Inappropriate TSH Secretion Syndrome https://greenmedinfo.com/taxonomy/term/2782/all en Organophosphate pesticide exposure may adversely effect the thyroid. https://greenmedinfo.com/article/organophosphate-pesticide-exposure-may-adversely-effect-thyroid PMID:  Toxicol Appl Pharmacol. 2010 Aug 5. Epub 2010 Aug 5. PMID: 20691716 Abstract Title:  Interaction between organophosphate pesticide exposure and PON1 activity on thyroid function. Abstract:  Organophosphate pesticides are widely used in agricultural purposes. Recently, a few studies have demonstrated the ability of these chemicals to alter the function of the thyroid gland in human. Moreover, the paraoxonase-1 enzyme (PON1) plays an important role in the toxicity of some organophosphate pesticides, with low PON1 activity being associated with higher pesticide sensitivity. This study evaluates the interaction between exposure to organophosphate compounds and PON1 enzyme activity on serum levels of TSH and thyroid hormones in a population of workers occupationally exposed to pesticides. A longitudinal study was conducted on a population of floriculture workers from Mexico, during two periods of high and low-intensity levels of pesticide application. A structured questionnaire was completed by workers containing questions on sociodemographic characteristics and other variables of interest. Urine and blood samples were taken, and biomarkers of exposure (dialkylphosphates), susceptibility (PON1 polymorphisms and activity) and effect (thyroid hormone levels) were determined. Interaction between dialkylphosphates and PON1 polymorphisms or PON1 activity on hormone levels was evaluated by generalized estimating equation (GEE) models. A significant interaction was found between serum diazoxonase activity and total dialkylphosphates (ΣDAP) on TSH levels. Thus, when PON1 activity was increased we observed a decrease in the percentage of variation of TSH level for each increment in one logarithmic unit of the ΣDAP levels. This interaction was also observed with the PON1(192)RR genotype. These results suggest a stronger association between organophosphate pesticides and thyroid function in individuals with lower PON1 activity. https://greenmedinfo.com/article/organophosphate-pesticide-exposure-may-adversely-effect-thyroid#comments Hypothyroidism Inappropriate TSH Secretion Syndrome Thyroid Diseases Endocrine Disruptor Organophosphates Pesticides Human Study Mon, 04 Oct 2010 01:01:15 +0000 greenmedinfo 57388 at https://greenmedinfo.com Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women. https://greenmedinfo.com/article/progesterone-prevents-sleep-disturbances-and-modulates-gh-tsh-and-melatonin-se PMID:  J Clin Endocrinol Metab. 2011 Feb 2. Epub 2011 Feb 2. PMID: 21289261 Abstract Title:  Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women. Abstract:  Context: A number of neuroactive progesterone metabolites produce sedative-like effects. However, the effects of progesterone administration on sleep are not well characterized. Objective: To investigate the effects of a 3-wk progesterone administration on sleep architecture and multiple hormonal profiles. Subjects: Eight healthy postmenopausal women, 48-74 yr old, without sleep complaints or vasomotor symptoms. None was on hormone replacement therapy. They did not take any medication for≥2 months. Design: Randomized, double-blind, placebo-controlled study. For 3 wk, subjects took daily at 2300 h a capsule of either 300 mg of progesterone or placebo. Sleep was polygraphically recorded during the last two nights, and blood samples were obtained at 15-min intervals for 24 h. Results: During the first night (no blood sampling), sleep was similar in both conditions. Under placebo, blood sampling procedure was associated with marked sleep disturbances, which were considerably reduced under progesterone treatment: mean duration of wake after sleep onset was 53% lower, slow-wave sleep duration almost 50% higher, and total slow-wave activity (reflecting duration and intensity of deep sleep) almost 45% higher under progesterone than under placebo (P ≤ 0.05). Nocturnal GH secretion was increased, and evening and nocturnal TSH levels were decreased under progesterone (P ≤ 0.05). Conclusions: Progesterone had no effect on undisturbed sleep but restored normal sleep when sleep was disturbed (while currently available hypnotics tend to inhibit deep sleep), acting as a "physiologic" regulator rather than as a hypnotic drug. Use of progesterone might provide novel therapeutic strategies for the treatment of sleep disturbances, in particular in aging where sleep is fragmented and of lower quality. https://greenmedinfo.com/article/progesterone-prevents-sleep-disturbances-and-modulates-gh-tsh-and-melatonin-se#comments Human Growth Hormone: Enhancement Inappropriate Growth Hormone Secretion Syndrome Inappropriate TSH Secretion Syndrome Low Human Growth Hormone Postmenopausal Disorders Progesterone TSH: Elevated Secretagogue Human Study Tue, 08 Feb 2011 22:44:16 +0000 greenmedinfo 60896 at https://greenmedinfo.com