Hodgkin Lymphoma https://greenmedinfo.com/taxonomy/term/2574/all en Increased sun exposure of children may also be associated with a decreased risk of developing both childhood non Hodgkin and Hodgkin lymphoma. https://greenmedinfo.com/article/increased-sun-exposure-children-may-also-be-associated-decreased-risk-developi PMID:  Cancer Causes Control. 2007 Nov;18(9):1031-7. Epub 2007 Jul 26. PMID: 17653828 Abstract Title:  Sun exposure, birth weight, and childhood lymphomas: a case control study in Greece. Abstract:  OBJECTIVES: To explore whether the inverse association of sun exposure with non Hodgkin lymphoma among adults is also evident among the childhood population and test the specificity of the relation by contrasting the findings to those for Hodgkin lymphoma.METHODS: A total of 87 cases of childhood (0-14 years) with non Hodgkin lymphoma and 71 with Hodgkin lymphoma, diagnosed in Greece through the national network of childhood Hematology-Oncology Units, during a 7-year period, along with 164 age- and gender-matched control children were enrolled in the study. The guardians of all eligible children were interviewed in person on the basis of a structured questionnaire covering socio-demographic, anthropometric, and perinatal characteristics. Average time of sunbathing per year at a seaside resort was used as a proxy variable of exposure to sun controlling for use of sun protection measures.RESULTS: The estimated incidence of 10.2 cases per 1,000,000 children-years {95% Confidence Intervals (CI), 8.4-12.1} for NHL during the study period in Greece is around the average figure in countries of the European Union. There was an inverse association of sun exposure with Non Hodgkin lymphoma, namely, for an increment of 15 days of sunbathing at seaside resorts children had almost 40% lower risk (Odds Ratio: 0.60, 95% CI: 0.43-0.83), whereas no such association was evident for Hodgkin lymphoma. The risk for non Hodgkin lymphoma has been found to be statistically and significantly higher in birth weight (Odds ratio: 1.42 and 95% CI, 1.04-1.92, for every 500 g increment), whereas there was no substantial indication that maternal education or maternal smoking during the child&#039;s life were important risk factors for the disease.CONCLUSIONS: This is the first study to provide epidemiological evidence that increased sun exposure of children may also be associated with a decreased risk of developing childhood non Hodgkin, but not Hodgkin lymphoma. https://greenmedinfo.com/article/increased-sun-exposure-children-may-also-be-associated-decreased-risk-developi#comments Cancer: Childhood Hodgkin Lymphoma Lymphoma Lymphoma: Non-Hodgkin Sunlight exposure Human Study Fri, 18 Feb 2011 17:28:30 +0000 greenmedinfo 61713 at https://greenmedinfo.com It was also found that heating of NS seeds before oil extraction produces oil that is more effective against cancer cells. https://greenmedinfo.com/article/it-was-also-found-heating-ns-seeds-oil-extraction-produces-oil-more-effective- PMID:  Drug Des Devel Ther. 2015 ;9:3119-24. Epub 2015 Jun 18. PMID: 26124636 Abstract Title:  Anticancer activity of Nigella sativa (black seed) and its relationship with the thermal processing and quinone composition of the seed. Abstract:  The traditional preparation process of Nigella sativa (NS) oil starts with roasting of the seeds, an allegedly unnecessary step that was never skipped. The aims of this study were to investigate the role and boundaries of thermal processing of NS seeds in the preparation of therapeutic extracts and to elucidate the underlying mechanism. NS extracts obtained by various seed thermal processing methods were investigated in vitro for their antiproliferative activity in mouse colon carcinoma (MC38) cells and for their thymoquinone content. The effect of the different methods of thermal processing on the ability of the obtained NS oil to inhibit the nuclear factor kappa B (NF-κB) pathway was then investigated in Hodgkin&#039;s lymphoma (L428) cells. The different thermal processing protocols yielded three distinct patterns: heating the NS seeds to 50°C, 100°C, or 150°C produced oil with a strong ability to inhibit tumor cell growth; no heating or heating to 25°C had a mild antiproliferative effect; and heating to 200°C or 250°C had no effect. Similar patterns were obtained for the thymoquinone content of the corresponding oils, which showed an excellent correlation with the antiproliferative data. It is proposed that there is an oxidative transition mechanism between quinones after controlled thermal processing of the seeds. While NS oil from heated seeds delayed the expression of NF-κB transcription, non-heated seeds resulted in only 50% inhibition. The data indicate that controlled thermal processing of NS seeds (at 50°C-150°C) produces significantly higher anticancer activity associated with a higher thymoquinone oil content, and inhibits the NF-κB signaling pathway. https://greenmedinfo.com/article/it-was-also-found-heating-ns-seeds-oil-extraction-produces-oil-more-effective-#comments Hodgkin Lymphoma Nigella sativa (aka Black Seed) Thymoquinone Antiproliferative Dose Response In Vitro Study Fri, 11 Sep 2015 01:46:54 +0000 greenmedinfo 120365 at https://greenmedinfo.com 90% of the breast cancers in Hodgkin's lymphoma patients receiving radiation are due to radiotherapy-associated uses. https://greenmedinfo.com/article/90-breast-cancers-hodgkins-lymphoma-patients-receiving-radiation-are-due-radio PMID:  Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):540-7. PMID: 20117289 Abstract Title:  Radiation-associated breast tumors display a distinct gene expression profile. Abstract:  PURPOSE: Women who received irradiation for Hodgkin&#039;s lymphoma have a strong increased risk for developing breast cancer. Approximately 90% of the breast cancers in these patients can be attributed to their radiation treatment, rendering such series extremely useful to determine whether a common radiation-associated cause underlies the carcinogenic process. METHODS AND MATERIALS: In this study we used gene expression profiling technology to assess gene expression changes in radiation-associated breast tumors compared with a set of control breast tumors of women unexposed to radiation, diagnosed at the same age. RNA was obtained from fresh frozen tissue samples from 22 patients who developed breast cancer after Hodgkin&#039;s lymphoma (BfHL) and from 20 control breast tumors. RESULTS: Unsupervised hierarchical clustering of the profile data resulted in a clustering of the radiation-associated tumors separate from the control tumors (p https://greenmedinfo.com/article/90-breast-cancers-hodgkins-lymphoma-patients-receiving-radiation-are-due-radio#comments Breast Cancer Hodgkin Lymphoma Radiation Induced Illness Radiotherapy Diseases that are Linked Human Study Thu, 09 Dec 2010 22:48:20 +0000 greenmedinfo 59436 at https://greenmedinfo.com A case report and review of the literature of spontaneous regression of Hodgkin lymphoma. https://greenmedinfo.com/article/case-report-and-review-literature-spontaneous-regression-hodgkin-lymphoma PMID:  Acta Haematol. 2018 Nov 15 ;141(1):14-18. Epub 2018 Nov 15. PMID: 30439716 Abstract Title:  Spontaneous Regression of Hodgkin Lymphoma: Case Report and Review of the Literature. Abstract:  Spontaneous regression of Hodgkin lymphoma (HL) is a rare event. We describe a 32-year-old woman with spontaneous regression of HL and review the literature. The patient presented with cervical lymphadenopathy and was diagnosed with stage IIA classical HL. The patient refused to receive any treatment for her disease. Positron emission tomography/computed tomography carried out 2 years later showed complete regression of the lymphadenopathy, without pathological uptake of fluorodeoxyglucose. At the last follow-up, 3.5 years after the initial presentation, the patient is with no evidence of disease. During workup for the HL, concomitant papillary thyroid carcinoma was diagnosed, for which the patient refused treatment as well. The thyroid malignancy has remained stable throughout the follow-up. <p><a href="https://greenmedinfo.com/article/case-report-and-review-literature-spontaneous-regression-hodgkin-lymphoma" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-and-review-literature-spontaneous-regression-hodgkin-lymphoma#comments Hodgkin Lymphoma Spontaneous Regression Human: Case Report Review Wed, 09 Jan 2019 20:06:08 +0000 greenmedinfo 177184 at https://greenmedinfo.com BREAKING: Bayer Ordered to Pay $2 Billion in Damages in 3rd Roundup-Cancer Trial; Is Bankruptcy On the Horizon? https://greenmedinfo.com/blog/breaking-bayer-ordered-pay-2-billion-damages-3rd-roundup-cancer-trial-bankruptcy- <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter" content="May 13 (Reuters) - A California jury on Monday awarded more than $2 billion to a couple who claimed Bayer AG's glyphosate-based Roundup weed killer caused their cancer, marking the third consecutive U.S. jury verdict against the company in litigation over the chemical." data-reactid="11" type="text"><img alt="BREAKING: Bayer Ordered to Pay $2 Billion in Damages in 3rd Roundup-Cancer Trial; Is Bankruptcy On the Horizon? " src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/roundup(2)(1).jpg" style="letter-spacing: 0px; height: 422px; width: 600px;" /></p><p><a href="https://greenmedinfo.com/blog/breaking-bayer-ordered-pay-2-billion-damages-3rd-roundup-cancer-trial-bankruptcy-" target="_blank">read more</a></p> https://greenmedinfo.com/blog/breaking-bayer-ordered-pay-2-billion-damages-3rd-roundup-cancer-trial-bankruptcy-#comments Glyphosate Toxicity Hodgkin Lymphoma Glyphosate formulations Roundup (herbicide) Mon, 13 May 2019 21:42:43 +0000 Sayer Ji 187462 at https://greenmedinfo.com Complete remission and long-term survival of a patient with a diffuse large b-cell lymphoma under Viscum album extracts. https://greenmedinfo.com/article/complete-remission-and-long-term-survival-patient-diffuse-large-b-cell-lymphom PMID:  Anticancer Res. 2018 Sep ;38(9):5363-5369. PMID: 30194190 Abstract Title:  Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma UnderExtracts After Resistance to R-CHOP: A Case Report. Abstract:  BACKGROUND: A nodular lymphocyte predominant Hodgkin&#039;s lymphoma (NLPHL) is a lymphoproliferative neoplasm with a fair prognosis, but the possibility of a malignant transformation into a diffuse large B-cell lymphoma (DLBCL) is high. DLBCL progresses aggressively. Introduction of rituximab into therapy had led to improved outcomes. The use of Viscum album extracts (VAE) in cancer is established, but their application in lymphoma are rare.CASE PRESENTATION: A 65-year-old patient was diagnosed with DLBCL stage IIa with splenomegaly, transformed from a NLPHL, after a 30-year history of repeatedly enlarged inguinal lymph nodes. The patient initially rejected chemotherapy. After his tumor pain increased, he accepted the consecutive therapies bendamustine plus vincristine plus prednisolone, trofosfamide, and rituximab plus cyclophosphamide plus hydroxydaunorubicin plus vincristine plus prednisone (R-CHOP), inducing only a slight regression of the splenic lesions. VAE was additionally applied to R-CHOP. Five months after termination of chemotherapy - under continued VAE therapy in increasing dosage- regression of paraaortal lesions was found. The patient fully recovered under continuous VAE application and is in ongoing complete remission and in a good state of health 17 years after the initial diagnosis.CONCLUSION: As complete remission of lymphoproliferative disorders after VAE treatment has been previously reported, further investigations of VAE in lymphoma seem highly worthwhile. <p><a href="https://greenmedinfo.com/article/complete-remission-and-long-term-survival-patient-diffuse-large-b-cell-lymphom" target="_blank">read more</a></p> https://greenmedinfo.com/article/complete-remission-and-long-term-survival-patient-diffuse-large-b-cell-lymphom#comments Hodgkin Lymphoma Mistletoe Chemotherapeutic Plant Extracts Human: Case Report Wed, 26 Sep 2018 23:43:04 +0000 greenmedinfo 171310 at https://greenmedinfo.com Curcumin may provide an ideal therapeutic agent for patients with Hodgkin's lymphoma which does not have the side effects associated with multi-drug chemotherapy. https://greenmedinfo.com/article/curcumin-may-provide-ideal-therapeutic-agent-patients-hodgkins-lymphoma-which- PMID:  Int J Cancer. 2008 Jul 1;123(1):56-65. PMID: 18386790 Abstract Title:  Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin&#039;s lymphoma cells. Abstract:  Although treatment of Hodgkin&#039;s lymphoma (HL) with a multi-drug approach has been very successful, its toxicity becomes evident after several years as secondary malignancies and cardiovascular disease. Therefore, the current goal in HL treatment is to find new therapies that specifically target the deregulated signaling cascades, such as NF-kappaB and STAT3, which cause Hodgkin and Reed-Sternberg (H-RS) cell proliferation and resistance of apoptosis. Based on the above information, we investigated the capacity of curcumin to inhibit NF-kappaB and STAT3 in H-RS cells, characterizing the functional consequences. Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1. Interestingly, curcumin caused cell cycle arrest in G2-M and a significant reduction (80-97%) in H-RS cell viability. Furthermore, curcumin triggered cell death by apoptosis, as evidenced by the activation of caspase-3 and caspase-9, changes in nuclear morphology and phosphatidylserine translocation. The above findings provide a mechanistic rationale for the potential use of curcumin as a therapeutic agent for patients with HL. (c) 2008 Wiley-Liss, Inc. https://greenmedinfo.com/article/curcumin-may-provide-ideal-therapeutic-agent-patients-hodgkins-lymphoma-which-#comments Curcumin Hodgkin Disease Hodgkin Lymphoma Lymphoma Superiority of Natural Substances versus Drugs In Vitro Study Fri, 22 May 2009 01:36:11 +0000 greenmedinfo 44399 at https://greenmedinfo.com Ecological evidence for lower risk of lymphoma with greater exposure to sunlight and higher altitude. https://greenmedinfo.com/article/ecological-evidence-lower-risk-lymphoma-greater-exposure-sunlight-and-higher-a PMID:  High Alt Med Biol. 2020 Mar ;21(1):37-44. Epub 2019 Nov 25. PMID: 31765244 Abstract Title:  Ecological Evidence for Lower Risk of Lymphoma with Greater Exposure to Sunlight and Higher Altitude. Abstract:  Sunlight exposure increases vitamin D-related immune modulation and motility of T lymphocytes. Blue light exposure from the sun can stimulate immune function and help promote healthy circadian rhythm. Hence, greater sunlight exposure may lower the risk of Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). Altitude may also lower the risk of these cancers through an oxygen-related mechanism, and because cosmic radiation has less shield from the atmosphere at higher levels, it allows for radiation hormesis.An ecological study design was used, with county-level lymphoma, sunlight, altitude, urban residency, poverty, smoking, obesity, and leisure-time physical inactivity data for 16 cancer registries (607 counties) in the contiguous United States, 2012-2016. Relative rate estimates were derived from two-level mixed effects Poisson regression models.Higher rates of NHL are associated with being older, male, and white. Higher rates of Hodgkin lymphoma are associated with ages 20 years and older, male, and white or black. The risk of NHL or Hodgkin lymphoma is lower among those living in poverty. Urban residency, smoking, obesity, and physical inactivity are not associated with these cancers. Both increased sunlight exposure and higher altitude are simultaneously associated with lower rates of Hodgkin lymphoma and NHL in adjusted models. The inverse association between sunlight and NHL is more pronounced with higher altitude. The inverse association between sunlight and Hodgkin lymphoma is only in altitudes below 500 m.Greater sunlight exposure and higher altitude are simultaneously associated with lower rates of Hodgkin lymphoma and NHL. The inverse associations are dependent on altitude, with the relationship only in lower altitudes for Hodgkin lymphoma and more pronounced in higher altitude for NHL. <p><a href="https://greenmedinfo.com/article/ecological-evidence-lower-risk-lymphoma-greater-exposure-sunlight-and-higher-a" target="_blank">read more</a></p> https://greenmedinfo.com/article/ecological-evidence-lower-risk-lymphoma-greater-exposure-sunlight-and-higher-a#comments Hodgkin Lymphoma Lymphoma Vitamin D Immunomodulatory Sunlight exposure Risk Reduction Human Study Fri, 17 Apr 2020 00:36:20 +0000 greenmedinfo 218716 at https://greenmedinfo.com Forcing Chemo on a 17-Year Old Is Deadly, Research Reveals https://greenmedinfo.com/blog/forcing-chemo-17-year-old-deadly-research-reveals <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2015<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Forcing Chemo on a 17-Year Old Is Deadly, Research Reveals" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/chemo(2).jpg" style="width: 640px; height: 360px;" /></p> <p class="rtecenter"><strong><span style="font-size:20px;"><a href="http://www.thepetitionsite.com/861/363/754/connecticut-dont-force-teen-to-undergo-chemo-respect-bodily-autonomy/" target="_blank">Sign the petition to support her cause.</a></span></strong></p> <p><em><span style="font-size:18px;"><strong>A 17-year old is being forced to receive chemotherapy that is guaranteed to cause her premature death. Will you stand up to save her?&nbsp;</strong></span></em></p><p><a href="https://greenmedinfo.com/blog/forcing-chemo-17-year-old-deadly-research-reveals" target="_blank">read more</a></p> https://greenmedinfo.com/blog/forcing-chemo-17-year-old-deadly-research-reveals#comments Curcumin Hodgkin Disease Hodgkin Lymphoma Lymphoma: Non-Hodgkin Cancer Chemotherapy Sat, 10 Jan 2015 02:24:44 +0000 Sayer Ji 115953 at https://greenmedinfo.com Infant formula is associated with increased risk for acute lymphocytic leukemia (ALL), Hodgkin's lymphoma (HL). https://greenmedinfo.com/article/infant-formula-associated-increased-risk-acute-lymphocytic-leukemia-all-hodgki AIM: Prolonged breastfeeding was shown to reduce the risk of childhood acute leukemia. The aim of the study was to investigate the protective effect of longer breastfeeding on the risk of lymphoid malignancies in children and its dependent socio-economic factors. METHODS: The study group comprised of 169 patients with acute lymphocytic leukemia (ALL), Hodgkin&#039;s (HL) and non-Hodgkin&#039;s lymphoma (NHL), age =or&lt;15 years, and 169 healthy controls, matched to patients by age and sex. Mothers of all study subjects provided information via telephone about the history of breastfeeding and parameters seen as proxies for viral infection. RESULTS: The mean age+/-SD of cases was 5.44+/- 3.29 years and of control subjects 5.51+/-3.62 years. The male/female ratio was 1.73. Overall, the mean number of months of breastfeeding in the male patients and controls was 9.1 (95% confidence interval [CI] 7.9-10.4) and 12.1 (95% CI 11.0-13.4), respectively (P&lt;0.001), and in the female patients and controls 8.4 (95% CI 6.9-10.1) and 11.5 (95% CI 10.0-13.0), respectively (P&lt;0.01). In 103 ALL patients, a shorter period of breastfeeding (0-6 months duration), was associated with increased odds ratio (OR) for males (OR=3.1, 95% CI 1.4-6.8) and females (OR=2.2, 95% CI 0.8-6.32) as compared to breastfeeding longer than 6 months. In 103 ALL patients, 32 HL and 34 NHL patients, there were no statistically significant differences in the duration of breastfeeding between the male and female patients and their respective controls. In multivariate analysis, statistically significant risk factors for the development of childhood lymphoid malignancy were: a shorter duration of breastfeeding, lower age and level of education of mother and higher income, larger size of accommodation and birth order in the family. CONCLUSION: The current study confirmed that a longer duration of breastfeeding has protective effect against ALL and HL. Additional factors found to be associated with an elevated risk of lymphoid malignancy were low age and low education of mother. All these factors can be related to an increased risk of early childhood infections. PMID:  Minerva Pediatr. 2008 Apr;60(2):155-61. PMID: 18449131 Abstract Title:  Does prolonged breastfeeding reduce the risk for childhood leukemia and lymphomas? Abstract:  AIM: Prolonged breastfeeding was shown to reduce the risk of childhood acute leukemia. The aim of the study was to investigate the protective effect of longer breastfeeding on the risk of lymphoid malignancies in children and its dependent socio-economic factors. METHODS: The study group comprised of 169 patients with acute lymphocytic leukemia (ALL), Hodgkin&#039;s (HL) and non-Hodgkin&#039;s lymphoma (NHL), age =or&lt;15 years, and 169 healthy controls, matched to patients by age and sex. Mothers of all study subjects provided information via telephone about the history of breastfeeding and parameters seen as proxies for viral infection. RESULTS: The mean age+/-SD of cases was 5.44+/- 3.29 years and of control subjects 5.51+/-3.62 years. The male/female ratio was 1.73. Overall, the mean number of months of breastfeeding in the male patients and controls was 9.1 (95% confidence interval [CI] 7.9-10.4) and 12.1 (95% CI 11.0-13.4), respectively (P&lt;0.001), and in the female patients and controls 8.4 (95% CI 6.9-10.1) and 11.5 (95% CI 10.0-13.0), respectively (P&lt;0.01). In 103 ALL patients, a shorter period of breastfeeding (0-6 months duration), was associated with increased odds ratio (OR) for males (OR=3.1, 95% CI 1.4-6.8) and females (OR=2.2, 95% CI 0.8-6.32) as compared to breastfeeding longer than 6 months. In 103 ALL patients, 32 HL and 34 NHL patients, there were no statistically significant differences in the duration of breastfeeding between the male and female patients and their respective controls. In multivariate analysis, statistically significant risk factors for the development of childhood lymphoid malignancy were: a shorter duration of breastfeeding, lower age and level of education of mother and higher income, larger size of accommodation and birth order in the family. CONCLUSION: The current study confirmed that a longer duration of breastfeeding has protective effect against ALL and HL. Additional factors found to be associated with an elevated risk of lymphoid malignancy were low age and low education of mother. All these factors can be related to an increased risk of early childhood infections. <p><a href="https://greenmedinfo.com/article/infant-formula-associated-increased-risk-acute-lymphocytic-leukemia-all-hodgki" target="_blank">read more</a></p> https://greenmedinfo.com/article/infant-formula-associated-increased-risk-acute-lymphocytic-leukemia-all-hodgki#comments Acute lymphoblastic leukemia (ALL) Cancers: Pediatric Hodgkin Lymphoma Infant Nutrition: Infant Formula Leukemia: Childhood Lymphomas: Childhood Infant Formula Human Study Fri, 19 Feb 2010 01:22:41 +0000 greenmedinfo 51748 at https://greenmedinfo.com Melittin increases cisplatin sensitivity and kills KM-H2 and L-428 Hodgkin lymphoma cells. https://greenmedinfo.com/article/melittin-increases-cisplatin-sensitivity-and-kills-km-h2-and-l-428-hodgkin-lym PMID:  Int J Mol Sci. 2020 Dec 31 ;22(1). Epub 2020 Dec 31. PMID: 33396195 Abstract Title:  Melittin Increases Cisplatin Sensitivity and Kills KM-H2 and L-428 Hodgkin Lymphoma Cells. Abstract:  Hodgkin lymphoma (HL) is neoplasia with high cure rates. However, not all patients can be cured with the current treatment. Chemo-resistance of tumor cells is one factor involved in treatment failure. In addition to its pore-forming activity on lipid bilayer membranes, the toxin melittin from bee venom is an inhibitor of several cancer-related signaling pathways. Moreover, melittin analogs have been shown to inhibit the activity of ATP binding cassette (ABC) transporters which are known to play important roles in the chemo-resistance of tumor cells. Therefore, we tested the toxicity of melittin for HL cell lines KM-H2 and L-428 and whether melittin can increase the chemo-sensitivity of cisplatin-resistant HL cells. We found high toxicity of melittin for KM-H2 and L-428 cells. In co-cultures with normal blood cells, melittin preferentially killed KM-H2 and L-428 cells. In addition, we observed increased cisplatin sensitivity of chemo-resistant L-428 cells after treatment with melittin. ABC transporter activity was not reduced after treatment with melittin. Our data suggest that melittin or melittin analogs might be promising agents for the future development of treatment strategies for HL patients with resistant disease. <p><a href="https://greenmedinfo.com/article/melittin-increases-cisplatin-sensitivity-and-kills-km-h2-and-l-428-hodgkin-lym" target="_blank">read more</a></p> https://greenmedinfo.com/article/melittin-increases-cisplatin-sensitivity-and-kills-km-h2-and-l-428-hodgkin-lym#comments Bee Venom Hodgkin Lymphoma Antineoplastic Agents Antiproliferative Apoptotic Chemosensitizer Chemotherapeutic Synergy: Cisplatin In Vitro Study Fri, 02 Apr 2021 14:19:19 +0000 greenmedinfo 237261 at https://greenmedinfo.com Procyanidin B2 inhibits NF-kappaB in in Hodgkin's lymphoma cells. https://greenmedinfo.com/article/procyanidin-b2-inhibits-nf-kappab-hodgkins-lymphoma-cells PMID:  Can J Physiol Pharmacol. 2001 Sep;79(9):793-8. PMID: 18275936 Abstract Title:  Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin&#039;s lymphoma cells independently of the presence of IkappaB mutations. Abstract:  Due to long-term toxicity of current Hodgkin&#039;s lymphoma (HL) treatment, the present challenge is to find new therapies that specifically target deregulated signaling cascades, including NF-kappaB, which are involved in Hodgkin (H) and Reed-Sternberg (RS) cell proliferation and resistance to apoptosis. We previously presented evidence that dimeric procyanidin B2 (B2) can interact with NF-kappaB proteins inhibiting the binding of NF-kappaB to DNA. Herein, we investigated if B2, acting at a late event in NF-kappaB signaling cascade, could be effective in inhibiting NF-kappaB in H-RS cells with different mechanisms of constitutive NF-kappaB activation. B2 caused a concentration-dependent inhibition of NF-kappaB-DNA binding to a similar extent (41-48% inhibition at 25 microM B2) in all the tested H-RS cell lines (L-428, KM-H2, L-540, L-1236 and HDML-2). This was associated with the inhibition of NF-kappaB-driven gene expression, including cytokines (IL-6, TNFalpha and RANTES) and anti-apoptotic proteins (Bcl-xL, Bcl-2, XIAP and cFLIP). The finding of similar amounts of RelA and p50 proteins in the nucleus, but decreased NF-kappaB-DNA binding, even in those H-RS cells characterized by mutations in the inhibitory IkappaB proteins, supports that B2 acts by preventing the binding of NF-kappaB to DNA. B2 did not inhibit AP-1 and STAT3 constitutive activation in H-RS cells, indicating that the moderate effects of B2 on cell viability are due to the complex signaling aberrations in HL. Thus, several signaling pathways should be targeted when designing therapeutics for HL. In this regard, the capacity of B2 to inhibit NF-kappaB could be valuable in a multi-drug approach. https://greenmedinfo.com/article/procyanidin-b2-inhibits-nf-kappab-hodgkins-lymphoma-cells#comments Catechin Hodgkin Lymphoma Procyanidin B2 NF-kappaB Inhibitor Proanthocyanidins In Vitro Study Tue, 17 May 2011 18:10:41 +0000 greenmedinfo 63920 at https://greenmedinfo.com Radiotherapy may cause secondary tumor formation. https://greenmedinfo.com/article/radiotherapy-may-cause-secondary-tumor-formation PMID:  Gan To Kagaku Ryoho. 1999 Nov;26(13):2015-20. PMID: 10584565 Abstract Title:  [Radiation-induced cancers following radiotherapy]. Abstract:  Improved radiotherapy for cancer has produced a large population of long-term survivors. These survivors, however, appear to have a greater risk of second primary cancers than would be expected based on the incidence of first primary cancers in the general population. The etiology of radiation-induced cancer is multifactorial and incompletely understood, and there is no firm diagnostic criteria for radiation-induced cancer because there are no specific histopathological findings. The incidence of radiation-induced cancers following radiotherapy was estimated to be about 0.3% in 5-year survivors, based on mail surveys (in 1979&amp;1984) in Japan. It seems that the benefit of treatment outweighs the risk of developing secondary tumors. However, we should avoid excess treatment of patients with Hodgkin&#039;s disease or many pediatric malignancies who will be able to survive a long time after treatment. The relative carcinogenicity of various combinations of radiation and chemotherapeutic agents is now being established. Chemoradiotherapy is now frequently used for treatment of various malignancies which are considered to be uncontrollable by chemotherapy or radiotherapy alone. We should minimize their carcinogenic effects and the risk of developing secondary treatment-related tumors, to produce an optimal therapeutic gain. Long-term close follow-up is necessary for these patients. https://greenmedinfo.com/article/radiotherapy-may-cause-secondary-tumor-formation#comments Cancers: All Cancers: Pediatric Hodgkin Lymphoma Radiotherapy Commentary Mon, 24 May 2010 18:44:02 +0000 greenmedinfo 55185 at https://greenmedinfo.com Resveratrol induces programmed cell death of hodgkin lymphoma cells. https://greenmedinfo.com/article/resveratrol-induces-programmed-cell-death-hodgkin-lymphoma-cells PMID:  Int J Cancer. 2013 Mar 1 ;132(5):1013-21. Epub 2012 Aug 7. PMID: 22833338 Abstract Title:  Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation. Abstract:  Resveratrol (RSV), a plant-derived stilbene, induces cell death in Hodgkin lymphoma (HL)-derived L-428 cells in a dose-dependent manner (IC50 = 27μM, trypan blue exclusion assay). At a lower range (25 μM), RSV treatment for 48 hr causes arrest in the S-phase of the cell cycle, while at a higher concentration range (50 μM), apoptosis can be detected, with activation of caspase-3. The histone/protein deacetylase SIRT1 has been described as aputative target of RSV action in other model systems, even though its role in cancer cells is still controversial. Here we show that RSV, at both concentration ranges, leads to a marked increase in p53, while a decrease of SIRT1 expression level, as well as enzyme activity, only occurred at the higher concentration range. Concomitantly, however, treatments at both concentration ranges resulted in a marked increase in K373-acetylated p53 and lysine-acetylated FOXO3a. Immunohistochemical stainings of human lymph nodes show a preferential distribution of SIRT1 in the germinal center of the follicles while the mantle zone shows nearly no staining to few positive cells. The classical HL-affected lymph nodes show a strong positivity of the diagnostic Hodgkin Reed-Sternberg cells. Notably, both the HL-derived cell lines and the Hodgkin Reed-Sternberg cells of the affected lymph nodes derive from germinal center-derived B cells. The study of SIRT1 distribution and expression on a larger number of biopsies might disclose a novel role for this histone/protein deacetylase as therapeutic target. https://greenmedinfo.com/article/resveratrol-induces-programmed-cell-death-hodgkin-lymphoma-cells#comments Hodgkin Lymphoma Resveratrol Stilbenes Apoptotic Tumor Suppressor Protein p53 Upregulation In Vitro Study Sat, 10 Jan 2015 19:01:21 +0000 greenmedinfo 115957 at https://greenmedinfo.com Review: there is a consistently strong inverse correlations with solar UVB for 15 types of cancers. https://greenmedinfo.com/article/review-there-consistently-strong-inverse-correlations-solar-uvb-15-types-cance PMID:  Anticancer Res. 2012 Jan ;32(1):223-36. PMID: 22213311 Abstract Title:  Ecological Studies of the UVB-Vitamin D-Cancer Hypothesis. Abstract:  UNLABELLED: Background/Aim: This paper reviews ecological studies of the ultraviolet-B (UVB)-vitamin D-cancer hypothesis based on geographical variation of cancer incidence and/or mortality rates.MATERIALS AND METHODS: The review is based largely on three ecological studies of cancer rates from the United States; one each from Australia, China, France, Japan, and Spain; and eight multicountry, multifactorial studies of cancer incidence rates from more than 100 countries.RESULTS: This review consistently found strong inverse correlations with solar UVB for 15 types of cancer: bladder, breast, cervical, colon, endometrial, esophageal, gastric, lung, ovarian, pancreatic, rectal, renal, and vulvar cancer; and Hodgkin&#039;s and non-Hodgkin&#039;s lymphoma. Weaker evidence exists for nine other types of cancer: brain, gallbladder, laryngeal, oral/pharyngeal, prostate, and thyroid cancer; leukemia; melanoma; and multiple myeloma.CONCLUSION: The evidence for the UVB-vitamin D-cancer hypothesis is very strong in general and for many types of cancer in particular. https://greenmedinfo.com/article/review-there-consistently-strong-inverse-correlations-solar-uvb-15-types-cance#comments Bladder Cancer Breast Cancer Cervical Cancer Colon Cancer Colorectal Cancer Endometrial Cancer Esophageal Cancer Hodgkin Lymphoma Lung Cancer Non-Hodgkin Lymphoma Ovarian Cancer Pancreatic Cancer Renal Cancer Vitamin D Vulvar Cancer Chemopreventive Sunlight exposure Meta Analysis Tue, 10 Jan 2012 02:19:58 +0000 greenmedinfo 70692 at https://greenmedinfo.com