Immune Disorders https://greenmedinfo.com/taxonomy/term/2760/all en Bee pollen boosts the early development of immune organs in chickens. https://greenmedinfo.com/article/bee-pollen-boosts-early-development-immune-organs-chickens PMID:  Zhongguo Zhong Yao Za Zhi. 2005 Oct;30(19):1532-6. PMID: 16335827 Abstract Title:  [Effect of bee pollen on development of immune organ of animal]. Abstract:  OBJECTIVE: To study on the effect of been pollen on development of immune organ of animal. METHOD: A total of 144 one day-old broilers were randomly divided into 2 groups, in which each group included 72 chickens. The control group was fed on the basal diet for 42 days, and that of experiment group supplemented 1.5% bee pollen. Six chickens in each group were selected and slaughtered at 7, 14, 21, 28, 35, 42 days respectively, and the thymuses, cloacal bursa and spleens were obtained, weighted, fixed in Bouin liquid and made into paraffin section. RESULT: Compared with control group, the weight and the relative weight of thymuses, cloacal bursa and spleens of experiment group increased significantly (P &lt; 0.05) or extremely significantly (P &lt; 0.01). In experiment group, the cortex of thymic lobule, bursa nodule and Periarterial Lymphatic Sheaths thicken obviously; the volume of bursa nodule, splenic nodule and ellipsoid augmented, and the germinal center of splenic nodule were obvious; the thymic corpuscle increased; the plica of cloacal bursa developed well and the degenerating of it retarded. CONCLUSION: The diet supplemented bee pollen could boost the early development of thymus and cloacal bursa, retard the degenerating of cloacal bursa and promote the immune response of spleen. https://greenmedinfo.com/article/bee-pollen-boosts-early-development-immune-organs-chickens#comments Bee Pollen Immune Disorders Animal Study Tue, 24 Nov 2009 14:46:25 +0000 greenmedinfo 48021 at https://greenmedinfo.com Bromelain may stimulate type 1 cells up-regulating both innate as well as the adaptive immune system. https://greenmedinfo.com/article/bromelain-may-stimulate-type-1-cells-regulating-both-innate-well-adaptive-immu PMID:  Eur J Med Res. 2005 Aug 17;10(8):325-31. PMID: 16131473 Abstract Title:  In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans. Abstract:  BACKGROUND: Proteolytic enzymes such as bromelain and trypsin are used as an adjuvant therapeutic approach in the treatment of chronic inflammatory, malignant and autoimmune diseases. In vitro studies have shown that proteolytic enzymes modulate surface adhesion molecules on T-cells. In this study we analysed the influence of bromelain and trypsin on the cytokine production and proliferation of peripheral blood mononuclear cells (PBMC) from patients with a classical cellular mediated autoimmune disorder, namely encephalomyelitis disseminata (ED) as well as from healthy controls. -METHODS: PBMC from patients with ED (n=12) and healthy controls (n=12) were cultured for seven days at 37 degrees C under three different conditions: without antigen, with bromelain and with trypsin (final concentrations 10-1000 microg/ml). Proliferation was determined by superset3H-thymidine incorporation. Secretion of cytokines into the supernatant was measured by a double sandwich ELISA. Intracellular cytokines were determined by flow cytometric analysis. -RESULTS: PBMC from patients with ED and healthy controls showed a significantly increased proliferative response to bromelain (ED: 14053+/- 7585 cpm with bromelain vs. spontaneous proliferation of 430+/- 255 cpm; healthy controls: 10689+/- 4607 cpm vs. 327+/-193) but not to trypsin. Bromelain induced in all 24 individuals a significant increase of the macro-phage/monocyte associated cytokines interleukin (IL)-6, granulocyte-macrophage-colony stimulating factor (GM-CSF), tumour necrosis factor alpha (TNFa) (p https://greenmedinfo.com/article/bromelain-may-stimulate-type-1-cells-regulating-both-innate-well-adaptive-immu#comments Bromelain Immune Disorders Antiproliferative Immunostimulatory In Vitro Study Mon, 11 Apr 2011 17:35:43 +0000 greenmedinfo 63203 at https://greenmedinfo.com Curcumin appears to be a safe and useful immunomodulator for the immune system. https://greenmedinfo.com/article/curcumin-appears-be-safe-and-useful-immunomodulator-immune-system PMID:  Int Immunopharmacol. 2008 May;8(5):688-700. Epub 2008 Feb 13. PMID: 18387511 Abstract Title:  Immunomodulatory effects of curcumin: in-vivo. Abstract:  Curcumin specifically exhibits cytostatic and cytotoxic effects against tumors of multiple origin. Previously we have demonstrated apoptotic activity of curcumin against tumor cells with no effect on normal cells in-vitro. Many anti-cancer drugs exhibit deleterious effects on immune cells, which restrict their wide use in-vivo. In the present study, we have evaluated the effect of curcumin on the major functions of T cells, natural killer cells, macrophages and on total splenocytes in-vivo, which insight the role of curcumin on their broad effector functions. This study demonstrates that prolonged curcumin-injections (i.p.) do not impair the cytotoxic function of natural killer cells, the generation of reactive oxygen species and nitric oxide from macrophages and the levels of Th1 regulatory cytokines remained unaltered. Interestingly, curcumin-injections enhanced the mitogen and antigen induced proliferation potential of T cells. We have also evaluated immunomodulatory effects of curcumin in ascites-bearing animals. This study strengthens our belief that curcumin is a safe and useful immunomodulator for the immune system. https://greenmedinfo.com/article/curcumin-appears-be-safe-and-useful-immunomodulator-immune-system#comments Curcumin Immune Disorders Antiproliferative Immunomodulatory Review Sat, 12 Feb 2011 03:22:33 +0000 greenmedinfo 61468 at https://greenmedinfo.com Five Reasons to Eat More Sweet Potatoes https://greenmedinfo.com/blog/five-reasons-eat-more-sweet-potatoes <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Five_Reasons_to_Eat_More_Sweet_potatoes-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /></p> <p><span style="font-size:18px;"><em><strong>From cognitive protection to immune support here are five compelling reasons to incorporate sweet potatoes into your everyday diet</strong></em></span></p> <p><span style="letter-spacing: 0px;">Sweet potatoes are more than just a popular staple food serving as a sweet appetizer, side dish or filling snack on their own. This starchy root vegetable has plenty to offer when it comes to achieving optimal health. Sweet potato is a common food source for many indigenous populations in Africa, Central and South Americas, the Caribbean and Hawaii.</span><sup style="letter-spacing: 0px;"><strong><a href="#_edn1" name="_ednref1" style="letter-spacing: 0px;" title="">[i]</a></strong></sup></p><p><a href="https://greenmedinfo.com/blog/five-reasons-eat-more-sweet-potatoes" target="_blank">read more</a></p> https://greenmedinfo.com/blog/five-reasons-eat-more-sweet-potatoes#comments Anthocyanins Calcium Cancers Diabetes Fiber Immune Disorders Iron Memory Disorders Potassium Sodium Sweet Potato Vitamin A Vitamin C Water Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods alternative medicine healing foods natural health Thu, 31 Mar 2022 16:55:58 +0000 GMI Research Group 255556 at https://greenmedinfo.com Immunological programming by breast milk creates an anti-inflammatory cytokine milieu in breast-fed infants compared to formula-fed infants. https://greenmedinfo.com/article/immunological-programming-breast-milk-creates-anti-inflammatory-cytokine-milie PMID:  Br J Nutr. 2012 Oct 30:1-9. Epub 2012 Oct 30. PMID: 23110822 Abstract Title:  Immunological programming by breast milk creates an anti-inflammatory cytokine milieu in breast-fed infants compared to formula-fed infants. Abstract:  Breast milk provides important maturational stimuli to an infant&#039;s developing immune system. However, data concerning the role of breast-feeding in reducing the risk of allergic disease remain contradictory. Previous studies have centred on comparative analyses of breast milk and formula compositions. We chose a slightly different angle, whereby we focused on the effects of the chosen diet on the infant himself, comparing the immune development of formula-fed and breast-fed children. The objective of the present study was to determine how the mode of feeding affects infant immunology. Altogether, eighteen formula-fed infants with limited breast-feeding for3 months were included in the study. Concentrations of interferonγ, TNF-α IL-10, IL-5, IL-4 and IL-2 were measured simultaneously from the same serum sample through use of a multiplexed flow cytometric assay at the ages of 1, 3, 6 and 12 months. Transforming growth factor β2 (TGF-β2) was measured using ELISA at the same time points. Serum TNF-α and IL-2 concentrations were significantly higher in formula-fed than in breast-fed infants during the first year of life (ANOVA, P = 0·002). The serum concentrations of TGF-β were significantly lower in formula-fed than in breast-fed infants throughout the first year of life (ANOVA, P ≤ 0·0001). Exclusive breast-feeding promotes an anti-inflammatory cytokine milieu, which is maintained throughout infancy. Such an immunological environment limits hyper-responsiveness and promotes tolerisation, possibly prohibiting the onset of allergic disease. https://greenmedinfo.com/article/immunological-programming-breast-milk-creates-anti-inflammatory-cytokine-milie#comments Breast Milk Immune Disorders Breastfeeding Infant Formula Human Study Thu, 15 Nov 2012 02:15:25 +0000 greenmedinfo 84932 at https://greenmedinfo.com Integrative genomics evidence support the immune and inflammation hypothesis of depression. https://greenmedinfo.com/article/integrative-genomics-evidence-support-immune-and-inflammation-hypothesis-depre PMID:  Curr Neuropharmacol. 2016 Jan 6. Epub 2016 Jan 6. PMID: 26733279 Abstract Title:  Systems genomics support for immune and inflammation hypothesis of depression. Abstract:  Immune system plays an important role in brain development and function. With the discovery of increased circulating inflammatory cytokine levels in depression over two decades ago, evidence implicating immune system alterations in the disease has increasingly accumulated. To assess the underlying etiology and pathophysiology, a brief overview of the hypothesis free genomic, transcriptomic and proteomic studies in depression is presented here in order to specifically examine if the immune and inflammation hypothesis of depression is supported. It is observed that genes identified in genome-wide association studies, and genes showing differential expression in transcriptomic studies in human depression do separately overrepresent processes related to both development as well as functioning of the immune system, and inflammatory response. These processes are also enriched in differentially expressed genes reported in animal models of antidepressant treatment. It is further noted that some of the genes identified in genome sequencing and proteomic analyses in human depression, and transcriptomic studies in chronic social defeat stress, an established animal model of depression, relate to immune and inflammatory pathways. In conclusion, integrative genomics evidence support the immune and inflammation hypothesis of depression. https://greenmedinfo.com/article/integrative-genomics-evidence-support-immune-and-inflammation-hypothesis-depre#comments Depression Immune Disorders Inflammation Diseases that are Linked Commentary Mon, 11 Jan 2016 21:28:49 +0000 greenmedinfo 123048 at https://greenmedinfo.com Multiple chemical sensitivity disorder is associated wtih higher blood levels of chloroform and possibly immune dysfunction. https://greenmedinfo.com/article/multiple-chemical-sensitivity-disorder-associated-wtih-higher-blood-levels-chl PMID:  Occup Med (Lond). 2004 Sep;54(6):408-18. Epub 2004 Sep 3. PMID: 15347780 Abstract Title:  Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures. Abstract:  BACKGROUND: Multiple chemical sensitivity (MCS), although poorly understood, is associated with considerable morbidity.AIM: To investigate potential biological mechanisms underlying MCS in a case-control study.METHODS: Two hundred and twenty-three MCS cases and 194 controls (urban females, aged 30-64 years) fulfilled reproducible eligibility criteria with discriminant validity. Routine laboratory results and serum levels of volatile organic compounds (VOCs) were compared. Dose-response relationships, a criterion for causality, were examined linking exposures to likelihood of case status.RESULTS: Routine laboratory investigations revealed clinically unimportant case-control differences in means. Confounder-adjusted odds ratios (OR) showed MCS was negatively associated with lymphocyte count and total plasma homocysteine, positively associated with mean cell haemoglobin concentration, alanine aminotransferase and serum vitamin B6, and not associated with thyroid stimulating hormone, folate or serum vitamin B12. More cases than controls had detectable serum chloroform (P = 0.001) with the OR for detectability 2.78 (95% confidence interval = 1.73-4.48, P https://greenmedinfo.com/article/multiple-chemical-sensitivity-disorder-associated-wtih-higher-blood-levels-chl#comments Immune Disorders Multiple Chemical Sensitivity Thyroid Diseases Chloroform Human Study Thu, 03 Feb 2011 21:34:03 +0000 greenmedinfo 60722 at https://greenmedinfo.com The current study clearly demonstrates that exposure to THC leads to suppression of the immune response. https://greenmedinfo.com/article/current-study-clearly-demonstrates-exposure-thc-leads-suppression-immune-respo PMID:  J Pharmacol Exp Ther. 2002 Aug ;302(2):451-65. PMID: 12130702 Abstract Title:  Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. Abstract:  Delta(9)-tetrahydrocannabinol (THC), the main psychoactive component of marijuana has been shown to suppress the immune response. However, the exact mechanism of THC-induced immunosuppression remains unclear. In the current study, we tested the hypothesis that exposure to THC leads to the induction of apoptosis in lymphocyte populations. Splenocytes of C57BL/6 mice cultured in the presence of 10 microM or greater concentrations of THC showed significantly reduced proliferative response to mitogens, including anti-CD3 monoclonal antibodies (mAbs), concanavalin A (Con A), and lipopolysaccharide (LPS) in vitro. Thymocytes and naive and activated splenocytes exposed to 10 microM or 20 microM THC showed significantly increased levels of apoptosis. Treatment with CB2 antagonist inhibited THC-induced apoptosis in thymocytes and activated splenocytes. Administration of 10 mg/kg body weight of THC into C57BL/6 mice led to thymic and splenic atrophy as early as 6 h after treatment. This effect could be partially inhibited by treatment with a caspase inhibitor in vivo. THC exposure led to reductions in the numbers of all subpopulations of splenocytes and thymocytes examined. Functional studies revealed that splenocytes from THC-treated mice had significantly reduced proliferative response to anti-CD3 mAbs, Con A, and LPS in vitro. Finally, thymocytes and splenocytes exposed to THC in vivo exhibited apoptosis upon in vitro culture. Together, these results suggest that in vivo exposure to THC can lead to significant suppression of the immune response by induction of apoptosis. https://greenmedinfo.com/article/current-study-clearly-demonstrates-exposure-thc-leads-suppression-immune-respo#comments Autoimmune Diseases Delta-tetrahydrocannabinol (THC) Immune Disorders Apoptotic Immunomodulatory Immunosuppressive Agents Dose Response Animal Study In Vitro Study Tue, 05 May 2015 01:10:07 +0000 greenmedinfo 117137 at https://greenmedinfo.com The experimental evidence reviewed in this article argues in favor of the therapeutic potential of these compounds in immune disorders and cancer. https://greenmedinfo.com/article/experimental-evidence-reviewed-article-argues-favor-therapeutic-potential-thes PMID:  Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):319-32. PMID: 12052046 Abstract Title:  Endocannabinoids in the immune system and cancer. Abstract:  The present review focuses on the role of the endogenous cannabinoid system in the modulation of immune response and control of cancer cell proliferation. The involvement of cannabinoid receptors, endogenous ligands and enzymes for their biosynthesis and degradation, as well as of cannabinoid receptor-independent events is discussed. The picture arising from the recent literature appears very complex, indicating that the effects elicited by the stimulation of the endocannabinoid system are strictly dependent on the specific compounds and cell types considered. Both the endocannabinoid anandamide and its congener palmitoylethanolamide, exert a negative action in the onset of a variety of parameters of the immune response. However, 2-arachidonoylglycerol appears to be the true endogenous ligand for peripheral cannabinoid receptors, although its action as an immunomodulatory molecule requires further characterization. Modulation of the endocannabinoid system interferes with cancer cell proliferation either by inhibiting mitogenic autocrine/paracrine loops or by directly inducing apoptosis; however, the proapoptotic effect of anandamide is not shared by other endocannabinoids and suggests the involvement of non-cannabinoid receptors, namely the VR1 class of vanilloid receptors. In conclusion, further investigations are needed to elucidate the function of endocannabinoids as immunosuppressant and antiproliferative/cytotoxic agents. The experimental evidence reviewed in this article argues in favor of the therapeutic potential of these compounds in immune disorders and cancer. https://greenmedinfo.com/article/experimental-evidence-reviewed-article-argues-favor-therapeutic-potential-thes#comments Cancers: All Cannabinoids Endocannabinoid System Endocannabinoids Immune Disorders Antiproliferative Apoptotic Immunosuppressive Agents Cannabinoid Receptors Review Tue, 05 May 2015 00:58:27 +0000 greenmedinfo 117136 at https://greenmedinfo.com The Science Behind Beta Glucan: A Game-Changer in Natural Healing https://greenmedinfo.com/content/science-behind-beta-glucan-game-changer-natural-healing <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/The_Science_Behind_Beta_Glucan-A_Game_Changer_in_Natural_Healing-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /></p> <p><span style="font-size:18px;"><em><strong><span style="letter-spacing: 0px;">Unlock the secret to optimal health with beta glucan, the natural powerhouse that's taking the wellness world by storm. From heart health to immune support, this extraordinary dietary fiber is revolutionizing the way we approach well-being</span></strong></em></span></p><p><a href="https://greenmedinfo.com/content/science-behind-beta-glucan-game-changer-natural-healing" target="_blank">read more</a></p> https://greenmedinfo.com/content/science-behind-beta-glucan-game-changer-natural-healing#comments Aging Allergic Rhinitis Barley Beta-glucan Cancers: All Cardiovascular Disease Diabetes Mellitus: Type 2 High Cholesterol Immune Disorders Inflammatory Bowel Diseases Medicinal Mushrooms Neurological Disorders Oats Obesity Oxidative Stress Radiation Wound Healing healing foods natural health nutrients Thu, 28 Mar 2024 21:12:39 +0000 GMI Research Group 293126 at https://greenmedinfo.com What We Didn't Know About the Brain That Changes Everything https://greenmedinfo.com/blog/what-we-didnt-know-about-brain-changes-everything <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2014<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="What We Didn't Know About the Brain That Changes Everything" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/brain_neuroimmunology_mysteries.jpg" style="height: 490px; width: 490px;" /></p> <p><span style="font-size:16px;"><em><strong>Sometimes science gets things wrong. With acknowledgement of these fundamental misapprehensions, whole swaths of dogma have to be unraveled, deconstructed, and rebuilt. The sooner the better.</strong></em></span></p> <p>Ten years ago, science assumed that immunity was in the body, not the brain, which was thought to have "immune privilege". What does it mean to learn that the brain has an immune system? Does this change our understanding of mental illness? Neurology? Cancer? What about risks of side effects to pharmaceutical interventions that target the immune system such as vaccines?</p><p><a href="https://greenmedinfo.com/blog/what-we-didnt-know-about-brain-changes-everything" target="_blank">read more</a></p> https://greenmedinfo.com/blog/what-we-didnt-know-about-brain-changes-everything#comments Aluminum Toxicity Immune Disorders Immune Disorders: Low Immune Function Vaccine-induced Toxicity Adjuvant Vaccination: All Vaccine Adjuvants Vaccine Effects Mon, 02 Jun 2014 21:58:00 +0000 drbrogan 112626 at https://greenmedinfo.com