Hyperlipidemia https://greenmedinfo.com/taxonomy/term/2654/all en Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle. https://greenmedinfo.com/article/berberine-attenuates-abnormal-ectopic-lipid-deposition-skeletal-muscle PMID:  Free Radic Biol Med. 2020 Jul 31. Epub 2020 Jul 31. PMID: 32745766 Abstract Title:  Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle. Abstract:  BACKGROUND: Lipid deposition in non-adipose tissue is associated with a propensity to obesity. Skeletal muscle mitochondrial dysfunction, evidenced by incomplete beta oxidation may contribute to ectopic lipid deposition during high fat diet-induced obesity. Berberine (BBR) has been proved to possess the properties of improving metabolic disorders in patients with obesity or type 2 diabetes mellitus. However, the precise mechanism remains obscure.METHODS: Mice were treated with berberine and metabolic profile were analyzed. Mitochondrial number and function were detected after berberine treatment in vitro and in vivo. The role of Adenosine 5&#039;-monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) was verified after RNA interference or adenovirus infection.RESULTS: In the current study, we investigated the influence of berberine on the lipid deposition of skeletal muscle and found that berberine could increase the mitochondrial number and function both in vivo and in vitro. Furthermore, berberine promoted the expression of PGC-1α, the crucial transcriptional coactivator related to mitochondrial biogenesis and function, through AMPK pathway. Berberine reduced the basal oxygen consumption rates (OCR) but increased the maximal OCR in C2C12 myocytes, which indicated that berberine could increase the potential function of mitochondria.CONCLUSION: Our results proved that berberine can protect the lean body mass from excessive lipid accumulation, by promoting the mitochondrial biogenesis and improving fatty acid oxidation in an AMPK/PGC-1α dependent manner. <p><a href="https://greenmedinfo.com/article/berberine-attenuates-abnormal-ectopic-lipid-deposition-skeletal-muscle" target="_blank">read more</a></p> https://greenmedinfo.com/article/berberine-attenuates-abnormal-ectopic-lipid-deposition-skeletal-muscle#comments Berberine Hyperlipidemia Obesity Hypolipidemic Animal Study Sun, 09 Aug 2020 15:07:47 +0000 greenmedinfo 224985 at https://greenmedinfo.com Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice. https://greenmedinfo.com/article/effect-selenium-enriched-kiwifruit-body-fat-reduction-and-liver-protection-hyp PMID:  Food Funct. 2021 Feb 3. Epub 2021 Feb 3. PMID: 33532813 Abstract Title:  Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice. Abstract:  This study aimed to investigate the effects and mechanism of selenium-enriched kiwifruit (Se-Kiwi) on lipid-lowering and liver protection in hyperlipidaemic mice induced by consuming a long-term high-fat diet. Selenium-enriched cultivation can significantly improve the contents of vitamins and functional elements in kiwifruits, especially vitamin C, selenium, and manganese, thus enhancing the activity of antioxidant enzymes in Se-Kiwi. Se-Kiwi can significantly improve the activity of antioxidant enzymes in the liver of hyperlipidaemic mice, restore the liver morphology of mice close to normal, reduce the fat content in the liver, and inhibit the accumulation of abdominal fat cells. Meanwhile, the expression levels of inflammation-related factors (TNF-α and NF-κB) and lipid synthesis related genes (SREBP-1c and FAS) are inhibited at the gene transcription and protein expression levels, and the expression levels of energy expenditure related genes (PPAR-α and CPT1) are increased, resulting in lipid reductions and liver protection. In conclusion, our results indicate that the protective mechanism of Se-Kiwi on high-fat diet mice is associated with enhancing the activity of antioxidant enzymes, reducing the degree of the inflammatory reaction, inhibiting the fat synthesis, and accelerating body energy consumption. <p><a href="https://greenmedinfo.com/article/effect-selenium-enriched-kiwifruit-body-fat-reduction-and-liver-protection-hyp" target="_blank">read more</a></p> https://greenmedinfo.com/article/effect-selenium-enriched-kiwifruit-body-fat-reduction-and-liver-protection-hyp#comments Hyperlipidemia Kiwifruit Selenium Antioxidants Hypolipidemic Animal Study Sun, 21 Feb 2021 00:51:03 +0000 greenmedinfo 234836 at https://greenmedinfo.com Evaluation of lipid and cholesterol-lowering effect of bioflavonoids from bergamot extract. https://greenmedinfo.com/article/evaluation-lipid-and-cholesterol-lowering-effect-bioflavonoids-bergamot-extrac PMID:  Nat Prod Res. 2020 May 22:1-6. Epub 2020 May 22. PMID: 32441543 Abstract Title:  Evaluation of lipid and cholesterol-lowering effect of bioflavonoids from bergamot extract. Abstract:  Several natural products have been reported to be involved in the suppression of adipogenesis. In this study, we reveal that a bergamot extract (BE) decreased the accumulation of intracellular lipids in murine pre-adipocytes 3T3-L1 cells during adipogenic differentiation. Both the inhibition of HMG-CoA reductase activity and the differentiation and proliferation of adipocytes could be used as a strategy for the treatment and prevention of obesity. The results of this study show a reduction of HMG-CoA activity and of lipid droplet accumulation in the presence of the BE, suggesting the potential of BE as an anti-adipogenic agent to lower the content of cholesterol and body fat and prevent a gain in body weight. Moreover, BE as the result of high percentages of flavonoid compounds such as neoriocitrin, naringin and neohesperidin, the main flavonoids contained in BE, led to significant inhibition of DPPH free radical, demonstrating a strong radical scavenging activity. <p><a href="https://greenmedinfo.com/article/evaluation-lipid-and-cholesterol-lowering-effect-bioflavonoids-bergamot-extrac" target="_blank">read more</a></p> https://greenmedinfo.com/article/evaluation-lipid-and-cholesterol-lowering-effect-bioflavonoids-bergamot-extrac#comments Bergamot Hyperlipidemia Obesity Anticholesteremic Agents In Vitro Study Thu, 17 Sep 2020 23:00:15 +0000 greenmedinfo 227127 at https://greenmedinfo.com Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents. https://greenmedinfo.com/article/hypoglycemic-and-hypolipidemic-effects-moringa-oleifera-leaves-and-their-funct PMID:  Food Chem. 2020 Jul 5 ;333:127478. Epub 2020 Jul 5. PMID: 32663752 Abstract Title:  Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents. Abstract:  Moringa oleifera Lam. (M. oleifera) leaves have long been consumed as both nutritive vegetable and popular folk medicine for hyperglycemia and hyperlipidemia in Kenya communities. In the current study, in vitro inhibition by M. oleifera leaf extract (MOLE, 90% (v/v) ethanol) ofα-glucosidase and pancreatic lipase was demonstrated, followed by determination of the effects of MOLE on both glucose consumption and lipid levels (TC, TG, HDL-C and LDL-C) in 3T3-L1 cells. Potential ligands in MOLE were fast screened using affinity ultrafiltration LC-MS, and 14 and 10 componentsdisplayed certain binding affinity to α-glucosidase and pancreatic lipase, respectively. Docking studies revealed the binding energies and hydrogen bonds between potential ligands and enzymes. This study suggests that M. oleifera leaves may be a promising natural source for the prevention and treatment of hyperglycemia and hyperlipidemia as well as a functional food or other product for health care in the near future. <p><a href="https://greenmedinfo.com/article/hypoglycemic-and-hypolipidemic-effects-moringa-oleifera-leaves-and-their-funct" target="_blank">read more</a></p> https://greenmedinfo.com/article/hypoglycemic-and-hypolipidemic-effects-moringa-oleifera-leaves-and-their-funct#comments Hyperglycemia Hyperlipidemia Alpha-glucosidase inhibitor Enzyme Inhibitors: Pancreatic Lipase Hypoglycemic Agents Hypolipidemic In Vitro Study Sat, 18 Jul 2020 23:01:06 +0000 greenmedinfo 223807 at https://greenmedinfo.com Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. https://greenmedinfo.com/article/hypoglycemic-and-hypolipidemic-effects-rutin-hyperglycemic-rats PMID:  J Tradit Chin Med. 2020 Aug ;40(4):640-645. PMID: 32744031 Abstract Title:  Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. Abstract:  OBJECTIVE: To study the effects of rutin on serum glucose and lipid levels in hyperglycemic rats.METHODS: Male Wistar rats were subjected to intraperitoneal streptozotocin injections and a high-sugar, high-fat diet to establish a hyperglycemic and hyperlipidemic model. The model was considered to be successfully established in rats with fasting blood sugar (FBS)≥ 11.1 mmol/L. The study included 6 groups with 10 rats each: a blank control group, a model group, a metformin group, and groups on large, medium and small doses of rutin. The groups received intraperitoneal streptozotocin or normal saline for 21 d. FBS, serum lipids, serum insulin, insulin sensitivity index (ISI), and levels of catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and malondialdehyde (MDA) levels were evaluated in all rats. Pancreatic tissue samples were harvested to observe structural changes in islet cells.RESULTS: Large, medium, and small doses of rutin were associated with significantly reduced FBS (P<p><a href="https://greenmedinfo.com/article/hypoglycemic-and-hypolipidemic-effects-rutin-hyperglycemic-rats" target="_blank">read more</a></p> https://greenmedinfo.com/article/hypoglycemic-and-hypolipidemic-effects-rutin-hyperglycemic-rats#comments Hyperglycemia Hyperlipidemia Rutin Hypoglycemic Agents Hypolipidemic Animal Study Fri, 07 Aug 2020 20:34:01 +0000 greenmedinfo 224844 at https://greenmedinfo.com Optimization of extraction flavonoids from Exocarpium Citri Grandis and evaluation its hypoglycemic and hypolipidemic activities. https://greenmedinfo.com/article/optimization-extraction-flavonoids-exocarpium-citri-grandis-and-evaluation-its PMID:  J Ethnopharmacol. 2020 Nov 15 ;262:113178. Epub 2020 Jul 28. PMID: 32736047 Abstract Title:  Optimization of extraction flavonoids from Exocarpium Citri Grandis and evaluation its hypoglycemic and hypolipidemic activities. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Exocarpium Citri Grandis (ECG; Huajuhong in Chinese) is a precious traditional Chinese medicine with a history of hundreds of years in China. It has been demonstrated to possess numerous pharmacological properties, including antitussive, expectorant, anti-inflammatory, hypoglycemic, and hypolipidemic. However, no in-depth report exists on the hypoglycemic and hypolipidemic properties of ECG.AIM OF THE STUDY: This study aimed to evaluate the hypoglycemic and hypolipidemic properties of ECG flavonoids extract in vitro and in vivo so as to lay the foundation for further researches in this field.MATERIALS AND METHODS: Total flavonoids (TF) and naringin were separately extracted from ECG, and the components of TF were identified by HPLC-MS. The antioxidant capacities of TF and naringin were determined by 2,2,1-diphenyl-1-picrylhydrazyl (DPPH)-free radical scavenging tests, and digestive enzymes activity inhibition assays in vitro in order to evaluate their hypoglycemic properties. Furthermore, diabetic mice experiments were performed to assess the hypoglycemic and hypolipidemic properties of TF and naringin in vivo.RESULTS: Five compounds were identified from TF, including naringin, rhoifolin, poncirin, bergaptol, and naringenin. The half maximal inhibitory concentration (IC) of TF and naringin to DPPH-free radicals were 0.269 and 1.946 mg/mL, respectively. TF and naringin demonstrated a certain inhibitory effect on α-glucosidase and a weaker inhibitory effect on α-amylase. The results of animal experiments showed that TF and naringin had no significant effect on the blood glucose levels, but they could lead to significant (p <p><a href="https://greenmedinfo.com/article/optimization-extraction-flavonoids-exocarpium-citri-grandis-and-evaluation-its" target="_blank">read more</a></p> https://greenmedinfo.com/article/optimization-extraction-flavonoids-exocarpium-citri-grandis-and-evaluation-its#comments Flavonoids Hyperglycemia Hyperlipidemia Hypoglycemic Agents Hypolipidemic Animal Study In Vitro Study Sat, 10 Oct 2020 11:50:12 +0000 greenmedinfo 227828 at https://greenmedinfo.com Vitamin C may be useful in maintaining cellular redox balance and protecting against lipidemic stress. https://greenmedinfo.com/article/vitamin-c-may-be-useful-maintaining-cellular-redox-balance-and-protecting-agai PMID:  Indian J Clin Biochem. 2023 Oct ;38(4):512-518. Epub 2022 Sep 6. PMID: 37746546 Abstract Title:  Vitamin C Improves Inflammatory-related Redox Status in Hyperlipidemic Rats. Abstract:  Excessive dietary fat is mainly responsible for metabolic diseases including atherosclerosis and cardiovascular disease. We have evaluated the role of Vitamin C in an experimental hyperlipidemic model of rats (male Wistar rat 12-16 months). The hyperlipidemic model of the rat was created by treatment with an atherogenic suspension: cholesterol, cholic acid, and coconut oil, for 30 days once daily, and supplemented with Vitamin C (Ascorbic acid) doses of 0.5 g/kg body weight (orally) for the 30 days once daily. Bodyweight, fasting glucose, triglyceride, cholesterol, ROS (Reactive oxygen species), MDA (Malondialdehyde), FRAP (Ferric reducing the ability of plasma), GSH (Reduced glutathione), PCO (Protein carbonyl), PON-1(Paraoxonase-1), AGE (Advanced glycation end product), PMRS (Plasma membrane reduced system), and inflammatory cytokines (TNF-αand IL-6) were estimated in blood and plasma. Our result shows that oxidative stress, and inflammatory markers, were increased in the HFD-treated group of rats. Vitamin C supplementation protected against lipidemic and, oxidative stress. We conclude that Vitamin C may be useful in maintaining cellular redox balance and protecting against lipidemic stress. <p><a href="https://greenmedinfo.com/article/vitamin-c-may-be-useful-maintaining-cellular-redox-balance-and-protecting-agai" target="_blank">read more</a></p> https://greenmedinfo.com/article/vitamin-c-may-be-useful-maintaining-cellular-redox-balance-and-protecting-agai#comments Hyperlipidemia Vitamin C Anti-Inflammatory Agents Antioxidants Interleukin-6 Downregulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Animal Study Tue, 24 Oct 2023 23:13:43 +0000 greenmedinfo 282657 at https://greenmedinfo.com "Hypolipidaemic effects of cyanidin 3-glucoside rich extract from black rice through regulating hepatic lipogenic enzyme activities." https://greenmedinfo.com/article/hypolipidaemic-effects-cyanidin-3-glucoside-rich-extract-black-rice-through-re PMID:  J Sci Food Agric. 2013 Jan 24. Epub 2013 Jan 24. PMID: 23471845 Abstract Title:  Hypolipidaemic effects of cyanidin 3-glucoside rich extract from black rice through regulating hepatic lipogenic enzyme activities. Abstract:  BACKGROUND: Black rice is rich in anthocyanins, especially cyanidin-3-glucoside (C3G). This study examined the effects of a C3G-rich extract from black rice on hyperlipidaemia induced by a high fat/cholesterol diet (HFCD) in rats. RESULTS: Male Sprague-Dawley rats were fed either HFCD or HFCD containing 150 mg kg(-1) body weight C3G (HFCD+C3G) for 4 weeks. We found that C3G significantly decreased serum levels of total cholesterol, free cholesterol, triglycerides, and free fatty acids in rats fed a HFCD. Similarly, hepatic cholesterol and triglyceride levels and the activities of hepatic lipogenic enzymes (malic enzyme and glucose-6-phosphate dehydrogenase) were significantly reduced by C3G supplementation. CONCLUSION: These results suggest that C3G can ameliorate HFCD-induced hyperlipidaemia in part by modulating the activities of hepatic lipogenic enzymes. © 2013 Society of Chemical Industry. https://greenmedinfo.com/article/hypolipidaemic-effects-cyanidin-3-glucoside-rich-extract-black-rice-through-re#comments Cyanidin 3-glucoside Hyperlipidemia Rice: Black Animal Study Fri, 15 Mar 2013 13:26:38 +0000 greenmedinfo 93225 at https://greenmedinfo.com "Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats." https://greenmedinfo.com/article/hypolipidemic-effect-fucoidan-laminaria-japonica-hyperlipidemic-rats PMID:  Pharm Biol. 2010 Apr ;48(4):422-6. PMID: 20645721 Abstract Title:  Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats. Abstract:  In this study, we investigated the effect of fucoidan polysaccharide sulfuric acid ester (FPS) from Laminaria japonica Aresch (Laminariaceae) on hyperlipidemic rats. FPS notably reduced the concentration of serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) of hyperlipidemic rats and increased the concentration of high-density lipoprotein cholesterol (HDL-C) and the activities of lipoprotein lipase (LPL), hepatic lipoprotein (HL), and lecithin cholesterol acyltransferase (LCAT). https://greenmedinfo.com/article/hypolipidemic-effect-fucoidan-laminaria-japonica-hyperlipidemic-rats#comments Fucoidan Hyperlipidemia Animal Study Tue, 18 Dec 2012 22:43:12 +0000 greenmedinfo 87038 at https://greenmedinfo.com 8 Healing Properties of Strawberries https://greenmedinfo.com/blog/8-healing-properties-strawberries <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="8 Juicy Reasons to Eat More Strawberries" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/Strawberries1.jpg" style="width: 500px; height: 333px;" /></p> <p><strong><span style="font-size:18px;"><em>Who doesn't love <a href="/substance/strawberry" rel="dofollow" target="_blank">strawberries</a>? And you don't need any reason other than the pleasure of their sweetness to eat them every day. But according to researchers from Oklahoma State University, there's lots more to strawberries than the flavor.</em></span><a href="#_edn1" name="_ednref1" title="">[i]</a></strong></p> <p>Their study was <strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/24345049" rel="nofollow" target="_blank">published in the journal <em>Critical Reviews in Food Science and Nutrition</em></a></strong> with funding from the NIH and the California Strawberry Commission. In it the researchers review over 130 studies attesting to the strawberry's status as a "functional food."</p><p><a href="https://greenmedinfo.com/blog/8-healing-properties-strawberries" target="_blank">read more</a></p> https://greenmedinfo.com/blog/8-healing-properties-strawberries#comments Alzheimer's Disease Anthocyanins Blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases Carotenoids Catechin Ellagic Acid Flavonoids Hyperglycemia Hyperlipidemia Hypertension Kaempferol Naringenin Parkinson's Disease Phytosterols Polyphenols Potassium Quercetin Strawberry Vitamin C Vitamin E Antioxidants Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods Alzheimer's disease Anthocyanins Antioxidants blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases CAROTENOIDS Catechin Ellagic Acid Flavonoids hyperglycemia hyperlipidemia hypertension Kaempferol Naringenin Parkinson's disease phytosterols POLYPHENOLS potassium QUERCETIN Strawberry Vitamin C VITAMIN E Sat, 18 Feb 2023 17:30:10 +0000 GMI Research Group 114933 at https://greenmedinfo.com >Wheatgrass supplementation at a dose of 3.5 g per day for a period of 10 weeks results in significant reductions in Apo B fraction, TC, and TAG without significantly reducing the HDL cholesterol. https://greenmedinfo.com/article/wheatgrass-supplementation-dose-35-g-day-period-10-weeks-results-significant-r PMID:  J Diet Suppl. 2017 Sep 3 ;14(5):503-513. Epub 2017 Jan 25. PMID: 28121470 Abstract Title:  Impact of Wheatgrass (Triticum aestivum L.) Supplementation on Atherogenic Lipoproteins and Menopausal Symptoms in Hyperlipidemic South Asian Women - A Randomized Controlled Study. Abstract:  OBJECTIVE: The purpose of this study was to evaluate the effect of wheatgrass (Triticum aestivum L.) on atherogenic lipoproteins, inflammation, and menopausal symptoms.METHODS: Fifty-nine hyperlipidemic women were randomized into control (n = 30) and intervention groups (n = 29). Intervention group was administered 3.5 g of freeze-dried wheatgrass powder in encapsulated form daily for 10 weeks, while the control group received no intervention.RESULTS: The intervention group experienced a reduction of 5.4% in total cholesterol (TC), 4.4% in low-density lipoprotein cholesterol, and 9.5% in triacylglycerols (TAG); however, high-density lipoprotein (HDL) also reduced by 6% following 10 weeks of intervention. Compared with the control group, the baseline-adjusted post-intervention levels of TC, TAG, and Apolipoprotein B (Apo B) were significantly lower in the experimental group compared with the control group (p = 0.043, 0.045, and 0.016, respectively). Prevalence of menopausal symptoms saw nonsignificant reductions: vasomotor, 42%; somatic, 33%; and psychological, 50%, while urogenital symptoms remained unaltered.CONCLUSIONS: Wheatgrass supplementation at a dose of 3.5 g per day for a period of 10 weeks results in significant reductions in Apo B fraction, TC, and TAG without significantly reducing the HDL cholesterol. <p><a href="https://greenmedinfo.com/article/wheatgrass-supplementation-dose-35-g-day-period-10-weeks-results-significant-r" target="_blank">read more</a></p> https://greenmedinfo.com/article/wheatgrass-supplementation-dose-35-g-day-period-10-weeks-results-significant-r#comments Apolipoprotein A/B ratio imbalances Apolipoprotein Disorders Hyperlipidemia Triglycerides: Elevated Wheat Grass Human Study Tue, 27 Dec 2022 21:40:01 +0000 greenmedinfo 268530 at https://greenmedinfo.com A combination of five main alkaloids from Rhizoma Coptidis showed a synergetic cholesterol-lowering efficacy. https://greenmedinfo.com/article/combination-five-main-alkaloids-rhizoma-coptidis-showed-synergetic-cholesterol PMID:  Life Sci. 2016 Apr 15 ;151:50-60. Epub 2016 Feb 11. PMID: 26876917 Abstract Title:  Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters. Abstract:  AIMS: Hyperlipidemia contributes to the progression of cardiovascular diseases. Main alkaloids from Rhizoma Coptidis including berberine (BBR), coptisine (COP), palmatine (PAL), epiberberine (EPI) and jatrorrhizine (JAT), improved dyslipidemia in hypercholesterolemic hamsters to a different degree. In this study, HepG2 cells and hypercholesterolemic hamsters were used to investigate the synergetic cholesterol-lowering efficacy of these five main alkaloids.MAIN METHODS: The cellular lipid and cholesterol accumulation and in HepG2 cells were evaluated by Oil Red O staining and HPLC analysis. LDL receptor, 3-Hydroxy-3-methylglutaryl CoA reductase (HMGCR) and cholesterol 7-alpha-hydroxylase (CYP7A1) that involving cholesterol metabolism in HepG2 cells were measured by qRT-PCR, western blot and immunofluorescence analysis. The serum profiles including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c), as well as TC and total bile acids (TBA) of feces in hypercholesterolemic hamsters were also measured.KEY FINDING: As compared to single alkaloids, the combination of five main alkaloids (COM) reduced the lipid and cholesterol accumulation in HepG2 cells more effectively and performed an advantageous effect on controlling TC, TG, LDL-c and HDL-c in hypercholesterolemic hamsters. More effective reduction of TBA and TC levels in feces of hamsters were achieved after the administration of COM. These effects were derived from the up-regulation of LDL receptor and CYP7A1, as well as HMGCR downregulation.SIGNIFICANCE: Our results demonstrated that COM showed a synergetic cholesterol-lowering efficacy, which was better than single alkaloids and it might be considered as a potential therapy for hypercholesterolemia. https://greenmedinfo.com/article/combination-five-main-alkaloids-rhizoma-coptidis-showed-synergetic-cholesterol#comments Cardiovascular Disease: Prevention Coptidis rhizoma Hypercholesterolemia Hyperlipidemia Anticholesteremic Agents Hepatoprotective Hypolipidemic Natural Substance Synergy Animal Study Tue, 05 Jul 2016 22:25:23 +0000 greenmedinfo 129693 at https://greenmedinfo.com A combination of Phellodendron and Citrus peel extract has a beneficial effect on cardiovascular risk factors; namely lipid levels, blood pressure and fasting glucose levels. https://greenmedinfo.com/article/combination-phellodendron-and-citrus-peel-extract-has-beneficial-effect-cardio PMID:  Nutr J. 2008;7:16. Epub 2008 May 20. PMID: 18492265 Abstract Title:  Phellodendron and Citrus extracts benefit cardiovascular health in osteoarthritis patients: a double-blind, placebo-controlled pilot study. Abstract:  BACKGROUND: The objective of this clinical study was to assess the potential benefit of a dietary supplement, NP 06-1, on cardiovascular protective properties in overweight and normal weight adults diagnosed with osteoarthritis of the knee. METHODS: An 8-week, placebo-controlled, randomized, double-blind study was conducted with four groups, comparing the effects of NP 06-1 to placebo in overweight and normal weight subjects diagnosed with primary osteoarthritis of the knee. NP 06-1 (a combination of two botanical extracts; Phellodendron amurense bark and Citrus sinensis peel) or matching placebo was given in a dose of two capsules (370 mg each) twice daily. The outcome measures reported are lipid levels, weight, BMI, blood pressure and fasting glucose. Analyses of variance were used to compare changes of physiological measures over the trial period and between groups. RESULTS: Eighty (80) subjects were enrolled and 45 subjects completed the study. No serious adverse events were reported. NP 06-1 administration was associated with a general improvement in lipid levels. Both the overweight and normal weight treatment groups had significant reductions in triglycerides and LDL-cholesterol, as well as a significant increase in HDL-cholesterol compared to their respective control groups. Overall there were decreases in blood pressure in both overweight and normal weight treatment groups compared to respective placebo groups. There was also a significant decrease in fasting glucose levels in the overweight treatment group compared to the start of the study and to the overweight placebo group. There was no change in fasting blood sugar for the normal weight groups. Both overweight and normal weight treatment groups lost a significant amount of weight compared to their respective placebo groups. The overweight treatment group lost an average of 5% body weight after 8 weeks, which was associated with a significant loss in BMI over time. CONCLUSION: In this pilot study NP 06-1 had a beneficial effect on cardiovascular risk factors; namely lipid levels, blood pressure and fasting glucose levels. Administration of NP 06-1 was also associated with weight loss. https://greenmedinfo.com/article/combination-phellodendron-and-citrus-peel-extract-has-beneficial-effect-cardio#comments Cardiovascular Diseases Citrus Peel Hyperlipidemia Hypertension Osteoarthritis Phellodendron Hypoglycemic Agents Hypolipidemic Plant Extracts Human Study Mon, 01 Feb 2010 14:02:47 +0000 greenmedinfo 50718 at https://greenmedinfo.com A daily intake of powdered seeds of Citrullus colocynthis can lower the triglyceride and cholesterol concentration significantly. https://greenmedinfo.com/article/daily-intake-powdered-seeds-citrullus-colocynthis-can-lower-triglyceride-and-c PMID:  Pak J Biol Sci. 2010 Dec 15 ;13(24):1202-7. PMID: 21313901 Abstract Title:  The hypolipidemic effect of Citrullus colocynthis on patients with hyperlipidemia. Abstract:  Citrullus colocynthis is one of the medical herbs that traditionally have been used as an antidiabetic medication in tropical and subtropical countries. The aim of this study was to investigate the hypolipidemic effect of Citrullus colocynthis beyond the hypoglycemic impact on human. One hundred dislipidemic patients were randomly divided into two groups namely treated (n = 50) group and placebo (n = 50) group. The subjects were treated daily by powdered seeds of Citrullus colocynthis (300 mg) and placebo for 6 weeks. The serums, TG, Chol, LDL-C, HDL-C, SGOT and SGPT were measured with enzymatic methods at the beginning and the end of the project. The significance of differences within these groups was calculated by Paired T-test and by analysis of covariance between them. There were significant differences within and between treated and placebo groups during our treatment in TG and in Cholesterol after intervention (p https://greenmedinfo.com/article/daily-intake-powdered-seeds-citrullus-colocynthis-can-lower-triglyceride-and-c#comments Bitter Apple Hyperlipidemia Placebo Effect Plant Extracts Human Study Wed, 16 Dec 2015 02:33:39 +0000 greenmedinfo 122677 at https://greenmedinfo.com A diet high in plant sterols, soy protein, viscous fibers and almonds compares favorably to statin therapy in reducing C-reactive protein. https://greenmedinfo.com/article/diet-high-plant-sterols-soy-protein-viscous-fibers-and-almonds-compares-favora PMID:  Eur J Clin Nutr. 2005 Jul;59(7):851-60. PMID: 15900306 Abstract Title:  Direct comparison of dietary portfolio vs statin on C-reactive protein. Abstract:  BACKGROUND: 3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) markedly reduce serum cholesterol and have anti-inflammatory effects. The effect of cholesterol-lowering diets on inflammatory biomarkers is less well known. OBJECTIVE: To compare the efficacy of a dietary combination (portfolio) of cholesterol-lowering foods vs a statin in reducing C-reactive protein (CRP) as a biomarker of inflammation linked to increased cardiovascular disease risk. METHODS: In all, 34 hyperlipidemic subjects completed three 1-month treatments as outpatients in random order: a very low-saturated fat diet (control); the same diet with 20 mg lovastatin (statin); and a diet high in plant sterols (1.0 g/1000 kcal), soy protein (21.4 g/1000 kcal), viscous fibers (9.8 g/1000 kcal), and almonds (14 g/1000 kcal) (portfolio). Fasting blood samples were obtained at weeks 0, 2, and 4. RESULTS: Using the complete data, no treatment reduced serum CRP. However, when subjects with CRP levels above the 75th percentile for previously reported studies (&gt;3.5 mg/l) were excluded, CRP was reduced similarly on both statin, -16.3 +/- 6.7% (n = 23, P = 0.013) and dietary portfolio, -23.8 +/- 6.9% (n = 25, P = 0.001) but not the control, 15.3 +/- 13.6% (n = 28, P = 0.907). The percentage CRP change from baseline on the portfolio treatment (n = 25) was greater than the control (n = 28, P = 0.004) but similar to statin treatment (n = 23, P = 0.349). Both statin and portfolio treatments were similar in reducing CRP and numerically more effective than control but only the change in portfolio was significant after the Bonferroni adjustment. CONCLUSIONS: A combination of cholesterol-lowering foods reduced C-reactive protein to a similar extent as the starting dose of a first-generation statin. https://greenmedinfo.com/article/diet-high-plant-sterols-soy-protein-viscous-fibers-and-almonds-compares-favora#comments Almond C-Reactive Protein Cardiovascular Diseases Fiber Hyperlipidemia Inflammation Plant Sterols/Stanols Soy Protein Therapeutic Action not Inferior to Drug Therapy Human Study Mon, 01 Feb 2010 04:11:28 +0000 greenmedinfo 50698 at https://greenmedinfo.com