Inflammation https://greenmedinfo.com/category/disease/inflammation en A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates. https://greenmedinfo.com/article/pervasive-scientific-overview-mangiferin-prevention-and-treatment-various-dise PMID:  J Complement Integr Med. 2020 May 19. Epub 2020 May 19. PMID: 32427121 Abstract Title:  A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates. Abstract:  Natural products are increasing used in preventing and treating various diseases. Mangiferin belongs to the xanthone family, and has potential antiangiogenic, anticancer, immunomodulatory and anti-inflammatory activity along with the antioxidant activity. It is also used in the treatment of cardiac problem, diabetes and neurodegenerative disease. Finding of various researchers proves that mangiferin has a broad spectrum therapeutic application. Motive of this review is to describe the various studies performed on mangiferin for its different pharmacological activities. It also discusses various challenges associated with mangiferin such as stability and bioavailability. Strategies and approaches to improve bioavailability of mangiferin have also been discussed. Both research and review articles were used to write the manuscript. They were collected from various search engines like Pub Med, Science Direct and Google Scholar, using keywords like mangiferin, polyphenol, bioavailability enhancement, solubility enhancement, and antioxidant. Mangiferin being a potent antioxidant is effective in the treatment of various diseases. With novel drug delivery approaches we can overcome poor solubility and bioavailability problem which eventually can result to better utilisation of mangiferin in treating a variety of diseases and make mangiferin a revolutionary drug. <p><a href="https://greenmedinfo.com/article/pervasive-scientific-overview-mangiferin-prevention-and-treatment-various-dise" target="_blank">read more</a></p> https://greenmedinfo.com/article/pervasive-scientific-overview-mangiferin-prevention-and-treatment-various-dise#comments Inflammation Mangiferin Oxidative Stress Anti-Inflammatory Agents Antioxidants Immunomodulatory Review Mon, 27 Jul 2020 19:17:03 +0000 greenmedinfo 224318 at https://greenmedinfo.com A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects. https://greenmedinfo.com/article/review-pharmacokinetics-paeoniflorin-and-its-anti-inflammatory-and-immunomodul PMID:  Biomed Pharmacother. 2020 Jul 15 ;130:110505. Epub 2020 Jul 15. PMID: 32682112 Abstract Title:  A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects. Abstract:  Increasing pharmacological evidence supports that paeoniflorin, a water-soluble monoterpene glycoside isolated from Paeonia lactiflora Pall. (Shaoyao in Chinese), has a wide range of medicinal properties including anti-inflammatory, antioxidant, antithrombotic, anticonvulsive, analgesic, cardioprotective, neuroprotective, hepatoprotective, antidepressant-like, antitumoral, and immune-regulatory activities; as well as enhancing cognition and attenuating learning impairment. In addition to pharmacodynamic studies, information on pharmacokinetics is also significant for the further development and utilization of paeoniflorin. The present review focuses on the absorption, distribution, metabolism, and excretion of paeoniflorin, especially main pharmacological activities of paeoniflorin on inflammation and immune function. According to the findings obtained both in vitro and in vivo, a broad application prospect has been opened for paeoniflorin. However, further studies are needed to clarity the direct molecular mechanisms and key targets underlying the beneficial effects of paeoniflorin on inflammation and immunity. <p><a href="https://greenmedinfo.com/article/review-pharmacokinetics-paeoniflorin-and-its-anti-inflammatory-and-immunomodul" target="_blank">read more</a></p> https://greenmedinfo.com/article/review-pharmacokinetics-paeoniflorin-and-its-anti-inflammatory-and-immunomodul#comments Inflammation Paeoniflorin Anti-Inflammatory Agents Immunomodulatory Review Sun, 16 Aug 2020 23:25:48 +0000 greenmedinfo 225388 at https://greenmedinfo.com Allicin reduces inflammation by regulating ROS/NLRP3 and autophagy in the context of A. fumigatus infection in mice. https://greenmedinfo.com/article/allicin-reduces-inflammation-regulating-rosnlrp3-and-autophagy-context-fumigat PMID:  Gene. 2020 Aug 8 ;762:145042. Epub 2020 Aug 8. PMID: 32777529 Abstract Title:  Allicin reduces inflammation by regulating ROS/NLRP3 and autophagy in the context of A. fumigatus infection in mice. Abstract:  OBJECTIVES: Inhibitory effect of allicin with broad-spectrum antimicrobial activity on A. fumigatus and the regulation mechanism of inflammation and autophagy in vitro and in vivo.METHODS: The corresponding concentration of allicin was prepared according to the needs of the experiment. In vitro, 2 ml 5 × 10of fungal spores suspension was added to the 6-well plate per hole, and different final concentrations of allicin (1 μl/ml, 2.5 μl/ml, 5 μl/ml, 10 μl/ml, 20 μl/ml, 30 μl/ml) were added. The fungal spores were stained by fluorescent dye SYTO 9 (green) every day, and the spore germination inhibition was detected by flow cytometry in different PH. RAW264.7 cells were cultured and stimulated by A. fumigatus spores for 3 h, then allicin solution was added. Then some cells were stained with ROS probe (green) and hochest33342 (blue). The effect of allicin on ROS was observed by fluorescence microscope. The other part of cells extracted protein from cell lysate and detected the effect of allicin on inflammatory factors and autophagy by Western-blotting. The green and red spots of RAW264.7 cells stably transfected with GFP-RFP-LC3 were observed by fluorescence microscopy. In vivo, A. fumigatus spore was injected intratracheally into mice, then allicin was injected intravenously at a concentrationof 5 mg/kg/day for 7 consecutive days. The survival status, pulmonary fungal load and weight of mice was recorded continuously for 30 days and detected the changes of lung by pathological examination and immunohistochemistry.RESULTS: In vitro, allicin significantly inhibited the spore germination of A. fumigatus within 24 h in a dose-dependent manner and it had a stable inhibition on the spore germination of A. fumigatus in acidic environment. Cell experiments showed that allicin inhibited intracellular spore germination by inhibiting ROS production, inflammation and autophagy. In the animal experiment, the survival rate and body weight of allicin injection group were higher than that of non injection group, while the spore load of lung was lower than that of non injection group (P <p><a href="https://greenmedinfo.com/article/allicin-reduces-inflammation-regulating-rosnlrp3-and-autophagy-context-fumigat" target="_blank">read more</a></p> https://greenmedinfo.com/article/allicin-reduces-inflammation-regulating-rosnlrp3-and-autophagy-context-fumigat#comments Allicin Aspergillosis Inflammation Anti-Inflammatory Agents Animal Study In Vitro Study Sun, 23 Aug 2020 21:12:18 +0000 greenmedinfo 225749 at https://greenmedinfo.com Anti-inflammatory effect of a flavonoid-rich extract of orange juice in adult zebrafish subjected to Vibrio anguillarum-induced enteritis. https://greenmedinfo.com/article/anti-inflammatory-effect-flavonoid-rich-extract-orange-juice-adult-zebrafish-s PMID:  Nat Prod Res. 2020 Apr 27:1-4. Epub 2020 Apr 27. PMID: 32338069 Abstract Title:  Anti-inflammatory effect of a flavonoid-rich extract of orange juice in adult zebrafish subjected to-induced enteritis. Abstract:  Inflammation-related pathologies remain a serious health problem with high costs for the community.flavonoids are known to possess important pharmacological properties, including anti-inflammatory activity. In this study we evaluated the effects of a flavonoid-rich extract of orange juice (OJe) in an experimental model of enteritis induced byin adult zebrafish (). Administration ofthrough live feed (nauplii) for three consecutive days caused evident signs of enteritis in zebrafish. Three days of treatment with OJe before the pathogenic insult resulted in a remarkable reduction of tissue inflammatory events as well as a molecular down-regulation of the inflammatory genes such as IL-1β, IL-6 and TNFα. Our data suggest that OJe counteracts the inflammation of zebrafish intestinal mucosa, indicating that the pool of flavonoids present in orange juice could be useful for the prevention of enteritis. <p><a href="https://greenmedinfo.com/article/anti-inflammatory-effect-flavonoid-rich-extract-orange-juice-adult-zebrafish-s" target="_blank">read more</a></p> https://greenmedinfo.com/article/anti-inflammatory-effect-flavonoid-rich-extract-orange-juice-adult-zebrafish-s#comments Inflammation Orange Anti-Inflammatory Agents Interleukin-1 beta downregulation Interleukin-6 Downregulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Animal Study Sat, 05 Sep 2020 00:14:47 +0000 greenmedinfo 226336 at https://greenmedinfo.com Anti-inflammatory effect of rosmarinic acid isolated from Blechnum brasiliense in adult zebrafish brain. https://greenmedinfo.com/article/anti-inflammatory-effect-rosmarinic-acid-isolated-blechnum-brasiliense-adult-z PMID:  Comp Biochem Physiol C Toxicol Pharmacol. 2020 Aug 14:108874. Epub 2020 Aug 14. PMID: 32805443 Abstract Title:  Anti-inflammatory effect of rosmarinic acid isolated from Blechnum brasiliense in adult zebrafish brain. Abstract:  Neuroinflammation has been associated to neurodegenerative disease development, with evidence suggesting that high levels of proinflammatory cytokines promote neuronal dysfunction and death. Therefore, it is necessary to study new compounds that may be used as adjuvant treatments of neurodegenerative diseases by attenuating the inflammatory response in the central nervous system (CNS). The aim of this study was to utilize the lipopolysaccharide (LPS) induction model of neuroinflammation to evaluate the modulation of inflammation by rosmarinic acid (RA) isolated from Blechnum brasiliense in adult zebrafish. First, we investigated the toxicity and antioxidant properties of fractionated B. brasiliense extract (ethyl acetate fraction- EAF) and the isolated RA in zebrafish embryos. Next, we developed a model of neuroinflammation induction by intraperitoneal (i.p.) injection of LPS to observe the RA modulation of proinflammatory cytokines. The median lethal concentration (LC) calculated was 185.2 ± 1.24 μg/mL for the ethyl acetate fraction (EAF) and 296.0 ± 1.27 μM for RA. The EAF showed free radical inhibition ranging from 23.09% to 63.44% at concentrations of 10-250 μg/mL. The RA presented a concentration-dependent response ranging from 18.24% to 47.63% at 10-250 μM.Furthermore, the RA reduced LPS induction of TNF-α and IL-1β levels, with the greatest effect observed 6 h after LPS administration. Thus, the data suggested an anti-inflammatory effect of RA isolated from B. brasiliense and reinforced the utility of the new model of neuroinflammation to test the possible neuroprotective effects of novel drugs or compounds. <p><a href="https://greenmedinfo.com/article/anti-inflammatory-effect-rosmarinic-acid-isolated-blechnum-brasiliense-adult-z" target="_blank">read more</a></p> https://greenmedinfo.com/article/anti-inflammatory-effect-rosmarinic-acid-isolated-blechnum-brasiliense-adult-z#comments Inflammation Rosemaric Acid Anti-Inflammatory Agents Animal Study Fri, 21 Aug 2020 15:34:31 +0000 greenmedinfo 225570 at https://greenmedinfo.com Anti-inflammatory effects of a period of aerobic training and vitamin D supplementation in postmenopausal women with metabolic syndrome. https://greenmedinfo.com/article/anti-inflammatory-effects-period-aerobic-training-and-vitamin-d-supplementatio PMID:  Int J Prev Med. 2022 ;13:60. Epub 2022 Apr 8. PMID: 35711279 Abstract Title:  Anti-Inflammatory Effects of a Period of Aerobic Training and Vitamin D Supplementation in Postmenopausal Women with Metabolic Syndrome. Abstract:  Background: Inflammatory markers of blood are critical predictors of chronic diseases as well as exacerbating risk factors. Exercise is a well-known strategy to reduce the risk of inflammation and chronic disease. The present study aimed to investigate the anti-inflammatory effects of a period of aerobic training and vitamin D supplementation (AT + Vit D) in postmenopausal women with metabolic syndrome.Methods: This quasi-experimental research was performed on forty-six patients with metabolic syndrome who were selected according to the available sampling method, and were randomly divided into four groups: AT + Vit D (50,000 IU), AT, Vit D (50,000 IU), and control (C). The training protocol consisted of 40-60 min of AT 60-75% of maximal heart rate, three times a week, for 8 weeks. One-way Analysis of variance (ANOVA) and-test were used to compare the between and within groups; the Bonferronitest was used if significant differences were found.Results: The combination of exercise and vitamin D significantly reduced C-reactive protein (CRP) (= 0.001), interleukin-6 (IL-6) (= 0.001), and improved the metabolic syndrome indices (= 0.001 in all indices). The results also show that the improvement in the metabolic syndrome indices, CRP, and IL-6 was more significant in AT + Vit D, compared to AT or Vit D alone.Conclusions: The findings from the present study suggested that a sedentary lifestyle and vitamin D deficiency accelerated the occurrence of metabolic syndrome probably by increasing the anti-inflammatory. Additionally, adequate levels of plasma vitamin D are necessary to achieve the beneficial metabolic effects of AT. <p><a href="https://greenmedinfo.com/article/anti-inflammatory-effects-period-aerobic-training-and-vitamin-d-supplementatio" target="_blank">read more</a></p> https://greenmedinfo.com/article/anti-inflammatory-effects-period-aerobic-training-and-vitamin-d-supplementatio#comments Inflammation Metabolic Syndrome X Vitamin D Anti-Inflammatory Agents Exercise: Aerobic Interleukin-6 Downregulation Human Study Sun, 19 Jun 2022 14:42:39 +0000 greenmedinfo 259285 at https://greenmedinfo.com Crocin: A fighter against inflammation and pain. https://greenmedinfo.com/article/crocin-fighter-against-inflammation-and-pain PMID:  Food Chem Toxicol. 2020 Jul 5 ;143:111521. Epub 2020 Jul 5. PMID: 32640351 Abstract Title:  Crocin: A fighter against inflammation and pain. Abstract:  Crocin, a water-soluble carotenoid, is known as a pharmacologically active compound, particularly for its potent anti-oxidant activity. The present work provides a comprehensive review of the available literature concerning the anti-inflammatory properties of crocin in various organs/systems as well as its anti-nociceptive effects. PubMed, Scopus, and Web of Science electronic databases were systematically searched up to 28 March 2020 to detect all relevant preclinical and human studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. In total, 104 studies were included for qualitative synthesis. This systematic search and review indicated that crocin not only combats reactive oxygen species production and suppresses pro-inflammatory cytokines secretion but also alleviates inflammation in various organs (e.g. the lung, heart, brain, and kidney), in a series of animal models and in vitro experiments, via regulating mainly NF-κB pathway and NF-κBp65 translocation to the cell nucleus. In this context, modulation of PI3K/Akt appears to be a favorable crocin target contributing to NF-κB pathway inhibition. Even though data is limited in humans with only one clinically relevant study retrieved, the results of preclinicalstudies regarding anti-inflammatory/anti-nociceptive effects of crocin are promising and warrant further testing in clinical settings. <p><a href="https://greenmedinfo.com/article/crocin-fighter-against-inflammation-and-pain" target="_blank">read more</a></p> https://greenmedinfo.com/article/crocin-fighter-against-inflammation-and-pain#comments Chronic Pain Crocin Inflammation Anti-Inflammatory Agents Antinoceceptive NF-kappaB Inhibitor Review Thu, 27 Aug 2020 21:29:18 +0000 greenmedinfo 225849 at https://greenmedinfo.com Effect of grape juice, red wine and resveratrol solution on antioxidant, anti-inflammatory, hepactic function and lipid profile in rats feds with high-fat diet. https://greenmedinfo.com/article/effect-grape-juice-red-wine-and-resveratrol-solution-antioxidant-anti-inflamma PMID:  Nat Prod Res. 2020 May 13:1-6. Epub 2020 May 13. PMID: 32400183 Abstract Title:  Effect of grape juice, red wine and resveratrol solution on antioxidant, anti-inflammatory, hepactic function and lipid profile in rats feds with high-fat diet. Abstract:  The objective was to investigate the role of consumption of grape juice (GJ), red wine (RW) or resveratrol solution (RS) on rats treated with a high-fat diet (HFD). Among the drinks offered, GJ had lower content of polyphenols and trans-resveratrol. Nevertheless, GJ showed similar content of anthocyanin and antioxidant activity to RW, although higher than RS. In rats treated with HFD, consumption of GJ presented best antioxidant and anti-inflammatory activity, reducing glutathione peroxidase and interleukin-6 serum levels. In addition, GJ promoted better levels of cholesterol and liver markers. On the other hand, RW aggravated the oxidizing effect of HFD, increasing catalase activity and interleukin-6 level. Already, RS showed no benefit in animals. Thus, GJ minimized the effects of HFD on oxidative stress and inflammation beyond promoted better levels of lipid profile and liver biomarkers. However, consumption of RS showed no benefit and RW revealed a pro-oxidant effect, as did HFD. <p><a href="https://greenmedinfo.com/article/effect-grape-juice-red-wine-and-resveratrol-solution-antioxidant-anti-inflamma" target="_blank">read more</a></p> https://greenmedinfo.com/article/effect-grape-juice-red-wine-and-resveratrol-solution-antioxidant-anti-inflamma#comments Grape Inflammation Oxidative Stress Red Wine Resveratrol Anti-Inflammatory Agents Antioxidants Hypolipidemic Animal Study Sat, 05 Sep 2020 15:05:33 +0000 greenmedinfo 226356 at https://greenmedinfo.com Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney. https://greenmedinfo.com/article/effect-oleuropein-oxidative-stress-inflammation-and-apoptosis-induced-ischemia PMID:  Life Sci. 2020 Aug 15 ;255:117833. Epub 2020 May 22. PMID: 32450167 Abstract Title:  Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney. Abstract:  AIMS: This study aimed to evaluate the effect of oleuropein (OLE), the main phenolic compound present in olive leaves, on kidney ischemia-reperfusion injury (IRI) and to explore the underlying protective mechanism.MAIN METHODS: Rat kidneys were subjected to 60 min of bilateral warm ischemia followed by 120 min of reperfusion. OLE was administered orally 48 h, 24 h and 30 min prior to ischemia at doses of 10, 50 and 100 mg/kg body weight. The creatinine, urea, uric acid concentrations and lactate dehydrogenase (LDH) activity in plasma were evaluated. Oxidative stress and inflammation parameters were also assessed. Renal expression of AMP-activated protein kinase (p-AMPK), endothelial nitric oxide synthase (eNOS), mitogen-activated protein kinases (MAPK), inflammatory proteins and apoptotic proteins were evaluated using Western blot.KEY FINDINGS: Our results showed that OLE at 50 mg/kg reduced kidney IRI as revealed by a significant decrease of plasmatic creatinine, urea, uric acid concentrations and LDH activity. In parallel, OLE up-regulated antioxidant capacities. Moreover, OLE diminished the level of CRP and the expression of cyclooxygenase 2 (COX-2). Finally, OLE enhanced AMPK phosphorylation as well as eNOS expression whereas MAPK, and cleaved caspase-3 implicated in cellular apoptosis were attenuated in the ischemic kidneys.SIGNIFICANCE: In conclusion, this study shows that OLE could be used as therapeutic agent to reduce IRI through its anti-oxidative, anti-inflammatory and anti-apoptotic properties. <p><a href="https://greenmedinfo.com/article/effect-oleuropein-oxidative-stress-inflammation-and-apoptosis-induced-ischemia" target="_blank">read more</a></p> https://greenmedinfo.com/article/effect-oleuropein-oxidative-stress-inflammation-and-apoptosis-induced-ischemia#comments Inflammation Ischemia Kidney Damage Oleuropein Oxidative Stress Anti-Apoptotic Anti-Inflammatory Agents Antioxidants Cyclooxygenase 2 Inhibitors Animal Study Wed, 05 Aug 2020 23:11:16 +0000 greenmedinfo 224772 at https://greenmedinfo.com Effects of red grape juice polyphenols in NADPH oxidase subunit expression in human neutrophils and mononuclear blood cells. https://greenmedinfo.com/article/effects-red-grape-juice-polyphenols-nadph-oxidase-subunit-expression-human-neu PMID:  Br J Nutr. 2009 Oct ;102(8):1125-35. Epub 2009 May 19. PMID: 19450372 Abstract Title:  Effects of red grape juice polyphenols in NADPH oxidase subunit expression in human neutrophils and mononuclear blood cells. Abstract:  The NADPH oxidase enzyme system is the main source of superoxide anions in phagocytic and vascular cells. NADPH oxidase-dependent superoxide generation has been found to be abnormally enhanced in several chronic diseases. Evidence is accumulating that polyphenols may have the potential to improve cardiovascular health, although the mechanism is not fully established. Consumption of concentrated red grape juice, rich in polyphenols, has been recently shown to reduce NADPH oxidase activity in circulating neutrophils from human subjects. In the present work we studied whether red grape juice polyphenols affected NADPH oxidase subunit expression at the transcription level. For this, we used human neutrophils and mononuclear cells from peripheral blood, HL-60-derived neutrophils and the endothelial cell line EA.hy926.Superoxide production was measured with 2&#039;7&#039;-dichlorofluorescein diacetate or lucigenin, mRNA expression by real-time RT-PCR and protein expression by Western blot. Each experiment was performed at least three times. In all cell types tested, red grape juice, dealcoholised red wine and pure polyphenols decreased superoxide anion production. Red grape juice and dealcoholised red wine selectively reduced p47phox, p22phox and gp91phox expression at both mRNA and protein levels, without affecting the expression of p67phox. Pure polyphenols, particularly quercetin, also reduced NADPH oxidase subunit expression, especially p47phox, in all cell types tested. The present results showing that red grape juice polyphenols reduce superoxide anion production provide an alternative mechanism by which consumption of grape derivatives may account for a reduction of oxidative stress associated with cardiovascular and/or inflammatory diseases related to NADPH oxidase superoxide overproduction. <p><a href="https://greenmedinfo.com/article/effects-red-grape-juice-polyphenols-nadph-oxidase-subunit-expression-human-neu" target="_blank">read more</a></p> https://greenmedinfo.com/article/effects-red-grape-juice-polyphenols-nadph-oxidase-subunit-expression-human-neu#comments Cardiovascular Diseases Flavonoids Grape Inflammation Polyphenols Anti-Inflammatory Agents Antioxidants Cardioprotective In Vitro Study Fri, 11 Sep 2020 21:44:22 +0000 greenmedinfo 226718 at https://greenmedinfo.com Extrapolation of hydroxytyrosol and its analogues as potential anti-inflammatory agents. https://greenmedinfo.com/article/extrapolation-hydroxytyrosol-and-its-analogues-potential-anti-inflammatory-age PMID:  J Biomol Struct Dyn. 2020 Jul 16:1-12. Epub 2020 Jul 16. PMID: 32672527 Abstract Title:  Extrapolation of hydroxytyrosol and its analogues as potential anti-inflammatory agents. Abstract:  Discovery of potential lead molecule is a challenging, and complex process which require lots of money, patience, and manpower. Human beings are using natural products, predominantly secondary metabolites, for this purpose since ancient time and they are still working on them as a potent source for drug discovery due to their wide structural diversity. Phenolic phytochemicals such as hydroxytyrosol and tyrosol are natural antioxidant and involved in many biological disease cure. Herein, we have carried out the quantum chemical calculations for conformational analysis, geometry optimization and computation of electronic as well as optical properties of hydroxytyrosol and its analogues () in terms of density functional theory by using Gaussian 09 program suite. The eventual charge transfer within the molecules has been confirmed by the analysis of frontier molecular orbitals. The molecular docking studies ofwith cyclooxygenase-2 showed the noticeable binding affinity as compared to other nonsteroidal anti-inflammatory drugs. aspirin, naproxen and celecoxib. Computation of pharmacokinetics and pharmacological properties confirmed the lead/drug like potential of these screened molecules. Furthermore, the molecular dynamics simulation of best three docked ligands (,and)-receptor complex and their binding free energy calculations reveals that these molecules bind in the catalytic cavity of cyclooxygenase-2 and found stable during the 100 ns of simulation. Communicated by Ramaswamy H. Sarma. <p><a href="https://greenmedinfo.com/article/extrapolation-hydroxytyrosol-and-its-analogues-potential-anti-inflammatory-age" target="_blank">read more</a></p> https://greenmedinfo.com/article/extrapolation-hydroxytyrosol-and-its-analogues-potential-anti-inflammatory-age#comments Hydroxytyrosol Inflammation Anti-Inflammatory Agents In Vitro Study Wed, 05 Aug 2020 21:35:32 +0000 greenmedinfo 224759 at https://greenmedinfo.com Fish Oil supplementation improves the repeated-bout effect and redox balance in 20-30-year-old men submitted to strength training. https://greenmedinfo.com/article/fish-oil-supplementation-improves-repeated-bout-effect-and-redox-balance-20-30 PMID:  Nutrients. 2023 Mar 31 ;15(7). Epub 2023 Mar 31. PMID: 37049548 Abstract Title:  Fish Oil Supplementation Improves the Repeated-Bout Effect and Redox Balance in 20-30-Year-Old Men Submitted to Strength Training. Abstract:  Herein, we investigated the effect of fish oil supplementation combined with a strength-training protocol, for 6 weeks, on muscle damage induced by a single bout of strength exercise in untrained young men. Sixteen men were divided into two groups, supplemented or not with fish oil, and they were evaluated at the pre-training period and post-training period. We investigated changes before and 0, 24, and 48 h after a single hypertrophic exercise session. Creatine kinase (CK) and lactate dehydrogenase (LDH) activities, plasma interleukin-6 (IL-6) and C-reactive protein (CRP) levels, and the redox imbalance were increased in response to the single-bout session of hypertrophic exercises at baseline (pre-training period) and decreased during the post-training period in the control group due to the repeated-bout effect (RBE). The fish oil supplementation exacerbated this reduction and improved the redox state. In summary, our findings demonstrate that, in untrained young men submitted to a strength-training protocol, fish oil supplementation is ideal for alleviating the muscle injury, inflammation, and redox imbalance induced by a single session of intense strength exercises, highlighting this supplementation as a beneficial strategy for young men that intend to engage in strength-training programs. <p><a href="https://greenmedinfo.com/article/fish-oil-supplementation-improves-repeated-bout-effect-and-redox-balance-20-30" target="_blank">read more</a></p> https://greenmedinfo.com/article/fish-oil-supplementation-improves-repeated-bout-effect-and-redox-balance-20-30#comments Fish Oil Inflammation Anti-Inflammatory Agents Antioxidants Interleukin-6 Downregulation Human Study Thu, 22 Jun 2023 21:14:09 +0000 greenmedinfo 275344 at https://greenmedinfo.com High fetal bisphenol A exposure enhances IL22 secretion: A proinflammatory cytokine. https://greenmedinfo.com/article/high-fetal-bisphenol-exposure-enhances-il22-secretion-proinflammatory-cytokine PMID:  Asian Pac J Allergy Immunol. 2021 Jan 2. Epub 2021 Jan 2. PMID: 33386784 Abstract Title:  High fetal bisphenol A exposure enhances IL22 secretion: A proinflammatory cytokine. Abstract:  BACKGROUND: Bisphenol A (BPA) is an industrial product, widely used in human consumed types of equipment that can be transmitted orally, by inhalation or through dermal absorption and is detectable in many body fluids including cord blood. A correlation between BPA concentration in maternal serum and cord blood has been demonstrated previously, suggesting a possible transfer of BPA via the transplacental path.OBJECTIVE: Our objective is to determine the impact of cord blood BPA level on cytokine responses.METHODS: In this cross-sectional study, healthy pregnant women who delivered healthy newborns followed by the Obstetrics and Gynecology Department between September 2016 to June 2017 were enrolled. Cord blood samples were obtained and BPA and IL4, IL5, IL10, IL17, IL22, IFN gama and TGF beta levels were studied by ELISA.RESULTS: Among 197 deliveries, 176 of them were included in the study. Due to lack of cut-off value, BPA levels were stratified as percentiles. No statistically significant difference was detected in comparison of cytokine levels based on BPA concentrations below and above the 25th and 50th percentiles. Significantly higher IL22 levels (p = 0.007) and increased ratio of IL22/TGFβ (p = 0.04) were detected in those with BPA level above 75th percentile (&gt;19.16 ng/ml) compared to the below group.CONCLUSIONS: This in vivo real-life study demonstrated that very high BPA levels in cord blood of expectant mothers enhances IL22 secretion in cord blood which is a proinflammatory cytokine. Studies evaluating long term immunological effects on those highly exposed newborns are necessitated. <p><a href="https://greenmedinfo.com/article/high-fetal-bisphenol-exposure-enhances-il22-secretion-proinflammatory-cytokine" target="_blank">read more</a></p> https://greenmedinfo.com/article/high-fetal-bisphenol-exposure-enhances-il22-secretion-proinflammatory-cytokine#comments Bisphenol Toxicity Fetal Origin of Adult Disease Inflammation Prenatal Chemical Exposures Bisphenol A Human Study Sun, 10 Jan 2021 03:04:58 +0000 greenmedinfo 232635 at https://greenmedinfo.com Inhibitory effects of Vitamin D on inflammation and IL-6 release. A further support for COVID-19 management? https://greenmedinfo.com/article/inhibitory-effects-vitamin-d-inflammation-and-il-6-release-further-support-cov PMID:  Eur Rev Med Pharmacol Sci. 2020 08 ;24(15):8187-8193. PMID: 32767348 Abstract Title:  Inhibitory effects of Vitamin D on inflammation and IL-6 release. A further support for COVID-19 management? Abstract:  The ongoing worldwide pandemic of Coronavirus disease 2019 (COVID-19), raised the urgency to address knowledge gaps and to establish evidence for improving management and control of this viral infection. Throughout a keen analysis of the World Health Organization (WHO) most updated data, a gender-specific difference in the occurrence of infection was determined, which seems to correlate with patient&#039;s vitamin D status. Therefore, our purpose is to provide insights into the nutritional importance of vitamin D for its immunomodulatory effect, in order to help counteracting the COVID-19 pandemic. Novel interesting findings suggest that vitamin D, by inducing progesterone-induced blocking factor (PIBF), might regulate the immune response and also modulate cytokine IL-6, which appears to be increased in COVID-19 infections. Therefore, in addition to the standard recommendations to prevent the infection, supplementation of vitamin D might be considered an approach to help counteracting this global epidemic. <p><a href="https://greenmedinfo.com/article/inhibitory-effects-vitamin-d-inflammation-and-il-6-release-further-support-cov" target="_blank">read more</a></p> https://greenmedinfo.com/article/inhibitory-effects-vitamin-d-inflammation-and-il-6-release-further-support-cov#comments Coronavirus Infection Inflammation Vitamin D Vitamin D Deficiency Anti-Inflammatory Agents Interleukin-6 Downregulation Review Wed, 09 Sep 2020 21:26:34 +0000 greenmedinfo 226585 at https://greenmedinfo.com Lactobacillus plantarum OLL2712 induces IL-10 production by intestinal dendritic cells. https://greenmedinfo.com/article/lactobacillus-plantarum-oll2712-induces-il-10-production-intestinal-dendritic- PMID:  Biosci Microbiota Food Health. 2020 ;39(2):39-44. Epub 2019 Nov 29. PMID: 32328399 Abstract Title:  OLL2712 induces IL-10 production by intestinal dendritic cells. Abstract:  Recently many researchers have revealed that certain lactic acid bacteria (LAB) have beneficial effects on the immune system. Understanding the mechanisms of how certain LAB induce immunomodulatory functions is important for the development of food ingredients that improve our health.OLL2712 has been shown to induce production of interleukin (IL)-10, an anti-inflammatory cytokine, by murine-induced dendritic cells (DCs) and peritoneal macrophages. However, it is probable that-induced DCs have different properties compared with intestinal DCs, and the effects of the LAB on intestinal DCs are not fully understood. In this report, we investigated whetherOLL2712 had efficacy for inducing intestinal DCs to produce IL-10and whether oral administration of the bacteria induced the same effect. Co-culture ofOLL2712 with purified DCs from the mesenteric lymph node (MLN) or Peyer&#039;s patch (PP) elevated IL-10 mRNA expression and protein production by both kinds of DCs. Addition of the LAB enhanced IL-10 production by T cells during antigen-specific responses in co-culture of MLN or PP DCs and T cells. Oral administration ofOLL2712 for 6 days increased IL-10 gene expression in MLN DCs, and upregulated IL-10 gene expression in PP DCs was observed 12 hr after oral administration of the LAB. Our results suggested thatOLL2712 could modulate immune responses by enhancing IL-10 production from intestinal DCs. <p><a href="https://greenmedinfo.com/article/lactobacillus-plantarum-oll2712-induces-il-10-production-intestinal-dendritic-" target="_blank">read more</a></p> https://greenmedinfo.com/article/lactobacillus-plantarum-oll2712-induces-il-10-production-intestinal-dendritic-#comments Inflammation Lactobacillus plantarum Immunomodulatory Interleukin-10 upregulation In Vitro Study Wed, 20 May 2020 18:47:35 +0000 greenmedinfo 220617 at https://greenmedinfo.com