Prolactin: Low https://greenmedinfo.com/taxonomy/term/24264/all en Resveratrol up-regulates prolactin secretion in both a dose- and time-dependent manner. https://greenmedinfo.com/article/resveratrol-regulates-prolactin-secretion-both-dose-and-time-dependent-manner PMID:  Phytother Res. 2000 Jun;14(4):272-4. PMID: 9772198 Abstract Title:  Phytoestrogens act as estrogen agonists in an estrogen-responsive pituitary cell line. Abstract:  There is renewed interest in the medicinal value of natural plant products. One group of plant compounds, the phytoestrogens (PE), has been given considerable attention due to their ability to decrease the incidence of certain estrogen-dependent cancers. In this study, we evaluate the effects of PE on estrogen-dependent pituitary tumor cells by using the immortalized pituitary cell line PR1. Several PE were found to be active in PR1 cells, in that they bound to the estrogen receptor (ER), stimulated growth of PR1 cells, and induced an estrogenic response, prolactin secretion. The PE genistein, coumestrol, and zearalenone bound to the ER present in PR1 cells with an affinity 100-times lower than that of estradiol. However, resveratrol, a plant antitumor agent found in grapes, showed no significant binding to the ER. Zearalenone, coumestrol, and genistein were found to induce prolactin secretion and to stimulate growth, whereas resveratrol showed prolactin secretion but no growth stimulation. The estrogenic effects of PE in PR1 cells were ER dependent, in that addition of the antiestrogen ICI-182,780 inhibited prolactin response. Although resveratrol did not bind to the ER or stimulate growth, it induced prolactin secretion in both a dose- and time-dependent manner. The data presented here demonstrate that PE are active in lactotroph cells of the pituitary. https://greenmedinfo.com/article/resveratrol-regulates-prolactin-secretion-both-dose-and-time-dependent-manner#comments phytoestrogens Prolactin: Low Resveratrol Secretagogues: Prolactin Up-Regulation In Vitro Study Tue, 10 May 2011 20:25:47 +0000 greenmedinfo 63746 at https://greenmedinfo.com Zinc improves testosterone and prolactin levels and erectile function in male rats. https://greenmedinfo.com/article/zinc-improves-testosterone-and-prolactin-levels-and-erectile-function-male-rat PMID:  J Hum Reprod Sci. 2009 Jul;2(2):57-61. PMID: 19881149 Abstract Title:  Effects of zinc supplementation on sexual behavior of male rats. Abstract:  Context: Effects of zinc on male sexual competence are poorly understood. Aim: To study the effects of different doses of zinc on the sexual competence of males using a rat model. Materials and Methods: Three subsets (eight in each subset) of sexually experienced adult male rats were supplemented with three different oral doses of zinc sulphate (a daily dose of 1 mg, 5 mg and 10 mg respectively) for two weeks. A subset of eight animals without zinc supplementation was used as the control group Sexual behavior was observed by placing them individually in cages with receptive females. Statistical Analysis : Data analysis was done using SPSS v10 for windows computer software. Results: Supplementation of 5 mg of zinc/day for two weeks led to a prolongation of ejaculatory latency; 711.6 sec. (SEM 85.47) vs. 489.50 sec. (SEM 67.66), P<0.05 and an increase in number of penile thrusting; 52.80 (SEM 11.28) vs. 26.50 (SEM 6.17), P<0.05, compared to controls. The same group had elevated prolactin (PRL) and testosterone (T) levels compared to controls at the end of treatment period; PRL- 7.22 ng/dl (SEM 3.68) vs. 2.90 ng/dl (SEM 0.34) and T- 8.21 ng/ml (SEM 6.09) vs. 2.39 ng/ml (SEM 1.79), P<0.05. In contrast, reduction of libido was evident in the same group, but this effect was not statistically significant ( P>0.05). However, partner preference index was positive and 5 mg zinc supplementation did not exert a significant adverse effect on the muscle strength and co-ordination. The subset of rats supplemented with 1 mg/day did not show a difference from the control group while supplementation with 10 mg/day led to a reduction of the libido index, number of mounts and intromissions. Conclusions : Zinc therapy improves sexual competence of male rats; the effect is dose dependent. Increase in the T levels is beneficial in this regard. However, increase in PRL is responsible for the reduced libido index. Further studies on pigs and monkeys are needed to evaluate the therapeutic use of zinc in sexual dysfunction. https://greenmedinfo.com/article/zinc-improves-testosterone-and-prolactin-levels-and-erectile-function-male-rat#comments Erectile Dysfunction Low Testosterone Prolactin: Low Sexual Dysfunction Zinc Animal Study Sat, 20 Feb 2010 04:14:51 +0000 greenmedinfo 52009 at https://greenmedinfo.com