Bone Marrow Suppression https://greenmedinfo.com/taxonomy/term/30357/all en A combination of two traditional Chinese herbs chuan xiong and angelica induce the expression of erythropoietin in a dose dependent manner in cell culture. https://greenmedinfo.com/article/combination-two-traditional-chinese-herbs-chuan-xiong-and-angelica-induce-expr PMID:  Planta Med. 2010 Oct;76(14):1525-9. Epub 2010 Mar 22. PMID: 20309798 Abstract Title:  Fo Shou San, an ancient herbal decoction prepared from Rhizoma Chuanxiong and Radix Angelicae Sinensis, stimulates the production of hemoglobin and erythropoietin in cultured cells. Abstract:  Fo Shou San (FSS) is an ancient herbal decoction comprised of Rhizoma Chuanxiong (RC; Chuanxiong) and Radix Angelicae Sinensis (RAS; Danggui) in a ratio of 2 : 3. It is mainly prescribed for patients having a blood deficiency. This combination is considered the most popular herb pair among Chinese medicines; however, the rationale of having these two chemically similar herbs within the decoction has historically not been made clear. Here, we attempted to reveal the chemical and biological properties of this decoction as a means to deduce its mechanism of action. The effects of FSS were determined in different cell culture models. With respect to stimulation of blood circulation, FSS inhibited ADP-mediated platelet aggregation in a dose-dependent manner. In order to reveal the hematopoietic effect of this decoction, FSS was applied onto cultured K562 human leukemia cells and Hep3B human hepatocellular carcinoma cells. Application of FSS in cultured K562 cells inhibited cell proliferation and subsequently induced the production of hemoglobin. Additionally, the mRNA expression of erythropoietin (EPO) was induced in a dose-dependent manner when FSS was applied to Hep3B cells. The current results reveal the effects of FSS in different cell models, paving a direction for mechanistic studies. https://greenmedinfo.com/article/combination-two-traditional-chinese-herbs-chuan-xiong-and-angelica-induce-expr#comments Anemia: Bone Marrow Suppression Associated Anemia: Iron Deficiency Associated Angelica Bone Marrow Suppression Chuan Xiong Erythropoietic Hematopoietic In Vitro Study Tue, 03 May 2011 18:37:59 +0000 greenmedinfo 63528 at https://greenmedinfo.com Angelica polysaccharides promote hematopoiesis. https://greenmedinfo.com/article/angelica-polysaccharides-promote-hematopoiesis PMID:  Zhongguo Zhong Yao Za Zhi. 2009 Dec;34(24):3268-71. PMID: 20353016 Abstract Title:  [Effect of angelica polysaccharides co-erythropoietin on JAK2/STAT5 signal transduction pathway in hematopoietic stem/progenitor cells]. Abstract:  OBJECTIVE: To investgate the signal transduction and regulation in erythropoiesis by angelica polysaccharides (APS) to clarify the mechanism for APS promoting hematopoiesis.METHOD: The mononuclear cells were isolated from foetus umbilic cord blood (mononuclear cells, MNCs), after MNCs were incubated in the presence of APS group (APS 200 mg x L(-1)) and control group for 24 h, the cells were stimulated with Epo (5 U x mL(-1)) for 0, 2, 5, 30 min, respectively. STAT5 was measured by ICC and laser confocal scanning microscope. JAK2, STAT5 in nucleus and cytoplasm were measured by western-blotting-ECL.RESULT: Angelica polysaccharide cooperated with Epo has significant impact on the expression of STAT5. The expression of STAT5 has significant difference between APS group and the control group at 4 time points. JAK2, STAT5 expressed in cytoplasm and nuclear of APS group significantly increased as compared to those of control group, and they expressed the strongest at 5 min.CONCLUSION: JAK2, STAT5 signal transduction molecule plays an important role in the effect of APS cooperated with Epo on promoting hematopoiesis. https://greenmedinfo.com/article/angelica-polysaccharides-promote-hematopoiesis#comments Angelica Bone Marrow Suppression Erythropoietic Hematopoietic In Vitro Study Tue, 03 May 2011 18:43:50 +0000 greenmedinfo 63529 at https://greenmedinfo.com Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice. https://greenmedinfo.com/article/chlorella-vulgaris-restores-bone-marrow-cellularity-and-cytokine-production-le PMID:  Food Chem Toxicol. 2011 Jul 26. Epub 2011 Jul 26. PMID: 21820028 Abstract Title:  Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice. Abstract:  Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit(+)Lin(-)), granulocyte-macrophage progenitors (Gr1(+)Mac1(+)) and total bone marrow cellularity. In mice gavage-treated daily with 50mg/kg dose of CV for 10days, concomitant to a continuous offering of 1300ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1α, TNF-α, IFN-γ, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-γ, IL-1α and TNF-α and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. The activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-γ, IL-1α, TNF-α and NK cells activity in normal mice. In addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV. https://greenmedinfo.com/article/chlorella-vulgaris-restores-bone-marrow-cellularity-and-cytokine-production-le#comments Bone Marrow Suppression Chlorella (Algae) Lead Poisoning Low Immune Function: Natural Killer Cells Immunostimulatory Immunotoxic Interleukin-1 alpha upregulation Lead Tumor Necrosis Factor (TNF) Alpha Upregulation Animal Study Fri, 12 Aug 2011 18:12:19 +0000 greenmedinfo 68065 at https://greenmedinfo.com Ciprofloxacin-induced bone marrow depression has been reported. https://greenmedinfo.com/article/ciprofloxacin-induced-bone-marrow-depression-has-been-reported PMID:  Postgrad Med J. 1999 Sep;75(887):571-3. PMID: 10616701 Abstract Title:  Ciprofloxacin-induced bone marrow depression. Abstract:  Ciprofloxacin, a broad-spectrum fluoroquinolone antibacterial agent, is generally considered to be a safe drug. However, occasionally it may have life-threatening complications. Two instances of bone marrow failure following use of ciprofloxacin are reported. In one case, the bone marrow reverted to normal following withdrawal of the drug. In the other case, the patient succumbed to irreversible bone marrow depression leading to severe thrombocytopenia and uncontrolled bleeding. This could have been an idiosyncratic reaction. https://greenmedinfo.com/article/ciprofloxacin-induced-bone-marrow-depression-has-been-reported#comments Bone Marrow Suppression Myelotoxicity Cipro Human Study Fri, 09 Apr 2010 19:17:56 +0000 greenmedinfo 53708 at https://greenmedinfo.com