Herpes Simplex: Labial https://greenmedinfo.com/taxonomy/term/2531/all en Melissa officinalis extract is effective for treating herpes simplex labialis. https://greenmedinfo.com/article/melissa-officinalis-extract-effective-treating-herpes-simplex-labialis PMID:  Phytomedicine. 1999 Oct;6(4):225-30. PMID: 10589440 Abstract Title:  Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis. Abstract:  A double-blind, placebo-controlled, randomized trial was carried out with the aim of proving efficacy of standardized balm mint cream [active ingredient: 1% Lo-701--dried extract from Melissa officinalis L. leaves (70:1)] for the therapy of herpes simplex labialis. Sixty six patients with a history of recurrent herpes labialis (at least four episodes per year) in one center were treated topically; 34 of them with verum and 32 with placebo. The cream had to be smeared on the affected area four times daily over five days. A combined symptom score of the values for complaints, size of affected area and blisters at day 2 of therapy was formed as the primary target parameter. There was a significant difference in the values of the primary target parameter between both treatment groups: verum 4.03 +/- 0.33 (3.0); placebo 4.94 +/- 0.40 (5.0); values given are mean +/- SEM (median) of the symptoms score on day 2 of therapy. The tested formulation is effective for the treatment of herpes simplex labialis. The significant difference in the combined symptom score on the second day of treatment is of particular importance having in mind that the complaints in patients suffering from herpes labialis are usually most intensive at that time. In addition to the shortening of the healing period, the prevention of a spreading of the infection and the rapid effect on typical symptoms of herpes like itching, tingling, burning, stabbing, swelling, tautness and erythema, the balm mint cream has a further advantage. The different mechanism of action of the balm mint extract rules out the development of resistance of the herpes virus. Some indication exists that the intervals between the periods with herpes might be prolonged with balm mint cream treatment. https://greenmedinfo.com/article/melissa-officinalis-extract-effective-treating-herpes-simplex-labialis#comments Cold Sore Herpes Simplex: Labial Melissa (Lemonbalm) Antiviral Agents Human Study Fri, 07 Aug 2009 01:17:36 +0000 greenmedinfo 46516 at https://greenmedinfo.com Melissa officinalis oil inhibits infectivity of enveloped herpesviruses. https://greenmedinfo.com/article/melissa-officinalis-oil-inhibits-infectivity-enveloped-herpesviruses PMID:  Food Chem Toxicol. 2010 May 10. Epub 2010 May 10. PMID: 19162154 Abstract Title:  Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Salvia species and Melissa officinalis are used for their memory-enhancing effects in European folk medicine. Teucrium polium was reported to be used in Anatolia for memory-enhancement in a very old book written by an Ottoman herbalist-physician. AIM OF THE STUDY: Alzheimer&#039;s disease (AD) is a progressive neurological disorder mostly affecting the elder population. Currently, there is no cure for the treatment of severe type of AD. Therefore, in this study, the hydroalcoholic extracts of three traditionally used Lamiaceae species for memory-enhancement; Salvia triloba L., Melissa officinalis L., and Teucrium polium L., were assessed for their in vivo antiamnesic activity along with in vitro anticholinesterase and antioxidant activities. MATERIALS AND METHODS: Scopolamine-induced antiamnesic activity was determined in mice by passive avoidance test, while anticholinesterase effect was measured by spectrophotometric Ellman method at 0.25, 0.50, 1.0, and 2.0 mg ml(-1) and antioxidant activity was assessed by scavenging effect against 2,2-diphenylpicrylhydrazyl (DPPH). Total phenol contents of the extracts were determined by Folin-Ciocalteau method. RESULTS: Salvia triloba was the most effective in antiamnesic experiment at 100, 200, and 400 mg kg(-1) doses having 22.7, 57.1, and 71.4% of relative effects, respectively. Teucrium polium was also active dose-dependently, whereas Melissa officinalis was completely inactive. In the anticholinesterase assay, the extracts showed similar inhibitions against acetylcholinesterase and Teucrium polium had the highest inhibition (65.8% at 1.0 mg ml(-1)). Concerning the antioxidant effect, all the extracts exerted the highest activity among all having IC50 values between 0.227 and 0.428 mg/ml. CONCLUSION: Our data suggest that Teucrium polium among the screened plants deserves to be examined further as a herbal alternative for AD treatment. https://greenmedinfo.com/article/melissa-officinalis-oil-inhibits-infectivity-enveloped-herpesviruses#comments Herpes family viruses Herpes Genitalis Herpes Labialis Herpes Simplex Virus Type 1 Herpes Simplex Virus Type 2 Herpes Simplex: Labial Herpes Zoster Melissa (Lemonbalm) Antioxidants Plant Extracts In Vitro Study Fri, 12 Feb 2010 23:05:41 +0000 greenmedinfo 51140 at https://greenmedinfo.com There was no difference in efficacy between topical kanuka honey and 5% aciclovir in the pharmacy-based treatment of herpes simplex labialis. https://greenmedinfo.com/article/there-was-no-difference-efficacy-between-topical-kanuka-honey-and-5-aciclovir- PMID:  BMJ Open. 2019 May 14 ;9(5):e026201. Epub 2019 May 14. PMID: 31092654 Abstract Title:  Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial. Abstract:  OBJECTIVE: To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis.DESIGN: Prospective parallel randomised controlled open-label superiority trial.SETTING: 76 community pharmacies across New Zealand between 10 September 2015 and 13 December 2017.PARTICIPANTS: 952 adults randomised within the first 72 hours of a herpes simplex labialis episode.INTERVENTIONS: Random assignment 1:1 to either 5% aciclovir cream or medical grade kanuka honey (90%)/glycerine (10%) cream, both applied five times daily.OUTCOME MEASURES: The primary outcome was time from randomisation to return to normal skin (stage 7). Secondary outcomes included time from randomisation to stage 4 (open wound), time from stage 4 to 7, maximal pain, time to pain resolution and treatment acceptability.RESULTS: Primary outcome variable: Kaplan-Meier-based estimates (95% CI) for the median time in days for return to normal skin were 8 (8 to 9) days for aciclovir and 9 (8 to 9) for honey; HR (95% CI) 1.06 (0.92 to 1.22), p=0.56. There were no statistically significant differences between treatments for all secondary outcome variables. No related serious adverseevents were reported.CONCLUSION: There was no evidence of a difference in efficacy between topical medical grade kanuka honey and 5% aciclovir in the pharmacy-based treatment of herpes simplex labialis.TRIAL REGISTRATION NUMBER: ACTRN12615000648527;Post-results. <p><a href="https://greenmedinfo.com/article/there-was-no-difference-efficacy-between-topical-kanuka-honey-and-5-aciclovir-" target="_blank">read more</a></p> https://greenmedinfo.com/article/there-was-no-difference-efficacy-between-topical-kanuka-honey-and-5-aciclovir-#comments Herpes Simplex: Labial Kanuka Honey Antiviral Agents Natural Substances Versus Drugs Human Study Wed, 22 May 2019 16:34:38 +0000 greenmedinfo 188072 at https://greenmedinfo.com