Infertility https://greenmedinfo.com/category/disease/infertility en Maternal Bisphenol S exposure affects the reproductive capacity of F1 and F2 offspring in mice. https://greenmedinfo.com/article/maternal-bisphenol-s-exposure-affects-reproductive-capacity-f1-and-f2-offsprin PMID:  Environ Pollut. 2020 Aug 16 ;267:115382. Epub 2020 Aug 16. PMID: 32866863 Abstract Title:  Maternal Bisphenol S exposure affects the reproductive capacity of F1 and F2 offspring in mice. Abstract:  Bisphenol S (BPS) is an endocrine disruptor which is widely used in commercial plastic products. Previous studies have shown that exposure to BPS has toxic effects on various aspects of mammalian, but there are few reports about reproductive toxicity. In order to investigate the effects of maternal BPS exposure on the reproductive of F1 and F2 female mice, the pregnant mice were orally administered with different dosages of BPS only once every day from 12.5 to 15.5 days post-coitus (dpc). The results showed that maternal BPS exposure to 2 μg per kg of body weight per day (2 μg/kg) and 10 μg/kg accelerated the meiotic prophase I (MPI) of F1 female mice and the expression of the genes related to meiotic were increased. Further studies showed that maternal BPS exposure resulted in a significant increase in the percentage of oocytes enclosed in primordial follicles in the 3 days post-partum (3 dpp) ovaries of F1 female mice. And at the time of 21 days post-partum (21 dpp) in F1 female mice, the number of antral follicles were significantly lower compare to controls. In the study of five-week female mice of F1, we found thatBPS disturbed the folliculogenesis, and the maturation rates and fertilization rates of oocytes were significantly decreased. Of note, maternal BPS exposure disrupted H3K4 and H3K9 tri-methylation levels in F1 ovaries. Maternal BPS exposure only affected the cyst breakdown in F2 female mice. Taken together, our results suggest that, maternal BPS exposure impaired the process of meiosis and oogenesis of F1 and F2 offspring, resulting in abnormal follicular development and serious damage to the reproduction. <p><a href="https://greenmedinfo.com/article/maternal-bisphenol-s-exposure-affects-reproductive-capacity-f1-and-f2-offsprin" target="_blank">read more</a></p> https://greenmedinfo.com/article/maternal-bisphenol-s-exposure-affects-reproductive-capacity-f1-and-f2-offsprin#comments Bisphenol Toxicity Infertility Prenatal Chemical Exposures Bisphenol S Risk Factors Animal Study Sat, 12 Sep 2020 22:58:00 +0000 greenmedinfo 226830 at https://greenmedinfo.com "Ingestion of Solanum species containing toxic amounts of glycoalkaloids may have negative effects on pre-implantation embryonic survival." https://greenmedinfo.com/article/ingestion-solanum-species-containing-toxic-amounts-glycoalkaloids-may-have-neg PMID:  Anim Reprod Sci. 2005 Feb ;85(3-4):243-50. PMID: 15581508 Abstract Title:  Effects of steroidal glycoalkaloids from potatoes (Solanum tuberosum) on in vitro bovine embryo development. Abstract:  alpha-Solanine and alpha-chaconine are two naturally occurring steroidal glycoalkaloids in potatoes (Solanum tuberosum), and solanidine-N-oxide is a corresponding steroidal aglycone. The objective of this research was to screen potential cyto-toxicity of these potato glycoalkaloids using bovine oocyte maturation, in vitro fertilization techniques and subsequent embryonic development as the in vitro model. A randomized complete block design with four in vitro oocyte maturation (IVM) treatments (Experiment 1) and four in vitro embryo culture (IVC) treatments (Experiment 2) was used. In Experiment 1, bovine oocytes (n=2506) were matured in vitro in medium supplemented with 6 microM of alpha-solanine, alpha-chaconine, solanidine-N-oxide or IVM medium only. The in vitro matured oocytes were then subject to routine IVF and IVC procedures. Results indicated that exposure of bovine oocytes to the steroidal glycoalkaloids during in vitro maturation inhibited subsequent pre-implantation embryo development. Potency of the embryo-toxicity varied between these steroidal glycoalkaloids. In Experiment 2, IVM/IVF derived bovine embryos (n=2370) were cultured in vitro in medium supplemented with 6 microM of alpha-solanine, alpha-chaconine, solanidine-N-oxide or IVC medium only. The results showed that the pre-implantation embryo development is inhibited by exposure to these glycoalkaloids. This effect is significant during the later pre-implantation embryo development period as indicated by fewer numbers of expanded and hatched blastocysts produced in the media containing these alkaloids. Therefore, we conclude that in vitro exposure of oocytes and fertilized ova to the steroidal glycoalkaloids from potatoes inhibits pre-implantation embryo development. Furthermore, we suggest that ingestion of Solanum species containing toxic amounts of glycoalkaloids may have negative effects on pre-implantation embryonic survival. https://greenmedinfo.com/article/ingestion-solanum-species-containing-toxic-amounts-glycoalkaloids-may-have-neg#comments Infertility Infertility: Female Miscarriage Potato Chaconine Glycoalkaloids: Solanaceae Solanine Solanum Species In Vitro Study Tue, 06 Mar 2012 12:36:25 +0000 greenmedinfo 73263 at https://greenmedinfo.com 'Self-Spreading' Vaccines Pose Multiple Risks to Society - Including the End of Informed Consent https://greenmedinfo.com/blog/self-spreading-vaccines-pose-multiple-risks-society-including-end-informed-consen <p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/images/Self-Spreading_Vaccines_Pose_Multiple_Risks_to_Society-GreenMedInfo.jpg" style="width: 600px; height: 314px;" /><br /> <span style="font-size:12px;"><strong>Originally published on <a href="https://childrenshealthdefense.org/defender/self-spreading-vaccines-risks-to-society-informed-consent/" rel="dofollow" target="_blank">www.childrenshealthdefense.org</a></strong></span></p> <p class="rtecenter">&nbsp;</p> <p><span style="font-size:18px;"><em><strong><span style="letter-spacing: 0px;">Proponents argue self-disseminating vaccines could mean they no longer have to run complex mass vaccination programs. Critics say the vaccines pose many health risks and would also spell the end of informed consent</span></strong></em></span></p> <p>&nbsp;</p> <p>&nbsp;</p><p><a href="https://greenmedinfo.com/blog/self-spreading-vaccines-pose-multiple-risks-society-including-end-informed-consen" target="_blank">read more</a></p> https://greenmedinfo.com/blog/self-spreading-vaccines-pose-multiple-risks-society-including-end-informed-consen#comments Coronavirus Disease Coronavirus Infection Infertility Vaccination: All Chemical and Drug Toxicity Health Guide: Chemical Exposures Health Guide: Corruption in Science Health Guide: Viruses corruption in science mass vaccination viral infections Wed, 02 Jun 2021 23:58:06 +0000 Children's Health Defense 240555 at https://greenmedinfo.com 10 GHz electromagnetic field radiation induces development delay and may affect fertility is Drosophilia melanogaster. https://greenmedinfo.com/article/10-ghz-electromagnetic-field-radiation-induces-development-delay-and-may-affec PMID:  Int J Radiat Biol. 2006 Jun ;82(6):435-41. PMID: 16846978 Abstract Title:  The effects of microwave frequency electromagnetic fields on the development of Drosophila melanogaster. Abstract:  PURPOSE: To investigate the effects of microwave frequency electromagnetic fields (EMF) on the development of Drosophila melanogaster.MATERIALS AND METHODS: Larvae of D. melanogaster were exposed to 10 GHz EMF continuously (3 h, 4 h and 5 h) and discontinuously (3 h exposure + 30 min interval + 3 h exposure). The percentages and times of transition from larvae to pupae and from pupae to adults were determined, and the mean offspring number was examined using the offspring of the females which had been exposed as larvae.RESULTS: No differences were found in the transition percentages from larvae to pupae and from pupae to adults (p&gt;0.05). However, it was found that the mean pupation time was delayed linearly with an increasing electromagnetic field (EMF) exposure period (p<p><a href="https://greenmedinfo.com/article/10-ghz-electromagnetic-field-radiation-induces-development-delay-and-may-affec" target="_blank">read more</a></p> https://greenmedinfo.com/article/10-ghz-electromagnetic-field-radiation-induces-development-delay-and-may-affec#comments Infant Neurological Development Infertility Radiation Induced Illness 5G Millimeter Wave Radiation Electromagnetic Field Harms Electromagnetic Radiation Electromagnetic Radiation: 6-24 GHz (5G) Neurotoxic Radio Frequency Electromagnetic Radiation Exposure Animal Study Mon, 30 Sep 2019 23:03:12 +0000 greenmedinfo 197664 at https://greenmedinfo.com 1800 MHz increases oxidative stress and apoptosis in mouse-derived sperm cells, but N-acetyl cysteine and autophagy prevented EMF-associated cell death. https://greenmedinfo.com/article/1800-mhz-increases-oxidative-stress-and-apoptosis-mouse-derived-sperm-cells-n- PMID:  Toxicol Lett. 2014 Aug 4 ;228(3):216-24. Epub 2014 May 9. PMID: 24813634 Abstract Title:  The protective effect of autophagy on mouse spermatocyte derived cells exposure to 1800MHz radiofrequency electromagnetic radiation. Abstract:  The increasing exposure to radiofrequency (RF) radiation emitted from mobile phone use has raised public concern regarding the biological effects of RF exposure on the male reproductive system. Autophagy contributes to maintaining intracellular homeostasis under environmental stress. To clarify whether RF exposure could induce autophagy in the spermatocyte, mouse spermatocyte-derived cells (GC-2) were exposed to 1800MHz Global System for Mobile Communication (GSM) signals in GSM-Talk mode at specific absorption rate (SAR) values of 1w/kg, 2w/kg or 4w/kg for 24h, respectively. The results indicated that the expression of LC3-II increased in a dose- and time-dependent manner with RF exposure, and showed a significant change at the SAR value of 4w/kg. The autophagosome formation and the occurrence of autophagy were further confirmed by GFP-LC3 transient transfection assay and transmission electron microscopy (TEM) analysis. Furthermore, the conversion of LC3-I to LC3-II was enhanced by co-treatment with Chloroquine (CQ), indicating autophagic flux could be enhanced by RF exposure. Intracellular ROS levels significantly increased in a dose- and time-dependent manner after cells were exposed to RF. Pretreatment with anti-oxidative NAC obviously decreased the conversion of LC3-I to LC3-II and attenuated the degradation of p62 induced by RF exposure. Meanwhile, phosphorylated extracellular-signal-regulated kinase (ERK) significantly increased after RF exposure at the SAR value of 2w/kg and 4w/kg. Moreover, we observed that RF exposure did not increase the percentage of apoptotic cells, but inhibition of autophagy could increase the percentage of apoptotic cells. These findings suggested that autophagy flux could be enhanced by 1800MHz GSM exposure (4w/kg), which is mediated by ROS generation. Autophagy may play an important role in preventing cells from apoptotic cell death under RF exposure stress. <p><a href="https://greenmedinfo.com/article/1800-mhz-increases-oxidative-stress-and-apoptosis-mouse-derived-sperm-cells-n-" target="_blank">read more</a></p> https://greenmedinfo.com/article/1800-mhz-increases-oxidative-stress-and-apoptosis-mouse-derived-sperm-cells-n-#comments Infertility Infertility: Male NAC (N-acetyl-L-cysteine) Oxidative Stress Radiation Induced Illness Sperm Count: Low Sperm Quality: Low Antioxidant Apoptotic Cell Phone Exposure Electromagnetic Field Harms Electromagnetic Radiation Electromagnetic Radiation: 1.8 GHz Microwave Radiation Mobile Phone Radiation Oxidant Autophagy Autophagy Up-regulation Cell Phones electromagnetic fields electromagnetic frequencies electromagnetic radiation EMF infertility male infertility Male Infertility and Cellular Phones Radio Frequency Electromagnetic Radiation Exposure In Vitro Study Fri, 02 Aug 2019 20:17:48 +0000 greenmedinfo 192634 at https://greenmedinfo.com 6 Health Benefits of Pomegranate https://greenmedinfo.com/blog/6-health-benefits-pomegranate <p class="rtecenter"><img alt="6 Health Benefits of Pomegranate" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/lrossi/images/pomegranate_health_benefits_greenmedinfo.jpg" style="width: 600px; height: 480px;" title="6 Health Benefits of Pomegranate" /></p> <p class="rtecenter"><strong><span style="font-size:12px;">Originally published on <a href="https://deannaminich.com/6-health-benefits-of-pomegranate/" target="_blank">deannaminich.com</a></span></strong></p> <p><strong style="letter-spacing: 0px;"><em><span style="font-size:18px;">These delicious seeds may be tiny, but they boast BIG therapeutic qualities over a wide range of conditions</span></em></strong></p><p><a href="https://greenmedinfo.com/blog/6-health-benefits-pomegranate" target="_blank">read more</a></p> https://greenmedinfo.com/blog/6-health-benefits-pomegranate#comments Atherosclerosis Blood Pressure: High Cholesterol: High Diabetes Infertility Oxidative Stress Pomegranate Pomegranate Seed Health Guides: Healing Foods 6 Health Benefits of Pomegranate Atherosclerosis Diabetes exercise performance high blood pressure infertility Juice seed Sat, 08 Apr 2017 15:05:07 +0000 deannaminich 146077 at https://greenmedinfo.com A review and update of human exposure and toxicity of pesticides. https://greenmedinfo.com/article/review-and-update-human-exposure-and-toxicity-pesticides PMID:  Arch Toxicol. 2017 Feb ;91(2):549-599. Epub 2016 Oct 8. PMID: 27722929 Abstract Title:  Pesticides: an update of human exposure and toxicity. Abstract:  Pesticides are a family of compounds which have brought many benefits to mankind in the agricultural, industrial, and health areas, but their toxicities in both humans and animals have always been a concern. Regardless of acute poisonings which are common for some classes of pesticides like organophosphoruses, the association of chronic and sub-lethal exposure to pesticides with a prevalence of some persistent diseases is going to be a phenomenon to which global attention has been attracted. In this review, incidence of various malignant, neurodegenerative, respiratory, reproductive, developmental, and metabolic diseases in relation to different routes of human exposure to pesticides such as occupational, environmental, residential, parental, maternal, and paternal has been systematically criticized in different categories of pesticide toxicities like carcinogenicity, neurotoxicity, pulmonotoxicity, reproductive toxicity, developmental toxicity, and metabolic toxicity. A huge body of evidence exists on the possible role of pesticide exposures in the elevated incidence of human diseases such as cancers, Alzheimer, Parkinson, amyotrophic lateral sclerosis, asthma, bronchitis, infertility, birth defects, attention deficit hyperactivity disorder, autism, diabetes, and obesity. Most of the disorders are induced by insecticides and herbicides most notably organophosphorus, organochlorines, phenoxyacetic acids, and triazine compounds. <p><a href="https://greenmedinfo.com/article/review-and-update-human-exposure-and-toxicity-pesticides" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-and-update-human-exposure-and-toxicity-pesticides#comments Alzheimer's Disease Amyotrophic lateral sclerosis (ALS) Asthma Attention Deficit Hyperactivity Disorder Autism Birth Defects Bronchitis Infertility Obesity Parkinson's Disease Pesticide Toxicity Neurotoxic Pesticides Risk Factors Review Mon, 08 May 2017 19:07:33 +0000 greenmedinfo 147413 at https://greenmedinfo.com A review of microplastic pollution as threat to marine ecosystem and human health. https://greenmedinfo.com/article/review-microplastic-pollution-threat-marine-ecosystem-and-human-health PMID:  Environ Sci Pollut Res Int. 2017 Sep ;24(27):21530-21547. Epub 2017 Aug 16. PMID: 28815367 Abstract Title:  Microplastic pollution, a threat to marine ecosystem and human health: a short review. Abstract:  Human populations are using oceans as their household dustbins, and microplastic is one of the components which are not only polluting shorelines but also freshwater bodies globally. Microplastics are generally referred to particles with a size lower than 5 mm. These microplastics are tiny plastic granules and used as scrubbers in cosmetics, hand cleansers, air-blasting. These contaminants are omnipresent within almost all marine environments at present. The durability of plastics makes it highly resistant to degradation and through indiscriminate disposal they enter in the aquatic environment. Today, it is an issue of increasing scientific concern because these microparticles due to their small size are easily accessible to a wide range of aquatic organisms and ultimately transferred along food web. The chronic biological effects in marine organisms results due to accumulation of microplastics in their cells and tissues. The potential hazardous effects on humans by alternate ingestion of microparticles can cause alteration in chromosomes which lead to infertility, obesity, and cancer. Because of the recent threat of microplastics to marine biota as well as on human health, it is important to control excessive use of plastic additives and to introduce certain legislations and policies to regulate the sources of plastic litter. By setup various plastic recycling process or promoting plastic awareness programmes through different social and information media, we will be able to clean our sea dustbin in future. <p><a href="https://greenmedinfo.com/article/review-microplastic-pollution-threat-marine-ecosystem-and-human-health" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-microplastic-pollution-threat-marine-ecosystem-and-human-health#comments Cancers: All DNA damage Infertility Microplastic Review Thu, 22 Mar 2018 16:33:35 +0000 greenmedinfo 161540 at https://greenmedinfo.com A systematic review of Mancozeb as a reproductive and developmental hazard. https://greenmedinfo.com/article/systematic-review-mancozeb-reproductive-and-developmental-hazard PMID:  Environ Int. 2017 Feb ;99:29-42. Epub 2016 Nov 23. PMID: 27887783 Abstract Title:  A systematic review of Mancozeb as a reproductive and developmental hazard. Abstract:  BACKGROUND: The potential adverse reproductive and developmental effects of Mancozeb, especially in sensitive subpopulations, have not been fully reviewed for this widely used fungicide.OBJECTIVE: To review the experimental and epidemiologic evidence for the association between exposure to Mancozeb and reproductive and developmental health outcomes using an adaptation of the National Toxicology Program&#039;s Office of Health Assessment and Translation (OHAT) systematic review framework.DATA SOURCES: Four databases (PubMed, TOXNET, Web of Science, Google Scholar) were searched for published studies on Mancozeb. Of 403 identified articles, 30 met our inclusion criteria for systematic review.RESULTS: Results from in vitro studies provide evidence that Mancozeb may indirectly disrupt or impair reproduction at the cellular level and should be regarded as a reproductive toxicant. Animal studies confirm reproductive and developmental toxicity in mammals and suggest that males chronically exposed to Mancozeb experience significant changes in physiological, biochemical, and pathological processes that may lead to infertility. Epidemiological studies were limited to indirect methods of exposure assessment and examined the effect of fungicides more broadly during pre-conception, pregnancy, and birth, yielding mixed results.CONCLUSIONS: High confidence ratings from in vitro and animal studies, in combination with moderate confidence ratings from epidemiologic studies employing indirect methods of exposure assessment, provide evidence that Mancozeb should be regarded as a suspected developmental hazard and a presumed reproductive hazard in humans. More population-based studies linking direct measures and/or biomarkers of exposure to adverse effects on male and female fertility, as well as in utero and early life development, are needed to improve the quality of the evidence base concerning the human reproductive and developmental consequences of Mancozeb exposure. <p><a href="https://greenmedinfo.com/article/systematic-review-mancozeb-reproductive-and-developmental-hazard" target="_blank">read more</a></p> https://greenmedinfo.com/article/systematic-review-mancozeb-reproductive-and-developmental-hazard#comments Infertility Pesticides Review Wed, 16 Aug 2017 20:10:27 +0000 greenmedinfo 151753 at https://greenmedinfo.com Adverse effects of microplastics and nanoplastics on the reproductive system. https://greenmedinfo.com/article/adverse-effects-microplastics-and-nanoplastics-reproductive-system PMID:  Sci Total Environ. 2023 Dec 10 ;903:166258. Epub 2023 Aug 12. PMID: 37579804 Abstract Title:  Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions. Abstract:  In recent years, microplastics (MPs) and nanoplastics (NPs) have caused ubiquitous environmental pollution and raised widespread concern about their potential toxicity to human health, especially in the reproductive system. Moreover, infertility affects&gt;15 % of couples worldwide, and the birth rate is decreasing. Environmental factors are some of the most important causes of infertility. However, little is known about the effects of MPs and NPs on the testes and ovaries. These particles can enter the body primarily via ingestion, inhalation, and skin contact, target the reproductive system in a size-dependent manner and disturb germ cell and other somatic cell development. Our study systematically reviewed the adverse effects of plastic particles on reproductive function and offers valuable insights into the different stages of germ cells and the potential mechanisms. Moreover, the synergistic reproductive toxicity of these particles and carried contaminants was summarized. Given the limited research scale, a shift toward innovative technologies and the adoption of multiple omics are recommended for advancing related studies. Further study is needed to explore the reproductive toxicity of MPs and NPs based on their size, polymer type, shape, and carried toxins, establish effective protective measures, and develop precision medicine for targeted reproductive damage. <p><a href="https://greenmedinfo.com/article/adverse-effects-microplastics-and-nanoplastics-reproductive-system" target="_blank">read more</a></p> https://greenmedinfo.com/article/adverse-effects-microplastics-and-nanoplastics-reproductive-system#comments Infertility Microplastic Toxicity Review Mon, 01 Jan 2024 22:10:40 +0000 greenmedinfo 285714 at https://greenmedinfo.com Adverse effects were observed as a result of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. https://greenmedinfo.com/article/adverse-effects-were-observed-result-feeding-solanidine-solasodine-and-tomatid PMID:  Food Chem Toxicol. 2003 Jan ;41(1):61-71. PMID: 12453729 Abstract Title:  Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. Abstract:  The aglycone forms of three steroidal glycoalkaloids-solanidine (derived by hydrolytic removal of the carbohydrate side chain from the potato glycoalkaloids alpha-chaconine and alpha-solanine), solasodine (derived from solasonine in eggplants) and tomatidine (derived from alpha-tomatine in tomatoes)-were evaluated for their effects on liver weight increase (hepatomegaly) in non-pregnant and pregnant mice and on fecundity in pregnant mice fed for 14 days on a diet containing 2.4 mmol/kg of aglycone. In non-pregnant mice, observed ratios of % liver weights to body weights (%LW/BWs) were significantly greater than those of the control values as follows (all values in % vs matched controls+/-S.D.): solanidine, 25.5+/-13.2; solasodine 16.8+/-12.0; and tomatidine, 6.0+/-7.1. The corresponding increases in pregnant mice were: solanidine, 5.3+/-10.7; solasodine, 33.1+/-15.1; tomatidine, 8.4+/-9.1. For pregnant mice (a) body weight gains were less with the algycones than with controls: solanidine, -36.1+/-14.5; solasodine, -17.9+/-14.3; tomatidine, -11.9+/-18.1; (b) litter weights were less than controls: solanidine, -27.0+/-17.1; solasodine, -15.5+/-16.8; tomatidine, no difference; (c) the %LTW/BW ratio was less than that of the controls and was significant only for solasodine, -8.7+/-13.7; and (d) the average weight of the fetuses was less than the controls: solanidine, -11.2+/-15.2; solasodine, -11.4+/-9.4; tomatidine, no difference. Abortion of fetuses occurred in five of 24 pregnant mice on the solanidine and none on the other diets. To obtain evidence for possible mechanisms of the observed in vivo effects, the four glycoalkaloids (alpha-chaconine, alpha-solanine, solasonine and alpha-tomatine) mentioned above and the aglycones solanidine and tomatidine were also evaluated in in vitro assays for estrogenic activity. Only solanidine at 10 microM concentration exhibited an increase in the MCF-7 human breast cancer cell proliferation assay. Generally, the biological effects of solanidine differ from those of the parent potato glycoalkaloids. Possible mechanisms of these effects and the implication of the results for food safety and plant physiology are discussed. https://greenmedinfo.com/article/adverse-effects-were-observed-result-feeding-solanidine-solasodine-and-tomatid#comments Birth Defects Eggplant Hepatomegaly Infertility Miscarriage Potato Solanum Species Tomato Abortive Teratogenic Animal Study Tue, 06 Mar 2012 12:49:12 +0000 greenmedinfo 73272 at https://greenmedinfo.com Air quality has an impact on overall health as well as on the reproductive function https://greenmedinfo.com/article/air-quality-has-impact-overall-health-well-reproductive-function PMID:  Environ Health. 2017 Jul 28 ;16(1):82. Epub 2017 Jul 28. PMID: 28754128 Abstract Title:  Does air pollution play a role in infertility?: a systematic review. Abstract:  BACKGROUND: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O3 or NO2 or PM2.5 or diesel or SO2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.CONCLUSION: Both animal and human epidemiological studies support the idea that air pollutants cause defects during gametogenesis leading to a drop in reproductive capacities in exposed populations. Air quality has an impact on overall health as well as on the reproductive function, so increased awareness of environmental protection issues is needed among the general public and the authorities. <p><a href="https://greenmedinfo.com/article/air-quality-has-impact-overall-health-well-reproductive-function" target="_blank">read more</a></p> https://greenmedinfo.com/article/air-quality-has-impact-overall-health-well-reproductive-function#comments Air Pollution Linked Toxicity Infertility Review Wed, 11 Oct 2017 21:39:51 +0000 greenmedinfo 154304 at https://greenmedinfo.com Antioxidant coenzyme Q10 restores fertility by rescuing bisphenol A-induced oxidative DNA damage. https://greenmedinfo.com/article/antioxidant-coenzyme-q10-restores-fertility-rescuing-bisphenol-induced-oxidati PMID:  Genetics. 2019 Dec 18. Epub 2019 Dec 18. PMID: 31852725 Abstract Title:  Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in theGermline. Abstract:  Endocrine-disrupting chemicals are ubiquitously present in our environment, but the mechanisms by which they adversely affect human reproductive health and strategies to circumvent their effects remain largely unknown. Here we show in, that supplementation with the antioxidant Coenzyme Q10 (CoQ10) rescues the reprotoxicity induced by the widely used plasticizer and endocrine disruptor bisphenol A (BPA) in part by neutralizing DNA damage resulting from oxidative stress. CoQ10 significantly reduces BPA-induced elevated levels of germ cell apoptosis, phosphorylated checkpoint kinase 1 (CHK-1), double-strand breaks (DSBs) and chromosome defects in diakinesis oocytes. BPA-induced oxidative stress, mitochondrial dysfunction, and increased gene expression of antioxidant enzymes in the germline are counteracted by CoQ10. Finally, CoQ10 treatment also reduced the levels of aneuploid embryos and BPA-induced defects observed in early embryonic divisions. We propose that CoQ10 may counteract BPA-induced reprotoxicity through the scavenging of reactive oxygen species and free radicals and that this natural antioxidant could constitute a low-risk and low-cost strategy to attenuate the impact on fertility by BPA. <p><a href="https://greenmedinfo.com/article/antioxidant-coenzyme-q10-restores-fertility-rescuing-bisphenol-induced-oxidati" target="_blank">read more</a></p> https://greenmedinfo.com/article/antioxidant-coenzyme-q10-restores-fertility-rescuing-bisphenol-induced-oxidati#comments Bisphenol Toxicity Coenzyme Q10 DNA damage Infertility Antioxidants Bisphenol A Genoprotective Animal Study Fri, 20 Dec 2019 23:10:51 +0000 greenmedinfo 205675 at https://greenmedinfo.com Big Pharma’s Dirty Little Secret: Vaccine-Induced Autoimmune Injury https://greenmedinfo.com/blog/pharma-s-dirty-little-secret-do-bleeding-calves-narcolepsy-and-infertility-have-sa <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2016<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Big Pharma’s Dirty Little Secret: Do Bleeding Calves, Narcolepsy and Infertility Have the Same Mechanism for Vaccine Injury? " src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/lrossi/images/2C06399400000578-3224953-image-a-5_1441617635990.jpg" style="width: 634px; height: 423px;" /></p> <p><em>Nasal flu vaccine left&nbsp; energetic and happy 10-year-old Bobby Hunter with disease that makes him afraid to smile (photo credit: <a href="http://www.dailymail.co.uk/news/article-3224953/Schoolboy-11-left-unable-smile-laugh-without-suffering-narcolepsy-fits-given-nasal-spray-flu-vaccine-government-scheme.html">Daily Express</a>)</em></p> <p><em style="font-size: 18px;"><strong>Scientists reveal how a&nbsp;hyperactivated&nbsp;immune system can unleash disease</strong></em></p><p><a href="https://greenmedinfo.com/blog/pharma-s-dirty-little-secret-do-bleeding-calves-narcolepsy-and-infertility-have-sa" target="_blank">read more</a></p> https://greenmedinfo.com/blog/pharma-s-dirty-little-secret-do-bleeding-calves-narcolepsy-and-infertility-have-sa#comments Epilepsy Infertility Narcolepsy Vaccination: All Vaccine Adjuvants Vaccine Effects Vaccine Information Center Big Pharma’s Dirty Little Secret: Do Bleeding Calves epilepsy narcolepsy Narcolepsy and Infertility Have the Same Mechanism for Vaccine Injury? Vaccine Tue, 17 May 2016 13:45:32 +0000 celestewriter 127531 at https://greenmedinfo.com Bisphenol A induces oxidative stress in bone marrow cells, lymphocytes, and reproductive organs. https://greenmedinfo.com/article/bisphenol-induces-oxidative-stress-bone-marrow-cells-lymphocytes-and-reproduct PMID:  Int J Toxicol. 2017 Mar/Apr;36(2):142-152. Epub 2017 Mar 21. PMID: 28403740 Abstract Title:  Bisphenol A Induces Oxidative Stress in Bone Marrow Cells, Lymphocytes, and Reproductive Organs of Holtzman Rats. Abstract:  Bisphenol A (BPA) is an estrogenic chemical used in the production of polycarbonate plastics and epoxy resins. Our earlier studies have demonstrated that BPA is a potent reproductive and genotoxic agent and affects the normal physiological functions. The objective of this study was to evaluate whether exposure to BPA induces oxidative stress. The male Holtzman rats were orally gavaged with BPA (0.01 mg and 5.0 mg/kg/bw) over the period of 6 days. Animals were euthanized by cervical dislocation at the end of the treatments; bone marrow cells and blood lymphocytes were aspirated; testis and epididymis were collected, immediately frozen in liquid nitrogen, and stored at -80°C. These samples were utilized for the determination of lipid peroxidation and various antioxidant enzymes such as superoxide dismutase, catalase, and nonenzymatic reduced glutathione. The results demonstrated that BPA caused an increase in lipid peroxidation and a decrease in activity of variousenzymatic and nonenzymatic antioxidants in bone marrow cells, blood lymphocytes, and testicular and epididymal tissues. The findings of the current study suggest that BPA exposure induced oxidative stress, which could be one of the possible mechanisms causing reproductive and genetic toxicity. <p><a href="https://greenmedinfo.com/article/bisphenol-induces-oxidative-stress-bone-marrow-cells-lymphocytes-and-reproduct" target="_blank">read more</a></p> https://greenmedinfo.com/article/bisphenol-induces-oxidative-stress-bone-marrow-cells-lymphocytes-and-reproduct#comments Bisphenol Toxicity Infertility Oxidative Stress Bisphenol A Animal Study Thu, 04 May 2017 19:38:59 +0000 greenmedinfo 147234 at https://greenmedinfo.com