Leg Ulcer https://greenmedinfo.com/taxonomy/term/2993/all en Application of topical hyperbaric oxygen therapy and medical active dressings in the treatment of arterial leg ulcers. https://greenmedinfo.com/article/application-topical-hyperbaric-oxygen-therapy-and-medical-active-dressings-tre PMID:  Sensors (Basel). 2023 Jun 14 ;23(12). Epub 2023 Jun 14. PMID: 37420748 Abstract Title:  Application of Topical Hyperbaric Oxygen Therapy and Medical Active Dressings in the Treatment of Arterial Leg Ulcers-A Pilot Study. Abstract:  Leg ulcers are a very serious worldwide medical problem. When the ulcer is extensive and deep the prognosis is usually unfavorable. The treatment requires comprehensive solutions that take into account modern specialized medical dressings, and more and more often, selected methods in the field of physical medicine. The study included 30 patients (13 women-43.4% and 17 men-56.6%) with chronic arterial ulcers of the lower limbs. The mean age of the treated patients was 65.63±8.77 years. Patients were randomly assigned to two study groups. In group 1 (16 patients), specialist ATRAUMAN Ag medical dressings and local hyperbaric oxygen therapy treatments were used. In group 2 (14 patients), only specialized ATRAUMAN Ag dressings were used. The treatment was carried out for 4 weeks. The progress of healing ulcers was assessed by using the planimetric method, while the intensity of pain ailments was assessed by the visual analog VAS scale. In both study groups, a statistically significant reduction in the mean surface area of the treated ulcers was obtained, respectively, from 8.53±1.71 cmto 5.55±1.11 cmin group 1 (<p><a href="https://greenmedinfo.com/article/application-topical-hyperbaric-oxygen-therapy-and-medical-active-dressings-tre" target="_blank">read more</a></p> https://greenmedinfo.com/article/application-topical-hyperbaric-oxygen-therapy-and-medical-active-dressings-tre#comments Leg Ulcer Wound Healing Hyperbaric Treatment Human Study Tue, 23 Jan 2024 15:11:03 +0000 greenmedinfo 286891 at https://greenmedinfo.com Daflon, a form of micronized diosmin and hesperidin, improves the healing of venous leg ulcers. https://greenmedinfo.com/article/daflon-form-micronized-diosmin-and-hesperidin-improves-healing-venous-leg-ulce PMID:  Angiology. 2005 Sep-Oct;56 Suppl 1:S33-9. PMID: 16193225 Abstract Title:  Daflon 500 mg and venous leg ulcer: new results from a meta-analysis. Abstract:  The objective of this study was to assess the effect of oral treatment with Daflon 500 mg (micronized purified flavonoid fraction [MPFF]) on leg ulcer healing. This study was conducted as a meta-analysis of randomized prospective studies using Daflon 500 mg as an adjunct to conventional treatment. Medical literature databases and the manufacturer&#039;s records were searched for relevant clinical trials. Five prospective, randomized, controlled studies in which 723 patients with venous ulcers were treated between 1996 and 2001 were identified. Conventional treatment (compression and local care) in addition to Daflon 500 mg 2 tablets daily was compared with conventional treatment plus placebo in two studies (n = 309), or with conventional treatment alone in three studies (n = 414). The primary end point was complete ulcer healing at 6 months. The results are expressed as a reduction in the relative risk (RRR) of healing with 95% confidence intervals (CI). Since, in the present case, the desired treatment effect is increased ulcer healing, RRR should be positive to indicate a benefit of adjunctive Daflon 500 mg over conventional therapy alone. Type 1 error was set at 5%. At 6 months, the chance of ulcer healing was 32% better in patients treated with adjunctive Daflon 500 mg than in those managed by conventional therapy alone (RRR, 32%; 95% CI, 3% to 70%). This difference was present from month 2 (RRR, 44%; 95% CI, 7% to 94%), and was associated with a shorter time to healing (16 weeks vs 21 weeks; p = 0.0034). The benefit of Daflon 500 mg was found in the subgroup of ulcers between 5 and 10 cm2 in area (RRR, 40%; 95% CI, 6% to 87%), as well as in patients with ulcers of 6 to 12 months&#039; duration (RRR, 44%; 95% CI, 6% to 97%). These results confirm that venous ulcer healing is accelerated by Daflon 500 mg treatment. Daflon 500 mg might be a useful adjunct to conventional therapy in large and longstanding ulcers that might be expected to heal slowly. https://greenmedinfo.com/article/daflon-form-micronized-diosmin-and-hesperidin-improves-healing-venous-leg-ulce#comments Diosmin Hesperidin Leg Ulcer Venous Ulcer Human Study Wed, 09 Sep 2009 17:40:36 +0000 greenmedinfo 46947 at https://greenmedinfo.com Enhancing wound healing in recalcitrant leg ulcers with aminolevulinic acid-mediated antimicrobial photodynamic therapy. https://greenmedinfo.com/article/enhancing-wound-healing-recalcitrant-leg-ulcers-aminolevulinic-acid-mediated-a PMID:  Photodiagnosis Photodyn Ther. 2020 Dec 17:102149. Epub 2020 Dec 17. PMID: 33346057 Abstract Title:  Enhancing wound healing in recalcitrant leg ulcers with aminolevulinic acid-mediated antimicrobial photodynamic therapy. Abstract:  Chronic leg ulcers affect millions of people around the world. It is imperative to search for alternative, effective treatments for such challenging ulcers. We reported the success of aminolevulinic acid-mediated antimicrobial photodynamic therapy (APDT) to enhance wound healing of chronic ulcers of 3 patients who were refractory to conventional treatments. These ulcers heal after one to three sessions of APDT and there was no recurrence for more than 29 months. Interestingly, no bacteria were isolated from the ulcers after APDT treatment. In vitro, APDT inactivated all bacteria isolated from the patients. APDT conditioned medium containing IL-6 enhanced keratinocyte migration. The results suggest in addition to bactericidal effects, APDT also alters the wound microenvironment. APDT may be an effective alternative treatment for patients with recalcitrant infected ulcers. <p><a href="https://greenmedinfo.com/article/enhancing-wound-healing-recalcitrant-leg-ulcers-aminolevulinic-acid-mediated-a" target="_blank">read more</a></p> https://greenmedinfo.com/article/enhancing-wound-healing-recalcitrant-leg-ulcers-aminolevulinic-acid-mediated-a#comments Leg Ulcer Wound Healing Photodynamic therapy Human Study Wed, 23 Dec 2020 19:53:02 +0000 greenmedinfo 231694 at https://greenmedinfo.com Irradiation with LED is a novel method of treatment of chronic wounds. https://greenmedinfo.com/article/irradiation-led-novel-method-treatment-chronic-wounds PMID:  Indian J Plast Surg. 2014 Sep-Dec;47(3):432-5. PMID: 25593435 Abstract Title:  Closure of chronic non healing ankle ulcer with low level laser therapy in a patient presenting with thalassemia intermedia: Case report. Abstract:  In this single case study, the possible effect of low-level laser therapy (LLLT) was explored in the form of light emitting diodes on a chronic non-healing wound of 6 months duration in an 18-year-old male patient suffering from thalassemia intermedia. After irradiation, with LLLT dosage of 17.3 J/cm(2) for 8 min for 2 weeks duration followed by proliferative dosage of 8.65-4.33 J/cm(2) for 4 min from 3(rd) week to 6(th) week for 2 min along with antibiotics vancomycin (15 mg/kg) and a combination of amoxicillin and clavulanic acid (1 g). Proliferation of healthy granulation tissue was observed with decrease in score of pressure ulcer scale with complete re-epithelialization eventually LLLT irradiation could be a novel method of treatment for chronic non-healing wound in a thalassemia intermedia patient and an useful adjunct to standard care of treatment of pressure ulcers. It is postulated that LED irradiation augments wound healing with an early closure and no recurrence at the irradiated site even after follow up of 6 months. https://greenmedinfo.com/article/irradiation-led-novel-method-treatment-chronic-wounds#comments Leg Ulcer Wound Healing Light-Emitting Diodes (LEDs) Therapy Human: Case Report Wed, 14 Oct 2015 00:46:34 +0000 greenmedinfo 121080 at https://greenmedinfo.com Manuka honey appears to be an effective antibacterial wound healing agent against MRSA-colonized leg ulcers. https://greenmedinfo.com/article/manuka-honey-appears-be-effective-antibacterial-wound-healing-agent-against-mr PMID:  J Dermatolog Treat. 2001 Mar;12(1):33-6. PMID: 12171686 Abstract Title:  Healing of an MRSA-colonized, hydroxyurea-induced leg ulcer with honey. Abstract:  BACKGROUND: With the everincreasing emergence of antibiotic-resistant pathogens, in particular methicillin-resistant Staphylococcus aureus (MRSA) in leg ulcers, a means of reducing the bacterial bioburden of such ulcers, other than by the use of either topical or systemic antibiotics, is urgently required. METHODS: We report the case of an immunosuppressed patient who developed a hydroxyurea-induced leg ulcer with subclinical MRSA infection which was subsequently treated with topical application of manuka honey, without cessation of hydroxyurea or cyclosporin. RESULTS: MRSA was eradicated from the ulcer and rapid healing was successfully achieved. CONCLUSION: Honey is recognized to have antibacterial properties, and can also promote effective wound healing. A traditional therapy, therefore, appears to have enormous potential in solving new problems. https://greenmedinfo.com/article/manuka-honey-appears-be-effective-antibacterial-wound-healing-agent-against-mr#comments Leg Ulcer Manuka Honey MRSA Staphylococcus aureus: Methicillin-resistant (MRSA) Anti-Bacterial Agents Antibiotic Resistance Human Study Mon, 20 Apr 2009 06:10:50 +0000 greenmedinfo 41892 at https://greenmedinfo.com Patients with leg ulcers have more vitamin D deficiency. https://greenmedinfo.com/article/patients-leg-ulcers-have-more-vitamin-d-deficiency PMID:  Rev Col Bras Cir. 2012 ;39(5):401-7. PMID: 23174792 Abstract Title:  Vitamin D and skin repair: a prospective, double-blind and placebo controlled study in the healing of leg ulcers. Abstract:  OBJECTIVE: To analyze the relation between vitamin D insufficiency and wound healing in patients with venous ulcers; to correlate vitamin D insufficiency with characteristics of the ulcer (size and pain) and to evaluate if reposition of vitamin D in these subjects expedites ulcer healing.METHODS: We selected 26 patients with leg ulcers, and 26 control patients without ulcers, matched for gender, age, systemic arterial hypertension and tobacco use. The venous ulcer group was divided in two subgroups: one that received placebo (nine patients) and other receiving vitamin D, 50.000 IU per week over two months (13 patients). Blood was collected for 25 OH vitamin D dosage before and after the medication. In the ulcer group, we obtained data concerning demographics, leg ulcer size, as well as pain severity, measured by an analogical visual scale. Data was grouped in contingency and frequency tables, the tests of Fisher and chi-squared being used for nominal variables and Mann-Whitney for numerical variables. The adopted significance was of 5%.RESULTS: We found vitamin D insufficiency in the great majority of the patients. The median level in the ulcer group was 17.05 ng/dl and 22.75 ng/dl in the group without ulcer (p=0,0182) No relation was found between the ulcer size without treatment and the level of vitamin D. After treatment, the average size of the ulcer changed from 25 cm²to 18 cm²in the patients that took vitamin D and from 27 cm²to 24,5 cm²in the placebo group (p=0,7051 and p=0,7877, respectively). Considering the variability of the size of the ulcer in the treatment group versus placebo group, the average size was equal to -0,75 cm²in the first group and +4cm²in the second (p=0,0676)CONCLUSION: Patients with leg ulcers have more vitamin D deficiency. No difference in the ulcer characteristics was noted between those with and without vitamin D deficiency. There was a trend toward a better healing in those with vitamin D reposition. <p><a href="https://greenmedinfo.com/article/patients-leg-ulcers-have-more-vitamin-d-deficiency" target="_blank">read more</a></p> https://greenmedinfo.com/article/patients-leg-ulcers-have-more-vitamin-d-deficiency#comments Leg Ulcer Vitamin D Vitamin D Deficiency Wound Healing Risk Factors Human Study Sat, 24 Feb 2024 04:10:07 +0000 greenmedinfo 288861 at https://greenmedinfo.com Using activated carbon cloth dressing could be a good way to reduce infection in chronic leg ulcers. https://greenmedinfo.com/article/using-activated-carbon-cloth-dressing-could-be-good-way-reduce-infection-chron PMID:  Br J Nurs. 2016 Jun 23 ;25(12):S38-44. PMID: 27345081 Abstract Title:  Reducing infection in chronic leg ulcers with an activated carbon cloth dressing. Abstract:  Zorflex is a new type of antimicrobial dressing composed of 100% activated carbon cloth. It attracts and binds bacteria to its surface, enabling them to be safely removed at dressing change. It has no reported toxic effects and can be used on either a short-or long-term basis. This article describes 4 case studies in which patients with recalcitrant chronic venous leg ulcers that were prone to recurrent infection were treated with the activated carbon cloth dressing. All of the wounds had failed to respond to antimicrobial dressings containing silver, iodine or polyhexamethylene biguanide (PHMB), and were heavily exuding and painful. In all cases, the signs of infection reduced significantly within 4 weeks, resulting in good patient outcomes. https://greenmedinfo.com/article/using-activated-carbon-cloth-dressing-could-be-good-way-reduce-infection-chron#comments Charcoal Leg Ulcer Wound Healing Significant Treatment Outcome Human Study Wed, 13 Jul 2016 01:58:58 +0000 greenmedinfo 130066 at https://greenmedinfo.com