celiac disease is a gluten-sensitive enteropathy that affects people of all ages worldwide. This disease has emerged as a major health-care problem, as advances in diagnostic and screening methods have revealed its global prevalence. Environmental factors such as gluten introduction at childhood, infectious agents and socioeconomic features, as well as the presence of HLA-DQ2 and/or HLA-DQ8 haplotypes or genetic variations in several non-HLA genes contribute to the development of celiac disease. Growing insight into the variable clinical and histopathological presentation features of this disease has opened new perspectives for future research. A strict life-long gluten-free diet is the only safe and efficient available treatment, yet it results in a social burden. Alternative treatment modalities focus on modification of dietary components, enzymatic degradation of gluten, inhibition of intestinal permeability and modulation of the immune response. A small group of patients with celiac disease (2-5%), however, fail to improve clinically and histologically upon elimination of dietary gluten. This complication is referred to as refractory celiac disease, and imposes a serious risk of developing a virtually lethal enteropathy-associated T-cell lymphoma. https://greenmedinfo.com/article/2-5-celiac-disease-does-not-respond-gluten-free-diet-and-may-lead-development-#comments Celiac Disease Celiac Disease: Refractory Lymphoma Lymphoma: T-cell Diseases that are Linked Human Study Wed, 10 Nov 2010 00:58:49 +0000 greenmedinfo 58551 at https://greenmedinfo.com A case report of Non-Hodgkin's lymphoma of the thyroid after many years of immunizations. https://greenmedinfo.com/article/case-report-non-hodgkins-lymphoma-thyroid-after-many-years-immunizations PMID:  Pol Merkur Lekarski. 2008 Aug ;25(146):155-7. PMID: 18942337 Abstract Title:  [Lymphoma of the thyroid in a patient with autoimmune thyroiditis and Sjögren&#039;s syndrome--case report]. Abstract:  We present the case of a 74 year old patient suffering from primary Non Hodgkin&#039;s lymphoma of the thyroid and Sjogren&#039;s syndrome. A massively enlarging goitre, causing breathlessness in a female patient previously treated for autoimmune inflammation of the thyroid (Hashimoto&#039;s disease) and Sjogren&#039;s syndrome, indicated the need for a fine needle aspiration biopsy (FNA) of the thyroid gland. Non Hodgkin&#039;s lymphoma of the thyroid was diagnosed and chemotherapy was begun. After 10 months of cytostatic treatment clinical tests and imaging indicated complete local regression. However, two months after cessation of chemotherapy the patient suffered a relapse of the disease owing to infiltration of the central nervous system. During the course of palliative radiotherapy the patient died. The main purpose for presenting this case was to describe the problem of primary lymphoma of the thyroid in cases of autoimmune disease. As many years of immunisation may lead to carcinogenesis it is important to raise awareness among medical staff with regard to cases of chronic autoimmune disease. In cases of Hashimoto&#039;s autoimmune disease of the thyroid, monitoring of the anti-thyroid antibodies is indicated, at least annually, as an increase in the concentration of these antibodies over a period of at least seven years would suggest further development of autoimmune disease. If such conditions are accompanied by tumours of the thyroid, surgery should be considered. It is worth keeping in mind that the thyroid can be a site for extra-lymphatic lymphoma. <p><a href="https://greenmedinfo.com/article/case-report-non-hodgkins-lymphoma-thyroid-after-many-years-immunizations" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-non-hodgkins-lymphoma-thyroid-after-many-years-immunizations#comments Hashimoto's thyroiditis Lymphoma Sjogren's Syndrome Thyroid Cancer Vaccine-induced Toxicity Vaccination: All Human: Case Report Fri, 13 Dec 2019 21:16:46 +0000 greenmedinfo 204741 at https://greenmedinfo.com A derived protein fraction from oyster mushroom exhibits anti-tumor properties in Dalton's lymphoma bearing mice. https://greenmedinfo.com/article/derived-protein-fraction-oyster-mushroom-exhibits-anti-tumor-properties-dalton PMID:  Int J Med Mushrooms. 2011 ;13(5):427-40. PMID: 22324408 Abstract Title:  Antitumor effect of culinary-medicinal oyster mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., derived protein fraction on tumor-bearing mice models. Abstract:  Previously, we reported the in vitro anticancer and immunomodulatory effect of a protein fraction designated as Cibacron blue affinity purified protein (CBAEP) obtained from the culinary-medicinal oyster mushroom, Pleurotus ostreatus. In the present study, we investigated the in vivo antitumor potential of CBAEP in different tumor-bearing mice models and studied the detailed mechanism of tumor regression in Dalton lymphoma (DL)-bearing mice. The lethal dose (LD50) of CBAEP was found to be 55 mg/kg body weight and sublethal doses (5 mg/kg and 10 mg/kg body weight) showed a prolonged tumor survival time in DL, Sarcoma-180, and B16F0 melanoma tumor-bearing mice. Further, CBAEP reduced about 35.68 and 51.43% DL cell growth in 5 and 10 mg/kg body weight, respectively. The in vivo CBAEP treatment showed an apoptotic feature as demonstrated in morphological study and sub-G0/G1 population in cell cycle and Western blot of DL cells. CBAEP also activated immunosuppression condition in DL tumor-bearing host. It also stimulated immune cells in the presence of nonspecific immunostunulator (LPS and ConA) ex vivo as well as enhanced Th1 response with production of TNF-α, IFN-γ, and IL-2. Moreover, it activated tumor-associated macrophages and NK cells. The present findings revealed the potent antitumor property of CBAEP, which might help in developing a new anticancer drug. https://greenmedinfo.com/article/derived-protein-fraction-oyster-mushroom-exhibits-anti-tumor-properties-dalton#comments Lymphoma Oyster Mushroom Antineoplastic Agents Fungal Proteins Animal Study Fri, 30 Mar 2012 02:52:26 +0000 greenmedinfo 73721 at https://greenmedinfo.com A fermented wheat germ extract attenuates the growth of human lymphoma cells through induction of programmed cell death. https://greenmedinfo.com/article/fermented-wheat-germ-extract-attenuates-growth-human-lymphoma-cells-through-in PMID:  Oncol Rep. 2009 Mar;21(3):787-91. PMID: 19212640 Abstract Title:  Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis. Abstract:  Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited the growth of sensitive H9 cells with IC50 values of 290 and 200 microg/ml, whereas the growth of 5-FdUrd/Ara-C cross-resistant H9 cells was attenuated with IC50 values of 180 and 145 microg/ml, respectively. Treatment with 300 microg/ml MSC for 48 h caused dose-dependent induction of apoptosis in 48% of sensitive H9 cells. In cross-resistant H9 cells, incubation with 200 microg/ml Avemar for 48 h led to 41% of apoptotic tumor cells. Growth arrest of sensitive H9 cells after exposure to various concentrations of MSC occurred mainly in the S phase of the cell cycle, thereby increasing the cell population from 54 to 73% while depleting cells in the G0-G1 phase from 40 to 19%. Growth arrest in cross-resistant H9 cells occurred also mainly in the S phase, increasing the cell population from 45 to 68% while depleting cells in the G0-G1 phase from 45 to 31%. As MSC treatment likely overcomes 5-FdUrd/Ara-C resistance, further investigations to elucidate the exact mechanisms are warranted. We conclude that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies. https://greenmedinfo.com/article/fermented-wheat-germ-extract-attenuates-growth-human-lymphoma-cells-through-in#comments Fermented Foods and Beverages Lymphoma Wheat Germ Apoptotic In Vitro Study Fri, 01 Jan 2010 00:18:07 +0000 greenmedinfo 48506 at https://greenmedinfo.com A genistein-rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines. https://greenmedinfo.com/article/genistein-rich-compound-inhibits-proliferation-and-induces-apoptosis-lymphoma- PMID:  Cancer Invest. 2007 Sep;25(6):411-8. PMID: 19394691 Abstract Title:  GCP, a genistein-rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines. Abstract:  Genistein combined polysaccharide (GCP), derived from soy bean extract, is comprised of deglycosylated isoflavones, such as genistein and daidzein. The goal of this work was to determine if GCP is effective in lymphoid cancers. In three human and four canine lymphoid cell lines, GCP inhibited proliferation and induced G2/M arrest. Additionally, increased apoptosis was observed in Ramos and Jurkat lines. These results demonstrate that GCP is effective in lymphoid cell lines of both human and canine origin. Due to its minimal toxicities, increased bioavailability, and in vitro efficacy, GCP may have clinical utility in the treatment of patients with lymphoma. https://greenmedinfo.com/article/genistein-rich-compound-inhibits-proliferation-and-induces-apoptosis-lymphoma-#comments Genistein Lymphoma Antiproliferative Apoptotic In Vitro Study Fri, 01 Jan 2010 00:15:47 +0000 greenmedinfo 48505 at https://greenmedinfo.com A high frequency of celiac disease was found in patients with lymphoma in the southeast region of Turkey. https://greenmedinfo.com/article/high-frequency-celiac-disease-was-found-patients-lymphoma-southeast-region-tur PMID:  Turk J Gastroenterol. 2009 Jun ;20(2):87-92. PMID: 19530040 Abstract Title:  Screening for Celiac disease in Hodgkin and non-Hodgkin lymphoma patients. Abstract:  BACKGROUND/AIMS: Celiac disease is an abnormal T cell-mediated immune response against dietary gluten in genetically predisposed individuals. The aim of our prospective study was to evaluate the frequency of Celiac disease in patients with lymphoma and to determine the usefulness of the anti-gliadin and anti-endomysial antibodies (EMA) for diagnosis of Celiac disease in this patient group.METHODS: We studied 119 patients with previously or newly diagnosed non-Hodgkin&#039;s lymphoma and 60 patients with Hodgkin&#039;s lymphoma who presented at the hematology and medical oncology divisions of Dicle University Hospital in Turkey between December 2002 and January 2006. Serological screening for Celiac disease was performed in all patients by searching for serum anti-gliadin immunoglobulin A and immunoglobulin G, and EMA immunoglobulin A and immunoglobulin G.RESULTS: In the Hodgkin&#039;s lymphoma group, anti-gliadin immunoglobulin A was detected in 9 (15%) patients (3 male, 6 female), and antigliadin immunoglobulin G was detected in 21 (35%) patients (15 male, 6 female). In the non-Hodgkin&#039;s lymphoma group, antigliadin immunoglobulin A was detected in 6 (5%) patients (2 M male 4 female), and anti-gliadin immunoglobulin G was detected in 30 (25.2%) patients (18 male, 12 female). EMA immunoglobulin A and immunoglobulin G were not detected in the Hodgkin&#039;s lymphoma and non-Hodgkin&#039;s lymphoma groups.CONCLUSIONS: Our report is the first to describe the frequency of Celiac disease in patients with lymphoma in the southeast region of Turkey. In our study, there was no evidence that Celiac disease is a pre-malignant condition for lymphoma. Serological screening for Celiac disease in lymphoma patients does not seem to be necessary. https://greenmedinfo.com/article/high-frequency-celiac-disease-was-found-patients-lymphoma-southeast-region-tur#comments Celiac Disease Lymphoma Non-Hodgkin Lymphoma Gliadin Human Study Fri, 30 Mar 2012 21:20:44 +0000 greenmedinfo 73750 at https://greenmedinfo.com A high-fiber diet and butyrate significantly inhibited the growth lymphoma tumors. https://greenmedinfo.com/article/high-fiber-diet-and-butyrate-significantly-inhibited-growth-lymphoma-tumors PMID:  Leuk Lymphoma. 2016 Feb 17:1-8. Epub 2016 Feb 17. PMID: 26885564 Abstract Title:  Butyrate production from high-fiber diet protects against lymphoma tumor. Abstract:  Gut microbiota and dietary fiber are critical for protecting body from obesity, diabetes and cancer. Butyrate, produced in the gut by bacterial fermentation of dietary fibers, is demonstrated to be protective against the development of colorectal cancer as a histone deacetylase (HDAC) inhibitor. We report that high-fiber diet and butyrate significantly inhibited the growth lymphoma tumors. Butyrate induced apoptosis of lymphoma tumor cells and significantly up-regulated histone 3 acetylation (H3ac) level and target genes such as Fas, P21, P27. Our results unravel an instrumental role of fiber diet and their metabolites on lymphoma tumor and demonstrate an intervention potential on the prevention and therapy of lymphoma. https://greenmedinfo.com/article/high-fiber-diet-and-butyrate-significantly-inhibited-growth-lymphoma-tumors#comments Butyrate Fiber Lymphoma Apoptotic Microbiota In Vitro Study Mon, 07 Mar 2016 03:43:36 +0000 greenmedinfo 124509 at https://greenmedinfo.com A higher intake of flavonoids may be associated with lower non-Hodgkin lymphoma risk. https://greenmedinfo.com/article/higher-intake-flavonoids-may-be-associated-lower-non-hodgkin-lymphoma-risk PMID:  Am J Clin Nutr. 2008 May ;87(5):1439-45. PMID: 18469269 Abstract Title:  Dietary flavonoid intake and non-Hodgkin lymphoma risk. Abstract:  BACKGROUND: The role of dietary factors in non-Hodgkin lymphoma (NHL) risk is not yet well understood. Dietary flavonoids are polyphenolic compounds proposed to be anticarcinogenic. Flavonoids are well-characterized antioxidants and metal chelators, and certain flavonoids exhibit antiproliferative and antiestrogenic effects.OBJECTIVE: We aimed to evaluate the hypothesis that higher flavonoid intake is associated with lower NHL risk.DESIGN: During 1998-2000, we identified incident NHL cases aged 20-74 y from 4 US Surveillance, Epidemiology, and End Results cancer registries. Controls without history of NHL were selected by random-digit dialing or from Medicare files and frequency-matched to cases by age, center, race, and sex. Using 3 recently developed US Department of Agriculture nutrient-specific databases, flavonoid intake was estimated from participant responses to a 117-item food-frequency questionnaire (n = 466 cases and 390 controls). NHL risk in relation to flavonoid intake in quartiles was evaluated after adjustment for age, sex, registry, education, NHL family history, and energy intake.RESULTS: Higher total flavonoid intake was significantly associated with lower risk of NHL (P for trend<p><a href="https://greenmedinfo.com/article/higher-intake-flavonoids-may-be-associated-lower-non-hodgkin-lymphoma-risk" target="_blank">read more</a></p> https://greenmedinfo.com/article/higher-intake-flavonoids-may-be-associated-lower-non-hodgkin-lymphoma-risk#comments Flavonoids Lymphoma Lymphoma: Non-Hodgkin Anticarcinogenic Agents Antioxidants Chemopreventive Proanthocyanidins In Vitro Study Wed, 05 Feb 2020 01:10:12 +0000 greenmedinfo 210554 at https://greenmedinfo.com A nutrient mixture, containing ascorbic acid, lysine, proline, green tea extract exhibit significant antiproliferative effects against aggressive non-Hodgkin's lymphoma cell lines. https://greenmedinfo.com/article/nutrient-mixture-containing-ascorbic-acid-lysine-proline-green-tea-extract-exh PMID:  Exp Oncol. 2009 Sep;31(3):149-55. PMID: 19783966 Abstract Title:  Antineoplastic effects of nutrient mixture on raji and jurkat t cells: the two highly aggressive non Hodgkin&#039;s lymphoma cell lines. Abstract:  Non-Hodgkin lymphomas incidence has increased more than 70% in last 25 years. Aggressiveness, higher relapse rate, and treatment complications pose significant barriers. Decreased food intake and side effects of treatments make cancer patients vulnerable to deficiency of essential nutrients such as vitamin C, lysine, and proline leading to the formation of weak extra cellular matrix susceptible to easy breakdown by matrix metalloproteinase enzymes. Inhibition of these enzymes has shown promise in stopping metastasis. Aim: In this study, we investigated the effects of a specific nutrient mixture, containing ascorbic acid, lysine, proline, green tea extract among others, in most aggressive forms of non-Hodgkin&#039;s lymphoma - Burkitt&#039;s lymphoma, and T-cell lymphoma - using Raji and Jurkat cells respectively. Methods: Nutrient mixture (NM) doses of 0, 10, 50, 100, 500, 1000 microg/ml, were used to study effects on cell proliferation, expression of matrix metalloproteinase, Matrigel invasion and apoptosis. Results: The results demonstrated that the dose response toxicity of the nutrient mixture on Raji cells gradually increased with increasing concentration. The nutrient mixture was non-toxic to Jurkat cells, however exhibited anti-proliferative properties at higher concentrations. Zymography demonstrated, NM had a significant inhibitory effect on matrix metalloproteinase-9 expression with total inhibition at 1000 microg/ml for Raji cells and at 500 microg/ml for Jurkat cells. The NM at 100 microg/ml completely inhibited Matrigel invasion for Raji cells, and at 1000 microg/ml for Jurkat cells. After the NM challenge virtually all Raji and Jurkat cells exposed to 1000 microg/ml were in late apoptosis. Conclusion: Considering the lack of treatment options and continually increasing incidence, NM could be further explored for its therapeutic potential in Burkitt&#039;s lymphoma and T-cell lymphoma. https://greenmedinfo.com/article/nutrient-mixture-containing-ascorbic-acid-lysine-proline-green-tea-extract-exh#comments Burkitt Lymphoma Green Tea Lymphoma Lymphoma: T-cell Lysine Non-Hodgkin Lymphoma Proline Proprietary Nutrient Formulas Vitamin C Antiproliferative In Vitro Study Fri, 01 Jan 2010 12:35:20 +0000 greenmedinfo 48511 at https://greenmedinfo.com A variety of carotenoids induce reduce resistance to chemotherapy in multidrug resistant lymphoma and human breast cancer cell lines. https://greenmedinfo.com/article/variety-carotenoids-induce-reduce-resistance-chemotherapy-multidrug-resistant- PMID:  In Vivo. 2004 Mar-Apr;18(2):237-44. PMID: 15113052 Abstract Title:  Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids. Abstract:  The multidrug resistance (MDR) proteins that belong to the ATP-binding casette superfamily are present in a majority of human tumors and are an important final cause of therapeutic failure. Therefore, compounds which inhibit the function of the MDR-efflux proteins may improve the cytotoxic action of anticancer chemotherapy. The effects of carotenoids were studied on the activity of the MDR-1 gene-encoded efflux pump system. The carotenoids, isolated from paprika and other vegetables, were tested on the rhodamine 123 accumulation of human MDR-1 gene-transfected L1210 mouse lymphoma cells and human breast cancer cells MDA-MB-231 (HTB-26). Capsanthin and capsorubin enhanced the rhodamine 123 accumulation 30-fold relative to nontreated lymphoma cells. Lycopene, lutein, antheraxanthin and violaxanthin had moderate effects, while alfa- and beta-carotene had no effect on the reversal of MDR in the tumor cells. Apoptosis was induced in human MDR1 transfected mouse lymphoma cells and human breast cancer MDA-MB-231 (HTB-26) cell lines in the presence of lycopene, zeaxanthin and capsanthin. The data suggest the potential of carotenoids as possible resistance modifiers in cancer chemotherapy. https://greenmedinfo.com/article/variety-carotenoids-induce-reduce-resistance-chemotherapy-multidrug-resistant-#comments Breast Cancer Cancers: Multi-Drug Resistant Carotenoids Lycopene Lymphoma Paprika Zeaxanthin Apoptotic Chemosensitizer Drug-Plant-Vitamin Synergies Animal Study Sat, 26 Dec 2009 22:32:37 +0000 greenmedinfo 48385 at https://greenmedinfo.com Allicin exhibits antitumor activity in mouse lymphoma. https://greenmedinfo.com/article/allicin-exhibits-antitumor-activity-mouse-lymphoma PMID:  Asian Pac J Cancer Prev. 2010 ;11(5):1241-4. PMID: 21198270 Abstract Title:  Antitumoral activity of allicin in murine lymphoma L5178Y. Abstract:  Epidemiological studies link increased garlic (Allium sativum) consumption with a reduced incidence of cancer in various human populations. Experimental carcinogenesis studies in animal models and in cell culture systems indicate that several allium-derived compounds exhibit inhibitory effects and that the underlying mechanisms may involve apoptosis. To provide a better understanding of the effects of allium derivatives regarding prevention of cancer, we examined antitumoral activity of allicin, a major component of garlic, in L5178Y lymphoma bearing mice. For in vitro studies, we utilized cell proliferation and apoptosis in the same tumor cell line. We found that allicin inhibited the growth of tumor cells at doses two fold superior to that in normal splenocytes. Allicin also induced apoptosis, and this was associated with an increase in caspase3 activity. https://greenmedinfo.com/article/allicin-exhibits-antitumor-activity-mouse-lymphoma#comments Allicin Lymphoma Anti-Proliferative Apoptotic Animal Study Sat, 17 Sep 2011 00:09:06 +0000 greenmedinfo 68652 at https://greenmedinfo.com Allicin inhibits cell growth and induces programmed cell death in leukemia and lymphoma cells. https://greenmedinfo.com/article/allicin-inhibits-cell-growth-and-induces-programmed-cell-death-leukemia-and-ly PMID:  J Nutr Biochem. 2008 Aug;19(8):524-35. Epub 2007 Dec 21. PMID: 18155508 Abstract Title:  Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells. Abstract:  In this article, the effects of allicin, a biological active compound of garlic, on HL60 and U937 cell lines were examined. Allicin induced growth inhibition and elicited apoptotic events such as blebbing, mitochondrial membrane depolarization, cytochrome c release into the cytosol, activation of caspase 9 and caspase 3 and DNA fragmentation. Pretreatment of HL60 cells with cyclosporine A, an inhibitor of the mitochondrial permeability transition pore (mPTP), inhibited allicin-treated cell death. HL60 cell survival after 1 h pretreatment with cyclosporine A, followed by 16 h in presence of allicin (5 microM) was approximately 80% compared to allicin treatment alone (approximately 50%). Also N-acetyl cysteine, a reduced glutathione (GSH) precursor, prevented cell death. The effects of cyclosporine A and N-acetyl cysteine suggest the involvement of mPTP and intracellular GSH level in the cytotoxicity. Indeed, allicin depleted GSH in the cytosol and mitochondria, and buthionine sulfoximine, a specific inhibitor of GSH synthesis, significantly augmented allicin-induced apoptosis. In HL60 cells treated with allicin (5 microM, 30 min) the redox state for 2GSH/oxidized glutathione shifted from EGSH -240 to -170 mV. The same shift was observed in U937 cells treated with allicin at a higher concentration for a longer period of incubation (20 microM, 2 h). The apoptotic events induced by various concentrations of allicin correlate to intracellular GSH levels in the two cell types tested (HL60: 3.7 nmol/10(6) cells; U937: 7.7 nmol/10(6) cells). The emerging mechanistic basis for the antiproliferative function of allicin, therefore, involves the activation of the mitochondrial apoptotic pathway by GSH depletion and by changes in the intracellular redox status. https://greenmedinfo.com/article/allicin-inhibits-cell-growth-and-induces-programmed-cell-death-leukemia-and-ly#comments Allicin Garlic Lymphoma Promyelocytic leukemia Antiproliferative Apoptotic Enzyme Inhibitors In Vitro Study Tue, 17 May 2011 17:42:42 +0000 greenmedinfo 63917 at https://greenmedinfo.com