Myopericarditis https://greenmedinfo.com/taxonomy/term/30542/all en A case report: symptomatic pericarditis post-COVID-19 vaccination. https://greenmedinfo.com/article/case-report-symptomatic-pericarditis-post-covid-19-vaccination PMID:  Eur Heart J Case Rep. 2021 Oct ;5(10):ytab375. Epub 2021 Sep 24. PMID: 34693198 Abstract Title:  A case report: symptomatic pericarditis post-COVID-19 vaccination. Abstract:  BACKGROUND: Thepandemic has led to the rapid development ofvaccine. The Centers for Disease Control and Prevention (CDC) has recently reported increase in myopericarditis incidence post-COVID-19 vaccination. Post-vaccination myopericarditis as side effect has been reported, however, is infrequent. We described a case of pericarditis post-first dose of Pfizer-BioNTech vaccine.CASE SUMMARY: A patient presented with typical symptoms of pericarditis and related electrocardiogram and echocardiogram changes, 7 days post receiving the first dose ofvaccine. No other causes were identified from series of investigations. Patient had good symptomatic relief with non-steroidal anti-inflammatory medication.DISCUSSION: The incidence of pericarditis post-vaccination is rare, with limited reporting in previous literatures. No causal relationship has yet to be established due to small number of cases. The benefits ofvaccination currently outweigh the side effect profile and are recommended as the first-line approach to control the current pandemic. <p><a href="https://greenmedinfo.com/article/case-report-symptomatic-pericarditis-post-covid-19-vaccination" target="_blank">read more</a></p> https://greenmedinfo.com/article/case-report-symptomatic-pericarditis-post-covid-19-vaccination#comments Myopericarditis Vaccine-induced Toxicity Cardiotoxic Vaccination: COVID-19 Human: Case Report Sun, 31 Jul 2022 21:37:04 +0000 greenmedinfo 261339 at https://greenmedinfo.com A report of 2 cases of myopericarditis after Vaccinia virus (smallpox) immunization. https://greenmedinfo.com/article/report-2-cases-myopericarditis-after-vaccinia-virus-smallpox-immunization PMID:  WMJ. 2011 Dec ;110(6):291-4. PMID: 22324207 Abstract Title:  A report of 2 cases of myopericarditis after Vaccinia virus (smallpox) immunization. Abstract:  BACKGROUND: To counter the possibility of smallpox being used as a biological weapon, in 2002 the US government restarted a smallpox vaccination campaign. Myopericarditis is a possible cardiac complication of smallpox vaccination. We report 2 cases of vaccine-associated myopericarditis in military recruits who were treated at our facility. Chest pain, shortness of breath, and electrocardiographic changes of pericarditis, with a recent history of smallpox vaccination, were useful in making the diagnosis of probable post-vaccinial myopericarditis. Nonsteroidal, anti-inflammatory drugs (NSAIDs) were used to manage myopericarditis. Both patients had complete resolution of symptoms and electrocardiographic changes and subsequently returned to active duty.CONCLUSION: Myopericarditis should be suspected when patients with recent history of smallpox vaccination present with chest pain or shortness of breath. Nonsteroidal anti-inflammatory drugs are useful in the management of post-vaccinial myopericarditis. <p><a href="https://greenmedinfo.com/article/report-2-cases-myopericarditis-after-vaccinia-virus-smallpox-immunization" target="_blank">read more</a></p> https://greenmedinfo.com/article/report-2-cases-myopericarditis-after-vaccinia-virus-smallpox-immunization#comments Myopericarditis Vaccine-induced Toxicity Vaccination: Smallpox Human: Case Report Sun, 21 Oct 2018 18:37:15 +0000 greenmedinfo 172800 at https://greenmedinfo.com Acute myopericarditis after multiple vaccinations in an adolescent. https://greenmedinfo.com/article/acute-myopericarditis-after-multiple-vaccinations-adolescent PMID:  Pediatrics. 2007 Jun ;119(6):e1400-3. Epub 2007 May 21. PMID: 17515437 Abstract Title:  Acute myopericarditis after multiple vaccinations in an adolescent: case report and review of the literature. Abstract:  We report a case of postvaccination acute myopericarditis in an adolescent. The patient presented with acute chest pain, diffuse ST-segment elevation, and elevated cardiac enzyme levels. Cardiac MRI was consistent with acute myocarditis. He recovered within a few days with nonsteroidal antiinflammatory treatment and remains clinically stable, with improvement of MRI findings at the 10-week follow-up. Postvaccination cases of myopericarditis reported in the pediatric literature are also reviewed. <p><a href="https://greenmedinfo.com/article/acute-myopericarditis-after-multiple-vaccinations-adolescent" target="_blank">read more</a></p> https://greenmedinfo.com/article/acute-myopericarditis-after-multiple-vaccinations-adolescent#comments Myopericarditis Vaccine-induced Toxicity Vaccination: All Human: Case Report Review Sun, 21 Oct 2018 15:26:49 +0000 greenmedinfo 172790 at https://greenmedinfo.com Among US military personnel vaccinated against smallpox, myopericarditis occurred at a rate of 1 per 12,819 primary vaccinees, and 3.6 fold higher in those without previous vaccinia vaccination. https://greenmedinfo.com/article/among-us-military-personnel-vaccinated-against-smallpox-myopericarditis-occurr PMID:  JAMA. 2003 Jun 25;289(24):3283-9. PMID: 12824210 Abstract Title:  Myopericarditis following smallpox vaccination among vaccinia-naive US military personnel. Abstract:  CONTEXT: In the United States, the annual incidence of myocarditis is estimated at 1 to 10 per 100,000 population. As many as 1% to 5% of patients with acute viral infections involve the myocardium. Although many viruses have been reported to cause myopericarditis, it has been a rare or unrecognized event after vaccination with the currently used strain of vaccinia virus (New York City Board of Health). OBJECTIVE: To describe a series of probable cases of myopericarditis following smallpox vaccination among US military service members reported since the reintroduction of vaccinia vaccine. DESIGN, SETTING, PARTICIPANTS: Surveillance case definitions are presented. The cases were identified either through sentinel reporting to US military headquarters surveillance using the Defense Medical Surveillance System or reports to the Vaccine Adverse Event Reporting System using International Classification of Diseases, Ninth Revision. The cases occurred among individuals vaccinated from mid-December 2002 to March 14, 2003. MAIN OUTCOME MEASURE: Elevated serum levels of creatine kinase (MB isoenzyme), troponin I, and troponin T, usually in the presence of ST-segment elevation on electrocardiogram and wall motion abnormalities on echocardiogram. RESULTS: Among 230,734 primary vaccinees, 18 cases of probable myopericarditis after smallpox vaccination were reported (an incidence of 7.8 per 100,000 over 30 days). No cases of myopericarditis following smallpox vaccination were reported among 95,622 vaccinees who were previously vaccinated. All cases were white men aged 21 years to 33 years (mean age, 26.5 years), who presented with acute myopericarditis 7 to 19 days following vaccination. A causal relationship is supported by the close temporal clustering (7-19 days; mean, 10.5 days following vaccination), wide geographic and temporal distribution, occurrence in only primary vaccinees, and lack of evidence for alternative etiologies or other diseases associated with myopericarditis. Additional supporting evidence is the observation that the observed rate of myopericarditis among primary vaccinees is 3.6-fold (95% confidence interval, 3.33-4.11) higher than the expected rate among personnel who were not vaccinated. The background incidence of myopericarditis did not show statistical significance when stratified by age (20-34 years: 2.18 expected cases per 100,000; 95% confidence interval [CI], 1.90-2.34), race (whites: 1.82 per 100,000; 95% CI, 1.50-2.01), and sex (males: 2.28 per 100,000; 95% CI, 2.04-2.54). CONCLUSION: Among US military personnel vaccinated against smallpox, myopericarditis occurred at a rate of 1 per 12 819 primary vaccinees. Myopericarditis should be considered an expected adverse event associated with smallpox vaccination. Clinicians should consider myopericarditis in the differential diagnosis of patients presenting with chest pain 4 to 30 days following smallpox vaccination and be aware of the implications as well as the need to report this potential adverse advent. https://greenmedinfo.com/article/among-us-military-personnel-vaccinated-against-smallpox-myopericarditis-occurr#comments Myopericarditis Vaccination: All Vaccination: Smallpox Human Study Sat, 17 Apr 2010 14:12:09 +0000 greenmedinfo 54942 at https://greenmedinfo.com An economic analysis of mass smallpox vaccination reveals that cardiovascular adverse events would be sizeable and costly. https://greenmedinfo.com/article/economic-analysis-mass-smallpox-vaccination-reveals-cardiovascular-adverse-eve PMID:  J Rheumatol. 1994 Jul;21(7):1305-9. PMID: 18284356 Abstract Title:  Economics of cardiac adverse events after smallpox vaccination: lessons from the 2003 US Vaccination Program. Abstract:  Of&gt;39,000 civilian public health responders vaccinated against smallpox in 2003, 203 reported cardiovascular adverse events (CAEs). An association exists between the US vaccinia strain and myocarditis and/or pericarditis (&quot;myo/pericarditis&quot; [MP]). Other associations are inconclusive. We used surveillance and follow-up survey data of CAE case patients to estimate the resources used during the 2003 smallpox vaccination program and used a probabilistic model to estimate the potential costs of CAEs in a mass vaccination campaign. For every million adult vaccinees, 3001 CAEs (including 351 MP cases) would occur, with&gt;92% in revaccinees. CAEs would require a median of 5934 outpatient visits, 1786 emergency department visits, 533 days in general wards, 132 days in intensive care units, 5484 cardiac enzymes tests, 3504 electrocardiograms, 3049 chemistry tests, 2828 complete blood counts, and 1444 transthoracic echocardiograms, among other procedures. CAEs would reduce productivity (15,969 work days lost) and cost $11 per vaccinee. In a mass vaccination campaign, the care of a sizable number of CAEs would be resource intensive. https://greenmedinfo.com/article/economic-analysis-mass-smallpox-vaccination-reveals-cardiovascular-adverse-eve#comments Myocarditis Myopericarditis Pericarditis Vaccination: All Vaccination: Smallpox Human Study Sat, 17 Apr 2010 14:28:17 +0000 greenmedinfo 54945 at https://greenmedinfo.com Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in mouse model. https://greenmedinfo.com/article/intravenous-injection-covid-19-mrna-vaccine-can-induce-acute-myopericarditis-m PMID:  Clin Infect Dis. 2021 Aug 18. Epub 2021 Aug 18. PMID: 34406358 Abstract Title:  Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in mouse model. Abstract:  BACKGROUND: Post-vaccination myopericarditis is reported after immunization with COVID-19 mRNA-vaccines. The effect of accidental intravenous injection of this vaccine on the heart is unknown.METHODS: We compared the clinical manifestations, histopathological changes, tissue mRNA expression and serum levels of cytokine/chemokine in Balb/c mice at different time points after intravenous(IV) or intramuscular(IM) vaccine injection with normal saline(NS) control.RESULTS: Though significant weight loss and higher serum cytokine/chemokine levels were found in IM group at 1 to 2 days post-injection(dpi), only IV group developed histopathological changes of myopericarditis as evidenced by cardiomyocyte degeneration, apoptosis and necrosis with adjacent inflammatory cell infiltration and calcific deposits on visceral pericardium, while evidence of coronary artery or other cardiac pathologies was absent. SARS-CoV-2 spike antigen expression by immunostaining was occasionally found in infiltrating immune cells of the heart or injection site, in cardiomyocytes and intracardiac vascular endothelial cells, but not skeletal myocytes. The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks and were markedly aggravated by a second IM- or IV-booster dose. Cardiac tissue mRNA expression of IL-1β, IFN-β, IL-6 and TNF-α increased significantly from 1dpi to 2dpi in IV but not IM group, compatible with presence of myopericarditis in IV group. Ballooning degeneration of hepatocytes was consistently found in IV group. All other organs appeared normal.CONCLUSIONS: This study provided in-vivo evidence that inadvertent intravenous injection of COVID-19 mRNA-vaccines may induce myopericarditis. Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk. <p><a href="https://greenmedinfo.com/article/intravenous-injection-covid-19-mrna-vaccine-can-induce-acute-myopericarditis-m" target="_blank">read more</a></p> https://greenmedinfo.com/article/intravenous-injection-covid-19-mrna-vaccine-can-induce-acute-myopericarditis-m#comments Inflammation Myopericarditis Vaccination: Coronavirus Cardiotoxic Inflammatory Vaccination: COVID-19 Animal Study Wed, 29 Sep 2021 00:36:11 +0000 greenmedinfo 246528 at https://greenmedinfo.com Myocarditis and pericarditis have been reported following smallpox vaccination in Europe, Australia and the United States. https://greenmedinfo.com/article/myocarditis-and-pericarditis-have-been-reported-following-smallpox-vaccination PMID:  Clin Infect Dis. 2008 Mar 15;46 Suppl 3:S242-50. PMID: 18284365 Abstract Title:  Myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination among civilians in the United States, January-October 2003. Abstract:  Myocarditis was reported after smallpox vaccination in Europe and Australia, but no association had been reported with the US vaccine. We conducted surveillance to describe and determine the frequency of myocarditis and/or pericarditis (myo/pericarditis) among civilians vaccinated during the US smallpox vaccination program between January and October 2003. We developed surveillance case definitions for myocarditis, pericarditis, and dilated cardiomyopathy after smallpox vaccination. We identified 21 myo/pericarditis cases among 37,901 vaccinees (5.5 per 10,000); 18 (86%) were revacinees, 14 (67%) were women, and the median age was 48 years (range, 25-70 years). The median time from vaccination to onset of symptoms was 11 days (range, 2-42 days). Myo/pericarditis severity was mild, with no fatalities, although 9 patients (43%) were hospitalized. Three additional vaccinees were found to have dilated cardiomyopathy, recognized within 3 months after vaccination. We describe an association between smallpox vaccination, using the US vaccinia strain, and myo/pericarditis among civilians. https://greenmedinfo.com/article/myocarditis-and-pericarditis-have-been-reported-following-smallpox-vaccination#comments Myocarditis Myopericarditis Pericarditis Vaccination: All Vaccination: Smallpox Human Study Sat, 17 Apr 2010 14:25:14 +0000 greenmedinfo 54944 at https://greenmedinfo.com Smallpox vaccination has been associated with cardiac complications such as myopericarditis. https://greenmedinfo.com/article/smallpox-vaccination-has-been-associated-cardiac-complications-such-myopericar PMID:  South Med J. 2009 May 7. Epub 2009 May 7. PMID: 19434043 Abstract Title:  Cardiac complications after smallpox vaccination. Abstract:  In 2002, the US Federal government initiated a campaign to vaccinate military personnel and members of the civilian population against smallpox to counter a possible bioterrorism attack. More than 1,200,000 military personnel and approximately 40,000 civilians have been vaccinated since that time. The incidence of myopericarditis in these vaccinees has clearly exceeded calculated background rates and has prompted discussion about cardiac inflammation and other potential vaccine-associated cardiac complications such as dilated cardiomyopathy (DCM) and myocardial ischemia. Although it seems reasonable to predict that some cases of smallpox-associated myopericarditis will progress to DCM, only small numbers have been documented so far, and a causal relationship is difficult to ascertain. With regard to myocardial ischemia, both historical and current data do not suggest a causal association with the vaccine. We describe a case report of myopericarditis following smallpox immunization and provide a review of all cardiac complications associated with vaccination. https://greenmedinfo.com/article/smallpox-vaccination-has-been-associated-cardiac-complications-such-myopericar#comments Myocarditis Myopericarditis Pericarditis Vaccination: All Vaccination: Smallpox Human Study Sat, 17 Apr 2010 14:08:50 +0000 greenmedinfo 54941 at https://greenmedinfo.com