Heart Hypertrophy https://greenmedinfo.com/taxonomy/term/2412/all en Alpha mangostin derived from Garcinia magostana ameliorates cardiomyocyte hypertrophy and fibroblast phenotypes. https://greenmedinfo.com/article/alpha-mangostin-derived-garcinia-magostana-ameliorates-cardiomyocyte-hypertrop PMID:  Biol Pharm Bull. 2021 ;44(10):1465-1472. PMID: 34602555 Abstract Title:  Alpha Mangostin Derived from Garcinia magostana Linn Ameliorates Cardiomyocyte Hypertrophy and Fibroblast Phenotypes in Vitro. Abstract:  Cardiac hypertrophy and fibrosis are significant risk factors for chronic heart failure (HF). Since pharmacotherapy agents targeting these processes have not been established, we investigated the effect of alpha-magostin (α-man) on cardiomyocyte hypertrophy and fibrosis in vitro. Primary cultured cardiomyocytes and cardiac fibroblasts were prepared from neonatal rats. After α-man treatment, phenylephrine (PE) and transforming growth factor-beta (TGF-β) were added to the cardiomyocytes and cardiac fibroblasts to induce hypertrophic and fibrotic responses, respectively. Hypertrophic responses were assessed by measuring the cardiomyocyte surface area and hypertrophic gene expression levels. PE-induced phosphorylation of Akt, extracellular signal-regulated kinase (ERK)1/2, and p38 was examined by Western blotting. Fibrotic responses were assessed by measuring collagen synthesis, fibrotic gene expression levels, and myofibroblast differentiation. In addition, TGF-β-induced reactive oxygen species (ROS) production was investigated. In cultured cardiomyocytes, α-man significantly suppressed PE-induced increases in the cardiomyocyte surface area, and the mRNA levels (atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP)). Treatment with α-man significantly suppressed PE-induced Akt phosphorylation, but not ERK and p38 phosphorylation. In cultured cardiac fibroblasts, α-man significantlysuppressed TGF-β-induced increases in L-proline incorporation, mRNA levels (POSTN and alpha-smooth muscle actin (α-SMA)), and myofibroblast differentiation. Additionally, it significantly inhibited TGF-β-induced reduced nicotinamide adenine dinucleotide phosphate oxidase4 (NOX4) expression and ROS production in cardiac fibroblasts. Treatment with α-man significantly ameliorates hypertrophy by inhibiting Akt phosphorylation in cardiomyocytes and fibrosis by inhibiting NOX4-generating ROS in fibroblasts. These findings suggest that α-man is a possible natural product for the prevention ofcardiac hypertrophy and fibrosis. <p><a href="https://greenmedinfo.com/article/alpha-mangostin-derived-garcinia-magostana-ameliorates-cardiomyocyte-hypertrop" target="_blank">read more</a></p> https://greenmedinfo.com/article/alpha-mangostin-derived-garcinia-magostana-ameliorates-cardiomyocyte-hypertrop#comments Heart Hypertrophy Mangosteen Cardioprotective In Vitro Study Sat, 01 Jan 2022 04:10:16 +0000 greenmedinfo 251034 at https://greenmedinfo.com Turmeric's Cardiovascular Benefits Found to be as Powerful as Exercise https://greenmedinfo.com/blog/turmerics-cardiovascular-benefits-found-be-powerful-exercise-a <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Turmeric's Cardiovascular Benefits In Aging Women As Powerful As Exercise" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/turmeric_curcumin.jpg" /></p> <p><span style="font-size:18px;"><strong><em>Nothing can replace exercise, but turmeric extract does a pretty good job of producing some of the same cardiovascular health benefits, most notably in women undergoing age-associated adverse changes in arterial health</em></strong></span></p> <p>Despite the general lack of interest by conventional medical practitioners in turmeric's role in preventing heart disease, there is a robust body of published research on its remarkable cardioprotective properties, with three dozen study abstracts on the topic available to view on our database alone: <strong><a href="/greenmed/topic/18768/focus/6063/page" rel="dofollow" target="_blank">turmeric's cardioprective properties</a></strong>.</p><p><a href="https://greenmedinfo.com/blog/turmerics-cardiovascular-benefits-found-be-powerful-exercise-a" target="_blank">read more</a></p> https://greenmedinfo.com/blog/turmerics-cardiovascular-benefits-found-be-powerful-exercise-a#comments Cardiovascular Diseases Curcumin Endothelial Dysfunction Heart Hypertrophy Hypertension Hypertension: Arterial Left Ventricular Dysfunction Left Ventricular Hypertrophy Turmeric Cardioprotective Exercise Heart Health Cardiovascular Disease spice turmeric heart Fri, 24 May 2013 21:00:00 +0000 Sayer Ji 98969 at https://greenmedinfo.com